INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Weichen Wang,Yu Dai,Cuilin Cheng,Rongchun Wang,Jiapei Ma,Qiuju Jing
In this study, zein-gum Arabic (GA)-flaxseed gum (FG) nanoparticles (ZGF) were prepared using the anti-solvent and electrostatic deposition methods to overcome the hydrophobicity and instability of curcumin (CUR). Additionally, the optimal mass ratio of GA to FG (4:1) and CUR to zein (1:40) was determined. Additionally, the initial concentration of the polysaccharide (0.04 %) was determined and the ZGF nanoparticles encapsulated with CUR (CUR-ZGF) were optimized. The formed CUR-ZGF nanoparticles were spherical, with a particle size of 188 nm and an embedding rate of 96.8 %. Furthermore, the CUR-ZGF nanoparticles showed excellent pH, thermal, storage, and salt stability. The encapsulate CUR exhibited antioxidant capacity and controlled release rate in the gastrointestinal digestive system in vitro. Animal experiments showed CUR-ZGF nanoparticles significantly enhanced exercise capacity and anti-fatigue effects. High-dose CUR-ZGF nanoparticles doubled exhaustion running time versus the model group, improving exercise endurance. Fatigue-related biochemical parameters (serum urea nitrogen, serum lactate, and creatine kinase) were significantly reduced, indicating rapid fatigue elimination. Meanwhile, significantly increased lactate dehydrogenase and fasting glucose levels suggested efficient energy replenishment to mitigate fatigue damage. These results indicate CUR-ZGF nanoparticles may be a promising natural anti-fatigue healthcare product in the future.
研究领域:
食品科学
·
生物医学工程
·
营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 10
·2009869
·
IF 18.808
Wu Bin Ying,Guyue Wang,Zhengyang Kong,Chen Kai Yao,Yubin Wang,Han Hu,Fenglong Li,Chao Chen,Ying Tian,Jiawei Zhang,Ruoyu Zhang,Jin Zhu
Polymeric elastomers play an increasingly important role in the development of stretchable electronics. A highly demanded elastic matrix is preferred to own not only excellent mechanical properties, but also additional features like high toughness and fast self-healing. Here, a polyurethane (DA-PU) is synthesized with donor and acceptor groups alternately distributed along the main chain to achieve both intra-chain and inter-chain donor-acceptor self-assembly, which endow the polyurethane with toughness, self-healing, and, more interestingly, thermal repair, like human muscle. In detail, DA-PU exhibits an amazing mechanical performance with elongation at break of 1900% and toughness of 175.9 MJ m −3 . Moreover, it shows remarkable anti-fatigue and anti-stress relaxation properties as manifested by cyclic tensile and stress relaxation tests, respectively. Even in case of large strain deformation or long-time stretch, it can almost completely restore to original length by thermal repair at 60 °C in 60 s. The self-healing speed of DA-PU is gradually enhanced with the increasing temperature, and can be 1.0–6.15 µm min −1 from 60 to 80 °C. At last, a stretchable and self-healable capacitive sensor is constructed and evaluated to prove that DA-PU matrix can ensure the stability of electronics even after critical deformation and cut off.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Ming Cai,Hua Zhu,Lei Xu,Jian Wang,Jing Xu,Zhenhao Li,Kai Yang,Jianyong Wu,Peilong Sun
This study was to investigate the antifatigue, prebiotic effects and their relationships to the structure properties of three ethanol precipitated polysaccharides from Dendrobium officinale (EPDO), as EPDO-40, EPDO-60 and EPDO-80. EPDOs with anti-fatigue activity were screened out by forced swimming test, and blood lactic acid (BLA), blood urea nitrogen (BUN), superoxide dismutase (SOD), liver glycogen, muscle glycogen, and intestinal microflora were investigated. Results showed that purified EPDO-60, 277.3 kDa, with a backbone consisted of 4-Man p and 4-Glc p . EPDO-60 had the best anti-fatigue activity, because it could significantly prolong the forced swimming time, as well as down-regulating the levels of BLA and BUN, increasing SOD. Proportions of Bacteroidetes and Firmicutes and abundance of Lactobacillus and Bifidobacterium in gut microflora increased after treated with EPDO-60. Accordingly, EPDO-60 could affect the community structure of gut microflora, leading to promote the balance of oxidation and antioxidation, and accelerated the fatigue metabolism in vivo .
研究领域:
食品科学
·
营养学
·
植物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2021
·Vol. 57
·期 1
·78-91
·
IF 3.713
Xiangna Chang,Xuefeng Chen,Pin Gong,Wenjuan Yang,Lan Wang,Ning Liu,Yao Su,Yuanyuan Zhao
Summary The anti-fatigue effects and structure-activity relationship of apple polysaccharides (APPs), the active components in apple pomace, remain unknown. We examined the effects of different extraction methods on polysaccharide structures and anti-fatigue activities. Additionally, the structural and biochemical properties of APPs prepared under acidic (ACAPP) or alkaline (ALAPP) conditions, were characterised. ACAPP and ALAPP were acidic heteropolysaccharides primarily comprising arabinose, rhamnose, galactose, glucose, xylose and galacturonic acid. The molecular weights of ACAPP and ALAPP were 110 kDa and 89.6 kDa, respectively. ALAPP had more branched chains than ACAPP and showed stronger free radical-scavenging and anti-fatigue properties. The anti-fatigue properties of APPs correlated with their anti-oxidant activities and were exerted through eliminating free radicals and mediating an oxidative balance. The stronger anti-fatigue activity of ALAPP is probably related to its structural characteristics. Collectively, our study provides a fundamental basis for the development and use of APPs in medicine and functional foods.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
Carbohydrate Polymer Technologies and Applications
·
2025
·
IF 6.5
Hurong Ge,Peipei Ma,Qing Huang,Shijie Wei,Zhizhong Wang
Objectives: To study the encapsulation of resveratrol by three cyclodextrin derivatives, investigate the impact of encapsulation technology on its anti-fatigue effect, and explore the anti-fatigue mechanism of the encapsulated resveratrol via transcriptomics analysis of exosomal miRNAs. Methods (1) UV spectroscopy and nuclear magnetic resonance (NMR) were used to investigate the encapsulation and encapsulation modes of resveratrol by β -CD, HP- β -CD and CM- β -CD; and the phase solubility method was used to calculate the solubilisation multiplicity of resveratrol by the three cyclodextrin derivatives. (2) Male C57BL/6 J mice were randomly divided into: fatigue model group (FM), FM+resveratrol group (SF+Res), FM+ β -CD, FM+HP- β -CD, FM+CM- β -CD, FM+ β -CD+Res, FM+HP- β -CD+Res, FM+CM- β -CD +Res, and after 30 days of rearing, the mice were subjected to exhaustion swimming experiment to detect fatigue-related indexes and observe the effects of the three cyclodextrin derivatives on the anti-fatigue effects of resveratrol. (3) Male C57BL/6 J mice were randomly divided into Control, FM, and FM+HP- β -CD+Res. After 30 days of rearing, except for the Control group, the remaining mice were subjected to exhaustion swimming experiments, and exosomes were extracted from cardiac tissue, skeletal muscle tissue, and liver tissue of the three groups of mice, and the transcriptomics technology was applied to sequence the exosomal miRNAs and to explore the mechanism of the effect of the HP- β -CD+Res envelope on fatigue. Results (1) The inclusion ratios of β -CD, HP- β -CD, and CM- β -CD encapsulated resveratrol were 1:1, 1:2, and 1:1, and the solubilisation multiplicities of resveratrol were 23, 39, and 21 fold, respectively; β -CD and CM- β -CD encapsulated Res, which was the benzene ring with two hydroxyl‑terminal ends of Res entered the cavity from the small-ported end of the cyclodextrins; HP- β -CD encapsulated Res, which was the Res containing one hydroxyl‑terminated benzene ring enters the cavity from the wide-mouth end of HP-β-CD. (2) Compared with the FM+Res group, all three inclusions were able to prolong the exhaustion swimming time of mice, with HP- β -CD+Res being the most effective. (3) After HP- β -CD+Res acted on the fatigued mouse model, cardiac tissue showed 1726 differentially expressed exosomal miRNAs, of which 840 were up-regulated and 886 were down-regulated, reversing the fatigue-induced changes in 64.96 % of the exosomal miRNAs (1170 shared differential exosomal miRNAs); Skeletal muscle tissue showed 1948 differentially expressed exosomal miRNAs, of which 718 were up-regulated and 1230 were down-regulated, reversing 80.57 % of the fatigue-induced changes in exosomal miRNAs (1576 shared differential exosomal miRNAs); Liver tissue showed 1442 differentially expressed exosomal miRNAs, of which 451 were up-regulated and 991 were down-regulated, reversing 84.31 % of fatigue-induced changes in exosomal miRNAs (1214 shared differential exosomal miRNAs). Target gene enrichment analysis of differentially expressed exosomal miRNAs in cardiac tissue, skeletal muscle tissue, and liver tissue had similar results, and the biological processes involved in HP- β -CD+Res were related to biological_process, signal transduction, G protein-coupled receptor signaling pathway, etc., and cellular components such as membrane, cytoplasm, integral component of membrane, etc., and molecular functions are closely related to protein binding, metal ion binding, molecular_function, etc.; mainly enriched in Axon guidance, MicroRNAs in cancer, Apoptosis and other signalling pathways. Conclusions (1) All three cyclodextrin derivatives encapsulated increased the solubility of resveratrol, with HP- β -CD having the best effect. (2) All three cyclodextrin derivative encapsulation techniques improved the anti-fatigue effect of resveratrol, with HP- β -CD being the most effective. (3) HP- β -CD+Res was able to induce differential expression of exosomal miRNAs in cardiac tissue, skeletal muscle tissue and liver tissue of fatigued mice.
研究领域:
药理学
·
分子生物学
·
生物信息学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Hua-jin Zeng,Cong-hui Cheng,Si-meng Liu,Yan Ding,Ran Yang,Ling-bo Qu
In this study, the liquid culture system of Pleurotus nebrodensis mycelium with high yield were established by using orthogonal experiments. Results indicated a 58.08 % increase in mycelium biomass and a 2.22 % increase in polysaccharide content after condition optimization. Experiments showed that the extracted polysaccharides have significant antioxidant and anti-exercise fatigue activities. They could effectively scavenge DPPH, ABTS, hydroxyl free radicals and superoxide anaion, prolong weight-loaded swimming time in mice, reduce levels of MDA, LD, and LDH in serum, enhance SOD activity, as well as increase hepatic and muscle glycogen reserves. The mechanism may be attributed to the activation of the Nrf2/Keap1 signaling pathway, inhibition of oxidative stress, and subsequent exerting anti-fatigue effects. The results in this work provides new avenue for easily accessible natural polysaccharide resources with a very convenient approach, which is beneficial for the development of anti-fatigue functional foods for public consumption.
研究领域:
食品科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Haidi Wu,Yongchuan Wu,Jun Yan,Wei Xiao,Yuqing Wang,Hechuan Zhang,Xuewu Huang,Huaiguo Xue,Ling Wang,Longcheng Tang,Yiuwing Mai,Jiefeng Gao
Hydrogels have been rapidly developed recently owing to their excellent flexibility and biocompatibility and exhibit promising applications in biomaterials, flexible electronics, etc. However, when compared to the biological materials, many hydrogels with similarly high water contents display relatively low mechanical properties and it is difficult to achieve a balance between strength, toughness and fatigue resistance simultaneously. Herein, a facile solvent exchange assisted Hofmeister effect strategy is proposed to prepare strong and fatigue-resistant hydrogels with widely tunable water content. The polymer solution is first transformed to an organogel by exchange of the good solvent (dimethyl sulfoxide) to a poor solvent (alcohol), and then the organogel converts to hydrogel after the second step exchange of the alcohol to a saline solution. The alcohol induced gelation assisted salting-out promote the conformation adjustment of macromolecular chain, which endow the hydrogels with excellent comprehensive mechanical properties, with the extraordinary high strength of 26.4 ± 1.6 MPa, superior stretchability of 1252.3 ± 116 %, ultra-high fracture energy of 139.45 ± 37.3 KJ/m 2 , large fatigue threshold of 1837.9 ± 63.4 J/m 2 (water content of 20.2 wt%) as well as ionic conductivity of 0.34 S/m. Therefore, this work put forward a viable design method to fabricate outstanding performance soft materials for applications in load-bearing material and strain sensor fields.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Wu Bin Ying,Haixiong Liu,Peiyuan Gao,Zhengyang Kong,Han Hu,Kai Wang,Ang Shen,Zhijin Jin,Lin Zheng,Hongxia Guo,Ruoyu Zhang,Jin Zhu
Considering the complicated environment in daily use of stretchable devices, the capabilities of anti-stress relaxation, anti-fatigue, anti-fungal and self-healing are very much appreciated, and the above four functionalities largely depend on the elastic matrix. Here, these demands are fulfilled by a poly(thiourethane-urethane) elastomer CBPU-3. In detail, a large amount of cyclohexane rings, with completely reversible boat–chair conformational transition, are introduced into the backbone of poly(thiourethane-urethane), and such non-planar ring imparts molecular elasticity and modulus into the elastomer, resulting in remarkable anti-stress relaxation and anti-fatigue abilities. Even after 20 h fixation at 300% strain and 1000 times cyclic tensile (50% strain), the recovery ratio could still be higher than 98%, and its stable microstructure is proved by SAXS scattering patterns. In addition, the thioether bond ensures the effective mildew proof ability, and the mechanical properties and transmittance change little even after a severe mildew pollution for 30 days. Simultaneously, the relatively lower bond energy of C-S (62.0 Kcal/mol) in thiourethane bonds endowes the poly(thiourethane-urethane) with self-healing capability (highest: 40 μm/min at 80 °C). Finally, the durability and usability of the deformable resistive sensor array based on this elastomer as the matrix are drastically enhanced due to the above integrated functionalities.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 1
·263
·
IF 4.2
Shuji Liu,Yue Zhang,Yihui Chen,Yongchang Su,Bei Chen,Yin Wang,Min Xu,Kun Qiao,Shuigen Li,Zhiyu Liu
Protamine is a cationic peptide derived from fish sperm and has several important functional properties: antibacterial properties, acting as a carrier for injectable insulin and as a heparin antagonist, combatting fatigue, etc. Thus, it has been widely used in medicinal applications and food products. CulturedTakifugu flavidusis a type of pufferfish with a delicious taste that is popular in China, and its production is increasing significantly. Therefore, protamine was extracted via acid extraction from the sperm ofTakifugu flavidusand further isolated and purified via sephadex gel chromatography, ion exchange chromatography, and desalination chromatography. Furthermore, the physicochemical properties of protamine were investigated. The results showed that the sperm of the culturedT. flaviduswere non-toxic, and the extracted and purified protamine had high contents of arginine (36.90%) and lysine (27.02%), respectively. The secondary structure of protamine was mainly β-folded and irregularly curled. Additionally, protamine exhibited high thermal stability with a denaturation temperature of 176 °C. This study would provide a theoretical basis for the structural analysis, bioactivity, and resource development of pufferfish protamine and help to promote the development of the pufferfish industry.
研究领域:
生物化学
·
医药学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2020
·
IF 1.701
Lijun Chen,Jia Shao,Qijian Yu,Sui Wang
Although self-healing hydrogels have attracted widespread attention in many fields, it remains a challenge for hydrogel simultaneously achieving toughness, self-healing, and self-healing capabilities. Thus, we introduced GO and borate ions into the PVA chain and successfully constructed a physical-chemical double-crosslinked PVA/Borax/GO hydrogel with excellent mechanical properties, self-recovery, self-healing ability at room temperature, and conductivity. Among them, the hydrogen bond and borate ion jointly stimulate the strong interaction between the PVA chain and each component, making the PVA/Borax/GO hydrogel network closer, providing a solid pressure-resistant platform with excellent anti-fatigue performance, in which dynamic PVA/Borax networks endow hydrogel with self-healing ability. The prepared PVA/Borax/GO hydrogel has high stability, elasticity and electrical conductivity, and can be suitable for the preparation of preparing sensing materials. This work provides a design strategy for the preparation of hydrogels with high mechanical properties, fatigue resistance and good self-healing capabilities.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF FOOD PROPERTIES
·
2022
·
IF 3.388
Duo Liu,Zenghui Shi,Siqi Wang,Liyuan Zhai,Dongxia Gou,Jun Zhao,Yanbo Hu
Black soybean hull, as main by-production in black bean processing, has significant biological activity. In this study, the polysaccharide from black soybean hull (BSPS-H) was obtained by enzymatic hydrolysis, the yield was 5.3%, and its chemical composition and structural composition were further studied. The results shown that BSPS-H was mainly composed of Mannose, Galactose, and Glucose (molar ratio = 48.1: 29.7: 15.8), and might be existed in the form of pyran ring in α/β-linkage type. The anti-oxidant activity shown that BSPS-H had a certain capacity of anti-oxidation in a concentration-dependent manner. Among them, it has the best scavenging effect on DPPH free radicals. When the polysaccharide concentration was 10 mg/ml, the scavenging rate reached 94.37%. The results of anti-fatigue effect indicated that BSPS-H could prolong the duration of exhaustive swimming in mice, increased the contents of liver glycogen, reduced the content of blood urea nitrogen (BUN), enhanced the activity of lactate dehydrogenase (LDH) and reduced the accumulation of lactic acid (LA). This study provides a fundamental basis for the development and use of BSPS-H in medicine and functional foods.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jianming Zhao,Abudureheman Bahatibieke,Guodong Liu,Jinming Li,Junfei Li,Feilong Zhao,Bohao Yao,Yajie Xie,Yudong Zheng
Injury to cardiac valves is a major contributor to mortality associated with cardiovascular diseases. Artificial valves are preferred for their mimicry of natural valve efficiency in optimizing hemodynamics and minimizing associated complications. To endure the substantial pressures of the cardiovascular system, these valves require exceptional fatigue resistance, calcification resistance, and blood compatibility. To address these demands, we have designed and synthesized a silane uniformly integrated polyurea-polyurethane elastomer (PSCU). The PSCU features a highly responsive hydrogen bond network, conferred by the integration of oxygen-containing spirochemical rings and polyurethane urea segments, which forms orientation to prevent material fatigue damage. Concurrently, PSCU has almost no adverse effects on the blood due to the uniform integration of silane, and long-term use will not cause calcification. In vivo evaluations have confirmed PSCU’s exceptional biocompatibility and stability, with no observable tissue inflammation or material accumulation. Moreover, fluid dynamics studies have demonstrated PSCU’s superior mechanical attributes, maintaining effective unidirectional blood flow under a sustained 60 mmHg pressure gradient. This breakthrough material represents a significant advancement in the field of cardiovascular medicine, offering enhanced durability and reliability for artificial heart valves.
研究领域:
生物材料学
·
心血管医学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）