ADVANCED FUNCTIONAL MATERIALS
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2024
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IF 18.5
Liang He,Xueyan Nan,Peipei Wang,Zhizhou Liu,Tong Wang,Pengli Bai
The nonconventional polymer luminophores (NPLs) with white emission are scarce due to the challenges in regulating their clustering structures. In this work, polystyrene is employed to develop a new kind of broad-emitting clusteroluminescence (CL) through suitable cross-linking and sulfonation. The sulfonated porous poly(styrene-co-divinylbenzene) microspheres (SPDMs) exhibit broad emission spectra (400–700 nm) in the visible light region. Further characterization and theoretical calculations show that through-space conjugation (TSC) enhanced with high cross-linking and sulfonation degrees (SD) is the main factor affecting the luminescence of microspheres. Monodisperse SPDMs with a low fluorescence distribution (CV < 5%) across 13 flow channels. Additionally, SPDMs microspheres is employed to construct binary, Cu 2+ , and pH-responsive microarrays to encrypt and decode important information. Finally, SPDMs are developed for utilization as single-component white and warm white light-converting light emitting diodes (LEDs). These LEDs demonstrate Commission International de L’Eclairage (CIE) coordinates and correlate color temperatures (CCT) of (0.31, 0.321) and (0.383, 0.41), 6611 and 4100 K, respectively. Notably, the color rendering index (CRI) value for SPDMs-50-2 in white LED applications reaches an impressive 92. This study provides an economical, simple, and effective design strategy for developing NPLs with both monodispersity and broad emission.
研究领域:
材料科学
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光学
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化学
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DOI
高影响因子
Journal of Materials Chemistry B
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2023
·Vol. 11
·期 37
·8916-8925
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IF 7
Guiming Niu,Fucheng Gao,Can Li,Yandong Wang,Hui Li,Yanyan Jiang
Carbon dot (CD)-based nanozymes have great potential in antibacterial applications. In order to achieve enhanced broad-spectrum antibacterial capacity, we synthesized Co-doped drug-based CDs (Co-Lvx-CDs) using levofloxacin and vitamin B12 as precursors by mimicking the catalysis of antibacterial activity of natural enzymes. The Co-Lvx-CDs retained not only the effective functional groups of the traditional antibiotic levofloxacin but also achieved oxidase-like and peroxidase-like activities to generate reactive oxygen species (ROS) through Co doping. Additionally, the Co-Lvx-CDs had superb fluorescence properties and could be applied in information encryption. The CDs were validated to have a broad-spectrum bactericidal effect against Gram-positive and -negative bacteria, compensating for the limitations of levofloxacin while also having enhanced sterilization ability. Importantly, the proposed Co-Lvx-CDs provide a new idea for the design of multifunctional CD-based nanozymes with preconceived outcomes.
研究领域:
生物材料学
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医学微生物学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
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2024
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IF 10
Meng-Meng Chen,Han-Wen Tian,Yuan-Qiu Cheng,Yu-Xin Yue,Yu-Chen Pan,Dong-Sheng Guo
Snakebite is a medical emergency that often leads to high mortality and morbidity in tropical and subtropical regions. The diversity in venom composition between various types of snakes necessitates the use of different specific antivenom treatments, which presents clinical and financial challenges in the management of snakebites. Therefore, developing a broad-spectrum antidote to neutralize complex and diverse snake venoms has assumed critical importance. Herein, a broad-spectrum antidote is developed through molecular recognition and coassembly to neutralize four kinds of snake venom toxins, those are three-finger toxin (3FTx), snake venom metalloproteinase (SVMP), phospholipase A 2 (PLA 2 ), and snake venom serine protease (SVSP), which have high abundance and toxicity. The coassembly of sulfonate-modified amphiphilic calixarene (SCA) and amphiphilic cyclodextrin (CD) is employed to neutralize the toxicity of 3FTx, 1,2-dodecanedithiol (DDT) and thioetheramide phosphorylcholine (TEAPC) are introduced through coassembly to neutralize toxicity of SVMP and PLA 2 , respectively, and the nafamostat (NT), which can be loaded through the host-guest complexation, is employed to neutralize toxicity of SVSP. The broad-spectrum antidote, NT@SCA/CD/DDT/TEAPC, effectively neutralizes key toxins from the most medically important cobra and vipers, significantly improving survival rates of poisoned mice. This study conceptually validated the feasibility of broad-spectrum detoxification and also offers a conveniently integrated supramolecular strategy.
研究领域:
医学
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生物化学
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药理学
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
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2024
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IF 5.1
Luyin Zhao,Jingmei Li,Jiayun Shao,Ling Zhang,Yuhao Ji,Xiulong Li,Dianmin Ju
The contamination of water resources in recent years has resulted in the dissemination of harmful bacteria via water sources, posing a significant threat to the safety and well-being of humans, animals, and plants. Consequently, there is a growing concern over the health and sanitation of water resources. Photocatalysis, a novel and very effective antibacterial method, has gained significant attention in the area of antibacterial research. Bismuth nitrate pentahydrate and sodium tungstate dihydrate were used in a straightforward hydrothermal process to create nanoflower spheres Bi 2 WO 6 /ZnO photocatalytic composites in molar ratios of 1:1, 1:2, 1:3, and 1:4. The first-ever demonstration of the photocatalytic broad-spectrum antibacterial activity of porous nanoflower spheres Bi 2 WO 6 /ZnO composites was shown. The samples were analyzed using X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FT-IR), and ultraviolet–visible spectroscopy (UV–vis). The antibacterial activity was evaluated using the dilution coated plate technique, with LED light irradiation. The findings indicate that the Bi 2 WO 6 /ZnO composite has a much superior antibacterial activity against both bacteria and fungus compared to individual Bi 2 WO 6 and ZnO. When exposed to LED lighting with an intensity of 35 W, the Bi 2 WO 6 /ZnO nanoparticles in a 1:2 ratio at a concentration of 1000 mg/L demonstrated complete antibacterial effectiveness against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis within 30 min. Similarly, the nanoparticles achieved 100 % antibacterial efficiency against Candida albicans within 90 min. The antibacterial efficacy of 1000 mg/L 1:2 Bi 2 WO 6 /ZnO nanoparticles against Escherichia coli and Staphylococcus aureus was found to be 100 % within 5 min under natural lighting conditions. The findings indicate that Bi 2 WO 6 /ZnO nanoparticles have excellent photocatalytic broad-spectrum antibacterial efficacy.
研究领域:
环境科学
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微生物学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
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2025
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IF 5.4
Man Liu,Li Zhao,Xupeng Huang,Zhenhao Tang,Yihang Zhong,Mengrong Yan,Shun Liu,Shunjing Wang,Zeyun Sun,Zixuan Rao,Linyi Yu,Yuying Fang,Wei Zhang,Hongbo Zhang,Wei Peng
The COVID-19 pandemic underscores the urgent need to develop broad-spectrum antivirals against coronaviruses (CoVs) to prepare for future outbreaks. In this study, we presented a systematic approach to developing broad-spectrum Mpro inhibitors, with a focus on high-risk CoVs. We optimised S-217622 as a lead compound, with the goal of enhancing conserved interactions within the S1, S2, and S3/S4 pockets of Mpro, leading to significantly improved inhibitory potency against representative CoVs. Compound 25 exhibited submicromolar activity across all ten CoVs, with IC50 values below 0.1 μM for six of them. The X-ray co-crystal structure of SARS-CoV-2 Mpro in complex with compound 25 revealed the structural basis of conserved interactions contributing to its broad-spectrum activity. This study demonstrates the feasibility of reinforcing conserved interactions to develop Mpro inhibitors with broad-spectrum activity and provides valuable strategies for combating future pandemics caused by unknown CoVs.
研究领域:
病毒学
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药物开发
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结构生物学
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DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2022
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IF 9.965
Min Wang,Guanghua Lu,Runren Jiang,Tianjian Dang,Jianchao Liu
In view of the increasing threat of overuse of broad-spectrum antibiotics to water environment, here, a series of small molecular intercalated bismuth oxychloride (SBC-X) composite photocatalysts were successfully constructed by a simple stirring synthesis at room temperature. Among them, SBC-0.5 showed excellent photocatalytic performance against the three target broad-spectrum antibiotics in visible light, which was 3.06 times, 5.93 times and 11.64 times higher than that of monomer for degrading tetracycline, norfloxacin and ciprofloxacin, respectively. Through analysis, it was found that the excellent photocatalytic degradation performance of SBC-0.5 was mainly attributed to the greatly improved specific surface area, which increased to 14 times of monomer, providing a large number of reaction sites for the subsequent photocatalytic degradation. Besides, intercalated molecules as charge transfer bridges between nanosheets greatly accelerated the efficiency of photogenerated charge transfer between layers. Free radical trapping experiments and electron spin resonance indicated that superoxide anion radicals played a major role in the photocatalytic degradation, followed by singlet oxygen. Furthermore, nine potential degradation intermediates were identified, and the toxicity was greatly reduced confirmed by ECOSAR software prediction and soybean seed germination and seeding growth experiment. Our work will provide useful information for the purification of wastewater containing antibiotics.
研究领域:
环境科学
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材料科学
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微生物学
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DOI
高影响因子
Small
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2025
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IF 12.1
Yumei Wang,Han Wu,Xin Liu,Zekai Ren,Yang Cao,Hailin Cong,Bing Yu
The development of biomaterials with rapid hemostatic and antibacterial activity is essential for the treatment of chronic bacterial infected wounds. In this study, bacterial membrane chromatography combined with one-bead-one-compound (OBOC) method is used for rapid screening of antimicrobial peptides with potential antimicrobial properties. The screened antimicrobial peptide LKAPI (AMP LI5) has broad-spectrum bactericidal properties. Besides, AMP LI5 exhibited superior activation of the coagulation cascade and increased adherence to blood cells and platelets, which allows it to quickly coagulate blood. The hemostatic results showed that the AMP LI5 has a desirable hemostatic effect on the mouse tail-breaking model (9 ± 0.47 s). Finally, an HA-base composite antimicrobial peptide hydrogel is prepared antibacterial and hemostatic effects, which have injectability, compressibility, self-healing, and good biocompatibility. In addition, the antimicrobial peptide hydrogel significantly accelerated wound healing in chronic bacterial infected wounds in mouse. In summary, antimicrobial-hemostatic peptide hydrogels are expected to be competitive and multifunctional wound dressings for hemostasis and healing of bacterial-infected wounds.
研究领域:
生物材料学
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医学
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药理学
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产品关联
DOI
PubMed
高影响因子
VETERINARY MICROBIOLOGY
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2022
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IF 3.246
Hongyan Luo,Mengru Li,Zhishuang Yang,Dekang Zhu,Pei Li
A novel chromosomally-located β-lactamase gene, bla RASA-1 , was identified in Riemerella anatipestifer RA-CH-1. The RASA-1, encoded by bla RASA-1 , was a class A extended-spectrum β-lactamase (ESBL), which shared 42.7% and 40.5% identities with the RAA-1 and CGA-1 β-lactamase, respectively. Overexpression of RASA-1 in Escherichia coli confers broad resistance to β-lactams and the purified native RASA-1 revealed ESBL-like hydrolysis activity. Blasting in GenBank showed that bla RASA-1 was exclusively detected in Riemerella anatipestifer . Moreover, sequence analysis revealed that this gene was located within the multi-resistance region of Riemerella anatipestifer genome.
研究领域:
微生物学
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抗药性研究
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DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2023
·Vol. 24
·期 11
·9288
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IF 5.6
Lizi Yin,Yuhong Gou,Yuyun Dai,Tao Wang,Kexin Gu,Ting Tang,Sajjad Hussain,Xiaoli Huang,Changliang He,Xiaoxia Liang,Gang Shu,Funeng Xu,Ping Ouyang
In recent years, infections caused by multidrug-resistant (MDR) bacteria have greatly threatened human health and imposed a burden on global public health. To overcome this crisis, there is an urgent need to seek effective alternatives to single antibiotic therapy to circumvent drug resistance and prevent MDR bacteria. According to previous reports, cinnamaldehyde exerts antibacterial activity against drug-resistantSalmonellaspp. This study was conducted to investigate whether cinnamaldehyde has a synergistic effect on antibiotics when used in combination, we found that cinnamaldehyde enhanced the antibacterial activity of ceftriaxone sodium against MDRSalmonellain vitro by significantly reduced the expression of extended-spectrum beta-lactamase, inhibiting the development of drug resistance under ceftriaxone selective pressure in vitro, damaging the cell membrane, and affecting its basic metabolism. In addition, it restored the activity of ceftriaxone sodium against MDRSalmonellain vivo and inhibited peritonitis caused by ceftriaxone resistant strain ofSalmonellain mice. Collectively, these results revealed that cinnamaldehyde can be used as a novel ceftriaxone adjuvant to prevent and treat infections caused by MDRSalmonella, mitigating the possibility of producing further mutant strains.Keywords:cinnamaldehyde;multidrug-resistant bacteria;cell membrane;extended-spectrum beta-lactamase
研究领域:
药理学
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微生物学
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传染病学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Yong Wang,Wen-Bo Zhao,Fu-Kui Li,Shu-Long Chang,Qing Cao,Rui Guo,Shi-Yu Song,Kai-Kai Liu,Chong-Xin Shan
Long-lasting and highly efficient antibacterial fabrics play a key role in public health occurrences caused by bacterial and viral infections. However, the production of antibacterial fabrics with a large size, highly efficient, and broad-spectrum antibacterial performance remains a great challenge due to the complex processes. Herein, we demonstrate sizable and highly efficient antibacterial fabrics through hydrogen bonding interaction and electrostatic interaction between surface groups of ZnO nanoparticles and fabric fibers. The production process can be carried out at room temperature and achieve a production rate of 300 × 1 m2 within 1 h. Under both visible light and dark conditions, the bactericidal rate against Gram-positive (S. aureus), Gram-negative (E. coli), and multidrug-resistant (MRSA) bacteria can reach an impressive 99.99%. Furthermore, the fabricated ZnO nanoparticle-decorated antibacterial fabrics (ZnO@fabric) show high stability and long-lasting antibacterial performance, making them easy to develop into variable antibacterial blocks for protection suits.
研究领域:
材料科学
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生物医学工程
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公共卫生
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Han Wu,Yumei Wang,Zekai Ren,Xin Liu,Mingtao Yu,Yang Cao,Hailin Cong,Bing Yu,Youqing Shen
Due to the extensive use of antibiotics, many highly resistant bacteria and extensively resistant bacteria have been produced. In recent years, the increase of drug-resistant bacteria and the resulting proliferation of drug-resistant bacteria have increased the incidence of hospital-acquired infections and caused great harm to human health. Antimicrobial peptides (AMPs) are considered to be an innovative antibiotic and belong to the latest advances in this field. We designed a polypeptide and verified its low minimum inhibitory concentration and broad-spectrum activity against Gram-positive bacteria, Gram-negative bacteria, and fungi in microbiology and pharmacology. Several experiments have confirmed that the screened antimicrobial peptides have significant antidrug resistance and also show significant therapeutic properties in the treatment of systemic bacterial infections. In addition, through our experimental research, it was proved that the antibacterial hydrogel composed of poly(vinyl alcohol), sodium alginate, and antimicrobial peptides had excellent antibacterial properties and showed good wound healing ability.
研究领域:
微生物学
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药理学
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医学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
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2022
·
IF 3.841
Chengcheng Tang,Yiran Song,Zhuang Wang,Da Wang,Xinyu Yao,Yuan Meng,Yang Li,Li Yang
Growing multidrug bacterial resistance has become a life-threatening problem. Polymyxins are a “last resort” antibiotic against Gram-negative bacteria (Gram-ne − ), but exhibit weak activity against Gram-positive bacteria (Gram-po + ) caused by different bacterial membrane structures. Herein, it is proposed that the challenge can be overcome by hydrophobically modified polymyxin E for enhancing the hydrophobic interaction with the membrane. After synthesizing mono-and di-fatty acyl conjugates to Thr residues of polymyxin E, seven new polymyxin analogs were screened out with in vitro activity against Gram-ne − and Gram-po + . Among them, di-caprylic acid-modified (comp. 2 ) and mono-linoleic acid-modified (comp. 3) compounds with the most potent activity against both bacteria. Moreover, the membrane research showed that polymyxin analogs obtain activity against Gram-po + by higher ability to dispute cell membrane and wall than polymyxin E. Additionally, the results showed a trend of increasing hydrophobicity of analogs showing the tendency to rise up at the beginning and declining in later against Gram-po + and gradually decreasing activity against Gram-ne − , hence, we speculated that controlling Log P at 1–3 helps to obtain broad-spectrum antibiotic. Crucially, the maximum tolerated doses (MTD) of analogs were significantly higher than polymyxin E, and reduced the nephrotoxicity. As expected, hydrophobic modification polymyxin E not only enhance the activity of Gram-po + , but also could retain the activity of Gram-ne − . This study offers more insights into the synthesis of new antibiotics based on polymyxin E structure, especially broad-spectrum antibiotics.
研究领域:
微生物学
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药理学
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生物化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）