FOOD CHEMISTRY
·
2025
·
IF 9.8
Xin Gao,Qi Li,Hanxiang Wu,Srushti Gadiyaram,Hongli Wen,Abdur Raheem Aleem,Wei Song,Lin Yu,Deshmukh Abdul Hakeem
Tracing antibiotics from food is crucial and challenging due to the widespread global implementation of antibiotics for animal disease prevention and controls, which could potentially cause serious health risks in humans. Herein, rare earth doped nanoparticles (RENPs) with amino-SiO 2 modification was designed for dual-mode luminescence sensing of furazolidone (FZD) antibiotic. FZD extensively suppressed the UV upconversion luminescence (UCL), keeping the green UCL unchanged as the internal reference; the downconversion luminescence (DCL) was significantly quenched by FZD. The RENPs@SiO 2 -NH 2 nanoprobe exhibited UCL ratiometric and DCL sensing with high sensitivity and specific recognition towards FZD in linear ranges of 0.05–300 and 1–300 μmol·L −1 , with 0.033 and 0.064 μmol·L −1 LOD, respectively. The RENPs@SiO 2 -NH 2 nanoprobe was validated using FZD reference material with recoveries in range of 96–114 %, and successfully detecting FZD from milk and chicken meat samples. The proposed dual mode luminescence nanoprobe is promising for precise and specific FZD determination in food samples.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ChemistrySelect
·
2026
·Vol. 11
·期 8
·e07116
·
IF 2.3
Xiongtao Yu,Haiping Xu,Rui Wang,Feng Zhou,Chunmin Yang
In this manuscript, Au nanoparticles (AuNPs) and a nanospherical conjugated microporous polymer (CMP) were prepared and then modified on the surface of screen-printed carbon electrode (SPCE) to construct an electrochemical sensor for high sensitivity and rapid detection of 3-amino-2-oxazolidinone (AOZ). The preparation process of the materials and electrodes were characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), cyclic voltammetry (CV), differential pulse voltammetry (DPV) and electrochemical impedance (EIS), and the test conditions were optimized. Under optimal conditions, the oxidation peak current of AOZ and the concentrations show a wider linear relationship in the ranges of 1.0×10 −8 ∼1.0×10 −6 and 1.0×10 −6 ∼ 1.0×10 −4 mol/L ( R 1 2 = 0.996, R 2 2 = 0.998), respectively, and a lower detection limit which is as low as 3.3×10 −9 mol/L (S/N = 3) compared to existing methods. The reason for this result may be that CMP exhibited abundant porous structures and numerous active sites, which could significantly improve response sensitivity; AuNPs also possess high specific surface area and make the diffusion and transport of electrolyte ions easier. CMP-AuNPs nanocomposites greatly improved the electron transport rate, signal intensity and electroactive surface of SPCE, thereby improving the sensitivity of the sensor. It is worth noting that the sensor also has strong anti-interference ability, stability, and reproducibility. When applied to detect AOZ in real samples, it also showed good recovery rate. Compared with HPLC-MS/MS, the sensor also obtained good accuracy and consistency, which has great application potential for rapid on-site analysis and detection in animal-derived food not only for AOZ but also for Furazolidone (FZD).
✓ 已验证
产品关联
DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2025
·
IF 9.7
Rijia Liu,Bolin Wu,Changru Xu,Chaojun Zhang,Meng Han,Meiting Zhao,Wein-Duo Yang,Rui Liu
This work developed an ultrasonically assisted synthesis of nickel cobaltite (NiCo 2 O 4 ) modified electrode for simultaneous detection of Furazolidone (FRZ) and Metronidazole (MTR) in biological samples. The structural and chemical properties of the as-prepared electrodes were systematically characterized through multiple analytical techniques. The NiCo 2 O 4 -modified glassy carbon electrode (NiCo 2 O 4 /GCE) demonstrated exceptional performance with wide linear ranges of 0.005–200 μM for MTR and 0.01–150 μM for FRZ, with remarkably low detection limits of 2.57 nM and 29.13 nM, respectively. The sensor exhibited excellent selectivity against common interferents, good reproducibility, and maintained > 90 % activity after 30 days. NiCo 2 O 4 /GCE can be used to detect MTR and FRZ in real pharmaceutical and serum samples, achieving excellent recovery rates within the range of 94.0 % to 114.0 %. This work not only presents a superior sensing platform for antibiotic monitoring but also establishes ultrasound-assisted synthesis as an effective strategy for developing advanced bimetallic oxide electrocatalysts.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biosensors-Basel
·
2022
·Vol. 12
·期 10
·904
·
IF 5.743
Rongfang Chen,Xia Peng,Yonghai Song,Yan Du
Herein, a paper-based electrochemical sensor based on PtNP/COFTFPB−DHzDS@rGO was developed for the sensitive detection of furazolidone. A cluster-like covalent organic framework (COFTFPB−DHzDS) was successfully grown on the surface of amino-functional reduced graphene oxide (rGO-NH2) to avoid serious self-aggregation, which was further loaded with platinum nanoparticles (PtNPs) with high catalytic activity as nanozyme to obtain PtNP/COFTFPB−DHzDS@rGO nanocomposites. The morphology of PtNP/COFTFPB−DHzDS@rGO nanocomposites was characterized, and the results showed that the smooth rGO surface became extremely rough after the modification of COFTFPB−DHzDS. Meanwhile, ultra-small PtNPs with sizes of around 1 nm were precisely anchored on COFTFPB−DHzDSto maintain their excellent catalytic activity. The conventional electrodes were used to detect furazolidone and showed a detection limit as low as 5 nM and a linear range from 15 nM to 110 μM. In contrast, the detection limit for the paper-based electrode was 0.23 μM, and the linear range was 0.69–110 μM. The results showed that the paper-based electrode can be used to detect furazolidone. This sensor is a potential candidate for the detection of furazolidone residue in human serum and fish samples.Keywords:paper-based electrode;reduced graphene oxide;covalent organic framework;furazolidone;electrochemical sensor
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2022
·
IF 4.598
Qingyuan Song,Xueling Shan,Liyin Bu,Anna Dai,Ding Jiang,Wenchang Wang,Hiroshi Shiigi,Zhidong Chen
A highly efficient electrochemiluminescence resonance energy transfer (ECL-RET) aptasensor was constructed for ultrasensitive detection of diethylstilbestrol (DES). The composite composed of silver orthophosphate and zirconium-based metal–organic frameworks (Ag 3 PO 4 -UiO-66) was prepared as a sensing platform for aptasensor incubation. Ag 3 PO 4 , a novel ECL donor, whose emission could be obviously enhanced through loading on UiO-66. Particularly, the composite of Ag 3 PO 4 -UiO-66 could minimize the aggregation of Ag 3 PO 4 , which provided a novel possibility for the construction of high ECL efficiency sensors. UiO-66 presented ultrahigh surface area to improve the loading capacity of Ag 3 PO 4 and DES-specific aptamer. Notably, Ag 3 PO 4 with superb catalytic properties could immobilize DES aptamer via Ag–NH 2 bond and further ensured the distance between the ECL donor and the energy receptor. To design a novel ECL-RET system, GO nanosheets were synthesized as a suitable ECL acceptor which could be fixed through electrostatic adsorption. Owing to the superior spectral overlap, GO could significantly quench the ECL emission of Ag 3 PO 4 . Under the optimal conditions, the constructed ECL-RET aptasensor showed a satisfactory response to DES in a linear range of 1.0 × 10 −14 ∼ 1.0 × 10 −8 M and the detection limit was 7.2 × 10 −15 M (S/N = 3). This paper not only developed a novel approach for environmental water quality monitoring but also offered more opportunities for building highly sensitive ECL-RET aptasensors.
✓ 已验证
产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Mi Yuan,Mingxuan Li,Pengchen Su,Long Yu,Yunfei Lu,Mingtai Sun,Chao Yuan,Mingshun Li,Suhua Wang
Development of accurate and efficient TCs residue analysis methods is of great significance for the protection of environment, food safety and public health. Herein, a dual-responsive ratiometric fluorescence sensor being capable of simple and sensitive detection of tetracycline (TC) was presented, which was constructed by immobilizing europium ions (Eu 3+ ) onto the mercaptopropionic acid stabilized copper nanoclusters (MPA-Cu NCs). In the presence of TC, the red fluorescence of Eu 3+ was enhanced through antenna effect (AE), while the green fluorescence of MPA-Cu NCs was quenched through internal filter effect (IFE), leading to an obvious fluorescence color evolution from green to red for the probe solution. In addition to successful design of a smartphone-assisted colorimetric analysis platform for portable detection, a logic gate device capable of intelligently monitoring TC concentration is also designed.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 4
·1-9
·
IF 6.408
Gao Xue,Sun Minjun,Liu Xiuying,Li Xuepeng,Li Jianrong
A simple smartphone-integrated ratiometric fluorescent sensing system for visual determination of copper ions (Cu 2+ ) and fluoroquinolones (FQs) was developed based on carbon dots (CDs) which were synthesized through the high-temperature pyrolysis of citric acid. In this system, with the fluorescence resonance energy transfer effect between CDs and 2,3-diaminophenazine (oxOPD), the detection of Cu 2+ and ciprofloxacin (CIP, an example for FQs) was realized. Cu 2+ catalyzes the oxidation of OPD to form oxOPD with yellow fluorescence, resulting in the quenching of CDs. In addition, CIP can inhibit the catalytic activity of Cu 2+ and induce the recovery of CDs fluorescence. Under the excitation of 400 nm, the changes of CDs fluorescence at 472 nm and oxOPD fluorescence at 556 nm were monitored. The detection results showed that the sensing system exhibited good selectivity and sensitivity to Cu 2+ and CIP with the limit of detection of 2.32 × 10 −8 mol L −1 and 0.2 ng mL −1 , respectively. In addition, a smartphone was developed as a portable analyzer to capture the change of fluorescence color and quickly analyze the concentration of Cu 2+ and CIP. The proposed smartphone-based sensing platform has satisfactory sensitivity, and it has application prospects for detecting Cu 2+ and FQs in food safety monitoring. Graphical abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Xueling Shan,Qingyuan Song,Chang Su,Chunping Dong,Ding Jiang,Wenchang Wang,Zhidong Chen
Normally, analytical applications of metal oxide semiconductors (MOS) in electrochemiluminescence (ECL) sensors need to be coupled with electrochemical catalysts, some special coreactants or resonance energy transfer method, since MOS exhibited relatively low ECL intensity. In this research, we developed a simple ECL intensity enhancement method for MOS by covering a nanogold-film (NAuF) on the surface of fluorine-doped tin oxide-coated (FTO) conductive glass electrode. Aminated MnO 2 nanoparticles (NH-MnO 2 ) was chosen as exemplary MOS emitter to discuss the role of NAuF in ECL system. The results indicated that the NAuF bridged ECL sensor using NH-MnO 2 as emitter (NH-MnO 2 -NAuF/FTO) exhibited a stronger ECL intensity and extremely better stability. In furazolidone (FZD) determination test, the quenched ECL intensity showed a good linear relationship to FZD concentrations in the range 1.0 × 10 −8 M ∼ 1.0 × 10 −5 M, with a detection limit of 6.6 × 10 −9 M, in optimized conditions. Given these attributes, we developed a novel platform for ECL system that could simply enhance the intensity and stability. This work also efficiently offered insights into application potential of ECL analysis.
✓ 已验证
产品关联
DOI
高影响因子
Foods
·
2021
·Vol. 10
·期 8
·1838
·
IF 4.35
Yu Wang,Jin-Yi Yang,Ying He,Lu Li,Jian-Xin Huang,Yuan-Xin Tian,Hong Wang,Zhen-Lin Xu,Yu-Dong Shen
Tylosin and tilmicosin (T&T) residues in livestock products have received extensive attention from consumers. Time-resolved fluorescence immunochromatographic assay (TRFICA), as a fast, efficient and sensitive immunoassay method, has played an increasingly important role in the food safety field. Therefore, herein a quantitative and visual TRFICA was established for simultaneously detecting T&T in milk in a group-screening manner. Under the optimal conditions, the standard curve range of developed TRFICA based on the T&T was 1.87~7.47 ng/mL, and the half-maximal inhibition concentrations (IC50) were 4.06 ng/mL and 3.74 ng/mL, respectively. The limits of detection (LOD) of the TRFICA method were from 1.72 ng/mL to 1.39 ng/mL, and the visual cut-off values were 31.25 ng/mL and 62.50 ng/mL for T&T in milk, respectively. Moreover, the stability experiments showed that the strips could be stored at 4 °C for more than 6 months, the total detection time was less than 13 min, and the cross-reactivities (CRs) with related compounds were less than 0.1%, which concluded that the developed TRFICA method could be used in real milk sample detection.Keywords:time-resolved fluorescence immunochromatographic assay;tylosin;tilmicosin;milk
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Shen Zhang,Zixin Wang,Yating Pang,Zerong Jing,Zheng Li,Fangfang Peng,Yiyan Zhao,Yuyu Guo
In this work, blue emission fluorescent carbon dots (CDs) were fabricated by using the hydrothermal strategy from coix seed for the first time. We found that the prepared CDs possessed many excellent characteristics including excitation-dependent properties, good solubility and strong photostability. The optimal excitation and emission wavelength of CDs were 363 and 435 nm, respectively. Unbelievably, the fluorescence of CDs was selectively and effectively quenched with the addition of furazolidone (Fu). The quenching mechanisms might be assumed to the static quenching and inner filter effect (IFE). Based on this principle, a novel fluorescence probe was developed for the determination of Fu. At the same time, the proposed probe showed excellent sensitivity and selectivity towards Fu with a wide linear range from 0.5 to 100 μM, and the corresponding detection limit was 0.096 μM. Moreover, the CDs also could be applied for the sensing of temperature. The practical application of the CDs for Fu detection in real samples was also confirmed with the satisfactory recoveries changing from 96.6% to 108.5%, which provided huge possibility in the field of medical analysis.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYST
·
2023
·
IF 4.2
Mingjiao Shi,Peizheng Shi,Xinxin Yang,Ningbin Zhao,Mengfan Wu,Jing Li,Chen Ye,He Li,Nan Jiang,Xiufen Li,Guosong Lai,Wan-Feng Xie,Li Fu,Gang Wang,Yangguang Zhu,Hsu-Sheng Tsai,Cheng-Te Lin
The presence of sulfamethoxazole (SMX) in natural waters has become a significant concern recently because of its detrimental effects on human health and the ecological environment. To address this issue, it is of utmost urgency to develop a reliable method that can determine SMX at ultra-low levels. In our research, we utilized PVP-induced shape control of a hydrothermal synthesis method to fabricate layer-like structured VS2, and employed it as an electrode modification material to prepare an electrochemical sensor for the sensitive determination of SMX. Thus, our prepared VS2 electrodes exhibited a linear range of 0.06–10.0 μM and a limit of detection (LOD) as low as 47.0 nM (S/N = 3) towards SMX detection. Additionally, the electrochemical sensor presented good agreement with the HPLC method, and afforded perfect recovery results (97.4–106.8%) in the practical analysis. The results validated the detection accuracy of VS2 electrodes, and demonstrated their successful applicability toward the sensitive determination of SMX in natural waters. In conclusion, this research provides a promising approach for the development of electrochemical sensors based on VS2 composite materials.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Zhenping Liu,Jun Zhou,Xianfeng Wang,Jinsong Zhao,Peng Zhao,Yi Ma,Suyi Zhang,Danqun Huo,Changjun Hou,Kang Ren
In view of the urgent need for fluoroquinolones contamination detection in the fields of food safety, a novel aptasensor based on the fluorescence quenching property of graphene oxide (GO) and the fluorescence characteristic of cadmium selenide quantum dots (CdSe QDs) was developed for fluoroquinolones highly sensitive detection in this work. The CdSe QDs with carboxyl-rich surface were synthesized successfully and fluoresced at 525 nm under the optimal excitation light of 366 nm. Based on the hydrophobic and π-π stacking between GO and aptamer, aptamer labeled by CdSe QDs fluorescence (CdSe QDs-apt) were adsorbed by GO and the fluorescence of CdSe QDs was quenched. After the aptamer combined specifically with fluoroquinolones, greater specific force lead to the desorption of CdSe QDs-apt from GO and fluorescence recovery. Represented by Ciprofloxacin (CIP), a member of fluoroquinolones, the fluorescence emission increased with the increasing of CIP concentrations from 8 nM to 500 nM, and the detection limit was 0.42 nM. The spiked recoveries in real samples of honey and milk were 91.5–96.9 % and 90.3–95.2 %, respectively, indicating that the aptasensor was reliable. Moreover, the fluorescence responses of multiple members of fluoroquinolones were found to be consistent, denoting that the fluorescence aptasensor can be used to detect the total amount of multiple members of fluoroquinolones. These results showed that the aptasensor can be used as a promising platform for fluoroquinolones detection.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）