NATURE
·
2025
·
IF 48.5
Zhu Yunfeng,Xiao Fang,Wang Yiling,Wang Yufang,Li Jialin,Zhong Dongmei,Huang Zhilei,Yu Miao,Wang Zhirong,Barbara Joshua,Plunkett Christopher,Zeng Mengxue,Song Yiyan,Tan Tian,Zhang Ruibin,Xu Kezhen,Wang Zhongxing,Cai Changjie,Guan Xiangdong,Hammack Scott,Zhang Liang,Shi Zheng,Xiang Fu-li,Shao Feng,Xu Jie
Plasma membrane integrity is vital for nearly all aspects of cell functioning 1 . Mechanical forces can cause plasma membrane damage 2 , but it is not known whether there are large molecules that regulate plasma membrane integrity under mechanical strain. Here we constructed a 384-well cellular stretch system that delivers precise, reproducible strain to cultured cells. Using the system, we screened 10,843 siRNAs targeting 2,726 multi-pass transmembrane proteins for strain-induced membrane permeability changes. The screen identified NINJ1, a protein recently proposed to regulate pyroptosis and other lytic cell death 3,4 , as the top hit. We demonstrate that NINJ1 is a critical regulator for mechanical strain-induced plasma membrane rupture (PMR), without the need of stimulating any cell death programs. NINJ1 level on the plasma membrane is inversely correlated to the amount of force required to rupture the membrane. In the pyroptosis context, NINJ1 on its own is not sufficient to fully rupture the membrane, and additional mechanical force is required for full PMR. Our work establishes that NINJ1 functions as a bona fide determinant of membrane biomechanical properties. Our study also suggests that PMR across tissues of distinct mechanical microenvironments is subjected to fine tuning by differences in NINJ1 expression and external forces.
研究领域:
细胞生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Shuai Zhao,Rong Zhu,Yu Fu
Conveyances of physical energies (such as force, heat, and electricity) from one to another exist in nature and have initiated manifold useful applications. Piezothermic transduction refers to a change in the thermal conduction of a material when a mechanical strain is applied, which can be applied in high-performance pressure sensing and smart energy control. Here, we propose the piezothermic concept and investigate the mechanism of its transduction in three functional composite materials, that is, particle-reinforced composites, porous materials, and series-model materials. Theoretical models for analyzing relatedness effects of material properties (e.g., thermal conductivity, Young’s modulus, and volume fraction) are established and validated by both finite element analyses and experimental measurements. The piezothermic transduction provides novel and promising strategies to implement high-performance mechanical sensing as well as energy control through optimizing composite materials. As a demonstration, a pressure sensor with a super high range-to-limit ratio of 50 000 that has a lower detection limit of 3.9 Pa and a large measurement range of 200 kPa is developed.
研究领域:
材料科学
·
物理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2020
·
IF 4.65
Saima Batool,Muhammad Idrees,Jie Kong,Jiaoxia Zhang,Sifang Kong,Mengyao Dong,Hua Hou,Jincheng Fan,Huige Wei,Zhanhu Guo
Silicon nanocomposites have great potential applications in lithium-ion batteries. However, huge mechanical strain, capacity retention and unstable solid electrolyte interface formation weaken their applications in the real world. To overcome the above challenges, a novel facile route was adopted to design nanostructured silicon core carbon shell composites (Si@C), where the carbonization of phenolic resins led to a uniform porous thin interfacial layer of carbon. The phenolic resin precursor endowed mesoporous morphology with the carbon layer due to the carbonization of aromatic carbon, methylene linkages and hydroxyl groups. The mesoporous conductive carbon helped effectively to control the mechanical strain of silicon nanoparticles which maintained the integrity of Si@C nanocomposites and provided effective channels to easy access of electrolyte and short lithium ions transport. This novel Si@C anode offered a stable specific capacity of ∼868 mAh g −1 at 0.1 Ag -1 up to 500 cycles with ≥99% columbic efficiency.
研究领域:
材料科学
·
电化学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-17
·
IF 10.6
Lai Xuan,Wang Menglei,Zhang Zhen,Chen Suya,Tan Xiner,Liu Wenjing,Liang Huimin,Li Li,Shao Longquan
Zinc oxide nanoparticles (ZNPs) are widely used in sunscreens and nanomedicines, and it was recently confirmed that ZNPs can penetrate stratum corneum into deep epidermis. Therefore, it is necessary to determine the impact of ZNPs on epidermis. In this study, ZNPs were applied to mouse skin at a relatively low concentration for one week. As a result, desmosomes in epidermal tissues were depolymerized, epidermal mechanical strain resistance was reduced, and the levels of desmosomal cadherins were decreased in cell membrane lysates and increased in cytoplasmic lysates. This finding suggested that ZNPs promote desmosomal cadherin endocytosis, which causes desmosome depolymerization. In further studies, ZNPs were proved to decrease mammalian target of rapamycin complex 1 (mTORC1) activity, activate transcription factor EB (TFEB), upregulate biogenesis of lysosome-related organelle complex 1 subunit 3 (BLOC1S3) and consequently promote desmosomal cadherin endocytosis. In addition, the key role of mTORC1 in ZNP-induced decrease in mechanical strain resistance was determined both in vitro and in vivo. It can be concluded that ZNPs reduce epidermal mechanical strain resistance by promoting desmosomal cadherin endocytosis via the mTORC1-TFEB-BLOC1S3 axis. This study helps elucidate the biological effects of ZNPs and suggests that ZNPs increase the risk of epidermal fragmentation. Graphical abstract
研究领域:
纳米技术
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皮肤病学
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细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Xiaoling Wu,Wenkang Wei,Haimen Lin,Tong Wu,Wenzhen Zheng,Guorong Chen,Weiang Luo,Conghui Yuan,Birong Zeng,Yiting Xu,Lizong Dai
Flexible photodetector (FPD) is a crucial component in modern wearable/flexible systems and plays a vital role in healthcare, environmental monitoring, flexible display, and other fields. However, achieving satisfactory interfacial adhesion among the electrode, photoactive material, and flexible substrate at the same time to fabricate FPDs with high flexibility, stretchability, stability, and mechanically compliance is still a challenge. In this study, we propose a green and eco-friendly water-system processing strategy to construct all-in-one FPDs, using borate ester polymers (BPs) as both the co-matrix of the photoactive layer substrate and the conductive ink. The flexible substrate exhibits a high adaptation to the conductive ink, and thus, efficient interface charge transfer with the complicated pattern electrode. The resulting FPD exhibits stable photoresponse under different bending angles and large mechanical strains. Even after 2000 cycles of light stimulation test at a whole device elongation of 50%, the FPD exhibits no significant decrease in the photoresponse performance. Such devices may provide new opportunities for multifunctional electronic skin and wearable electronic devices.
研究领域:
材料科学
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电子工程
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纳米技术
·
可穿戴技术
✓ 已验证
产品关联
DOI
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2023
·
IF 5.1
Xulian Hu,Shaoxian Chen,Hu Wang,Zhao-Xi Zhou,Jinbiao Min,Qihui Chen,Maochun Hong,Heqing Fu
Hydrogels are important materials for mechanical sensors of artificial intelligence, and their good electrical conductivity and mechanical properties have broad application space in the field of multifunctional materials. However, it is still a challenge to prepare hydrogels with excellent conductivity and sensing, anti-freezing and water retention, resilience and fatigue resistance . Herein, chitosan/poly(acrylic acid-acrylamide‑sodium p-styrenesulfonate)/glycerol/samarium hydrate (C/P/G/S) double-network (DN) hydrogels were prepared by Interpenetrating Polymer Networks (IPNs) of chitosan (CS) with acrylic acid (AA), acrylamide (AM), sodium p-styrenesulfonate (SSS), glycerol (GL) and samarium hydrate (SH) under ultraviolet (UV) light. The C/P/G/S DN hydrogels have satisfactory mechanical properties , conductivity, mechanical strain sensing performances, water retention and frost resistance capacities. Specially, the compressive stress of hydrogels at 80% compressive strain is up to 1.7 MPa. It also shows preeminent fatigue resistance and resilience in continuous cyclic stretching and cyclic compression (5 and 100 times). The conductivity of the hydrogels can reach 1.9 S/m when the SH is 1.8 g. Meanwhile, mechanical strain sensing tests of the hydrogels at room temperature and low temperature were also performed simultaneously. The hydrogels have stable mechanical strain sensing properties and good electrical conductivity even at −20 °C. More importantly, when C/P/G/S DN hydrogels were placed at room temperature and ventilated for 30 days, the water loss rate of hydrogels was only 13.9%.
研究领域:
材料科学
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机械工程
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电气工程
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高分子科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Electronic Materials
·
2025
·
IF 4.7
Jiale Huang,Linfeng Lan,Bo Huang,Jiayi Pan,Baozhong Chen,Qi Zhou,Huimin Su,Jintao Xu,Jiajun Lin,Yutian Liu,Yang Lu,Simeng Gong,Junbiao Peng
Recent advancements in organic electronics highlight the potential of stretchable organic field-effect transistors for neuromorphic applications. However, maintaining a high electrical performance under mechanical strain remains a critical challenge. Here, we present a stretchable organic synaptic transistor with a phase-separating method. By blending poly(3-hexylthiophene) (P3HT) with styrene–ethylene–butylene–styrene (SEBS), P3HT–SEBS phase-separated films were obtained that combine high mechanical stretchability with good charge transport property. The organic synaptic transistors (OSTs) were able to withstand a mechanical strain of greater than 80%. Remarkably, by combining SEBS-induced stress dissipation with ionic gel-driven synaptic modulation, the OSTs were able to mimic synaptic dynamics under strain, facilitating neurobiological behaviors. Our work addresses the critical need for strain-resilient organic devices in next-generation human–machine collaboration.
研究领域:
有机电子学
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神经形态工程
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材料科学
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可拉伸电子学
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合成生物学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-12
·
IF 15.7
Li Yalu,Zou Can,Liu Da,Li Qing,Zhu Yan,Lin Miaoyu,Zeng Sihan,Wei Zhanpeng,Liu Xinyi,Zheng Yichu,Peng Yu,Hou Yu,Yang Hua Gui,Yang Shuang
Flexible integration of perovskite materials has driven diverse applications, from wearable detectors, portable energy systems to foldable displays. However, due to the intrinsic brittleness of perovskite, mechanical strain inevitably causes the degradation and variation of electronic performance of the devices. Here, we establish a periodic multilayered polymer-perovskite membrane that showcases plastic-like mechanical behaviors of small Young’s modulus (5.41 GPa) and bending tolerance (radius of 0.5 mm), yet retains the perovskite’s carrier transport capacity ( μτ product of 1.04 × 10 −4 cm 2 V −1 ). The mechanistic study shows that the formation of bicontinuous perovskite-polyimide structure in the membrane accounts for the carrier transport and load transfer functions, respectively, thus unifies paradoxical mechanical and electronic properties. Using a lateral device configuration, X-ray detector based on the membrane delivers a high X-ray sensitivity of 8380.80 μC Gy air −1 cm −2 , and withstands 30,000 repeated bending cycles under a bending radius of 1.5 mm without notable performance degradation.
研究领域:
材料科学
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纳米技术
·
光电子学
·
柔性电子学
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聚合物复合材料
·
机械工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2023
·Vol. 11
·期 10
·3634-3643
·
IF 6.4
Jundang Liang,Botian Li,Xiaodong Gai,Ning Li,Jian Wang,Yichi Zhang,Qiong Zhou,Yuchao Sun
The excessive use of paper causes serious resource consumption and environmental pollution. Environmentally friendly light printing based on a photochromic system with the advantages of being noncontact, rapid, and inkless has attracted increasing attention; however, several problems need to be addressed, such as slow discoloration and irreversibility. In this work, a composite of MoO3−x inorganic nanorods and the conductive polymer poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) was employed as a color-changing electrode, and a photochromic/electrochromic strain sensor (PESS) was obtained by assembling the color-changing electrode with an organohydrogel electrolyte and a flexible indium tin oxide (ITO) film. Due to the photochromic/electrochromic effect of MoO3−x and the conductivity of PEDOT:PSS, the sensor turned cyan-blue under UV irradiation or a negative bias voltage, and it could be rapidly bleached by applying a positive bias voltage. The photochromic/electrochromic behavior of the PESS could be optimized by tuning the amount of PEDOT:PSS, and the device could perform cyclic light printing/electroerasing with a fast and stable response. Moreover, the flexible strain sensor could be utilized to monitor mechanical strain by translating a series of deformations into electrical signals. The properties of photochromism/electrochromism and strain sensing make the device potentially applicable to outdoor wearable devices capable of light-based printing.
研究领域:
材料科学
·
电化学
·
光电
·
传感器
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
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