Nano Research
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2023
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IF 9.9
Fang Diyi,Liu Chuanlei,Chen Yu,Peng Qilong,Wu Kongguo,Chen Yuxiang,Jiang Hao,Wu Yuan,Shen Benxian,Wu Qiumin,Wu Di,Sun Hui
Porous heterogeneous lyophobic systems (HLSs) find potential applications in energy restoring, dissipating, and absorbing. However, the development of controllable HLSs still lacks rational structure design of nanoporous materials matching the molecular sizes of adopted liquids. Besides that, thoroughly understanding the underlying transportation mechanism in the confined nano channels is greatly challenging. In this work, a series of Co/Zn bimetallic zeolitic imidazolate frameworks (ZIFs) with tunable structures were synthesized via regulating the Co to Zn ratios and employed to investigate the intrusion–extrusion of liquid water in confined nanopores. Structural characterizations confirm the heterometallic coordination in the Co/Zn-doped frameworks. Water intrusion–extrusion experiments unlock the relationship between the intrusion pressure and the nanopore size and realize the evolution of the HLSs between molecular spring and shock-absorber. In addition, cycling tests indicate the reversible structure change of Co/Zn ZIFs encountering pressure-induced water intrusion. In combination with molecular dynamics simulations, we present that the water multimers intrude into nanopores of ZIFs in chain-like forms along with dissociation of hydrogen bonds (HBs). Water molecules in the pre-intrusion state exhibit reduced HBs in response to the increase of pressure and linear structure with 1.6–3.0 HBs on average. After transition to the post-intrusion situation, the associative configuration of water tends to exhibit the tetrahedral structure. Herein, we highlight the roles of pore size and HB in synergically dominating the pressure-induced intrusion–extrusion of liquid water in hydrophobic nanopores. Furthermore, the present work can also guide the development of functional guest–host systems based on porous architectures.
研究领域:
材料科学
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化学工程
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Yang Zhang,Chao Wu,Shouzheng Jiao,Haoyu Gu,Yingbin Song,Yuyan Liu,Zhongjun Cheng
Efficient removal of droplets from solid surfaces is significant in various fields, including fog collection and condensation heat transfer. However, droplets removal on common surfaces with static structures often occurs passively, which limits the possibility of increasing removal efficiency and lacks intelligent controllability. In this paper, an active strategy based on extrusion ejection is proposed and demonstrated on the magnetic responsive polydimethylsiloxane (PDMS) superhydrophobic microplates (MPSM). The MPSM can reversibly transit between the upright and tilted state as the external magnetic field is alternately applied and removed. Under the magnetic field, the direction and trajectories of droplets departure can be intelligently controlled, demonstrating excellent controllability. More importantly, compared with the static structure where the droplet must reach a certain size before departure, droplets can be ejected at smaller sizes as the MPSM is tilted. These advantages are of great significance in many fields, such as a highly efficient fog harvesting system. This strategy of extrusion ejection based on dynamic surface structure control reported in this work may provide fresh ideas for efficient droplet manipulation.
研究领域:
表面科学
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微纳加工
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智能材料
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流体操控
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仿生工程
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2025
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IF 11.3
Weiping Cai,Fei Dang,Yujun Wang
Mercury sulfide nanoparticles (HgS NPs) are ubiquitous in nature and are methylated to neurotoxic methylmercury (MeHg) by microorganisms. However, there is a paucity of knowledge regarding the biokinetics of HgS NPs in microorganisms. Here, the biokinetic uptake and efflux of HgS NPs in the model bacterium ( Escherichia coli ) were quantified and compared with those of Hg-dissolved organic matter complexes (Hg-DOM). The results demonstrate that the uptake of HgS NPs was time- and concentration-dependent. The uptake rate constant of HgS NPs was 0.031 ± 0.006 L g −1 h −1 , which was 2.4-fold higher than that of Hg-DOM. Meanwhile, the internalized Hg in E. coli was depurated, as evidenced by the presence of Hg-containing NPs in the culture media. The efflux rate constant of HgS NPs and Hg-DOM were comparable (0.028 ± 0.007 h −1 vs. 0.031 ± 0.009 h −1 ). Consequently, HgS NPs exhibited a significantly higher bioconcentration factor (BCF; 1107 ± 63 L kg⁻ 1 ) than Hg-DOM (419 ± 57 L kg⁻ 1 ), suggesting their enhanced bioavailability and therefore greater methylation potential in Hg-methylating bacteria. These results demonstrate the unique characteristics of HgS NP uptake kinetics, which are essential for capturing their bioaccumulation mechanisms and providing more reliable and accurate risk assessments.
研究领域:
微生物学
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环境科学
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毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
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2021
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IF 8.071
Wen Chen,Qiang Chu,Xiang Ye,Yuhao Sun,Yangyang Liu,Ruoyi Jia,Yonglu Li,Pengcheng Tu,Qiong Tang,Ting Yu,Chuan Chen,Xiaodong Zheng
Increasing attention has been brought to microplastics pollution recently, while emerging evidences indicate that nano-plastics degraded from microplastics are more of research significance owing to stronger toxicity. However, there is little study focused on the prevention of nano-plastics induced toxicity until now. Canidin-3-glucoside (C3G), a natural anthocyanin proved to possess multiple functions like antioxidant and intestinal tissue protection. Thus, we proposed whether C3G could act as a molecular weapon against nano-plastics induced toxicity. In Caco2 cell and Caenorhabditis elegans ( C. elegans ) models, we found that polystyrene (PS) nano-plastics exposure resulted in physiological toxicity and oxidative damage, which could be restored by C3G. More significantly in Caco2 cells, we observed that autophagy was activated via Sirt1-Foxo1 signaling pathway to attenuate PS induced toxicity after C3G intervention and further verified by adding autophagy inhibitor 3-Methyladenine (3-MA). Meanwhile, PS co-localization with lysosomes was observed, indicating the encapsulation and degradation of PS. In C. elegans , by detecting LGG-1/LC3 expression in GFP-targeted LGG-1 report gene (LGG-1:GFP) labeled transgenic DA2123 strain, the co-localization of LGG-1:GFP with PS was found as well, means that autophagy is involved in C3G’s beneficial effects. Furthermore, we were surprised to find that C3G could promote the discharge of PS from N2 nematodes, which reduces PS toxicity more directly.
研究领域:
环境科学
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毒理学
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细胞生物学
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分子生物学
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
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2024
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IF 4.4
Li Shuyu,Hao Hongxun,Wu Di,Yu Hui,Zhao Hongtu,Wu Wenbo,Huang Xin,Wang Na,Zhou Lina,Wang Ting
In-situ API crystallization in carrier matrices has attracted extensive attention in recent years for its advantages over traditional preparation processes. However, due to the lack of systemic research on molecular self-assembly behaviors, the products obtained by in-situ crystallization suffer from the problems of polymorphic transformation and drug expulsion during storage, limiting its industrial application. This paper investigates the in-situ sequential crystallization behavior of tristearin (SSS) and fenofibrate (FEN), utilizing SSS as the carrier and FEN as the API. It was found that the behavior of mixed crystallization significantly differs from single-component crystallization, including direct formation of stable form of SSS and the rapid crystallization of FEN. During the crystallization process , the melting FEN promotes the movement of SSS molecules, while the sliding of SSS lamellae, in turn, provides a mechanical stimulus to enhance the nucleation of FEN. Based on the observed synergistic crystallization behavior, the distribution and stability of the API within FEN solid lipid microparticles (SLMs) during storage were evaluated, while also examining the stability variations in SLMs formulated at different cooling rates and drug loading concentrations. The findings indicate that the initial nucleated FEN results in a decrease in the surrounding molten FEN and the irregularity of the SSS lamellas, thereby preventing the remaining molten FEN from achieving complete crystallization within a brief period. Due to the compatibility between FEN and SSS, some SSS may blend with the molten FEN, potentially resulting in further crystallization during storage and consequently increasing the risk of drug expulsion.
研究领域:
药学
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材料科学
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化学
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
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IF 5.999
Huiyi Yin,Yongshi Guo,Simin Lai,Longfei Fan,Lihuan Wang,John H. Xin,Hui Yu
Taking inspiration from the structures of roots, stems and leaves of trees in nature, a biomimetic three-layered scaffold was designed for efficient water management and cell recruitment. Using polycaprolactone (PCL) and polyacrylonitrile (PAN) as raw materials, radially oriented nanofiber films and multistage adjustable nanofiber films were prepared through electrospinning technology as the base skin-friendly layer (roots) and middle unidirectional moisture conductive material (stems), the porous polyurethane foam was integrated as the outer moisturizing layer (leaves). Among which, radially oriented nanofiber films could promote the directional migration of fibroblasts and induce cell morphological changes. For the spatially hierarchically nanofiber films, the unidirectional transport of liquid was effectively realized. While the porous polyurethane foam membrane could absorb 9 times its weight in biofluid and retain moisture for up to 10 h. As a result, the biomimetic three-layered scaffolds with different structures can promote wound epithelization and drain biofluid while avoiding wound inflammation caused by excessive biofluid, which is expected to be applied in the field of skin wounds.
研究领域:
组织工程
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生物材料
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伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TOXICOLOGY
·
2023
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IF 4.5
Si-Cheng Zhao,Feng-Xin Qiao,Ming-Xin Sun,Yue-Cen Liu,Hai-Long Wang,Zhi-Ran Xu,Yu Liu
Cobalt is a kind of heavy metal which is widely used in petrochemical and biomedical industries. Animal studies have reported that cobalt would exert systemic toxicity, but its effects on the ovarian function in mammals, especially for oocyte quality remains unknown. In the present study, we report that cobalt chloride treatment affects ovary coefficient and follicular growth. Oocytes in cobalt chloride exposed mice exhibited a decreased development potential, with the evidence of decreased occurrence rate of germ vesicle breakdown and polar body extrusion. Besides, cobalt chloride disorganized meiotic spindle formation and movement, mechanically associated with affecting TACC3 and Ac-a-tubulin levels, and disturbing actin reorganization. In addition, cobalt chloride exposure result in mitochondrial cristae structures disappear, cluster distribution and potential depolarization. Altogether, these findings suggest that cobalt chloride impairs the ovarian follicle growth and affects oocyte development by disrupted spindle assembly and mitochondrial function.
研究领域:
生殖毒理学
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发育生物学
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细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Mei Liu,Ruimin Xie,Chi Ma,Jielin Xu,Run Zhao,Lili Deng,Shiyan Chen,Jianping Yang,Liming Zou,Huaping Wang,Jing Wu
Conventional disposable absorbent hygiene products (DAHPs) currently represent a significant type of solid waste in landfills and are a substantial producer of fiber-based microplastics. In this work, a novel multifunctional cellulose nonwoven (CNW) is reported. The key structural design of this material was achieved by covalently grafting a naturally cycloheptatriene product namely hinokitiol and a silane covalent bridge, successfully transforming the original super hydrophilic substrate into a single-layered, multifunctional material with precisely designed liquid-discharging molecular channels and a tailored, sophisticated hydrophobic/hydrophilic distribution structure. This 3D structure perfectly mimics the conventional adhesive-bonded polyolefin/polyesters laminates comprising a top sheet and a liquid acquisition and distribution layer (ADL). The results of XPS and 1 H NMR indicated the hinokitiol was successfully chemically bonded to the CNW surface. Compared with polyolefin or cotton substrates, the optimal CNW product ( CNW-H-A-2 ) exhibits significantly improved long-term wearing comfort by minimizing the liquid strike-through time (by 26–27%), reducing wet-back amount (by 65–90%), and ensuring an outstanding air-permeability (3011 mm·s - 1 ). Excellent antibacterial properties against Staphylococcus aureus (86.4%) and Escherichia coli (97.3%) were achieved due to the good preservation of the bioactive phenol groups of hinokitiol. Additionally, it can be completely enzymatically-degraded within 24 h. This strategy holds promise as a potential solution for mitigating fiber-based microplastics pollution of DAHPs.
研究领域:
材料科学
·
环境科学
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化学工程
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）