International Journal of Nanomedicine
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2025
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IF 6.5
Can Li,Guiju Chen,Xiongwei Yan,Bingyang Hu,Xiangyun Zhang,Jun Song
Introduction Osteoarthritis (OA) is one of the major menaces to human health. Currently, no sufficiently effective medications are available to treat OA clinically. OA is an inflammatory joint disorder. The overproduction of reactive oxygen species (ROS) plays a critical role in initiating and developing OA pathogenesis. ROS scavenging has become a vital target for OA therapy. Although chromium sesquioxide (Cr2O3) nanoparticle has been proven to have excellent ROS scavenging ability, its clinical application is limited due to its poor biocompatibility. Polydopamine (PDA) is an excellent carrier with outstanding biocompatibility. PDA-based nanomaterials exhibit significant potential for various ROS-related diseases.Methods PDA was synthesized through oxidative autopolymerization of dopamine in an alkaline environment. Subsequently, the novel nanozyme PDA-Cr2O3 was synthesized by loading Cr2O3 onto PDA nanoparticles with the assistance of hydrazine hydrate. Afterward, the cytotoxicity and ROS scavenging capacity of PDA-Cr2O3 were examined. Finally, the ability of PDA-Cr2O3 to treat OA was explored at both cellular and animal levels.Results PDA-Cr2O3 had low cytotoxicity and toxic side effects in vivo. Moreover, PDA-Cr2O₃ exhibited a remarkable capacity to scavenge ROS both in cell-free in vitro systems, such as kit-based assays, and in cellular models. It also dramatically decreased the transcriptional level of inflammation-associated genes and the secretion of inflammatory factors of the OA chondrocytes. In animal experiments, PDA-Cr2O3 markedly suppressed the progression of OA.Conclusion PDA-Cr2O3 nanozyme had good biocompatibility and could effectively suppress the development of OA by efficiently scavenging ROS, which has important application prospects in OA treatment. This study might offer some new ideas for the treatment of ROS-related diseases.
研究领域:
纳米医学
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生物化学
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药理学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2024
·
IF 2.7
Shengdong Liu,Da Li,Tianhua Xiao,Zhufeng Yuan,Huanhuan Zhang,Yonggang Min
Polyetheretherketone (PEEK) emerges as a highly promising biopolymer due to its mechanical properties and elastic modulus akin to those of human cortical bone. Despite these advantages, the clinical utilization of PEEK is often hindered by its limited bioactivity and suboptimal capability for bone integration. Herein, we introduce a facile and expeditious method for enhancing the osseointegration efficacy of PEEK substrates by depositing polydopamine (PDA) chelated with magnesium ions at varying concentrations (0.02, 0.1, and 0.5 M) as a surface coating (PDA-Mg). This PDA-Mg-modified PEEK surface exhibits distinctive properties, including antibacterial properties (antibacterial rate of 93.267%), improved vascular regeneration, and osteogenic promotion (ALP activity increased by 239.5%). Moreover, the Mg 2+ ions are released in a regulated way, and the impact of Mg 2+ concentration on the aforementioned properties has been thoroughly examined. Our study demonstrates that PDA-Mg-modified PEEK offers a highly promising prospect for clinical applications. Specifically, these implants stand out as exceptional candidates for bone graft materials, with the potential to significantly improve patient outcomes and accelerate recovery processes.
研究领域:
生物材料
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组织工程
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骨科
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材料科学
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2015
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IF 4.383
Xiang Gao,Xiaohong Zhang,Jinlin Song,Xiao Xu,Anxiu Xu,Mengke Wang,Bingwu Xie,Enyi Huang,Feng Deng,Shicheng Wei
The construction of functional biomimetic scaffolds that recapitulate the topographical and biochemical features of bone tissue extracellular matrix is now of topical interest in bone tissue engineering. In this study, a novel surface-functionalized electrospun polycaprolactone (PCL) nanofiber scaffold with highly ordered structure was developed to simulate the critical features of native bone tissue via a single step of catechol chemistry. Specially, under slightly alkaline aqueous solution, polydopamine (pDA) was coated on the surface of aligned PCL nanofibers after electrospinning, followed by covalent immobilization of bone morphogenetic protein-7-derived peptides onto the pDA-coated nanofiber surface. Contact angle measurement, Raman spectroscopy, and X-ray photoelectron spectroscopy confirmed the presence of pDA and peptides on PCL nanofiber surface. Our results demonstrated that surface modification with osteoinductive peptides could improve cytocompatibility of nanofibers in terms of cell adhesion, spreading, and proliferation. Most importantly, Alizarin Red S staining, quantitative real-time polymerase chain reaction, immunostaining, and Western blot revealed that human mesenchymal stem cells cultured on aligned nanofibers with osteoinductive peptides exhibited enhanced osteogenic differentiation potential than cells on randomly oriented nanofibers. Furthermore, the aligned nanofibers with osteoinductive peptides could direct osteogenic differentiation of human mesenchymal stem cells even in the absence of osteoinducting factors, suggesting superior osteogenic efficacy of biomimetic design that combines the advantages of osteoinductive peptide signal and highly ordered nanofibers on cell fate decision. The presented peptide-decorated bone-mimic nanofiber scaffolds hold a promising potential in the context of bone tissue engineering.
研究领域:
生物材料
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组织工程
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生物医学工程
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干细胞生物学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Yingying Wang,Taipeng Jiang,Shangmin Si,Jian Wu,Lan He,Weijie Wei,Lingling Zeng,Sheng Chen,Meng Li,Zhuwei Gao
Photothermal materials have attracted considerable attention for efficient solar energy conversion. A promising strategy involves leveraging the photothermal effect to reduce crude oil viscosity, thereby facilitating efficient oil–water separation. In this study, we reported the in-situ polymerization of covalent organic framework (COF) layers on cotton wool (CW). Subsequently, polydopamine (PDA) and polydimethylsiloxane (PDMS) were sequentially coated to obtain a novel sandwich-structured composite (PDMS@PDA@COF@CW). The composite exhibited excellent superhydrophobic properties with a water contact angle of 153.5°. Furthermore, it maintained an oil–water separation efficiency of 98.1 % even after 50 consecutive cycles. The material also demonstrated remarkable chemical stability under various harsh environmental conditions and possessed excellent flame retardancy. Critically, the synergistic interaction between the PDA coating and the COF framework significantly enhanced photothermal performance. Consequently, the surface temperature of PDMS@PDA@COF@CW rapidly reached 83.8 °C within 180 s under 1.0 kW/m 2 light irradiation. This study presents a highly promising solution for mitigating crude oil spills, offering valuable insights into the design of multifunctional materials for environmental remediation.
研究领域:
环境科学
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材料科学
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化学工程
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纳米技术
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2025
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IF 8.2
Chunqing Yang,Dongzhi Zhang,Weiwei Wang,Jun Wang,Yukun Liu,Lina Zhou,Yihong Guo,Jiahui Shao
In recent years, smart textiles and flexible wearable products have garnered significant attention in fields such as human-computer interaction, medical rehabilitation training, and motion monitoring. Flexible pressure sensors have attracted significant attention due to their excellent flexibility, stability, and multifunctional integration. Herein, a multifunctional wearable MXene/polydopamine (PDA)@cotton fabric pressure sensor was developed by modifying weft-knitted cotton fabric based on a dual hydrogen bond self-assembly strategy. The MXene/PDA@cotton fabric pressure sensor demonstrates wide linear detection range (0–146 kPa), high sensitivity (0.95 kPa–1), fast response/recovery times (16.434 and 11.952 ms), and outstanding stability after over 5000 cyclic tests. This sensor can achieve the monitoring of physiological parameters for human state detection, such as facial expression signals, abdominal respiratory signals, and joint bending signals. Furthermore, by integrating the MXene/PDA sensors into the interphalangeal and metacarpophalangeal joints of a cotton glove, combined with intelligent algorithms and the human-computer interaction system, static gesture recognition and dynamic sign language translation were successfully realized based on the smart glove. This work demonstrates the potential application of flexible pressure sensors in intelligent human-computer interaction, providing new insights for developing next-generation sign language recognition systems.
研究领域:
材料科学
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纳米技术
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可穿戴电子器件
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人机交互
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人工智能
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Wen-Long Liu,Tao Liu,A-Min Cao,Si-Yong Qin,Jun Feng,Xian-Zheng Zhang
Tumor relapse and cancerometastasis frequently occur post tumor treatments, leading to poor prognosis with high mortality. Unfortunately, therapy-exacerbated inflammation is among the chief causes of poor prognosis, especially for photothermal therapy (PTT). To overcome this mismatch between therapy and prognosis, we design a built-in Pt/polydopamine(PDA) nanoconstruction (PNP) that makes the anti-inflammation potency and therapy outcome positively inter-linked by virtue of their temperature dependency. PDA not only works as the PTT agent but also provides a self-reductive nano-substrate (∼150 nm) for the in-situ generation of ultrasmall Pt nanodots (∼4 nm). The embedding of Pt nanodots affects insignificantly the PTT potency of PDA while importing the enzyme-like ROS-scavenging function to defend inflammation in a therapy-enhanced manner. Specifically, PNP exhibits the increasing anti-inflammation effect with the elevated temperature caused by PTT, which enables the anti-inflammation pathway to match perfectly PTT modality. In vivo results indicate that PNP leads to better antitumor performance and effective inhibition of tumor relapse and cancerometastasis. This study provides new ideas for systematical tumor treatments with improved prognosis by coordinating anti-inflammation and antitumor actions harmoniously.
研究领域:
肿瘤学
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纳米技术
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治疗学
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DOI
高影响因子
LANGMUIR
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2025
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IF 3.9
Dinghao Sun,Rong Du,Jin Zhang,Heng Zhang,Yi Li,Hang Xiao,Haibo Wang,Qingzhu Sun,Zhiyuan Ma
Improving the dispersion and compatibility of fillers in epoxy resin (EP) is crucial for enhancing the thermal stability, mechanical properties, and tribological performance of coatings. This study presents a novel biomimetic modification strategy. MoS2–TiN hybrid fillers are uniformly dispersed in the EP matrix and strongly bonded through comodification with polydopamine (PDA) and γ-aminopropyltriethoxysilane (KH550). The successful synthesis of MoS2–TiN@(PDA+KH550) fillers is confirmed by using Fourier transform infrared spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Scanning electron microscopy, transmission electron microscopy, and dispersion tests show that the aggregation of MoS2 and TiN is alleviated. Compared to pure EP, the PDA@MoS2–KH550@TiN (2:1)/EP (PMT2@EP) coating shows significant improvements in several aspects. In terms of thermal stability, the residual carbon rate at 800 °C increased from 9.38 to 11.98%. For mechanical properties, the storage modulus increased by 7.2%, the glass transition temperature (Tg) increased by 24.6%, the tensile strength increased by 42.1%, the tensile modulus increased by 60.9%, the hardness increased by 58.3%, and the flexural strength increased by 59.1%. Additionally, the coating exhibits enhanced tribological performance, with a reduction in the friction coefficient of 81.8% (from 0.555 to 0.101) and a decrease in the wear rate of 77.8% (from 11.64 × 10–5 mm3/(N m) to 2.58 × 10–5 mm3/(N m)). This biomimetic interface design provides important experimental and technical support for developing high-performance, wear-resistant, low-friction EP coatings.
研究领域:
材料科学
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聚合物复合材料
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摩擦学
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表面工程
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纳米材料
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2020
·Vol. 138
·期 19
·50392
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IF 2.52
Xing Cao,Xiangli Liu,Yan Liu,Rui Ma,Shichang Sun
Numerous cells grow in columnar tissues and organs with different curvatures and curvature gradients. Therefore, it is necessary to study the effect of curvature on cell behavior to control and promote cell development. Herein, we prepared polydimethylsiloxane (PDMS) with different micro-nano patterns using ultraviolet soft lithography. Hydrophilic polydopamine (PDA) was modified on the PDMS surface to prepare PDMS/PDA to improve its biocompatibility. The PDMS/PDA was characterized by contact angle tester and scanning electron microscopy (SEM). The effect of curvature on bone cell migration and differentiation was studied through SEM, inverted phase contrast microscope and fluorescence microscopy. We found that different curvatures had different effects on the bone cell migration and differentiation. Chondrocytes migrated rapidly in grooves with a curvature range of 1/575–1/875 μm −1 . Bone mesenchymal stem cells (BMSCs) had high efficiency of differentiation into chondrocytes in the grooves with a curvature range of 1/775–1/1375 μm −1 . Furthermore, BMSCs showed high efficiency of differentiation into chondrocytes at the edges of micro-nano patterns with different perimeter curvatures, and the differentiation efficiency was the highest at 120° convex curvature. This work shows that curvature is a principle to be considered in bone tissue regeneration engineering and provides inspiration for future biomaterials design.
研究领域:
生物医学工程
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细胞生物学
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组织工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Huijuan Zhang,Kexuan Cao,Chaoqun Wang,Yingmei Tian,Lin Hou
Drug thrombolysis is the main means of clinical treatment for thrombotic-related diseases. However, serious bleeding complications caused by low drug delivery efficiency and secondary vascular embolism usually lead to unsatisfactory therapeutic effects. Herein, we constructed a thrombin and near-infrared (NIR) dual-responsive drug-loaded intelligent system to solve the above problems. The CREKA-modified polydopamine (PDA) nanoparticles (NPs) were crosslinked by thrombin-responsive peptide (Pep), to obtain Pep-PPC nanocarriers with special mesoporous nanostructures. Subsequently, NO donor BNN6 and thrombolytic drug UK were loaded on the surface and into the mesoporous of Pep-PPC, to get the multifunctional Pep-NO@PPC/UK. In vitro and in vivo results proved that Pep-NO@PPC/UK could effectively recognize and aggregate at the thrombus site via CREKA-mediated active targeting. Then local abundant thrombin cleaved the nanoplatform to release UK. Meanwhile, PDA converted NIR light into heat and synchronously triggered NO release. This transformed the DDS into a “heat-gas” dual propulsion nanomotor in situ, driving deep penetration of UK in thrombus tissue. Under the combined action of UK and PTT, arterial thrombosis rapidly dissolved with relatively low bleeding risk. More importantly, NO generated in situ could prevent re-embolism of blood vessels at the thrombolytic site by inhibiting activated platelet aggregation, ultimately improving vascular reperfusion rate through a combination of attack and defense mode.
研究领域:
药学
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纳米技术
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生物医学工程
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治疗学
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产品关联
DOI
高影响因子
FIBERS AND POLYMERS
·
2022
·Vol. 23
·期 9
·2511-2516
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IF 2.347
Song Mengqi,Zhao Qian,Wang Xiuting,Shi Chuan,Hu Xiao,Li Jiwei
In this study, an asymmetric wettable composite wound dressing consists of hydrophobic polyvinylidene fluoride (PVDF) outer layer and a hydrophilic polydopamine (PDA) coated Ag nanoparticles (Ag NPs)/PVDF layer (PVDF-Ag-PDA) was successfully prepared through electrospinning and PDA coating. The results show that the contact angle of the PVDF surface is 132.8°, while the PDA-coated surface is nearly 0°, indicating an asymmetric wettability. The highly hydrophilic PVDF-Ag-PDA layer can significantly reduce bacterial growth, while the PVDF layer with a small pore size and high hydrophobicity can prevent bacterial adherence. In addition, cytotoxic assays showed that PVDF/PVDF-Ag-PDA present a high cell viability percentage (above 80 %), which is attributed to that the thin layer of PDA can alleviate the cytotoxicity of Ag NPs. Therefore, the Janus wound dressing noted as PVDF/PVDF-Ag-PDA has the potential for practical applications with the advantages mentioned above.
研究领域:
材料科学
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生物医学工程
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纳米技术
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伤口愈合
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
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IF 13.3
Jiayi Qin,Jia Su,Hong Li,Ling Zhang,Ling Zhang,Ke Jiang
The development of novel antibacterial strategies as alternatives to antibiotics is of great significance but remains considerable challenges due to the lack of safe, effective, and broad-spectrum agents. Here, we explored the potential of a biocompatible metal–organic framework Fe-MIL-53-NH 2 (FM) for reactive oxygen species (ROS)-based antibacterial applications. However, FM was found to be catalytically inert due to the very weak reducibility of Fe 3+ toward H 2 O 2 . To address this challenge, we incorporated a small amount of Co 2+ (0.98 %) into FM (CFM), successfully activating Fenton chemistry and achieving a notable 5.5-fold improvement in Fenton activity. Density functional theory (DFT) calculations revealed that a very small amount of Co 2+ doping significantly reduces the energy barrier of the Fenton reaction by shifting the d-band center to the Fermi level and optimizing the charge density of active Co atoms. We further enhanced the antibacterial properties of CFM by modifying it with the photothermal agent polydopamine (PDA), resulting in CFMP. Through the synergistic effects of ROS and photothermal properties, CFMP exhibited remarkable antibacterial activity, with bacterial eradication rates exceeding 99 % against both E. coli and S. aureus . Moreover, in vivo experiments demonstrated the exceptional efficacy of CFMP in sterilizing S. aureus -infected wounds, while causing negligible damage to other major organs. This study not only highlights the role of atom engineering in activating Fenton reaction, but also provides rational designs for a synergistic antibacterial strategy via powerful MOFs chemistry.
研究领域:
材料科学
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纳米技术
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生物医学工程
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化学
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微生物学
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产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
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2024
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IF 5.8
Jiaofeng Ye,Shuanglong Chen,Libang Feng,Jianbin Zhang,Yanhua Liu,Danbin Zhu
Self-healing polyurethane used in architectural engineering often suffers from contradictory mechanical and self-healing properties, limited repair options and low repair efficiency. In this research, a series of self-healing polyurethane materials were manufactured by introducing Fe 3 O 4 , polydopamine (PDA) and Fe 3 O 4 @PDA nanoparticles into polyurethanes based on thermo-reversible Diels-Alder reaction. These nanoparticles endowed self-healing polyurethane with multiple responses to thermal, NIR and microwave. Consequently, the evident cracks were renovated quickly and repeatedly upon these excitations. Therefore, the nanoparticles not only improved the healing efficiency markedly, but also endowed polyurethane with multiple responsive self-healing ability. Interestingly, due to the synergistic interaction between photothermal effect, microwave effect, and rigidity of Fe 3 O 4 as well as photothermal effect and compatibility with organic matrix of PDA, Fe 3 O 4 @PDA-modified polyurethane was empowered with the most exceptional mechanical and self-healing properties. Results revealed that Fe 3 O 4 @PDA nanoparticles-modified polyurethane exhibited high mechanical properties such as strength, toughness and hardness as well as excellent multiple stimulus response self-healing performance. More importantly, results revealed that the recycled self-healing and multiple stimulus response ability of nanoparticles-modified self-healing polyurethane was implemented grounded on four synergistic effects of photothermal effect of nanoparticles, thermo-reversible Diels-Alder reaction, thermal movement of molecular chains and nanoparticles, and the dissociation and regeneration of hydrogen bonds. This research provided an ideal approach for numerous options for cracks repairing used in construction industry when exposed in harsh environments.
研究领域:
材料科学
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纳米技术
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高分子化学
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工程材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）