JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2022
·
IF 5.062
Lixin Liu,Qi An,Yunan Zhang,Weitong Sun,Jinjing Li,Yanru Feng,Yiding Geng,Guangdong Cheng
With the purpose of improving the solubility and reducing the hygroscopicity of enrofloxacin (ENR), an unreported pharmaceutical salt cocrystal of enrofloxacin with both neutral and anionic p-nitrobenzoic acid (PNB) (ENR-PNB, C 19 H 23 FN 3 O 3 ·C 7 H 4 NO 4 ·C 7 H 5 NO 4 ) was designed and synthesized by changing the reaction molar ratio (1:2) of ENR and coformer PNB on the basis of summarizing the past experience of our group, and its crystal structure was characterized. Single-crystal X-ray diffraction (SCXRD) analysis revealed that the salt cocrystal consists of ENR + , PNB − and PNB neutral molecule in a 1:1:1 ratio. The two asymmetric units that become centrosymmetric form an X-shaped structure centered on the ENR dimer R 2 2 (20). The adjacent X-shaped structures are interconnected by hydrogen bonds to form 1D chain and form the octamer R 8 8 (42) at the same time. As we expected, the formation of the salt cocrystal ENR-PNB results in a simultaneous improvement in the solubility and hygroscopicity of ENR. This may be the fact that ENR and PNB depend on CAHBs to raise the hydrous enthalpy of salt cocrystal. And the presence of PNB neutral molecules lower hygroscopicity of ENR in high humidity environments. Unexpectedly, the permeability of ENR-PNB was also increased compared to that of pure ENR. It is speculated that the number of polar sites in the system is greatly reduced because of hydrogen bonds formation, which increases the permeability of the ENR salt cocrystal. In addition, the in vitro antibacterial activities of ENR-PNB are enhanced at different concentrations compared to ENR. The present study implies that it is possible to improve the solubility, hygroscopic stability, permeability and antibacterial activity of enrofloxacin by changing the chemical reaction molar ratio to form salt cocrystal containing both neutral and anionic coformers, which provides a new strategy and insight to simultaneously improve the solubility and hygroscopicity and even permeability of the active ingredients of solid drugs.
研究领域:
药物化学
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晶体学
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产品关联
DOI
高影响因子
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
·
2022
·Vol. 37
·期 5
·e9428
·
IF 2.586
Xin Qiu,Fengming Chen,Tong Liu,Feng Feng,Yuan Zhang,Xuesong Feng,Feng Zhang
Antibiotics have important medical value, but they need to be monitored when used as veterinary drugs. We report α-cyano-4-hydroxycinnamic acid/ p -phenylenediamine (CHCA/PPD) hybrid as a novel matrix for enhanced matrix-assisted laser desorption/ionization-mass spectrometry imaging (MALDI-MSI) in situ the spatial distribution of antibiotic drugs in grass carp tissues. Method We have used MALDI-TOF-MSI in positive ion mode for the analysis of quinolones and sulfonamides in grass carps. A novel CHCA/PPD matrix was prepared and applied using a simple method to improve the analysis. Results Compared with the traditional matrix, CHCA/PPD significantly improved the detection intensity of quinolones and sulfonamides with better sensitivity (17.20%–94.30%) and reproducibility. For demonstration, this novel matrix was successfully applied to visualize enrofloxacin (ENR) in grass carp tissues, with the entire abundance differences clearly observed based on MALDI-MSI. The concentration levels in different tissues were determined, with a calibration curve of 10–2000 μg/ml (R 2 > 0.993). Conclusion This study was the first to introduce CHCA/PPD as a novel matrix, and the classical acid–base mixing was used to improve the ionization effect of the traditional matrix CHCA in MALDI. Based on CHCA/PPD, MALDI-MSI detected ENR in different grass carp tissues for the first time and realized the spatial distribution and concentration detection.
研究领域:
分析化学
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药物分析
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生物医学
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DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2024
·
IF 2.8
Jun Chen,Xue Li,Xiaohong Yang,Yutong Wang,Zongsheng Zhan,Dawei Teng,Mingxia Du,Dong Lv,Kaiqi Yao,Chunnian Da,Mengqiu Xu
BACKGROUND Piezoelectric catalysis using perovskite-type barium titanate (BaTiO 3 ) has been applied to the decomposition of refractory organic pollutants through piezoelectric catalytic persulfate (PS). Nevertheless, challenges such as a limited specific surface area, poor electrical conductivity and a tendency towards agglomeration in BaTiO 3 necessitate the exploration of novel methods to enhance its piezoelectric efficiency. RESULTS Sludge carbon (SC) from sewage treatment and BaTiO 3 was utilized to develop a novel piezoelectric catalytic material (BaTiO 3 /SC). The specific surface area of BaTiO 3 /SC reached 67.92 m 2 g −1 , which is nine times larger than that of BaTiO 3 alone. The inclusion of SC in the composite enhanced the number of active sites and contributed to a higher degree of graphitization, improved electrical conductivity, and provided a more stable structure for BaTiO 3 /SC. This material was capable of harvesting mechanical vibration energy from ultrasound, thereby generating piezoelectric catalytic properties and activating PS to achieve a 93% decomposition ratio of enrofloxacin (ENR) in water within 80 min. The activation of PS by BaTiO 3 /SC piezocatalysis led to the production of reactive oxygen species (ROS), such as • OH and SO 4 −• . These ROS attack the quinolone ring of ENR, which is susceptible to cleavage, resulting in the decomposition of ENR into intermediates of lower toxicity. CONCLUSION The incorporation of SC has enhanced the piezoelectric performance of BaTiO 3 , rendering BaTiO 3 /SC a novel perovskite-type piezoelectric catalytic material that improves piezoelectric efficiency. The BaTiO 3 /SC system, through its piezoelectric catalytic activation of PS, demonstrates potential for decomposition of refractory organic pollutants in water treatment. © 2024 Society of Chemical Industry (SCI).
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2024
·Vol. 36
·期 4
·045501
·
IF 2.9
Liyun Ding,Pan Wang,BaoQuan Xiao,Zelin Gao,Dekui Zhang,Tuanjie Che,Juanjuan Zuo,Yumai Li
Enrofloxacin (ENR), as a synthetic broad-spectrum antibiotic is widely utilized in veterinary medicine to treat animal diseases and promote livestock growth, it can inhibit bacterial DNA gyrase subunit A, thereby preventing bacterial DNA replication and exerting its antibacterial effect. However, excessive use of enrofloxacin poses significant risks to ecological balance and human health due to residual contamination. We have developed a novel ENR aptamer sensor based on the gold nanoparticles/aptamer (AuNPs-Apt) complexes, in which AuNPs were synthesized via the seed method and functionalized with aptamers. The optical properties, particle size, functional groups and morphology of the AuNPs-Apt probe were characterized by transmission electron microscope, Fourier transform infrared spectrometer and UV–vis spectrophotometer, respectively. The aptamer biosensor can specifically identify enrofloxacin, with a wide detection range (0.05–100 μg ml−1) and a good linear relationship ({R^2}=0.99) within the detection range. In addition, the biosensor also has the advantages of short detection time, low biological toxicity, good stability, and low detection cost. Therefore, it shows a great prospect for practical application in the field of detecting enrofloxacin residues.
研究领域:
生物化学
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纳米技术
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环境科学
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兽医学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Xuan Liao,Ruiyu Guo,Meng Mei,Jinping Li,Teng Wang,Jingxin Liu,Si Chen,Wenxia Wang
Natural lignocellulose-based materials have numerous strengths such as abundance, cheap price and biodegradability, which indicates a brilliant prospect for environmental protection. This work aimed to design an efficient sorbent (NaSS-PSD) by pine sawdust (PSD) for the surveillance and management of enrofloxacin (ENR). In the study, sodium styrenesulfonate (NaSS) was chosen as an effective monomer to ameliorate the performance of PSD by graft copolymerization. The removal of ENR by NaSS-PSD was enhanced in comparison with the ungrafted ones under investigated conditions. Pseudo-second-order and Temkin were the best-fitted models to describe the adsorption behavior. For the first time, NaSS-PSD was employed as a novel extractant of solid-phase extraction (SPE) and dispersive solid-phase microextraction (DSPME) to develop accurate, eco-friendly and economic analytical techniques for trace ENR determination. Good linearity and reproducibility were obtained. The limits of detection were 0.41 μg/L for DSPME-HPLC-DAD technique and 0.15 μg/L for SPE-HPLC-DAD technique. These two methods exhibited satisfying practicability when applied to quantify ENR residue in real waters. The study on interfacial interaction mechanism and preferential binding sites suggested that hydrogen bond and π-π interactions took the primary responsibility. Our work provides a good perspective for tailoring natural lignocellulosic biomass to be alternative adsorbents for emerging pollutants.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Rui Yang,Jinhua Wang,Lusheng Zhu,Jun Wang,Lili Yang,Shushuai Mao,Jeremy L. Conkle,Yangyang Chen,Young Mo Kim
Antibiotics are detected in association with heavy metals in the soil. However, interactions between antibiotics and heavy metals on soil enzyme activity have yet to been studied thoroughly. In this study, soil enzyme activity (urease, sucrase, phosphatase , and Rubisco) were measured after exposure to soils dosed with copper (Cu) and/or enrofloxacin (ENR) over 28 days. Enzyme responses to ENR only treatments varied, but Cu exhibited a strong negative response from all soil enzymes except Rubisco. An interaction between the effects of the two pollutants on soil enzymes was observed in the combined contamination treatments. Greater comprehensive toxicity to soil enzyme activity was observed in combined treatment groups compared to other groups. We anticipate our studies can provide a scientific theoretical basis for the combined pollution of antibiotics and heavy metals in soil.
研究领域:
环境科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 54
·34096-34103
·
IF 3.108
Yuehan Su,Ping Chen,Fengliang Wang,Qianxin Zhang,Tiansheng Chen,Yingfei Wang,Kun Yao,Wenying Lv,Guoguang Liu
A novel visible-light-driven carbon dot (CDs)/TiO2/g-C3N4 photocatalyst was successfully synthesized by doping CDs in TiO2 nanoparticles and the surface of g-C3N4 nanosheets via a facile hydrothermal process and was confirmed by characterization methods. UV-vis diffuse reflectance spectra (DRS) revealed that CDs/TiO2/g-C3N4 showed obvious additional absorption in the 370–450 nm region. DMPO spin-trapping ESR spectra demonstrated the existence of O2˙− and ·OH. The photocatalytic activity of the CDs (1.0 wt%)/TiO2/g-C3N4 was remarkably enhanced as compared to that of the single components (TiO2 and g-C3N4) and double component (TiO2/g-C3N4) towards the degradation of enrofloxacin (ENX) under visible-light irradiation. About 91.6% of ENX was decomposed by CDs (1.0 wt%)/TiO2/g-C3N4 in 1 h, which is nearly 3.95 times, 4.82 times, and 1.69 times that for TiO2, g-C3N4, and TiO2 (90.0 wt%)/g-C3N4, respectively. Scavenging experiments revealed that O2˙− and ·OH played key roles during the photocatalytic degradation of ENX. This study provides a simple and convenient method to modify materials with enhanced photocatalytic performance, and the CDs/TiO2/g-C3N4 catalyst is efficient, stable, and reusable for environmental practical applications.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Jiaxing Huang,Daguang Li,Ruobai Li,Ping Chen,Qianxin Zhang,Haijin Liu,Wenying Lv,Guoguang Liu,Yiping Feng
Anatase TiO 2 nanoparticles coated with P and O co-doped g-C 3 N 4 were prepared via a single-step procedure. The resulting POCN/anatase TiO 2 demonstrated remarkable performance in the degradation of enrofloxacin (ENFX). The photocatalytic activity of this heterojunction was 28.9 and 3.71 times better than that of the CN and anatase TiO 2 , respectively. The microtopography of the POCN/anatase TiO 2 was revealed in this study. Co-doping with P and O increased the visible light adsorption capacity of the g-C 3 N 4 , whereas the anatase TiO 2 nanoparticles enhanced the adsorption properties of the ENFX and the separation of the photoinduced carriers of the POCN/anatase TiO 2 . The O 2 ·− and h + were the main reactive oxidative species in the photocatalytic degradation of ENFX. The results of the detection of H 2 O 2 and ESR confirmed that POCN/anatase TiO 2 was a type Z-scheme photocatalyst. Finally, the ENFX degradation pathways were estimated through the detection of by-products.
研究领域:
环境科学
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材料科学
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光催化技术
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Xinyi Zhang,Weibao Liu,Yuerong Zhou,Yunhe Li,Ying Yang,Jianfeng Gou,Jiangwei Shang,Xiuwen Cheng
In order to further expand the practical applicability of nano photo-activators, a low-toxicity bismuth ferrite mixture (BFO) combined with MnO 2 were used to construct nano-catalyst@nickel foam (NF) composite material. A variety of characterization methods were applied to determine the physical, chemical and photoelectrochemical properties of BFO/MnO 2 @NF. Subsequently, the performance of BFO/MnO 2 @NF/PMS/Light degradation system was evaluated through the enrofloxacin (ENR) removal experiment. And 87.5% of ENR could achieve removal with 4 cm 2 of BFO/MnO 2 (3:1)@NF and 0.6 g L −1 of peroxymonosulfate (PMS) at the pH of 6.86 in the coupled system. In addition, during the ENR degradation process, the leaching percentages of Bi, Fe, and Mn ions in the BFO/MnO 2 nano powder and BFO/MnO 2 @ NF were 0.041%, 0.29%, 0.12% and 0.035%, 0.068%, 0.084% (0.035% of Ni dissolution), respectively. It could be seen that the leaching concentration of metal ions during the reaction of the nickel foam-supported composite material was much lower than that of the corresponding nano-catalysts powder. Furthermore, the coupled system maintained excellent catalytic performance even after 8 running cycles. Thus, the BFO/MnO 2 @NF was easy to recover from the system and met the needs of practical applications, which would provide more opportunities for the design of nano-catalysts and practical applications in wastewater treatment processes.
研究领域:
环境科学
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材料科学
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水处理技术
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产品关联
DOI
高影响因子
Materials Today Communications
·
2021
·
IF 3.383
Jun-Lan Yang,Hou-Qun Yuan,Bao-Sheng Liu,Jia-Xin He,Qing Fan,Ke Deng,Deping Song,Guang-Ming Bao
Enrofloxacin is a broad spectrum antibacterial agent with an excellent killing effect against bacteria, commonly infecting the respiratory and intestinal tracts of livestock and poultry. However, its bitter taste and significant irritation to the gastrointestinal tract often lead to a failure of the commonly used current drug delivery system to achieve the desired therapeutic effect due to inefficient release of drugs. In the present study, pH-responsive enrofloxacin nanoparticles ( ENR-NPs ) for treating bacterial infections were fabricated through a facile one-pot approach to achieve the amphiphilic functionalization of chitosan (CS) through acid-labile Schiff-base with cinnamaldehyde and drug encapsulation. The structure and morphology of ENR-NPs were characterized by FTIR, X-Ray Diffraction (XRD), transmission electron microscopy (TEM), and dynamic light scattering (DLS). The ENR-NPs were uniform in size and full in shape with an average particle size of 135 nm. The encapsulation rate (76.61%) and drug loading capacity (3.3%) were measured by ultraviolet spectrophotometry . The in vitro experiments elucidated that the release rate of enrofloxacin from ENR-NPs was significantly faster at pH 5.0 than at pH 7.4 due to the cleavage of the acid-sensitive Schiff-base bond. Further, the antimicrobial studies revealed that the inhibitory effects were improved with the increase of acidity of the culture medium. Therefore, ENR-NPs provide a potential application of enrofloxacin for bacterial-response drug delivery.
研究领域:
药剂学
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生物材料
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微生物学
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Fengjiao Yang,Bingyu Yang,Xinyue Gu,Minghua Li,Kezhen Qi,Ya Yan
Water-soluble AgInS 2 (AIS) quantum dots (QDs) were successfully prepared through the one-pot water phase method with thioglycolic acid (TGA) as the stabilizing agent. Because enrofloxacin (ENR) effectively quenches the fluorescence of AIS QDs, a highly-sensitive fluorescence detection method is proposed to detect ENR residues in milk. Under optimal detection conditions, there was a good linear relationship between the relative fluorescence quenching amount (Δ F / F 0 ) of AgInS 2 with ENR and ENR concentration ( C ). The detection range was 0.3125–20.00 μg/mL, r = 0.9964, and the detection limit (LOD) was 0.024 μg/mL (n = 11). The average recovery of ENR in milk ranged from 95.43 to 114.28%. The method established in this study has advantages including a high sensitivity, a low detection limit, simple operation and a low cost. The fluorescence quenching mechanism of AIS QDs with ENR was discussed and the dynamic quenching mechanism of light-induced electron transfer was proposed.
研究领域:
食品科学
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分析化学
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生物医学
✓ 已验证
DOI
PubMed
高影响因子
Sustainability
·
2025
·Vol. 17
·期 2
·516
·
IF 3.3
Zhichao Li,Xiao Meng,Xiaoyong Shi,Chunyue Li,Chuansong Zhang
Microplastics can transfer antibiotics in water through adsorption and desorption, causing adverse effects on the water environment. Therefore, understanding the interaction between microplastics and antibiotics is important in order to assess their impact on the environment. In this study, the adsorption–desorption behaviors of two commonly used antibiotics [enrofloxacin (ENR) and trimethoprim (TMP)] in aquaculture and their interactions with three typical microplastics [polystyrene (PS), polyvinyl chloride (PVC), and polyethylene (PE)] were investigated through laboratory experiments. The results showed that the adsorption capacity of the three microplastics was 1.229–1.698 mg/g for ENR and 1.110–1.306 mg/g for TMP, correlating with the octanol–water partition coefficients (logKow) of antibiotics. Due to the larger specific surface areas and special functional groups of microplastics, the antibiotic adsorption capacity of PS and PVC was higher than that of PE. The adsorption behavior followed pseudo-second-order kinetics and a Freundlich isotherm model, indicating a non-uniform surface with multilayer adsorption. A thermodynamic analysis showed that these were all spontaneous endothermic adsorptions. X-ray photoelectron spectroscopy (XPS) and Fourier-transform infrared spectroscopy (FTIR) analyses indicated that the adsorption mechanism was dominated by physical adsorption, involving π–π conjugation, halogen bonds, hydrogen bonding, and electrostatic interactions. High salinity and alkaline environments were conducive to desorption, and the ENR and TMP desorption rates of the microplastics ranged from 20.65% to 24.95%. This indicates that microplastics adsorbed with antibiotics will desorb antibiotics when entering the seawater system, thereby affecting marine ecosystems. These findings reveal the interaction mechanism between microplastics and aquaculture antibiotics in aqueous systems, providing theoretical support for environmental protection and sustainable development.
研究领域:
环境科学
·
水污染控制
·
药理学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）