Journal of Materials Chemistry B
·
2025
·
IF 5.7
Jiale Zhang,Pengtao Chen,Jinlong Hu,Shuqing Wu,Yue Lin,Yao Lu,Junyu Xia,Jingcheng Wang,Jie Li,Yuan Liang
Implant-related infections (IRIs) pose a major challenge in orthopedic applications due to the persistence of biofilms, which are highly resistant to conventional antibiotics. This study introduces oxygen vacancy-engineered Zn–Fe spinel nanoparticles as microwave-responsive antibacterial agents. The oxygen vacancies in the spinel structure enhance reactive oxygen species (ROS) generation under microwave irradiation, providing a dual-mode antibacterial mechanism of thermal and oxidative stress. Zn–Fe spinel nanoparticles were synthesized using a sol–gel method and evaluated for their antibacterial efficacy against Staphylococcus aureus biofilms. Under microwave irradiation, the Zn–Fe spinel demonstrated significant biofilm disruption and bacterial eradication. Mechanistic studies revealed that oxygen vacancies promoted ROS generation, leading to bacterial membrane damage. In vivo experiments using a mouse infection model confirmed the material's antibacterial efficacy and biocompatibility, with no observed toxicity. This study highlights the potential of oxygen vacancy-enhanced Zn–Fe spinel as a microwave-assisted, antibiotic-free strategy for treating deep-seated infections associated with orthopedic implants.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
抗菌治疗
·
骨科
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产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Lianjun Wu,Yiwen Dong,Litao Yao,Chuantong Liu,Abdullrahman M Al-Bishari,Kendrick Hii Ru Yie,Hualin Zhang,Jinsong Liu,Gang Wu
Zirconia has become a new dental implant material because of its excellent esthetics, biocompatibility, and minimal ion release. However, biological inertness of zirconia surface results in weak integration with bone tissue in the early stage of osseointegration. To enhance the early osseointegration of zirconia implant, a homogeneous nanoporous tantalum (TaNS) coating (~30 nm in diameter and 1 μm in length) with good adhesion strength was prepared on zirconia surface via magnetron sputtering combined with anodization. The roughness and hydrophilicity in ZrO 2 /TaNS groups were significantly improved as compared to other groups. The protein adsorption, initial adhesion, spreading and proliferation of MC3T3-E1 cells were significantly enhanced in ZrO 2 /TaNS group as compared to ZrO 2 and ZrO 2 /Ta group. Moreover, the osteogenic differentiation of MC3T3-E1 cells was significantly improved in ZrO 2 /TaNS groups than other groups by up-regulating the expression of the osteogenic-related genes (RunX2, ALP , COL-1, OSX, OCN and OPG). Histological analysis displayed that more newly regenerated bone was deposited around ZrO 2 /TaNS group than other groups, and the bone-implant contact in ZrO 2 /TaNS group was enhanced correspondingly. In conclusion, the TaNS coating with good adhesion strength can be successfully prepared on zirconia surface by magnetron sputtering combined with anodization. This novel coating will be a promising clinical application in improving osseointegration of the zirconia implant.
研究领域:
牙科材料
·
生物医学工程
·
组织工程
·
材料科学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Gang Yang,Rongrong Deng,Yincheng Chang,Hongbo Li
Developing titanium-based dental implants with both excellent antibacterial properties and good osseointegration is crucial for the success of the implant operation and the long-term durability of the implant. In this study, a polydopamine-based coating was created by attaching TiO 2 nanosheets-cyanine composites onto the titanium surface, enabling the integration of effective photothermal antibacterial therapy with osseointegration. The exceptional dual-photothermal conversion abilities of polydopamine and cyanine in the coating resulted in outstanding photothermal antibacterial and antibiofilm therapy against four types of bacteria. Furthermore, TiO 2 nanosheets promoted the adhesion, proliferation and early osteogenic differentiation of osteoblasts. In an infected dental implant model in rats, the developed coating exhibited potent antibacterial activity and remarkable osteogenic differentiation in the bone, leading to increased bone formation around the implants. This innovative approach, combining photothermal therapy with osteogenic two-dimensional nanomaterials, presents a novel method for surface functionalization of implants to achieve effective antibacterial and osseointegration capabilities.
研究领域:
生物材料
·
牙科种植学
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光热疗法
·
组织工程
·
生物医学工程
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DOI
PubMed
高影响因子
Nanoscience and Nanotechnology Letters
·
2015
·Vol. 7
·期 3
·233-239
·
IF 1.431
Xiao Xiang,Xu Yao,Fu Jijiang,Gao Biao,Huo Kaifu,Chu Paul K.
Titanium (Ti) and its alloy are widely used in biomedical implant but the poor bioactivity of Ti restricts some direct applications. Polydopamine (PDA), a functional polymeric substance mimicking the mussel adhesive protein, is deposited on Ti surface to improve the bioactivity by means
of a mild and facile technique employing an alkaline dopamine solution. The PDA coated Ti implant accelerates nucleation and growth of hydroxyapatite (HAP), enhances osteoblast cell adhesion and proliferation, and improves the ALP activity thus having promising biomedical applications.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Zhong Wang,Ya Zhao,Yuyu Zhao,Yi Zhang,Xiaohong Yao,Ruiqiang Hang
Copper, a frequently used additive of implant materials, can alter macrophage phenotype thus directing the fate of the implants. Exosomes, secreted by mammalian cells, can target to recipient cells and mediate their functions. However, whether exosomes derived from macrophages upon copper ion stimulation can modulate angiogenesis, a key index for implant osseointegration, is still unclear. Herein, the influence of copper ions on macrophage-derived exosome secretion, ingestion behavior by endothelial cells, and angiogenic-induction ability is investigated. The results show copper ions (0–100 μM) have little influence on the secretion of macrophage-derived exosomes. Endothelial cells can uptake the exosomes from all the groups in a time-dependent manner. The exosomes have little influence on endothelial adhesion and proliferation, but can upregulate angiogenic ability of endothelial cells in vitro and in vivo , which may be related to trafficking of integrin β1. The results provide insight into the effect of copper ions on immunomodulatory mechanism of macrophages, which is important for implant design from the perspective of material compositions.
研究领域:
免疫学
·
材料科学
·
细胞生物学
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2018
·
IF 3.862
Ning Yang,Huanfei Chen,Huijie Han,Yuanyuan Shen,Song Gu,Yong He,Shengrong Guo
Intratumoral implants have aroused great interests for local chemotherapy of cancer, however, how to efficiently control drug release from implants is still a great challenge. Herein, we designed and prepared a new hollow bullet-shaped implant with porous surface by 3D printing, loaded chemotherapeutic agent cytoxan (CTX) with tetradecyl alcohol or lecithin as matrix and coated it with poly (lactic acid) to obtain a CTX implant, which has a highly tuned drug release property with a drug release time from 4 h to more than 1 month. The drug release from the implant can be easily controlled by changing pore sizes, kinds of matrices, and coating thickness.
研究领域:
肿瘤学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Limin Qu,Xiangzhou Li,Jun Zhou,Kairui Cao,Qiuen Xie,Peng Zhou,Wei Qian,Yanhong Yang
Infection associated with implants and devices is a problem in medicine, especially when bacterial colonization leads to the formation of biofilms on the implant surface. Here, we report an effective strategy to develop dual-functional coatings on titanium implants with antibacterial and antifouling properties to combat biofilm infections. Coating monomers with antibacterial and antifouling blocks were prepared by conjugating curcumin-derived curcumin carboxylic acid (Cur-COOH) with different chain lengths of allyl polyethylene glycol (APEG; MW 1200 or 2400). The coating monomer (APEG 1200/2400 -Cur) was grafted onto the surface of the titanium implant through azobisisobutyronitrile (ABIN)-induced radical polymerization to form dual-functional coatings with antibacterial and antifouling properties. Scanning electron microscopy & energy dispersive spectroscopy (SEM & EDS), contact angle (CA), and X-ray spectroscopy (XPS) confirmed successful grafting of coupling compounds. The coatings exhibited excellent antibacterial activity against Gram-negative bacteria ( Escherichia coli ) and Gram-positive bacteria ( Staphylococcus aureus ) and prevented biofilm formation. The coatings also reduced the adsorption of proteins and the adhesion of platelets, indicating their excellent antifouling properties. Notably, the coatings also exhibited favorable biocompatibility with mammalian erythrocytes and pre-osteoblasts. In summary, this dual-functional coating showed remarkable potential for application in preventing and treating infections caused by biofilms.
研究领域:
生物医学工程
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Zishuo Hou,Kun Wang,Guming Liu,Zhang Yuan,Haowei Peng,Yue Yuan,Hongbo Wei,Tengjiao Wang,Peng Li
The balance of antibacterial and osseointegration-promoting properties on titanium (Ti) implants in a simple and efficient manner is crucial for the management of implant-associated infections, a condition that has become a significant global health concern. Herein, a nitric oxide (NO)-mediated dual-function smart coating with antibacterial and osseointegration-promoting properties is developed for Ti implants. The coating leverages the distinct properties of NO at high and low concentrations to enable an on-demand functional switch. Specifically, antibacterial function is achieved through a rapid release of high-dose NO in response to the infection microenvironment and near-infrared stimulation. Once the infection is resolved and normal physiological conditions are restored, the coating gradually releases low-dose NO to promote osseointegration. In vitro tests confirm that the coating exhibits antibacterial ratio of 97.84% and 97.18% against methicillin-resistant Staphylococcus aureus and its biofilms, respectively, and demonstrates the ability to activate osteoblasts. The rat femoral implant-associated infection model further certifies that the responsive NO release mechanism of the coating efficiently facilitates the on-demand functional switch between antibacterial and osseointegration-promoting properties. Notably, the use of the dual-functional nonantibiotic agent, NO, significantly mitigates the risk of bacterial resistance.
研究领域:
生物医学工程
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Qi Wang,Huiyu Yan,Biyang Ling,Wenhua Li,Jianxi Xiao
Skin aging is a pervasive concern that profoundly impacts human well-being and quality of life, while also heightening the risk of skin diseases, including skin cancer. Implants offer a promising treatment option for skin aging, but current implants degrade quickly and have low bioactivity, resulting in reduced therapeutic efficacy. This study introduces a novel injectable, long-lasting, highly bioactive collagen-coated nanoparticle implant for skin rejuvenation. The nanowood, produced through delignification, air-assisted superfine grinding, and sieving, demonstrates excellent injectability. The collagen-coated nanowood implant exhibits remarkable biocompatibility and bioactivity, significantly enhancing the proliferation, adhesion, and migration of human foreskin fibroblast-1 cells. In photoaged mouse skin models, the implant substantially improves dermal density and skin elasticity, creating an environment conducive to fibroblast activity and collagen regeneration. Furthermore, the implant shows excellent biosafety, with no pyrogenic or hemolytic risks. Injectable nanowood implants are a promising approach to skin regeneration with important potential applications in dermatology and tissue engineering.
研究领域:
生物医学工程
·
组织工程
·
皮肤病学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS TECHNOLOGY
·
2015
·
IF 1.227
T. He,W. Zhu,X. Wang,P. Yu,S. Wang,G. Tan,C. Ning
Copper(II) were immobilised onto medical titanium surface by polydopamine (PDA) chelating, to build intrinsic antibacterial implant materials for inhibition of implant infection. A scanning electrical microscope showed that the modified titanium surface morphology was a porous nanostructure. An energy dispersive spectrometer showed the existence of Cu, and X-ray photoelectron spectroscopy results further confirmed that the immobilised copper element was in the form of Cu(II). Bacteria plate colony counting results showed that modified titanium surface had decent antibacterial property, matching the ion release outcomes. It could be conclude that the PDA assisted Cu(II) immobilisation was an efficient and effective method for antibacterial modification of titanium.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2017
·Vol. 28
·期 9
·1-12
·
IF 2.325
Shuai Cijun,Yang Youwen,Peng Shuping,Gao Chengde,Feng Pei,Chen Jian,Liu Yong,Lin Xin,Yang Sheng,Yuan Fulai
Mg-5.6Zn-0.5Zr alloy (ZK60) tends to degrade too rapid for orthopedic application, in spite of its natural degradation, suitable strength and good biocompatibility. In this study, Nd was alloyed with ZK60 via laser melting method to enhance its corrosion resistance. The microstructure features, mechanical properties and corrosion behaviors of ZK60- x Nd ( x = 0, 1.8, 3.6, 5.4 wt.%) were investigated. Results showed that laser melted ZK60- x Nd were composed of fine ɑ-Mg grains and intermetallic phases along grain boundaries. And the precipitated intermetallic phases experienced successive changes: divorced island-like MgZn phase → honeycomb-like T phase → coarsened and agglomerated W phase with Nd increasing. It was worth noting that ZK60-3.6Nd with honeycomb-like T phase exhibited an optimal corrosion behavior with a corrosion rate of 1.56 mm year −1 . The improved corrosion behavior was ascribed to: (I) dense surface film caused by the formation of Nd 2 O 3 hindered the invasion of immersion solution; (II) the three-dimensional honeycomb structure of intermetallic phases formed a tight barrier to restrain the propagation of corrosion. Moreover, ZK60-3.6Nd exhibited good biocompatibility. It was suggested that ZK60-3.6Nd was a preferable candidate for biodegradable bone implant.
研究领域:
材料科学
·
生物医学工程
·
腐蚀科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
·
2023
·
IF 22.1
Shiwei Guan,Zhenhao Hou,Ji Tan,Xianming Zhang,Junyu Liu,Huihui Du,Hongqin Zhu,Yuqin Qiao,Zixiao Liu,Xuanyong Liu
Near-infrared (NIR) light-triggered photocatalysis antibacterial therapy has attracted significant attention. Herein, we designed a straddle-type heterostructure film of ZnS/Ag 2 S nanorod on the titanium implant, which showed excellent NIR photocatalytic ability. Under NIR, the electrons of Ag 2 S cascaded jump to ZnS conduction band (CB), and the electron of ZnS was half-jumped to Ag 2 S valence band (VB). The VB of Ag 2 S acted as a consumption platform for the holes of Ag 2 S and the electrons of ZnS, improving photocatalytic efficiency. To prove the feasibility of this mechanism, another straddle-type heterostructure of ZnS/Bi 2 S 3 with similar energy band structure was fabricated, and its NIR photocatalytic ability was also distinctly enhanced. Furthermore, the ZnS/Ag 2 S heterostructure films rapidly removed bacteria in vitro and in vivo under the NIR irradiation. This work innovatively discovered NIR photocatalytic effect of the straddle-type heterostructure, which complemented the design of heterostructures in photocatalysis.
研究领域:
材料科学
·
生物医学工程
·
光催化技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）