JOURNAL OF RARE EARTHS
·
2021
·
IF 3.712
Zhao Cao,Zeyu Cheng,Jieliang Wang,Yongdan Cao
Bastnaesite is an important rare earth mineral and is usually beneficiated by flotation . Sodium silicate is commonly used to depress calcium-bearing gangue minerals, however it can also depress bastnaesite when Ca 2+ ions exist in the pulp. In this study, the effect of Ca 2+ ions and sodium silicate individually or in combination on bastnaesite flotation was studied through micro-flotation, zeta potential , fluorescence spectroscopy and X-ray photoelectron spectroscopy (XPS) measurements. Micro-flotation results show that the combination of Ca 2+ ions and sodium silicate depresses bastnaesite more severely due to their synergistic effect. Zeta potential results show that the combination renders the surface potential of bastnaesite negatively shifted more significantly. Fluorescence spectroscopy shows that the combination decreases the surface hydrophobicity of bastnaesite more severely. XPS shows that the combination increases the adsorption of sodium silicate on bastnaesite by forming hydrophilic Ca-SiO 3 precipitate, which causes more serious depression on bastnaesite flotation.
研究领域:
矿物学
·
化学工程
✓ 已验证
DOI
高影响因子
FUEL
·
2024
·
IF 6.7
Bang Wu,Xin Guo,Xulinjia Liu
The effect of calcium on the synergy evolution mechanism of Zhundong coal and polyethylene (PE) co-pyrolysis was explored by thermogravimetric (TG), fixed-bed experiments, and the ReaxFF simulation method. The weight loss characteristics of coal and PE pyrolysis, obtained through ReaxFF simulations, exhibited good agreement with TG experimental results. The distribution of coal/PE co-pyrolysis products was examined via fixed-bed fast pyrolysis experiments and Reaxff isothermal pyrolysis simulation. The results reveal that calcium substantially reduces co-pyrolysis tar while simultaneously enhancing co-pyrolysis char and gas to varying extents. Besides, the experimental temperature of 973 K and the simulated temperature of 2600 K yield the highest decrease in co-pyrolysis tar, with reductions of 9.52 % and 14.03 %, respectively. It is discovered that the addition of calcium enhances the synergy degree to 100 % between coal and PE molecules, which means that coal molecules become more firmly attached to PE molecular fragments. Additionally, calcium induces polymerization in co-pyrolysis char, causing the char molecules to become larger and increasing their average molecular weight. Ca-containing tars are rich in aliphatic hydrogens, and synergistic molecules prefer light tars, whereas Ca-free tars have a slightly broader range of aromatic hydrogens, and synergistic molecules favor heavy tars, indicating that the addition of calcium may promote the ring-opening process of coal molecules, releasing more branched-chain hydrogen. In the Ca-free and Ca-containing systems, 24.67 % and 29.51 % of the hydrogen content of the coal molecules migrated toward the co-pyrolysis tar, respectively. The proportion of coal tar fragments decreases while the proportion of PE tar and synergistic tar fragments increases in Ca-containing tar when compared to Ca-free tar, indicating that calcium promotes the polymerization of coal tar molecules with PE tar molecules, which leads to larger char molecules and smaller gas molecules.
研究领域:
能源科学
·
化学工程
✓ 已验证
DOI
高影响因子
Journal of Water Process Engineering
·
2025
·
IF 6.7
Yulin Chen,Danying Xing,Yang Sui,Zexin Liu,Xiaodan Zhao
Tetracycline, representing as the typical antibiotics, is widely utilized and commonly detected at high concentrations in aquatic environments. Advanced oxidation technologies leveraging the high reactivity of radicals generated by activated peracetic acid via iron-based heterogeneous activators exhibit excellent effectiveness for tetracycline removal, yet this process is hampered by the slow reduction of >Fe(III) to >Fe(II). Regarding the redox reversibility of CuFeS 2 and the electron-donating properties of sulfur components in accelerating the reduction of >Fe(III) to >Fe(II), the combination of CuFeS 2 and peracetic acid (simplified as the CuFeS 2 /PAA system) is developed. At a low CuFeS 2 dosage of 0.03 g L −1 , tetracycline was degraded with a degradation rate of 0.167 min −1 under neutral conditions, which was more effective than CuS and FeS 2 . The efficacy is consistent the electron-transferring ability of CuFeS 2 , CuS and FeS 2 . CuFeS 2 exhibits enhanced catalytic activity due to its unique redox properties, in which >Fe(II) sites facilitate PAA activation, while >Cu(I) is essential for >Fe(III) reduction, creating a synergistic interaction that accelerates >Fe(III) reduction to >Fe(II). As the main radical generated, CH 3 C( O )OO• plays a key role in tetracycline degradation. It is also indicated that different water quality parameters slightly impact tetracycline degradation, highlighting the system's robust practical application potential. By facilitating the rapid reduction of >Fe(III) to >Fe(II), the CuFeS 2 /PAA system can achieve effective tetracycline degradation. This study is expected to provide a feasible method for the treatment of the water and wastewater containing antibiotics.
研究领域:
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2020
·
IF 6.092
Peiqian Zhang,Yuanyuan Ma,Mei Cui,Jieying Wang,Renliang Huang,Rongxin Su,Wei Qi,Zhimin He,Wim Thielemans
Biological pretreatment is a safe and environmentally friendly method for disrupting recalcitrant lignocellulose structures. Expansin and expansin-like proteins are used to open up the cellulose structure and display significant synergism when mixed with cellulases that catalyze the breakdown of (hemi)cellulose into sugars. However, the adsorption behavior of expansin in the presence of sugar products is yet unknown. In this work, we monitored the effects of various sugars on the real-time adsorption of Bacillus subtilis expansin (BsEXLX1) onto cellulose films using a quartz crystal microbalance with dissipation. Cellobiose and xylose at low concentrations enhanced BsEXLX1 adsorption, whereas they disrupted adsorption at higher concentrations. Arabinose and mannose continuously inhibited expansin adsorption with increasing concentration. No obvious influence of glucose and galactose on BsEXLX1 adsorption was found. Contact angle measurements and atomic force microscopy of cellulose upon BsEXLX1 adsorption in the presence of sugars showed that both hydrophilicity and roughness increased with BsEXLX1 treatment. These results give us the ability to modulate and control expansin adsorption and provide insights into effective expansin use during enzymatic hydrolysis of lignocellulose in biorefineries.
研究领域:
生物化学
·
可再生资源与环境科学
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产品关联
DOI
PubMed
高影响因子
Antibiotics-Basel
·
2025
·Vol. 14
·期 8
·799
·
IF 4.6
Sijin Hang,Li Wang,Zhe Ji,Xuqing Shen,Xinyu Fang,Wanqian Li,Yuanying Jiang,Hui Lu
Background/Objectives: The diminished efficacy of azoles in treating fungal infections is attributed to the emergence of resistance among pathogenic fungi. Employing a synergistic approach with other compounds to enhance the antifungal activity of azoles has shown promise, yet the availability of clinically valuable adjuvants for azoles and allylamines remains limited. Studies have demonstrated that the human host environment provides multiple carbon sources, which can influence the susceptibility ofC. albicansto antifungal agents. Therefore, a comprehensive investigation into the mechanisms by which carbon sources modulate the susceptibility ofC. albicansto azoles may uncover a novel pathway for enhancing the antifungal efficacy of azoles. Methods: This study explored the impact of various carbon sources on the antifungal efficacy of azoles through methodologies including minimum inhibitory concentration (MIC) assessments, super-MIC growth (SMG) assays, disk diffusion tests, and spot assays. Additionally, the mechanism by which galactose augments the antifungal activity of azoles was investigated using a range of experimental approaches, such as gene knockout and overexpression techniques, quantitative real-time PCR (qRT-PCR), Western blot analysis, and cycloheximide (CHX) chase experiments. Results: This study observed that galactose enhances the efficacy of azoles againstC. albicansby inhibiting the translation of Erg1. This results in the suppression of Erg1 protein levels and subsequent inhibition of ergosterol biosynthesis inC. albicans. Conclusions: InC. albicans, the translation of Erg1 is inhibited when galactose is utilized as a carbon source instead of glucose. This novel discovery of galactose’s inhibitory effect on Erg1 translation is expected to enhance the antifungal efficacy of azoles.
研究领域:
微生物学
·
分子生物学
·
药理学
·
真菌学
·
感染性疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2025
·
IF 5.6
Xiaofeng Liu,Chaojing Li,Fan Zhao,Robert Guidoin,Kaitai Liu,Fujun Wang,Lu Wang
Stent implantation is a widely used palliative treatment for relieving strictures in malignant esophageal cancer. However, conventional fully covered stents play a role in preventing the tumor from ingrowth but increasing the risk of migration. Therefore, there is an urgent need for a multifunctional stent that not only reduces migration but also provides synergistic therapeutic benefits to inhibit tumor growth. This study proposed a braided esophageal stent with synergistic photothermal and chemotherapy functions to achieve precise controllable drug release. The stent was braided of Nitinol fiber and polyethylene terephthalate fiber in one-step, in which Nitinol loaded with high-efficiency photothermal conversion agent gold nanoparticles and polyethylene terephthalate loaded anti-tumor drugs release mediated by a temperature-responsive coating. The stent showed anti-migration ability and orchestrated the localized hyperthermia plus thermal-stimuli drug release during the tumor lesion. Cell experiments confirmed that the stent showed a significantly synergistic tumor cell killing effect (28.29 %). In 3D tumor sphere model, the apoptosis rate of tumor cells reached 31.34 %. In summary, the composite stent design strategy integrates anti-migration features and photoheating-controlled drug release for synergistic cancer therapy, providing a new design idea for the application of nickel-titanium alloy stents in the treatment of malignant esophageal stenosis.
研究领域:
生物医学工程
·
肿瘤学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Sugar Tech
·
2021
·Vol. 24
·期 3
·832-840
·
IF 1.591
Yang Yujiao,Zheng Rui,Zhang Pingling,Wen Jing,Luo Yue,Zhao Zhengang,You Lijun,Ho Chi-Tang
Sugarcane is one of the most important crops in the world and rich in polyphenols. In this study, quercetin, apigenin, luteolin, tricin and p -coumaric acid, the major polyphenols in sugarcane, were used to evaluate the antiproliferative activities toward MCF-7 human breast cancer cells independently and in combination. These five polyphenols all showed inhibitory effects against MCF-7 cells within different dose ranges. The combinations of luteolin and three polyphenols (quercetin, apigenin, p -coumaric acid) were studied. p -Coumaric acid together with luteolin exhibited synergistic effects at all concentrations tested: the CI (Combination Index) values at 50%, 75% and 90% inhibition of MCF-7 cell growth were 0.68 ± 0.06, 0.70 ± 0.08 and 0.83 ± 0.09, respectively. Although the two-way combination of luteolin and apigenin showed moderate antagonistic effect (CI, 1.26 ± 0.24) at EC 50 , the CI value dropped as the inhibition rate increased, showing a synergistic effect at the inhibition rate above 70%. The combination of luteolin and quercetin indicated antagonistic effect at the inhibition rate above 50% (Fa 0.5, CI = 1.10 ± 0.05). p -Coumaric acid with quercetin exhibited antagonistic actions (Fa 0.5, CI = 1.62 ± 0.22) at all concentrations tested. In addition, the EC 50 values of luteolin and quercetin against MCF-7 cells decreased by 1.91 and 2.62-fold after combining with 20 µM tricin. The results provide evidence of synergistic relation among polyphenols present in sugarcane in inhibition of cancer cell growth and of their potential clinical application.
研究领域:
肿瘤学
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植物化学
·
药理学
✓ 已验证
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2022
·Vol. 29
·期 33
·50177-50191
·
IF 5.19
Wang Meng-lu,Zhao Zhe,Lin Shumin,Su Ming,Liang Bolong,Liang Shu-xuan
The present study aimed to investigate the co-adsorption and application of water stabilized Fe 3 O 4 @ZIF-8 composite with magnetic cubic crystal structure. This new material was successfully prepared by facile modification strategy and rational design, which was used for simultaneous adsorption of oxytetracycline (OTC) and Pb(II) in aqueous solution. The co-adsorption behavior and mechanism of the composite for OTC and Pb(II) were systematically investigated by characterization techniques and batch experiments, and its application potential was effectively evaluated. The results showed that the synthesized Fe 3 O 4 @ZIF-8 composite innovatively retained the cubic crystal structure of ZIF-8 and was successfully loaded on the surface of Fe 3 O 4 particles with small particle size to form a core-shell structure. The Fe 3 O 4 @ZIF-8 composite possessed a large specific surface area (1722 m 2 /g), magnetic separation performance (13.4 emu/g), and rich functional groups. The co-adsorption of OTC and Pb(II) on Fe 3 O 4 @ZIF-8 had fast reaction kinetics (equilibrium within 90 min) and large adsorption capacity (310.29 mg/g and 276.06 mg/g respectively). The adsorption process for both contaminants followed pseudo-second order kinetics and Langmuir isotherm models and had synergistic and competitive effects at the same time. π-π stacking and electrostatic interaction were the main mechanisms of adsorption. Fe 3 O 4 @ZIF-8 had good adsorption performance after cyclic adsorption for 4 times and it performed well in the treatment of real waste water. This study provided a new sight for the control of combined pollution of OTC and Pb(II) and proved Fe 3 O 4 @ZIF-8 composites have great application potentials for complex wastewater treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
MINERALS ENGINEERING
·
2020
·
IF 3.795
Peng Yang,Xianzhi Hu,Futing Zi,Baomin Yang,Qiang Wang,Yunlong Chen,Shuliang Chen
Because it is difficult to hydrophobically agglomerate fine kaolinite particles to obtain stronger, larger flocs using only dodecylamine (DDA) as a flocculant , octanoic acid (OA) was used as a synergistic flocculant to improve DDA-induced fine-kaolinite particle agglomeration. Particle settlement tests were conducted to study flocculation and synergistic flocculation behaviours of fine kaolinite particles for different DDA and/or OA concentrations. Results showed that OA strengthened DDA-induced particle agglomeration. Aggregate sedimentation rates and Stokes’ equivalent diameters exceeded 21.7 m/h and 84.4 µm, respectively. A clearer kaolinite suspension was obtained and a more compact aggregate layer accumulated within 3 min. Contact angles and Fourier-transform infrared (FTIR) spectroscopy were used to investigate kaolinite hydrophobicity before and after hydrophobisation and mechanisms of DDA and/or OA interactions with the kaolinite surface. Results suggested that faster sedimentation and larger equivalent-diameter aggregates were both related to significantly increased kaolinite-surface hydrophobicity. FTIR data confirmed that enhanced kaolinite surface hydrophobicity was owed to DDA and OA physisorption . The kaolinite micro-particle aggregation mechanism was analysed by SEM images. Kaolinite particle self-aggregation changed after OA was adsorbed on the kaolinite Si–O basal plane. Owing to DDA/OA synergistic effects, kaolinite particles hydrophobically agglomerated by actions of Al–O/Al–O and Al–O/Si–O faces, thereby promoting fine-kaolinite particle agglomeration and sedimentation. Study findings could lead to development of enhanced water-purification methods.
研究领域:
矿物加工工程
·
环境科学与工程
✓ 已验证
DOI
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Chunquan Li,Yujiao Zhang,Zengjie Zuo,Liqiu He,Fang Yuan,Shuilin Zheng,Zhiming Sun
The migration of free antibacterial agents in the coating will lead to the rapid decline of the antibacterial effect. Consequently, achieving sustained antibacterial efficacy has become a critical focus currently. In this study, through liquid-phase ion exchange and dry modification, Cu 2+ and cetyltrimethylammonium chloride (CTAC) were successively loaded onto stellerite (STI) to synthesize Cu 2+ /STI and Cu 2+ /CTAC/STI composites, then Polyvinyl alcohol (PVA) was used as the matrix to construct Cu 2+ /CTAC/STI/PVA antimicrobial coatings. The results demonstrated that the modified material retained the crystal structure of stellerite while achieving superior antibacterial properties. The incorporation of stellerite not only enhanced the stability of the antibacterial agent but also facilitated its unique delivery function. Specifically, stellerite served as an effective reservoir for antibacterial components, enabling efficient sterilization through the synergistic release of CTAC and Cu 2+ coupled with bacterial adsorption. In addition, Cu 2+ /CTAC/STI/PVA coating exhibited excellent bacterial efficacy and long-lasting antimicrobial performance, indicating the promising application prospects of stellerite-based antibacterial composites in functional coating fields.
研究领域:
材料科学
·
微生物学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Xiaoyun Jiang,Huifang Lv,Yang Lu,Yongling Lu,Lishuang Lv
Acrolein (ACR) is a toxic unsaturated aldehyde that is formed during different steps of thermal food processing. Here, we explored the kinetics of curcumin and ACR and elucidated the pathway of curcumin trapping ACR by preparing a mono-adduct of ACR (CMA-1) conjugated with curcumin. The synergistic scavenging effect and mechanism of curcumin combined with quercetin on ACR was analyzed by liquid chromatography–tandem mass spectrometry (LC–MS/MS). Comparing the uses of curcumin and quercetin both individually and in combination, we found that quercetin in combination resulted in more curcumin being transformed into CMA-2, while curcumin in combination made the amount of di-ACR conjugated to quercetin (QDA) increase. We also added combined curcumin and quercetin into grilled chicken wings to demonstrate that curcumin and quercetin could scavenge ACR by forming their own ACR adducts and antioxidant activity during the process. Our results have noted a new strategy, in which some combinations of dietary polyphenols might contribute to the removal of toxic ACR produced during thermal food processing.
研究领域:
食品科学
·
生物化学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2021
·
IF 5.645
Yijuan Chen,Jiaxuan Luo,Nan Zhang,Wenjuan Yu,Jiexian Jiang,Guanghui Dai
Plant essential oils are the powerful candidates to develop natural insect management agents. Their chemical compounds along with their biological activity are often affected by many factors. However, the relationships between the composition and bioactivity of the compounds are not well understood. In this study, eight plant essential oils were screened, and the main compounds from the most effective oil showing insecticidal properties against third-instar larvae of the beet armyworm ( Spodoptera exigua Hübner) were evaluated for comparative and synergistic interactions by topical application. The results indicated that Salvia hispanica L. essential oil showed significant insecticidal activity against S. exigua compared with the other seven essential oils. Fifteen major compounds were identified from S. hispanica via gas chromatography-mass spectrometry, with the most abundant compound (α-thujone) possessing the highest insecticidal activity. Several combinations of the four major compounds (α-thujone, (+)-camphor, 1,8-cineole, and α-caryophyllene) from S. hispanica exhibited synergistic insecticidal activities. This study demonstrates the potential of S. hispanica essential oil and α-thujone as effective botanical insecticides in the control of beet armyworm and provides a better understanding of essential oil compound-pest interactions.
研究领域:
植物学
·
昆虫学
·
农业科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）