Light-Science & Applications
·
2019
·Vol. 8
·期 1
·1-13
·
IF 14
Dai Bo,Jiao Ziao,Zheng Lulu,Bachman Hunter,Fu Yongfeng,Wan Xinjun,Zhang Yule,Huang Yu,Han Xiaodian,Zhao Chenglong,Huang Tony Jun,Zhuang Songlin,Zhang Dawei
In this article, we demonstrated a handheld smartphone fluorescence microscope (HSFM) that integrates dual-functional polymer lenses with a smartphone. The HSFM consists of a smartphone, a field-portable illumination source, and a dual-functional polymer lens that performs both optical imaging and filtering. Therefore, compared with the existing smartphone fluorescence microscope, the HSFM does not need any additional optical filters. Although fluorescence imaging has traditionally played an indispensable role in biomedical and clinical applications due to its high specificity and sensitivity for detecting cells, proteins, DNAs/RNAs, etc., the bulky elements of conventional fluorescence microscopes make them inconvenient for use in point-of-care diagnosis. The HSFM demonstrated in this article solves this problem by providing a multifunctional, miniature, small-form-factor fluorescence module. This multifunctional fluorescence module can be seamlessly attached to any smartphone camera for both bright-field and fluorescence imaging at cellular-scale resolutions without the use of additional bulky lenses/filters; in fact, the HSFM achieves magnification and light filtration using a single lens. Cell and tissue observation, cell counting, plasmid transfection evaluation, and superoxide production analysis were performed using this device. Notably, this lens system has the unique capability of functioning with numerous smartphones, irrespective of the smartphone model and the camera technology housed within each device. As such, this HSFM has the potential to pave the way for real-time point-of-care diagnosis and opens up countless possibilities for personalized medicine.
研究领域:
生物医学工程
·
医学影像
·
光学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-11
·
IF 9.429
Xie Maowen,Yao Guang,Zhang Tianyao,Wang Qian,Mo Xiaoyi,Dong Qiwei,Lou Wenhao,Lu Fang,Pan Taisong,Gao Min,Jiang Dawei,Zhao Kangning,Lin Yuan
As a non-invasive innovative diagnosis platform, advanced flexible contact lenses can dynamically monitor vital ocular indicators, spot abnormalities and provide biofeedback guidance for real-time diagnosis and rehabilitation tracking of chronic eye diseases. However, most of the state-of-the-art reported contact lenses either can only monitor a single indicator at a time or realize multifunctional integration based on multiple materials. Herein, we developed a flexible multifunctional contact lens based on inorganic γ-Fe 2 O 3 @NiO magnetic oxide nanosheets, which can be attached conformally and seamlessly to the eyeball to simultaneously monitor glucose level in tears, eyeball movement, and intraocular pressure. The optimized contact lens has a reliable glucose detection limit (0.43 μmol), superior eye movement measurement accuracy (95.27%) and high intraocular pressure sensitivity (0.17 MHz mmHg − 1 ). This work presents a concept in the biochemical and biophysical integrated sensing of ocular signals using contact lens via an innovative material, and provides a personalized and efficient way for health management. Graphical Abstract
研究领域:
生物医学工程
·
纳米技术
·
视光学
·
材料科学
·
健康监测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Youwei Zhao,Qingzheng Jia,Yuxuan Zhang,Xinyuan Zhang,Ling Li,Yucang Zhang,Wenming Zhang
Wearable medical devices are gaining significant attention for their potential in intelligent health monitoring, particularly in response to the needs of an aging global population. However, conventional systems often suffer from limitations in power supply, mechanical adaptability, and real-time diagnostic capabilities. In this work, a flexible, self-powered intelligent sensing system is reported, based on a carbon cloth substrate modified with a pomegranate-inspired Polyaniline-Prussian blue (CC@PANI-PB) composite. This multifunctional composite simultaneously serves as a high-performance cathode material for lithium-oxygen (Li-O₂) batteries and as an active sensing layer for pressure and ECG signal acquisition. The unique microstructured morphology and optimized interfacial interactions enable both high energy output and ultrasensitive tactile sensing. The resulting sensor exhibits a wide detection range (30–100 000 Pa), exceptional mechanical durability (over 9000 cycles), and ultrahigh sensitivity (S max = 4.16 × 10⁷ kPa⁻¹). Integrated with a Li-O₂ energy unit and signal processing module, the system enables continuous pulse signal acquisition and ECG classification, achieving a disease prediction accuracy of 95.90% and ECG classification accuracy of 93.75%. This integrated platform demonstrates strong potential for next-generation wearable healthcare systems, combining real-time sensing, energy autonomy, and intelligent diagnosis within a unified framework.
研究领域:
生物医学工程
·
材料科学
·
纳米技术
·
传感器技术
·
可穿戴设备
·
心脏病学
·
能量存储
·
医疗人工智能
·
中西医结合
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）