ChemElectroChem
·
2020
·Vol. 7
·期 5
·1207-1212
·
IF 4.154
Abubakar Abdussalam,Yiran Guan,Guobao Xu
Graphical Simplify to amplify : Isatin is investigated as a new efficient co-reactant for Ru(bpy) 3 2+ electrochemiluminescence (ECL), and the ECL response of the Ru(bpy) 3 2+ /isatin system in borate buffer solution is about 12 times more intense than in phosphate buffer of the same pH, enabling sensitive ECL detection of isatin. Isatin is an endogenous indole derivative that has been reported to possess various pharmacological and therapeutic activities of clinical importance. To date, isatin has been detected mainly by mass spectrometry. Here, we report for the first time the intense anodic electrochemiluminescence (ECL) of tris(2,2′-bipyridyl)ruthenium(II) with isatin as an efficient co-reactant. Interestingly, the ECL response of the Ru(bpy) 3 2+ /isatin system in borate buffer solution is about 12 times more intense than in phosphate buffer of the same pH; and approximately 114 times greater than the ECL intensity of the luminophore. Under the optimal conditions, the ECL of Ru(bpy) 3 2+ increases linearly with the concentration of the isatin in the range of 1.0 μM to 1.0 mM (R 2 =0.998) with a limit of detection (LOD) of 0.28 μM (3σ/m). Moreover, the method has been successfully applied to the detection of isatin in human urine. The developed method has shown excellent recoveries in the range of 99.7–101.3 %. The anodic ECL assay reported in this work is superior in terms of linear range and selectivity than the previously reported methods and can be applied for the detection of isatin in real samples.
研究领域:
分析化学
·
生物医学
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DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 13
·1674-1683
·
IF 4.927
Liguo Xu,Fan Zhou,Min Liao,Rongrong Hu,Ben Zhong Tang
The development of a new polymerization methodology affords polymer materials with new structures and functionalities. Multicomponent polymerizations (MCPs) as a facile tool for preparing multifunctional polymers with complicated structures have attracted increasing attention from polymer scientists, owing to their high efficiency, high atom economy, simple procedure, structural diversity, and environmental benefit. In this work, a series of efficient one-pot multicomponent polymerizations of diynes, disulfonyl azides, and N-protected isatins are developed to afford oxindole-containing poly(N-acylsulfonamide)s with advanced properties. After optimization of the polymerization conditions, the MCP can proceed smoothly at room temperature or 30 °C in dichloromethane/t-BuOH with CuI as the catalyst and LiOH as the base, generating poly(N-acylsulfonamide)s with high molecular weights of up to 30 600 g mol−1 in excellent yields of up to 98%. This MCP enjoys general applicability of a series of electron-rich or electron-deficient alkynes and alkyl group or aromatic group-substituted isatins, generating six poly(N-acylsulfonamide)s from different combination of monomers, and nitrogen gas as the only byproduct, demonstrating high atom economy and environmental benefit. The obtained poly(N-acylsulfonamide)s can be dissolved in alcohol or alcohol/water mixtures, but cannot be dissolved in THF or dichloromethane, which show opposite solubility after the polymers are acidified with HCl, indicating reversibly tunable hydrophilicity of the polymers. Furthermore, water can participate in the MCP as the fourth component when the MCP is conducted in DMF with CuI as the catalyst and Na2CO3 as the base, generating random copolymers consisting of 3-alkenyloxindole moieties and two chiral center-containing 3-hydroxyindole moieties in the backbone. Some of the oxindole-containing poly(N-acylsulfonamide)s exhibit yellow to red emission in their solid state. These MCPs provide an efficient approach for the synthesis of functional polymers with unique structures, which directly build the oxindole and N-acylsulfonamide moieties in situ, demonstrating high synthetic efficiency.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
·
2019
·
IF 4.745
Yong-Long Zhao,Xing-Hai Fei,Yong-Qin Tang,Peng-Fei Xu,Fen-Fen Yang,Bin He,Xiao-Zhong Fu,Yuan-Yong Yang,Meng Zhou,Yuan-Hu Mao,Yong-Xi Dong,Chun Li
An organocatalytic asymmetric α-sulfenylation of 2-substituted indolin-3-ones with N-(alkylthio or arylthio)succinimides has been developed for the first time using Cinchona-derived squaramide as the catalyst. Various chiral 2,2-disubstituted indole-3-ones with S- and N-containing heteroquaternary carbon stereocenters were obtained with up to 98% yield and 99% ee.
研究领域:
有机化学
·
合成化学
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DOI
PubMed
高影响因子
RUSSIAN JOURNAL OF GENERAL CHEMISTRY
·
2023
·Vol. 93
·期 6
·1468-1473
·
IF 0.9
Wang Jialing,Fu Linlin,Wang Chang,Zhang Xuelian,Wang Zhuo,Zhao Xuemei
Abstract A series of new isatin derivatives was synthesized and evaluated for anti-proliferative activity against SNU-398 and LO2 cells through CCK-8 assay. Among them, 3-{2-[4-(benzyloxy)phenyl]-2-oxoethyl}-3-hydroxy-1-phenethylindolin-2-one exhibited the most inhibitory activity against SNU-398 cells (IC 50 = 6.69 μM), which could be as a lead compound to develop more potent anti-tumor agents.
研究领域:
药理学
·
肿瘤学
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DOI
高影响因子
CATALYSIS LETTERS
·
2024
·
IF 2.3
Zhao Xiao-Ting,Li Wen-Dian,Tao Fei-Yan,Wang Na
Pictet-Spengler reaction is one of the main ways to synthesize spiroindolones, which widely exists in natural products and pharmaceutical agents. We accidentally discovered bovine serum albumin (BSA) had catalytic activity for Pictet-Spengler reaction previously. After a series of exploratory experiments around the catalytic process, it was found that some amino acids played a key role. It is worth noting that, Pictet-Spengler reaction catalyzed by amino acids has been rarely described. Herein, we report the cysteine-catalyzed Pictet-Spengler reaction between tryptamine and isatin under metal-free and convenient conditions. The catalytic performance of amino acid was optimized through screening reaction conditions such as time, temperature, solvent, molar ratio and catalyst amount and a series of spiroindolones can be obtained in moderate to excellent yields. The present investigation featured relatively mild reaction conditions with good functional group tolerance and provided an alternative method for preparation of spiroindolones. Graphical Abstract
研究领域:
有机化学
·
药物化学
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产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2020
·
IF 6.182
Xukang Wang,Zhigao Huang,Minlong Lai,Lin Jiang,Yun Zhang,Huamin Zhou
The weak interfacial adhesion between carbon fibers (CFs) and poly(ether ether ketone) (PEEK) strongly hinders the true potential of composites in high performance applications. Herein, a novel heterocyclic derivative of PEEK was utilized as a linkage between CFs surface and PEEK matrix by a facile and high effective two-step method. CFs were firstly grafted with sodium sulfonate groups via aryl diazonium treatment, and then modified by the sizing agent poly(aryl indole ketone) (PAIK). This promising method takes advantages of strong cation-π interaction between PAIK and activated CFs, increased surface roughness of CFs, as well as good compatibility between PAIK and PEEK. As a result, the tensile strength and interlaminar shear strength (ILSS) of CF/PEEK composites were both improved after aryl diazonium treatment and PAIK sizing. The highest ILSS obtained for the 1 wt% PAIK modified CF/PEEK composites, which was 62.97% higher than that of untreated CFs based composites. Finally, the interfacial reinforcing mechanism in modified composites was proposed by analyzing the interfacial microstructure. This research provided a promising approach to produce high performance CF reinforced thermoplastic polymeric composites.
研究领域:
材料科学
·
复合材料
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产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Ying Ma,Peng Song,Jiaye Liu,Fuli Wang,Hao Wang,Zhenghui Zhang,Quan-Fu An
Redox flow batteries (RFBs) are recognized as a safe and cost-effective technology for large-scale electrical energy storage (EES). The ion exchange membrane (IEM) is a crucial component of RFBs, facilitating the rapid conduction of charge carrier ions while minimizing the crossover of redox active species. In this study, a high-performance sulfonated poly(indole ketone) (SPIK) membrane was designed and synthesized for the application in aqueous organic redox flow batteries (AORFBs) . The main chain of the SPIK consists entirely of rigid indole rings and carbonyl groups without any ether bonds. Such structure provides strong resistance to free radical oxidation. Also, the incorporation of nitrogen-containing heterocyclic rings reduced the swelling rate (SR) of membrane and enhanced its mechanical strength (SR<10% at 25 °C, mechanical strength >58 MPa in the dry state). Additionally, the introduction of sulfonic acid groups improved the ion conductivity of the membrane (>120 mS cm -1 at 25 °C). Among all SPIK membranes, SPIK 50/50 demonstrated exceptional performance in AORFBs, exhibiting an area-specific resistance as low as 0.93 Ω cm 2 and achieving a power density of 66.06 mW cm -2 . Furthermore, at a current density of 20 mA cm -2 , the voltage efficiency (VE) reached 92.48%, highlighting its potential for high-efficiency energy storage applications. In terms of the membrane stability, SPIK 50/50 maintained an energy efficiency (EE) over 80% without obvious decay in Coulombic efficiency (CE) over 600 cycles at a current density of 60 mA cm -2 . Also, such membrane was evaluated in iron-chromium redox flow battery and vanadium flow battery to further prove its applicability in RFBs.
研究领域:
材料科学
·
电化学
·
能源存储
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产品关联
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 22
·5384
·
IF 4.2
He Huang,Yating Zhang,Qiu Du,Changji Zheng,Chenghua Jin,Siqi Li
The escalating threat of antibiotic-resistant bacteria and fungi underscores an urgent need for new antimicrobial agents. This study aimed to synthesize and evaluate the antimicrobial activities of two series of 3-alkylidene-2-indolone derivatives. We synthesized 32 target compounds, among which 25 exhibited moderate to high antibacterial or antifungal activities. Notably, compounds10f,10g, and10hdemonstrated the highest antibacterial activity with a minimum inhibitory concentration (MIC) of 0.5 μg/mL, matching the activity of the positive control gatifloxacin against three Gram-positive bacterial strains:Staphylococcus aureusATCC 6538, 4220, and Methicillin-resistantStaphylococcus aureusATCC 43300. Moreover, the three most active compounds10f,10g, and10hwere evaluated for their in vitro cytotoxicity in the HepG2 cancer cell line and L-02; only compound10hwas found to exert some level of cytotoxicity. These findings suggest that the synthesized 3-alkylidene-2-indolone derivatives hold potential for further development as antibacterial agents.
研究领域:
药物化学
·
微生物学
·
抗感染研究
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DOI
PubMed
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2016
·
IF 3.169
Wenzhi Yang,Yibei Zhang,Huiqin Pan,Changliang Yao,Jinjun Hou,Shuai Yao,Luying Cai,Ruihong Feng,Wanying Wu,Dean Guo
Increasing challenge arising from configurational interconversion in aqueous solvent renders it rather difficult to isolate high-purity tautomeric reference standards and thus largely hinders the holistic quality control of traditional Chinese medicine (TCM). Spiro oxindole alkaloids (SOAs), as the markers for the medicinal Uncaria herbs, can easily isomerize in polar or aqueous solvent via a retro-Mannich reaction. In the present study, supercritical fluid chromatography (SFC) is utilized to separate and isolate two pairs of 7-epimeric SOAs, including rhynchophylline ( R ) and isorhynchophylline ( IR ), corynoxine ( C ) and corynoxine B ( CB ), from Uncaria macrophylla . Initially, the solvent that can stabilize SOA epimers was systematically screened, and acetonitrile was used to dissolve and as the modifier in SFC. Then, key parameters of ultra-high performance SFC (ultra-performance convergence chromatography, UPC 2 ), comprising stationary phase, additive in modifier, column temperature, ABPR pressure, and flow rate, were optimized in sequence. Two isocratic UPC 2 methods were developed on the achiral Torus 1-AA and Torus Diol columns, suitable for UV and MS detection, respectively. MCI gel column chromatography fractionated the U. macrophylla extract into two mixtures ( R / IR and C / CB ). Preparative SFC, using a Viridis Prep Silica 2-EP OBD column and acetonitrile-0.2% diethylamine in CO 2 as the mobile phase, was finally employed for compound purification. As a result, the purity of four SOA compounds was all higher than 95%. Different from reversed-phase HPLC, SFC, by use of water-free mobile phase (inert CO 2 and aprotic modifier), provides a solution to rapid analysis and isolation of tautomeric reference standards for quality control of TCM.
研究领域:
中药学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2021
·
IF 6.024
Tuo Zhao,Chuan Long,Zhiqian Wang,Hong Zhu
As a key component of anion exchange membrane fuel cells (AEMFCs), anion exchange membranes (AEMs) have been investigated in the last decades. Herein, a series of multication cross-linkers were introduced into side-chain-type poly(p-terphenyl isatin) to develop high-performance and long-term stable AEMs. Additionally, the effects of the hydrophilic cross-linker length on the membrane performance were systematically investigated. The resulting cross-linked membranes possess a low swelling ratio (<18% at 80 °C) and high tensile strength (51.1–58.3 MPa). Notably, the cross-linker length influences the AEM internal morphology. With hexyl as the spacer between backbones and cation groups in the cross-linker, 0.9q-PTI-6C exhibits the highest hydroxide ion conductivity of 118.5 mS/cm at 80 °C, which is ascribed to well-developed ion channels. Furthermore, alkyl spacer chains and cross-linked networks contribute to the excellent alkali stability of membranes. After immersion in 2 M NaOH for 1200 h at 80 °C, 0.9q-PTI-8C only shows 11 and 12.7% losses in ion conductivity and ion exchange capacity (IEC), respectively. The fuel cell fabricated using 0.9q-PTI-6C can achieve the maximum power density of 310 mW/cm2 at 80 °C.
研究领域:
材料科学
·
化学工程
·
能源技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）