CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
·
2020
·Vol. 37
·期 3
·411-418
·
IF 1.063
Huang Libing,Liu Yueqi,Sang Xinyu,Song Jinghui,Hu Ping,Liu Yong
T he alum-borneol nanoemulsion(ABN), which combines the mineral medicine alum and the botanical medicine borneol, has been applied for approximately 40 years in the clinical treatment of burns, scalds, radiation dermatitis and shingles, and has a good curative effect. However, the current formula and dosage form of ABN pose problems of low borneol content and ease of precipitation, which greatly affects the efficacy of the drug. In this study, polyvinylpyrrolidone(PVP) was selected as a carrier mixed with different proportions of alum and borneol to produce alum-borneol-PVP fibers(ABPF) by electrospinning. The results showed that the stable system with good drug dispersion was 2:3(alum:borneol). The dissolution content of borneol from the ABPF was about 80% in 4 h, which was much higher than that of the alum-borneol liquid(ABL) and ABN. The ABPF membrane showed a more significant inhibitory effect on Staphylococcus aureus than the ABL and ABN. The composite fiber markedly increased the drug content of borneol, which was 800 times of that in ABN. The fiber had a higher solubility than the nanoemulsion in vitro , which is of great importance for the development of new forms for the clinical application of alum and borneol.
研究领域:
药剂学
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材料科学
·
生物医学工程
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产品关联
DOI
高影响因子
Materials Today Chemistry
·
2025
·
IF 6.7
Yuansen Xiao,Huimin Li,Zheng Wang,Zhihan Liu,Chenyang Li,Bin Wu,Longfei Yan,Huidong Zheng,Fuweng Zhang
Borneol synthesis faces challenges from co-generated impurities (isoborneol/camphor) and competing dehydration/dehydrogenation during isomerization. Here, Co/TiO 2 is demonstrated as a selective catalyst for isoborneol-to-borneol isomerization, effectively suppressing structural degradation. Controlled acidity and cobalt dispersion are identified as critical factors: TiO 2 's moderate acidity promotes isomerization, while strongly acidic supports (e.g., Mordenite) favor dehydration to camphene. Reduced cobalt particle size enhances active-site accessibility, lowering activation energy and boosting borneol yield. A one-pot two-step process achieves >62 % borneol content with <0.5 % camphor, meeting ChPC purity standards. This strategy bypasses traditional purification bottlenecks, offering a scalable route for high-purity borneol synthesis. The mechanistic insights into acid strength and metal dispersion provide a framework for rational catalyst design in industrial isomerization applications.
研究领域:
催化
·
有机化学
·
材料科学
·
化学工程
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产品关联
DOI
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 35
·28659-28665
·
IF 4.6
Chenyang Li,Zhihan Liu,Huimin Li,Yunsen Xiao,Ying Huang,Yuting Lin,Jie Liu,Bin Wu,Fuweng Zhang,Huidong Zheng,Longfei Yan
Borneol, a pharmaceutically important monoterpenoid, has emerged as a key ingredient in modern medicinal formulations. Here, we report a highly efficient heterogeneous catalytic system using transition metal-doped Co/TiO2 catalysts for the continuous-flow isomerization of isoborneol to borneol. Through systematic screening of bimetallic combinations, we demonstrate that Cu and Ni dopants synergistically enhance the redox properties of Co species, particularly improving hydrogenation–dehydrogenation efficiency in the isomerization of isoborneol. The optimized 1Cu–3Co/TiO2 catalyst (Cu : Co = 1 : 3 mass ratio) enabled a two-stage continuous-flow system, achieving 58% molar yield of borneol with <0.4% camphor byproduct formation after solvent removal. Remarkably, the catalyst maintained >99% metal retention during a total of 200 h of continuous reaction. This work not only provides fundamental insights into promoter effects in bimetallic catalysis but also establishes a commercially viable platform for continuous production of high-purity botanical therapeutics.
研究领域:
催化化学
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化学合成
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药物化学
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材料科学
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反应工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
·
2024
·
IF 2.1
Lifen Xiao,Hongwei Peng,Xiaoming Zhu,Yang Huang,Geng Huang,Wei Li
Endo-norbornene derivatives are much cheaper and more accessible. However, it is difficult to prepare endo-polynorbornenes with ultra-high molecular weight (UHMW) by ring opening metathesis polymerization (ROMP) owing to the low activity. The molecular weight of poly(endo-NB-2OH)n could only reach to 309.1 kg mol−1 for 24 h via ROMP. While, UHMW poly(endo-NB-2OH)m was prepared by combining ROMP and acyclic metathesis reaction in much shorter time. The effects of residual monomer, amount of H2SO4, concentration, temperature and reaction time were investigated in depth. The UHMW P(endo-NB-2OH)m (Mn=2645.5 kg mol−1, PDI = 1.74) could be obtained at 80 °C for 5 min with H2SO4/G3 as 10/1 and concentration of 0.1 M. Moreover, UHMW P(endo-NBI-OH)m(Mn=1114.2 kg mol−1, PDI = 1.95) was also successfully prepared by this method. However, the H2SO4/G3 should increase to 30/1, and reacted for 45 min owing to the steric resistance of the cyclic dicarboximide. For P(exo-NBI-OH)n with lower activity, reaction time should prolong to 3 h to obtain UHMW P(exo-NBI-OH)m(Mn=1716.7 kg mol−1, PDI = 1.93). Finally, UHMW P(endo-NB-2alkyne)m, P(endo-NBI-alkyne)m, and P(exo-NBI-alkyne)m were successfully prepared via post-modification. Acyclic metathesis reaction is a robust and universal reaction to prepare other functional UHMW polynorbornenes, especially for the UHMW endo-polynorbornenes, which could not be prepared by ROMP efficiently.
研究领域:
高分子化学
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有机合成
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功能高分子
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材料科学
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聚合物化学
✓ 已验证
DOI
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 4
·1875
·
IF 4.6
Zhong-Lei Meng,Rong-Xiu Qin,Ru-Si Wen,Gui-Qing Li,Zhong-Yun Liang,Jun-Kang Xie,Yong-Hong Zhou,Zhang-Qi Yang
This study examined the preparation of isobornyl acetate/isoborneol from camphene using an α-hydroxyl carboxylic acid (HCA) composite catalyst. Through the study of the influencing factors, it was found that HCA and boric acid exhibited significant synergistic catalysis. Under optimal conditions, when tartaric acid–boric acid was used as the catalyst, the conversion of camphene and the gas chromatography (GC) content and selectivity of isobornyl acetate were 92.9%, 88.5%, and 95.3%, respectively. With the increase in the ratio of water to acetic acid, the GC content and selectivity of isobornol in the product increased, but the conversion of camphene decreased. The yield of isobornol was increased by adding ethyl acetate or titanium sulfate/zirconium sulfate to form a ternary composite catalyst. When a ternary complex of titanium sulfate, tartaric acid, and boric acid was used as the catalyst, the GC content of isobornol in the product reached 55.6%. Under solvent-free conditions, mandelic acid–boric acid could catalyze the hydration reaction of camphene, the GC content of isoborneol in the product reached 26.1%, and the selectivity of isoborneol was 55.9%. The HCA–boric acid composite catalyst can use aqueous acetic acid as a raw material, which is also beneficial for the reuse of the catalyst.Keywords:α-hydroxyl carboxylic acid;camphene esterification reaction;camphene hydration reaction;green synthesis
研究领域:
化学
·
催化
·
有机合成
·
绿色化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2011
·Vol. 212
·期 21
·2378-2388
·
IF 2.437
Bin Yuan,Xiaohui He,Yiwang Chen,Kaiti Wang
Covalently immobilized silica-supported acetylacetonate dichloride palladium(II) precatalyst is prepared by the reaction of silica particles grafted acetylacetonate ligand further exchange with [Et 4 N] 2 PdCl 4 . The silica-supported catalyst is used in slurry polymerizations of norbornene (NB) to afford a highly productive NB addition polymerization system in combination with B(C 6 F 5 ) 3 cocatalyst. It exhibits productivity of 84 kg of PNB (mol Pd) −1 h −1 at the initial activity, and the catalyst deactivation kinetics in the early stage of polymerization are fitted well by the first-order deactivation kinetics. The obtained vinyl-type polynorbornene is confirmed to be nanosilica hybrid PNB nanocomposite by SEM, TEM with an energy dispersive spectrometer, TGA, and XRD.
研究领域:
高分子化学
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纳米复合材料
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催化化学
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有机金属化学
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材料科学
✓ 已验证
DOI
高影响因子
DRUG DELIVERY
·
2019
·
IF 3.829
Yujia Zhang,Nan Zhang,Hui Song,He Li,Jin Wen,Xiaochuan Tan,Wensheng Zheng
Gout is a kind of joint disease characterized by the accumulation of monosodium urate (MSU) crystals in the joint and its surrounding tissue, causing persistent hyperuricemia. Colchicine is the first choice of treatment for acute gout attacks. Due to strong toxicity of colchicines oral tablets, there are high fluctuations of blood drug concentration and serious irritation of gastrointestinal tract, and hence a transdermal preparation can help to slow down the blood drug concentration, reduce the frequency of drug taking, and improve the patients' compliance of the drug. The ethosome is a lipid carrier with high concentration of ethanol and has been proved to promote the penetration of drugs into the skin. Borneol (BO) is an excellent penetration enhancer in Chinese medicine, which can promote the entry of drugs into the skin. This paper prepared the borneol-physically-modified colchicine ethosome (COL-bpES) and used the prepared borneol-dioleoyl phosphoethanloamine (BO-DOPE) to prepare borneol-chemically-modified colchicine ethosome (COL-bcES). Compared to the free colchicine aqueous solution (free COL) and normal colchicine ethosome (COL-ES), the borneol-modified colchicine ethosome (COL-bES) demonstrated better drug penetration effect, while the particle size of the COL-bcES was lower than that of the COL-bpES. Toxicity, in vitro diffusion, pharmacokinetics and pharmacodynamics are superior to those of COL-bpES, providing a better delivery system for the treatment of small molecule inflammatory drugs.
研究领域:
药剂学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2018
·
IF 4.427
Lingfei Ma,Chaoyi Wang,Haipu Li,Fangyuan Peng,Zhaoguang Yang
Geosmin (GSM) and 2-methylisoborneol (2-MIB) are two common odor compounds in drinking water . In this paper, the performance of UV/chlorine was compared with that of chlorine and UV to degrade GSM (100 ng L −1 ) and 2-MIB (100 ng L −1 ) in water. UV/chlorine was further exploited, and a steady-state kinetic model was used to conduct a detailed study on efficiency, rate, reactive species and pathway. The results showed that UV/chlorine greatly could improve the removal ratio to 90% within 5 min, from approximately 20% with only UV or dark chlorine in 60 min. The removal ratio and rate depended on UV light intensity , free chlorine dosage, reaction time and water quality parameters (e.g. pH, concentrations of HCO 3 − and Cl − ). Among these factors, the first two obviously could accelerate the rate and increase the ratio. The degradation was also significantly improved in an acidic condition, while alkaline conditions and HCO 3 − had inhibitory effects, and Cl − created no difference. Contributions of OH and Cl to the degradation of 2-MIB and GSM were further revealed, and OH was found to be the most important reactive species. In the UV/chlorine process, 6 degradation byproducts of 2-MIB, including 1 alcohol, 2 ketones, and 3 olefins , were identified, and 14 degradation byproducts of GSM, including 6 ketones, 1 aldehyde, 2 alcohols, 3 naphthenes , and 2 olefins, were found by using solid-phase microextraction coupled to gas chromatography-mass spectrometry. The possible degradation pathways of GSM and 2-MIB in UV/chlorine thus were proposed.
研究领域:
环境科学
·
饮用水处理
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2018
·
IF 2.082
Yude Liu,Lian Rao,Hongguan Zhang,Yanyou Cen,Kaili Cheng
Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood–brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the benefits of vitamin E d-ɑ-tocopheryl poly(ethylene glycol) succinate (E-TPGS) (or TPGS) and guar gum to get TPGS-g-guar gum as a drug delivery system to carry borneol, which could improve the solubility of borneol and increase the drug-loading capacity efficiently. The results showed that TPGS-g-guar gum nanoparticles delivery system was suitable to carry borneol and release the drug effectively, and TPGS-g-guar gum/borneol nanoparticles would be a potential platform for improving the treatment of central nervous system illness and cerebrovascular disease.
研究领域:
药剂学
·
神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Chen Chen,Songtao Wang,Wenjing Niu,Fang Liu,Wensheng Xie,Guofeng Li,Dongsheng Kong,Xing Wang
Infections caused by microorganisms on the surfaces of medical implants and devices represent a significant challenge in the field of medicine. At present, a considerable number of antimicrobial coatings have been developed with the objective of preventing bacterial contamination. However, the problem of mold contamination is often underestimated. To address this issue, a bi-molecular composite coating was developed using sulfobetaine and borneol unites, which enabled the modification of polydimethylsiloxane (PDMS) substrates. Furthermore, by modifying the ratio of sulfobetaine and borneol groups, the coating can simultaneously demonstrate anti-bacterial, anti-mold adhesion and anti-biofilm properties. Notably, the bi-molecular polymer coating exhibited a synergistic effect in inhibiting bacterial biofilm formation. Subsequent in vivo subcutaneous implantation in mice confirmed its favorable biocompatibility. Therefore, this approach offers novel insights into the development of antimicrobial adhesion coatings for medical device surfaces, particularly those need to prevent biofilm formation.
研究领域:
微生物学
·
生物材料
·
医学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Pharmaceutics
·
2018
·Vol. 10
·期 3
·146
·
IF 3.746
Yifan Yang,Yunzhi Yin,Jun Zhang,Tiantian Zuo,Xiao Liang,Jing Li,Qi Shen
Oral delivery is considered the preferred route of administration due to its convenience and favorable compliance. Here, docetaxel (DTX) loaded polylactic-co-glycolic acid (PLGA) nanoparticles, coated with polyethyleneimine–folic acid (PEI-FA) and polyethyleneimine–borneol (PEI-BO), were designed to enhance oral absorption (FA/BO-PLGA-NPs). The FA/BO-PLGA-NPs were spherical and smooth with an average size of (137.0 ± 2.1) nm. Encapsulation efficiency (EE%) and drug loading (DL%) were (80.3 ± 1.8)% and (2.3 ± 0.3)%, respectively. In vitro release studies showed that approximately 62.1% of DTX was released from FA/BO-PLGA-NPs in media at pH 7.4. The reverted gut sac method showed that the absorption of FA/BO-PLGA-NPs in the intestines was approximately 6.0 times that of DTX. Moreover, cellular uptake suggested that the obtained FA/BO-PLGA-NPs could be efficiently internalized into Caco-2 cells via FA-mediated active targeting and BO-mediated P-glycoprotein (P-gp) inhibition. Pharmacokinetics study demonstrated that after oral administration of DTX at a dose of 10 mg/kg in FA/BO-PLGA-NPs, the bioavailability of FA/BO-PLGA-NPs was enhanced by approximately 6.8-fold compared with that of DTX suspension. FA/BO-PLGA-NPs caused no obvious irritation to the intestines. Overall, the FA/BO-PLGA-NP formulation remarkably improved the oral bioavailability of DTX and exhibited a promising perspective in oral drug delivery.Keywords:docetaxel;nanoparticles;dual-functional;folic acid;borneol;oral absorption
研究领域:
药学
·
纳米技术
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2018
·Vol. 32
·期 6
·e4210
·
IF 1.688
Weiguo Liao,Xiaojie Huang,Yongxin Yin,Bin Liu,Runzhi Zhu
Tetramethylpyrazine (TMP) has been widely used in the treatment of ischemic cerebrovascular disease. However, the mechanism of TMP and how to increase its bioavailability need to be further explored. In our study, an in vivo microdialysis sampling technique coupled with ultra-performance liquid chromatography–mass spectrometry method was developed to investigate the pharmacokinetic properties of TMP and its interaction with different doses of borneol (BO) in rats. Linearity of TMP in brain and blood dialysates exhibited good linear relationships over the concentration range of 0.991–555.14 ng/mL. The specificity, linearity, accuracy, precision, matrix effect and stability were within acceptable ranges. The results demonstrated that BO had a marked impact on the pharmacokinetic properties of TMP. After co-administration, the areas under the concentration–time curve (AUC) of TMP in brain and blood were significantly increased. Meanwhile, the peak concentration of TMP in brain was also enhanced. The AUC Brain /AUC Blood of TMP, increased from 44% to 56 and 60.8% after co-administration with BO (15 and 30 mg/kg). The pharmacodynamic results showed that TMP co-administration with BO enhanced the cerebral blood flow during the period of ischemia and reduced the infarct volume. Overall, it might be an effective way to treat stroke to use TMP co-administered with BO.
研究领域:
药理学
·
神经科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）