JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2023
·
IF 4.3
Yuanqian Xiong,Dong Zhang,Cuizhu Ye,Yu Wang,Xiangrui Deng,Danwen Deng,Chunhong Xiong,Jinsheng Zhang,Qianhui Gu,Ganhui Huang
Ciprofloxacin hydrochloride is widely used to treat animal diseases. However, its chronic abuse has caused severe accumulation in animal-derived foods , which has seriously damaged human health. Thus, in this study, a novel molecularly imprinted electrochemical sensor (MIES) was designed for selective and ultra-sensitive detection of ciprofloxacin hydrochloride (CPFX) in milk. The sensor was based on the molecularly imprinted polymers (MIPs) synthesized with poly-pyrrole (PPy) as the functional monomer , AuNPs and S-CoFe-MOFs (CoFe-Metal organic frameworks coated with chitosan) as the Supporting materials , and CPFX as the template molecule. The electrochemical behavior of MIPs/S-CoFe-MOFs/AuNPs/GCE was studied by several electrochemical methods, which showed a wider detection linear range (0.05 ∼ 500 ng·mL -1 ) and lower detection limit (0.0033 ng·mL -1 ) than those in previous reports. The optimization of experiments confirmed the good selectivity and stability of the sensors----- with the milk sample recovery of 89.04∼110.26%, and the relative standard deviations (RSD) of less than 5.5%, which was close to HPLC. In conclusion, the sensor we constructed has a high selectivity and stability potential in detecting CPFX in milk.
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 40
·19153-19160
·
IF 3.925
Zhenyu Lu,Gongke Li,Yufei Hu
A Tb3+ functionalized triazine-porous organic framework (Tb3+/TAPOF) was prepared by introducing Tb3+ into a triazine-porous organic framework through a coordination bond. Combining the advantages of both Tb3+ and TAPOF, Tb3+/TAPOF showed good thermal stability, a high specific surface area, and excellent fluorescence performance. As the concentration of ciprofloxacin became higher, the intensity of the peak at 544 nm increased, while that of the peak at 440 nm did not change. Thus, a ratiometric fluorescent sensor based on Tb3+/TAPOF for selective ciprofloxacin determination was constructed, and the mechanism of ciprofloxacin determination was studied using the UV-vis and phosphorescence spectra and fluorescence lifetime. A good linear relationship, under the optimized conditions, was obtained between the I544/I440 value and the ciprofloxacin concentration in the range of 0.06 μmol L−1 to 5.0 μmol L−1, and the limit of detection (LOD, S/N = 3) was 19 nmol L−1. Moreover, the ratiometric fluorescent sensor based on Tb3+/TAPOF was applied to the determination of ciprofloxacin in aquatic products with recoveries in the range of 96.1–108.6%. These results obtained by the ratiometric fluorescence method and the high-performance liquid chromatography (HPLC) method are consistent for determination of aquatic products, which further proves that this method based on Tb3+/TAPOF is accurate. Generally, these results demonstrate that the Tb3+/TAPOF based ratiometric fluorescent sensor has an extensive application prospect in ciprofloxacin determination in the aquatic product industry.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2022
·
IF 9.231
Jin'ai Chen,Yuting Jin,Taotao Ren,Shuo Wang,Xianghong Wang,Fuyuan Zhang,Yiwei Tang
Fluoroquinolones, a family of synthetic broad-spectrum antibiotics, are widely used in clinical medicine, farm animals and aquaculture. Residues of fluoroquinolones in samples have attracted much attention because of growing food safety and public health concerns. Here, a novel Tb 3+ ion-enrofloxacin aptamer coordination probe was prepared to develop a sensitive and rapid label-free fluorescence assay for specific detection three fluoroquinolones. In presence of the target, Tb 3+ ion- enrofloxacin aptamer probe specifically bound with enrofloxacin, norfloxacin and ciprofloxacin , leading to a sharp increase in fluorescence emission of the probe. Under the optimized conditions, fluorescence increased linearly in the 1.0–100.0 ng/mL range for the three fluoroquinolones, with 0.053 ng/mL limit of detection for ciprofloxacin, 0.020 ng/mL limit of detection for norfloxacin and 0.061 ng/mL limit of detection for enrofloxacin. Satisfactory recovery (80.10–102.48%) in spiked honey and water samples were obtained for the three fluoroquinolones with relative standard deviations between 0.21% and 5.44% (n = 3).
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 9
·4226-4232
·
IF 3.925
Zhiwen Li,Jiyue Zhang,Qiyao Sun,Wenwen Shi,Tingxian Tao,Yingqiang Fu
A new method of ratiometric fluorescence detection of moxifloxacin (MOX) was developed based on carbon quantum dots (CQDs). Through a one-step hydrothermal method using soluble starch and acetic acid buffer solution as precursors, blue fluorescent CQDs with excitation wavelength-dependence were prepared. MOX could combine with CQDs to form a CQDs/MOX through hydrogen bonding. The absorption spectrum of CQDs/MOX and the fluorescence emission spectrum of CQDs overlapped to a certain extent, which allowed for fluorescence resonance energy transfer (FRET) formation between CQDs/MOX and CQDs. For MOX detection, as the MOX concentration increased, the intensity of the fluorescence emission peak of CQDs decreased gradually, the intensity of the fluorescence emission peak of CQDs/MOX increased gradually, and the fluorescence emission peaks of CQDs and CQDs/MOX both had a red-shift. Based on the FRET system between CQDs and CQDs/MOX, a new method for ratiometric fluorescence detection of MOX was established. This method was more effective for MOX detection in the concentration range 3.3 × 10−7 to 2 × 10−6 M. Our method had high sensitivity and selectivity, and the limit of detection was 2.59 nM. The recovery rate of simulated water samples was 98.37–101.15%, which showed that this method was feasible for MOX analysis of actual water samples.
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Chemistry
·
2023
·
IF 7.3
L. Wang,D. Wang,Y. Tao,J. Wang,M. Tian,Q. Liu,Y. Yang,Y. Zou,F. Ke,X. Guo,X. Li,D. Gao
Phenylboronic acid functionalized high-crystallinity fluorescent covalent organic framework ( [email protected] ), which can be applied for rifamycin antibiotics and water sensing, and for rifamycin antibiotics adsorption, was synthesized for the first time. To effectively form [email protected] by post-synthetic modification, a fluorescent COF (COF–OMe) was prepared using deep-eutectic solvent as solvent without using catalyst. The [email protected] showed good fluorescence property and adsorption capacity, which owned superior effects in detecting and adsorbing rifampicin, rifapentine, and rifabutin. The results of fluorescence quenching mechanisms showed that internal filtration effect, dynamic quenching, and photoinduced electron transfer were the major mechanisms. Moreover, mainly due to the pore selectivity of [email protected] , hydrogen bonding, and π-π interaction, [email protected] showed good selectivity for three antibiotics. Finally, a dual-function platform based on [email protected] was successfully developed for sensing and adsorbing three antibiotics from various samples. Besides, [email protected] also showed good effect to detect water amount in ethanol (0.1−50%, v/v).
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2023
·Vol. 13
·期 40
·28299-28306
·
IF 3.9
Jun Guo,Wei Gan,Ruixin Chen,Miao Zhang,Zhaoqi Sun
TiO2 nanorod arrays have been widely used in photocatalytic processes, but their poor visible light absorption and rapid carrier recombination limit their application. Both introducing oxygen vacancies and using precious metals as surface plasmon resonance (SPR) stimulators are effective strategies to enhance their photocatalytic performance. Herein, Au nanoparticle sensitized blue TiO2 nanorod arrays (Au/B-TiO2) were successfully fabricated for efficient Gatifloxacin photodegradation. The degradation efficiency of Gatifloxacin was up to 95.0%. Moreover, the corresponding reaction rate constant (Ka) was up to 0.02007 min−1. Additionally, it was suggested that Gatifloxacin could be subject to three different degradation pathways. The superior catalytic activity of Au/B-TiO2 is a result of the combined effect of the two components. Firstly, TiO2 nanorod arrays provide a larger surface area for Au deposition and act as efficient transfer channels. Secondly, the presence of oxygen vacancies in blue TiO2 nanorod arrays enhances the catalytic activity. Thirdly, Au acts as a SPR activator, providing a large number of high-energy electrons in the photocatalysis process. Lastly, the improved light capture capabilities are essential for efficient removal of Gatifloxacin. This work provides a new approach for the construction of a high-performance heterojunction photocatalyst in advanced oxidation processes.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2023
·
IF 5.9
Guangli Li,Xuan Wan,Yonghui Xia,Du Tuo,Xiaoman Qi,Tianyu Wang,Mohammad Mehmandoust,Nevin Erk,Quanguo He,Qing Li
The excessive use of levofloxacin (LEV) can lead to significant environmental pollution, while also damaging human health. The accurate detection of its concentration is therefore essential to protect both the environment and human health. Herein, we report the simple synthesis of α-zirconium phosphate supported on nitrogen-doped graphene nanosheets (α-ZrP/NG) and its application in the voltammetric determination of trace LEV in real samples. The surface morphology, microstructure, and electrochemical properties of α-ZrP/NG were investigated by microscopic and spectroscopic techniques. The analytical parameters, including the accumulation potential, accumulation time, loading volume, and buffer pH, were optimized to improve the electrocatalytic sensing performance of α-ZrP/NG. Owing to the synergetic interaction between α-ZrP and NG, the proposed sensor exhibited an excellent electrocatalytic activity for the electrical oxidation of LEV. In the range of 0.01–5.0 μM, the anodic peak current of LEV increased linearly with an increase in the LEV concentration, and the limit of detection was 2.6 nmol L–1. Finally, the LEV levels in wastewater, human serum, milk, and eye drop samples were determined by using the α-ZrP/NG system combined with a glassy carbon electrode to give satisfactory recoveries (98.48–103.2%), indicating that the prepared sensor demonstrates promise for use in environmental, food, and drug monitoring applications.
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2023
·
IF 6.1
Baisen Chen,Rongxia Tan,Yanhui Zhong,Yufei Hu,Gongke Li
Ce-PA-Tb polymer with Ce and Tb as metal ion centers was prepared and applied in chemiluminescence (CL) reaction. The structure and property of Ce-PA-Tb were explored. Ce-PA-Tb combines both the oxidant ion (Ce(IV)) and luminescence ion (Tb(III)). Difloxacin can enhance the CL signal of Ce-PA-Tb-SO 3 2- reaction in acidic medium. Under the optimized affecting factors, a CL method for the selective difloxacin determination was established. The CL intensity showed a good linear relationship from 10.0 to 300.0 μg/L (r = 0.9996) with the limit of detection was 1.1 μg/L. The method with the signal response at 0.5 s and completed the CL process within 10 s. The method was used to determine difloxacin in aquatic products, and the recovery rate was in the range of 88.1%–104.0%. The CL method designed Ce-PA-Tb based is demonstrated to be an excellent tool for difloxacin determination in aquatic products.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Wei Wang,Pengyin Deng,Xiqing Liu,Yuqin Ma,Yongsheng Yan
The abuse of tetracycline (TC) antibiotics would seriously affect human health and hence the detection had become essential. Here, we had constructed a hydrophobicity of fluorescence sensor based on the excellent photoluminescence emission of CsPbBr 3 QDs and the hydrophobic ability of Boron Nitride (BN). This design effectively solved the instability of CsPbBr 3 QDs and realized the sensitive detection of TC. Under optimum conditions, the linear range of TC was 0–0.44 mg L −1 with the 6.5 μg L −1 . Furthermore, the sensor was successfully used for the recognition of TC in honey and milk samples. This work also provided an ideal for designing CsPbBr 3 QDs-based on fluorescence sensor.
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2020
·
IF 5.88
Fan Zhang,Xiangsheng Han,Chuanlong Guo,Hui Yang,Jun Wang,Xiaochen Wu
Bacterial infections severely retard the wound healing process. Antibacterial drugs were loaded onto aramid nanofibers (ANFs) hydrogels through a convenient strategy to fabricate dressings for bacterial infected wound healing. ANFs hydrogels owned good mechanical properties, high water content (>98%), high water adsorption property (>10,000%) and good water retention ability (a water retention of >5000% after incubating at RH 30% for 8 h), capable to absorb and retain the wound exudate to form a moist environment. The incorporation of antibacterial drugs promised the ANFs hydrogels with durable antibacterial properties. Furthermore, the drug loaded ANFs hydrogels had no cytotoxicity nor hemolytic potential. In vivo skin wound healing results confirmed that the composite hydrogels accelerated the healing rate of infection wounds on mice and were suitable as a potential anti-infective wound dressing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
·
2020
·
IF 2.365
Guigang Li,Lingjuan Xu,Menglin Jiang,Xianggen Wu
The aim was to reveal the characteristic profiles of the marketed levofloxacin eye drops (5 mg/ml) and levofloxacin eye gel (3 mg/g) from the pharmacokinetics and pharmacodynamics views of rabbits’ eyes. A mild and a heavy bacterial keratitis models in rabbits were established. Different regimens of levofloxacin eye drops and eye gel, including phosphate buffer solution (the PBS group), the 4-Sol + 1-Gel group (rabbits were treated with 4 doses of levofloxacin eye drops and 1 dose levofloxacin eye gel per day), the 3-Sol + 1-Gel group (3 doses drops and 1 dose gel), the 4-Sol group (4 doses drops), the 4-Gel group (4 doses gel), the 3-Sol group (3 doses drops), and the 3-Gel group (3 doses gel), were applied to evaluate their efficacies. The ocular pharmacokinetics of levofloxacin eye drops and gel were also investigated. The results of mild infection groups showed that all treatment regimens significantly relieved the infection symptoms, and the treatment effect followed this order: 4-Gel > 4-Sol + 1-Gel > 3-Sol + 1-Gel > 4-Sol > 3-Gel > 3-Sol. In the heavy infection groups, all the treatment regimens significantly relieved the infection symptoms, and the treatment effect also followed the order with the mild infection results. All treatment regimens lowered the number of corneal colony forming units (CFU). Levofloxacin eye gel significantly increased intraocular penetration in rabbits’ eyes. It can be concluded that the levofloxacin eye gel was more effective in treating bacterial keratitis than the levofloxacin eye drops in rabbit keratitis model with a proper treatment regimen such as 4-Gel.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2020
·
IF 6.306
Kaili Yu,Mei-E. Yue,Jie Xu,Ting-Fu Jiang
A simple and sensitive salting out-assisted dispersive liquid-liquid microextraction method using deep eutectic solvent combined with back extraction and micellar electrokinetic capillary chromatography (SO-DLLME-DES-BE-MECC) was developed for the determination of fluoroquinolones in milk, honey and water samples. Several parameters affecting the extraction efficiency including DES volume, vortex time, centrifugation time, salt type and amount, sample pH and volume, etc. were investigated. Good linearity were obtained for fluoroquinolones in a range of 0.020–3.200 μg mL −1 and 0.030–4.800 μg mL −1 with LODs less than 0.010 μg mL −1 . The recoveries were in the ranges of 95.0–104.9%, 90.1–110.2% and 87.8–114.1% for water, honey and milk samples, respectively. The relative standard deviations for reproducibility were all below 7.6%. Under the optimized conditions, the enrichment factors for analytes were achieved in the range from 531 to 858 folds. The presented method was successfully applied for the determination of fluoroquinolones in milk, honey and water samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）