ORGANIC ELECTRONICS
·
2024
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IF 2.7
Cangyu Wang,Xiaoge Song,Sinyeong Jung,Wansi Li,Maggie Ng,Season Si Chen,Man-Chung Tang
Recent research on anthracene-based hydrocarbon (PNA) as the emissive layer host found that deuteration mediated the formation of these adduct species, presumably quenchers, and thus improved the device lifetime. Meanwhile, studies on deuterium in PNA host materials with stepwise deuteration are scarce. In this work, we report a systematic study of isotopic effects through independent deuteration of the phenyl or/and the dibenzofuran unit on a series of PNA materials polyaromatic dibenzofuran ( PAF , PAF- d 5 , PAF- d 7 and PAF- d 12 ). We fabricated fluorescent OLED based on this triplet-triplet up-conversion active host materials for conventional MR-TADF emitter. A short-lived excited delayed lifetime of less than 2 μs has been observed in their electroluminescence decay studies. In addition, LT 80 of up to 12.7 h has been observed in PAF- d 12 at the brightness of 1000 cd m −2 , corresponding to a 4-fold enhancement of OLED stability compared to the non-deuterated counterpart. We hope the current research can provide insights for further device improvement.
研究领域:
材料科学
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有机电子学
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产品关联
DOI
高影响因子
Science Bulletin
·
2020
·
IF 9.511
Bing Zhang,Chuntian Qiu,Shan Wang,Hua Gao,Kunyi Yu,Zhaofei Zhang,Xiang Ling,Wei Ou,Chenliang Su
Tandem water electrolysis for the transformation of universal feedstock to value-added chemicals integrated with hydrogen generation and in situ utilization is a promising approach to address the economic challenges of electrochemical hydrogen evolution and storage. Herein, we present the controllable electrocatalytic deuteration of halides using inexpensive and reusable heavy water (D 2 O) as a D-source for the preparation of valuable D-labelled chemicals and pharmaceuticals under mild conditions. This electrochemical deuteration method with high efficiency and selectivity furnishes a series of D-labelled chemicals and pharmaceuticals in high yields with excellent D-incorporation. The reaction efficiency and selectivity, that is, the precise substitution of deuterium atoms at different halogen positions, can be tuned by varying the applied voltages . The results show the great potential of green and economical electrocatalytic methods for producing value-added fine chemicals in addition to hydrogen evolution.
研究领域:
化学工程
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电化学
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产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2024
·Vol. 11
·期 29
·2308523
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IF 14.3
Zimin Yao,Xiaokun Wen,Xia Hong,Ran Tao,Feifei Yin,Shuo Cao,Jiayi Yan,Kexin Wang,Jiwei Wang
Constrained by a limited understanding of the structure and luminescence mechanisms of carbon dots (CDs), achieving precise enhancement of their photoluminescence (PL) performance without altering the emission wavelength and color remains a challenge. In this work, a deuterated CD is first achieved by simply replacing the reaction solvent from H 2 O to D 2 O. The substitution of D atoms for H atoms is not limited on the surface but also within the internal structure of CDs. Deuteration affects the formation of the π -conjugated network structure by altering the content of sp 2 carbon and sp 3 carbon, ultimately inducing a reconstruction for energy level structure of CDs. Both the intrinsic state and surface state emission, including quantum yield, emission intensity and lifetime, are significantly enhanced after deuteration. It benefits from the reduction in non-radiative transitions, since the lowered vibrational frequencies of D atoms and optimized local energy level distribution in CDs structure. The deuterated CDs are applied in the fabrication of white-light-emitting diodes to show their application potential. This work provides a highly versatile route for improving and controlling photoluminescence performance of CDs and has opportunities to guide the development of CDs for practical applications.
研究领域:
材料科学
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光学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
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2023
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IF 3.6
Chenxu Zheng,Zhi-Jiang Jiang,Ke Jin,Qian Wang,Jian-Fei Bai,Gang Xu,Zhanghua Gao
As a representative scaffold of alkaloids, indoles have been extensively subjected to deuteration, but the regioselective C4 labeling has not been achieved due to its low reactivity. In this work, a Pd-catalyzed deuterium labeling at the indole’s C4 position has been developed under the strategy of transient directing, using D2O as a deuterium source. The substituent effect is found to be crucial in facilitating this H/D exchange process, where the reversing C–D bond formation favors an electron-enriched ligation contrary to its C–H halogenation counterpart.
研究领域:
有机化学
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药物化学
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DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-9
·
IF 15.7
Zhang Xiu-Feng,Zhang Shi-Nan,Zhang Zhao,Leng Bing-Liang,Lu Kai-Yuan,Chen Jie-Sheng,Li Xin-Hao
Deuterated organic compounds have gained significant attention due to their diverse applications, including reaction mechanism studies, probes for metabolism and pharmacokinetics, and raw materials for labeled compounds and polymers. Conventional reductive deuteration methods are limited by the high cost of deuterium sources (e.g., D₂ gas) and challenges in product separation and D₂O recycling. Electrochemical deuteration using D₂O is promising, but existing methods still suffer from low Faradaic efficiency (FE) and high separation costs. Herein, we report a deuterium ion diffusion-based all-solid electrolyser, featuring a RuO₂ anode for D + generation from pure D 2 O and a Pd/nitrogen-doped carbon-based liquid diffusion cathode (Pd δ+ /NC LDC) with tunable electron deficiencies Pd δ+ /NC to enhance selective deuteration. This system achieves over 99% selectivity for deuterated benzyl alcohol with a FE of 72%, and demonstrates broad applicability for the deuteration of aldehydes, ketones, imines, and alkenes with high FE and selectivity. Moreover, the Pd δ+ /NC-based electrolyser can achieve ten-gram-scale production of deuterated benzyl alcohol over 500 hours, showcasing its potential for high-throughput, solvent-free deuteration reactions in practical applications.
研究领域:
有机化学
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药物化学
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合成化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2019
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IF 2.813
Yingyue Yi,Guanghui Ren,Ming Zheng,Di Zhao,Ning Li,Xijng Chen,Yang Lu
JJH201501, a deuterated modification for multi-target antidepressant vortioxetine, is currently in phase I clinical trial. This study aimed to establish a sensitive and rapid UPLC-MS/MS method that was capable of simultaneously detecting JJH201501 and its major metabolite JJH201501-01 quantitatively in human plasma. The pretreatment was achieved by protein precipitation using 4-fold(v:v) acetonitrile with 5 ng/mL fluoxetine as internal standard precipitant. For method validation, the method was investigated in terms of the selectivity, inter- and intra-run precision and accuracy, carryover, matrix effect, extraction recovery and stability. The total running time was 3 min, and the retention time of JJH201501 and JJH201501-01 was 1.17 min and 1.05 min, respectively. The linear concentration range for JJH201501 and JJH201501-01 was 0.2 to 50 ng/mL and 0.4 to 100 ng/mL, respectively. The results showed that this method was in line with the guidelines for bioanalytical method proposed by FDA. In addition, the method was successfully applied to a plasma pharmacokinetic study of JJH201501 tablets in healthy volunteers which was part of the phase I trial.
研究领域:
药物分析
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临床药理学
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分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF ORGANIC CHEMISTRY
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2023
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IF 3.6
Jianbo Tang,Junhua Kong,Hui Xu,Zhi-Jiang Jiang,Yifan She,Jianfei Bai,Bencan Tang,Jia Chen,Zhanghua Gao,Kun Gao
Silver-catalyzed deuteration of nitroaromatics has been achieved using D2O as the deuterium source. Distinct from the well-established directing group-guided hydrogen-isotope exchange, this protocol showed an interesting deuteration pattern, where considerable deuterium accumulation was observed around the aromatic rings. Controlling experiments suggested that the deuteration was initiated by a silver-promoted C–H activation. Therefore, a tentative two-stage deuteration mechanism involving aryl-silver species was proposed to explain the deuteration on meta- and para-positions.
研究领域:
有机化学
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同位素化学
✓ 已验证
DOI
PubMed
高影响因子
Nature Communications
·
2024
·Vol. 15
·期 1
·1-10
·
IF 14.7
He Meng,Li Rui,Cheng Chuanqi,Liu Cuibo,Zhang Bin
The high Faradaic efficiency (FE) of the electrocatalytic deuteration of organics with D 2 O at a large current density is significant for deuterated electrosynthesis. However, the FE and current density are the two ends of a seesaw because of the severe D 2 evolution side reaction at nearly industrial current densities. Herein, we report a combined scenario of a nanotip-enhanced electric field and surfactant-modified interface microenvironment to enable the electrocatalytic deuteration of arylacetonitrile in D 2 O with an 80% FE at −100 mA cm −2 . The increased concentration with low activation energy of arylacetonitrile due to the large electric field along the tips and the accelerated arylacetonitrile transfer and suppressed D 2 evolution by the surfactant-created deuterophobic microenvironment contribute to breaking the trade-off between a high FE and large current density. Furthermore, the application of our strategy in other deuteration reactions with improved Faradaic efficiencies at −100 mA cm −2 rationalizes the design concept.
研究领域:
化学工程
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电化学
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催化科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
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IF 8.2
Mingyue Xie,Yong Wu,Hao Gu,Yuhao Peng,Shan Zhang,Feng Ryan Wang,Wei Xiao,Dong Gu
Deuterated compounds have broad applications across various fields, with dehalogenative deuteration serving as an efficient method to obtain these molecules. However, the diverse electronic structures of active sites in the heterogeneous system and the limited recyclability in the homogeneous system significantly hinder the advancement of dehalogenative deuteration. In this study, we present a catalyst composed of copper single-atom sites anchored within an ordered mesoporous nitrogen-doped carbon matrix, synthesized via a mesopore confinement method. The Cu1/OMNC-1100 catalyst, characterized by Cu–N4 sites, demonstrates exceptional performance, high functional group tolerance, and remarkable durability in the deuteration of 2-bromo-6-methoxynaphthalene under relatively mild conditions (80 °C, 2 MPa of CO). Experimental results combined with X-ray absorption fine structure analysis reveal that Cu–N3 sites can be converted into more stable Cu–N4 counterparts at higher pyrolysis temperatures, resulting in enhanced catalytic activity. This work demonstrates a strategy for designing single-atom site catalysts with tunable coordination environments, providing a promising approach to improving catalytic performance in selective dehalogenative reactions under relatively mild conditions.
研究领域:
化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
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2025
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IF 0.9
Jiaojiao Zuo,Jing Kang,Jingjing Hong,Jingwen Li,Yi Fang,Chunyi Liu,Minhao Xie,Zhengping Chen
Dopamine transporter (DAT) is closely associated with neurodegenerative diseases such as Parkinson's disease (PD). To develop an in vivo stable radioligand targeting DAT, we synthesized a novel iodine-131-labeled tropane analog [ 131 I] 1 with deuteration on both the N -fluoropropyl and 2 β -carbomethoxy positions of the tropane scaffold and then biologically compared with the previously reported analog [ 131 I]FP-CIT-d 6 with deuteration only on the N -fluoropropyl group. The radioligand [ 131 I] 1 was obtained via a radioiodine-destannylation reaction with a radiochemical yield of ~95%, a radiochemical purity of > 99% and a molar activity of 12.72 GBq/μmol. [ 131 I] 1 exhibited a high in vitro binding affinity for DAT with an IC 50 value of 2.2 nM. Metabolic stability studies demonstrated that [ 131 I] 1 displayed superior in vivo stability compared with [ 131 I]FP-CIT-d 6 . Biodistribution studies revealed that [ 131 I] 1 had better DAT affinity, specificity, and a higher target-to-background ratio than [ 131 I]FP-CIT-d 6 . Ex vivo autoradiography and blocking experiments validated the selective and reversible binding of [ 131 I] 1 to DAT and superiority to [ 131 I]FP-CIT-d 6 . These preliminary results suggest that deuterated radioligand [ 131 I] 1 , with enhanced in vivo stability and higher target-to-background ratio, is a promising DAT probe, warranting the development and application of 123 I-labeled counterpart ([ 123 I] 1 ) for SPECT imaging in DAT-related disorders.
研究领域:
医学影像学
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神经生物学
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放射化学
✓ 已验证
DOI
PubMed
高影响因子
FUSION ENGINEERING AND DESIGN
·
2021
·
IF 1.453
Jie Du,Xinxin Tan,Liping Wang,Cheng Qin,Xiaoqiong Chen,Zhigang Wu,Biao Guo,Wenhua Luo
Deuterated-tritiated polymers are a type of promising target materials for inertial confinement fusion (ICF). The preparation of a deuterated-tritiated polymer was performed from a deuterated polybutadiene under tritium through solid state catalytic tritiation with 5 wt% Pd/BaSO 4 as a catalyst. After reaction, the gas mixture in the vessel and the raw T 2 /Ar mixture in the flask were analyzed with a gas chromatography, a quadrupole mass spectrometer and a high resolution gas analysis mass spectrometer. The 2 H-NMR and 3 H-NMR spectra were employed to characterize the deuterated-tritiated polymer. Both isotopic exchange and addition during the reaction were confirmed and the tritium ratio of the deuterated-tritiated polymer was determined to be 26.5 %.The solid state tritiation free of solvents can avoid the generation of high radioactive liquids.
研究领域:
材料科学
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核物理学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2023
·Vol. 14
·期 1
·1-12
·
IF 16.6
Jung Sinyeong,Cheung Wai-Lung,Li Si-jie,Wang Min,Li Wansi,Wang Cangyu,Song Xiaoge,Wei Guodan,Song Qinghua,Chen Season Si,Cai Wanqing,Ng Maggie,Tang Wai Kit,Tang Man-Chung
The realization of operationally stable blue organic light-emitting diodes is a challenging issue across the field. While device optimization has been a focus to effectively prolong device lifetime, strategies based on molecular engineering of chemical structures, particularly at the subatomic level, remains little. Herein, we explore the effect of targeted deuteration on donor and/or acceptor units of thermally activated delayed fluorescence emitters and investigate the structure-property relationship between intrinsic molecular stability, based on isotopic effect, and device operational stability. We show that the deuteration of the acceptor unit is critical to enhance the photostability of thermally activated delayed fluorescence compounds and hence device lifetime in addition to that of the donor units, which is commonly neglected due to the limited availability and synthetic complexity of deuterated acceptors. Based on these isotopic analogues, we observe a gradual increase in the device operational stability and achieve the long-lifetime time to 90% of the initial luminance of 23.4 h at the luminance of 1000 cd m −2 for thermally activated delayed fluorescence-sensitized organic light-emitting diodes. We anticipate our strategic deuteration approach provides insights and demonstrates the importance on structural modification materials at a subatomic level towards prolonging the device operational stability.
研究领域:
材料科学
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化学工程
·
光学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）