MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 4
·272
·
IF 5.4
Yang Dong,Li Xiangyu,Wu Jing,Yao Tuanli,Chen Chaoxian,Li Xuhua,Chen Jifan,Lan Xueyun,Wang Jiao,Wang Haihua
Semicarbazide (SEM), a metabolite of nitrofurazone, poses potential risks as a carcinogen and teratogen in animal-derived foods. This research is centered on creating a homemade electrochemical sensor with high sensitivity for detecting SEM with dual signals. The working electrode was modified through the in-situ growth of a copper-iron bimetallic organic framework (Cu/Fe-BTC) on carbon cloth (CC), followed by the decoration of gold nanoparticles (AuNPs) on the Cu/Fe-BTC/CC surface. The Cu/Fe-BTC component provides abundant metallic active sites, resulting in a distinct [Fe(CN) 6 ] 3−/4− peak observed at 0.67 V (I 1 , vs. SCE). Concurrently, the incorporation of AuNPs enhances the electrode high electron transfer capacity, which amplifies the signal peaked at 0.18 V (I 2 , vs. SCE), thereby establishing an effective dual-signal detection system. Furthermore, a molecularly imprinted polymer (MIP) layer was electropolymerized onto the modified electrodes, utilizing resorcinol as the functional monomer and SEM as the template. Then, the peak intensities of the dual signals decreased upon target (SEM) recognition and increased during template elution, generating a measurable detection signal. By calculating the current changes, ΔI D = ΔI 1 + ΔI 2 , the adsorbed template molecule concentration could be quantified. Under optimal conditions, the sensor has excellent stability, accuracy, and repeatability in analyzing various samples, including serum, urine, meat, egg, honey, canned food, flour, milk powder, fish, and shrimp. The determination range is linear, spanning from 0.005 to 100 nM, with a limit of detection at 3.9 pM. Therefore, the Cu/Fe-BTC and AuNPs-based MIP sensor represents a reliable dual-signal strategy for the quantitative determination of SEM. Graphical
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Xinmei Qian,Chunxiang Li,Mingyu Zheng,Keqin Deng
A flower-like S, N-codoped carbon nanosheets loaded with hybrid magnetic nanoparticles (HMNPs/S,N-CNSs) by using MOF as precursor was prepared. The morphology, composition, microstructure, and property were evaluated by SEM, HRTEM, EDS, XRD, XPS, magnetic analysis, and cyclic voltammetry. The hybrid nanoparticles were composed of most Fe 3 O 4 , some CoFe alloy, and a few Fe 2 S. The magnetic material showed high magnetism and brilliant electrocatalysis towards the electrochemical reduction of antibiotic nitrofurazone (NFZ). By utilizing screen-printed electrode (SPE) and HMNPs/S,N-CNSs, a disposable electrochemical NFZ sensor (HMNPs/S,N-CNSs/SPE) was fabricated by magnetic control. The current signal of NFZ at HMNPs/S,N-CNSs was 6.38 times higher than that of bare SPE. It displayed a wide detection range of 0.01–50 μM with a detection limit of 4.2 nM (S/N = 3). The practical applicability of the sensor in real samples presented satisfactory results. The disposability, low cost, high sensitivity, low consumption volume in analyses, and good selectivity make the proposed sensor a promising tool for NFZ detection.
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ANALYTICA CHIMICA ACTA
·
2026
·
IF 6.1
Xue Wang,Zhaoyang Zhou,Shuang Jiang,Qi Sun,Xianlu Lei,Yong Xie,Tao Le
Norfloxacin (NOR) has been widely applied in animal husbandry and aquaculture because of its potent antibacterial activity, broad-spectrum efficacy and cost-efficient. Nevertheless, its inappropriate use may result in teratogenic and carcinogenic risks to humans, making the accurate and rapid detection of NOR residues in food critically important. In this study, a strong affinity (Kd = 84 nM) and high selectivity anti-NOR aptamer was obtained by screening with Graphene Oxide Systematic Evolution of Ligands by Exponential Enrichment (GO-SELEX), and a colorimetric aptasensor was fabricated. The limit of detection of the aptasensor was 1.04 ng/mL, and the linear range was 1.56-100 ng/mL. Average recoveries of the aptasensor in shrimp and fish sample analyses ranged from 89.33% to 103.24%, accompanied by coefficients of variation from 3.63% to 9.43%, indicating good analytical precision and accuracy. The aptasensor constructed in this study showed high consistency with the High-Performance Liquid Chromatography (HPLC) for NOR detection, indicating that it is an efficient and promising sustainable strategy for monitoring NOR.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2026
·
IF 4.8
Xiaojing Mao,Huachang Li,Jiemin Liu,Jijun Liu,Pengcheng Han,Haijiao Xie
Fe 3+ and nitrofurazone (NFZ) can raise a risk for environment and human health due to accumulation in water. Hence, a post-synthetic modification strategy was employed to develop a visualization sensor for detecting Fe 3+ and NFZ. In this study, we selected a Zinc-based metal organic framework in combination with fluorescein to develop a fluorescent dyes-encapsulated sensor (Flu@Zn-MOF). The sensing experimental indicated that the Flu@Zn-MOF demonstrated excellent recognition performance for Fe 3+ and NFZ. The detection limits (LODs) of Fe 3+ and NFZ are 1.27 and 0.89 μM, respectively. Furthermore, the color of Flu@Zn-MOF turn from yellow-green to blue in the presence of NFZ. The proposed sensor can accurately identify Fe 3+ and three nitrofuran analogs (NFZ, NFT and FTD) by principal component analysis (PCA). In addition, satisfactory recovery rates and low standard deviation for detection of Fe 3+ and NFZ in real water samples confirms the practicability of Flu@Zn-MOF. Then, a sensing system was created that leverages smartphone technology for the quantitative and real-time monitoring of NFZ. Therefore, this work presents a new strategy for designing a novel sensing method for on-site recognition of nitrofurans pollutants in water.
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CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Guozhi Fan,Yi Chen,Yuchan Lu,Qunpeng Cheng,Bo Chai,Guangsen Song
UiO-66-derived H 2 N-UiO-66-SO 3 H with acid-base active sites was used for the co-production of 5-hydroxymethyl furfural (5-HMF) and furfural (FUR) in the direct conversion of holocellulose composed of cellulose and hemicellulose. The prepared catalyst was further characterized by various techniques, confirming its formation, structure, and composition. H 2 N-UiO-66-SO 3 H displayed excellent performance for the selective conversion of holocellulose to 5-HMF and FUR, achieving yields of 39.1 % and 28.2 %, respectively. The reusability of the catalyst was also investigated by direct use after recycling without any pretreatment. The results indicated that H 2 N-UiO-66-SO 3 H had good stability, and after four cycles, the yields of 5-HMF and FUR decreased only slightly to 37.2 % and 27.1 %, respectively. The recyclable catalyst H 2 N-UiO-66-SO 3 H for the effective conversion of holocellulose to 5-HMF and FUR demonstrated application potential for the utilization of lignocellulosic biomass.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Yan Wu,Yue Zhou,Hongchen Long,Xiangyu Chen,Yuanyuan Jiang,Lei Zhang,Tao Le
The study investigates a bimetallic organic framework (Zn/Eu-MOF) based fluorescent probe for visual detection of ofloxacin (OFL) in pork, beef and fish. The developed sensing probe recognizes OFL through internal filtration and cation-π interaction between OFL and Zn/Eu-MOF, resulting in a distinct color change from orange-red to light green. The content of OFL can be determined through RGB analysis by a mobile-phone. The developed sensing probe offers several advantages such as broad linear range (0.1 ∼ 80 μM), rapid response time (30 s), low detection line (0.44 μM). The effectiveness of the sensing probe can last for five rounds with good recovery. Moreover, the application of the sensing probe on pork, beef and fish samples are reliable, with recoveries ranging from 93.4 to 112.1%, and the relative standard deviations (RSD) within 1.17% to 2.06%. These results suggest that the developed sensing probe could have significant potential for practical on-site test in food.
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APPLIED CATALYSIS A-GENERAL
·
2023
·
IF 5.5
Peng Zhang,Pan Hou,Mingwei Ma,Ke Bu,Qi Guo,Huijuan Yue,Ge Tian,Shouhua Feng
The transformation of lignocellulosic biomass to platform compounds (γ-valerolactone, GVL) was a significant component in biomass development. Herein, sulfonated Zr-based metal-organic frameworks (MOF-808), a bifunctional heterogeneous catalyst with Lewis and Bronsted acid sites, were prepared to catalyze the one-pot cascade reaction of furfural (FUR) to GVL. The successful modification of the sulfonic group on MOF-808 was substantiated by multiple characterization methods. By adjusting the sulfuric acid concentration to balance the Lewis acid and Bronsted acid sites of the catalyst, S-808–2.37 was confirmed as the preferred catalyst and a 60.4 % GVL yield was achieved with 99.1 % carbon balance under the optimal conditions. Moreover, the 72.8 % GVL yield reached in the 40x magnification experiment also boded well for the catalyst’s application potential. The work in this paper opened up new perspectives for the application of MOF-808 porous materials in the field of selective catalytic conversion of biomass involving multi-step reactions.
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Food Analytical Methods
·
2023
·Vol. 16
·期 4
·709-720
·
IF 2.9
Zhou Binbin,Sheng Xingxin,Xie Hao,Zhou Sisi,Huang Lijun,Zhang Zuokun,Zhu Yongbo,Zhong Ming
Nitrofurazone (NF) is a kind of synthetic antibiotic with teratogenic and carcinogenic properties, which is often residual in animal food, so it is of great significance to detect it with high selectivity and rapid. In this study, a molecularly imprinted electrochemical sensor was constructed by electropolymerization for the high-specificity, high sensitivity,and rapid detection of NF in milk. By sequentially modifying reduced graphene oxide (RGO) and gold nanoparticles (AuNPs) on the glassy carbon electrode, the effective surface area and electron transfer ability of the electrode are improved, the double amplification of the electrical signal is realized, and the sensitivity and stability of the sensor are improved. A molecularly imprinted polymer (MIP) is polymerized on the surface of the modified electrode by using NF as a target molecule and o -phenylenediamine ( o –PD) as a functional monomer to improve the specific detection ability of the sensor for NF. The experimental conditions (the number of turns of depositing RGO, the thickness of the MIP, the elution time, and the adsorption time) were optimized to attain the best detection performance of the sensor. Differential pulse voltammetry (DPV) was used to detect NF by redox probe ([Fe(CN) 6 ] 3−/4− ). The constructed sensor exhibited an admirable linear relationship between 5 and 1000 nmol L −1 ( R 2 = 0.9968) and the detection limit was 0.18 nmol L −1 (S/N = 3). Compared to the non-imprinted sensor, the imprinting factor was found to be 3.09. In addition, the sensor also showed excellent repeatability (RSD = 1.17%) and stability, and also showed a good recovery rate in actual sample detection (99.06–101.46%), which is expected to be applied to the detection of other harmful substances in food.
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ANALYTICA CHIMICA ACTA
·
2023
·
IF 6.2
Yangguang Zhu,Xiufen Li,Mengfan Wu,Mingjiao Shi,Qichen Tian,Li Fu,Hsu-Sheng Tsai,Wan-Feng Xie,Guosong Lai,Gang Wang,Nan Jiang,Chen Ye,Cheng-Te Lin
Developing a rapid, sensitive, and efficient analytical method for the trace-level determination of highly concerning antibiotic ciprofloxacin (CIP) is desirable to guarantee the safety of human health and ecosystems. In this work, a novel electrochemical aptasensor based on polyethyleneimine grafted reduced graphene oxide and titanium dioxide (rGO/PEI/TiO 2 ) nanocomposite was constructed for ultrasensitive and selective detection of CIP. Through the in-situ electrochemical oxidation of Ti 3 C 2 T x nanosheets , TiO 2 nanosheets with good electrochemical response were prepared in a more convenient and eco-friendly method. The prepared TiO 2 nanosheets promote charge transferring on electrode interface, and [Fe(CN) 6 ] 3-/4- as electrochemical active substance can be electrostatically attracted by rGO/PEI. Thus, electrochemical detection signal of the aptasensor variates a lot after specific binding with CIP, achieving working dynamic range of 0.003–10.0 μmol L −1 , low detection limit down to 0.7 nmol L −1 (S/N = 3) and selectivity towards other antibiotics. Additionally, the aptasensor exhibited good agreement with HPLC method at 95% confidence level, and achieved good recoveries (96.8–106.3%) in real water samples, demonstrating its suitable applicability of trace detection of CIP in aquatic environment.
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ANALYST
·
2022
·Vol. 147
·期 22
·5011-5017
·
IF 5.227
Jiaxi Yin,Hairong Cui,Ling Lei,Kangbing Wu
Graphene nanosheets (GS) were prepared by ultrasonic exfoliation of bulk graphite in N-methyl-2-pyrrolidone with the assistance of sodium pyrophosphate. The obtained GS suspension was modified on a glassy carbon electrode (GS/GCE), and then functionalized at different voltages (e.g. 1.0, 1.4 and 1.6 V) for 2 min in pH 7.0 phosphate buffer. The electrochemically functionalized GS/GCE (i.e. EGS/GCE) possesses more oxygen-containing groups and a higher defect level. More importantly, the active response area, electron transfer ability and interface adsorption capacity of the EGS/GCE enhanced remarkably. The possible mechanism of the performance enhancement is discussed, and the sensing application of the EGS/GCE in the detection of nitrofurazone (NFZ) is investigated. Compared with the GS/GCE, the EGS/GCE is much more active for NFZ oxidation and greatly increases the detection sensitivity. As a result, a highly sensitive electrochemical detection method has been developed for NFZ, with a detection limit of 2.1 nM. The practical application of the EGS/GCE was tested in fish meat samples, showing good accuracy and feasibility.
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JOURNAL OF FOOD AND DRUG ANALYSIS
·
2022
·
IF 6.157
Jia Wang,Chengyi Hong,Zhengzhong Lin,Zhi-Yong Huang
A simple fluorescence method to quantitatively monitor malachite green (MG) was introduced based on the conformation switch effect of MG-aptamer (Apt) and the fluorochrome of SYBR Green I (SGI). SGI can embed in the stem-loop structure of Apt to produce fluorescence. However, the fluorescence will be quenched when MG is introduced because of the specific binding of Apt to MG. Under the optimal conditions, the fluorescence method displayed excellent linear relationship between the fluorescence quenching efficiencies and the MG concentrations ranging from 0.02 μmol L −1 to 1.0 μmol L −1 . The detection limit of the method was 0.67 μg kg −1 (3 α / κ , n = 9) which is lower than the limit (1 μg kg −1 ) specified in the national standard of China (GB/T 19857–2005) and the limit (2 μg kg −1 ) specified by the European Food Safety Authority (EFSA, 2016). Excellent recoveries between 87.1% and 106.9% tested by spiking standards were achieved with RSD less than 6.4%. The data were confirmed by the method of HPLC, and the results proved that the established fluorescence method could be used for the rapid detection of MG in fish with high accuracy and sensitivity.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Jiangli Sun,Jinhang Yang,Jiaxiang Liang,Lingli Tu,Yuejing Bin,Yanping Hou
It is crucial to design efficient photocatalysts for elimination of combined pollutants in wastewater. Herein, the S-scheme Zn 3 In 2 S 6 -BGQDs/AgBr (ZBA) heterojunction was synthesized through co-modification of Zn 3 In 2 S 6 with B-doped graphene quantum dots (BGQDs) and AgBr nanoparticles using solvothermal method for synchronous removals of nitrofurazone (NFZ) and Cr (VI). Characterization results revealed that ZBA showed superior photocatalytic activity than the counterparts. In NFZ-Cr (VI) coexistence environment, removal efficiencies towards NFZ and Cr (VI) were 95.23% and 99.39% using the ZBA photocatalyst within 2 h of visible light irradiation. Results demonstrated that ∙OH, h + and ∙O 2 − played major role for NFZ removal, while mainly e - and ∙O 2 − contributed to Cr (VI) reduction. The S-scheme heterojunction mechanism of ZBA was confirmed by energy band structure analysis, ESR and calculated work function. Possible pathways and mechanisms of NFZ degradation were proposed according the identified intermediates. Besides, the ecotoxicity of intermediates was analyzed. This study advances the development of photocatalytic treatment of combined-polluted wastewater.
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