MEASUREMENT
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2026
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IF 6.1
Yuan Jin,Junyuan Song,Nanke Ma,Guangli Li
NiMoO 4 micro-rods/MWCNT-COOH composite first applied for FLX detection. • Low LOD (0.012 μM), wide range (0.05–20 μM), high sensitivity (μA μM −1 ). • Enrichment via electrostatic attraction, H-bonding, and π‑π stacking (adsorption-controlled). • Good anti-interference, 82% stability over 30 days, recoveries 94–104% in real samples. • Structural and functional complementarity (conductivity + catalysis) of the composite. Fleroxacin (FLX), a commonly utilized fluoroquinolone antibiotic, has been identified as a significant environmental and human health hazard due to its presence and accumulation in the environment. In this study, an electrochemical sensor employing a NiMoO 4 /MWCNT-COOH composite material was devised for the highly selective and highly sensitive detection of FLX in environmental water samples. The nickel molybdate microrod/carboxylated multiwalled carbon nanotube composites (NiMoO 4 /MWCNT COOH) synergistically combines the catalytic properties of NiMoO 4 with the exceptional conductivity and dispersibility of MWCNT-COOH, thereby enhancing electron transfer rates and the effective electroactive surface area. The sensor demonstrated a favorable linear response within the concentration range of 0.05–20 μM, with a limit of detection of 0.012 μM, a sensitivity of 2.988 μA μM −1 , good anti-interference capabilities, and sustained stability (signal retention rate of 82% over 30 days). Furthermore, spiked recovery experiments conducted in authentic water samples (tap water, lake water, serum and bean sprout) yielded recoveries ranging from 94.04% to 103.8% and the relative standard deviations (RSDs) are less than 5%, affirming the method’s suitability for the reliable analysis of FLX in complex matrices. This approach offers a robust sensing platform for environmental antibiotic monitoring.
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Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·124778
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IF 7.5
Nanke Ma,Huiling Peng,Anqi Wei,Yuan Jin,Guangli Li
The extensive use of ciprofloxacin (CIP) has raised growing concerns regarding environmental pollution, food safety, and public health, thereby driving an urgent demand for rapid, sensitive and cost-effective detection methods. Herein, an electrochemical sensing platform is constructed by integrating MIL-101(Fe) with MWCNTs-COOH, which synergistically couples the effective analyte preconcentration and catalytic Fe–O active sites of MIL-101(Fe) with the exceptional conductivity and large surface area of MWCNTs-COOH. Notably, the reversible Fe 2+ /Fe 3+ redox cycle in MIL-101(Fe) facilitates rapid electron shuttling, further amplifying the electrochemical signal toward CIP oxidation. This dual-functional interface enables simultaneous preconcentration and signal amplification, yielding a broad linear response spanning 0.05–15 μM, accompanied by a high sensitivity of 5.6492 μA·μM −1 , as well as an ultralow LOD of 0.006 μM. Additionally, this sensor also demonstrates outstanding selectivity, good repeatability, excellent reproducibility, and durable stability, retaining approximately 96.1% of its initial current signal after 21 days of storage. Furthermore, to rigorously validate practical feasibility, acceptable recoveries between 92.9% and 105.3% were measured in honey, tap water, and CIP eye drops, demonstrating its versatility across food, environmental, and pharmaceutical matrices. Overall, this work establishes a design blueprint for high-performance electrochemical sensors based on MIL-series MOF/carbon composites, opening new avenues for rapid, on-site antibiotic monitoring to ensure food safety, environmental protection, and pharmaceutical quality control.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Wanning Li,Xiangjie Kong,Mengting Fu,Yike Han,Shuo Xie,Penghui Li,Liyun Kong
An in situ DES-LLME/HPLC-DAD method was developed for detecting trace quinolones in wastewater. • Quinolones were used as hydrogen bond acceptors for in situ DES formation. • The method showed good linearity with low LODs of 0.094–0.905 μg/L and satisfactory recoveries. • The method was applied to real samples, confirming its potential for antibiotic monitoring. Background Quinolone antibiotics are widely used in human and veterinary medicine due to their broad-spectrum antibacterial activity and cost-effectiveness. However, their environmental persistence and frequent occurrence in aquatic systems have raised concerns regarding potential ecological risks. Accurate risk assessment requires sensitive analytical methods capable of detecting trace levels of quinolones in complex environmental matrices. Traditional preconcentration techniques like solid-phase extraction and liquid-liquid extraction face several limitations including high-cost sorbents, sorbent degradation, memory effects, labor-intensive procedures, large solvent consumption, and the use of toxic organic solvents. Results To address these challenges, we developed a sensitive method for the determination of trace quinolones in water samples by integrating in-situ deep eutectic solvent-based liquid-liquid microextraction with high performance liquid chromatography coupled with a diode array detector. A key innovation of this approach lies in the utilization of the target quinolones as hydrogen bond acceptors during in situ DES formation, enabling direct extraction from aqueous media. Through theoretical screening using the conductor-like screening model for real solvents (COSMO-RS) and subsequent experimental verification, butyl 4-hydroxybenzoate was identified as the optimal hydrogen bond donor. Under the optimized extraction conditions, enrichment factors ranged from 33.43 to 66.50, with corresponding extraction recoveries of 33.43–66.50%. The method demonstrated satisfactory sensitivity, with limits of detection ranging from 0.094 to 0.905 μg/L, good linearity with determination coefficients exceeding 0.99, high accuracy with recoveries of 82.25%–122.08%, and acceptable precision with relative standard deviations below 13.76%. Application to real wastewater samples successfully detected enrofloxacin (20–39 μg/L) and moxifloxacin (20 μg/L), confirming the practical feasibility of the proposed method. Significance This in situ deep eutectic solvent-based liquid-liquid microextraction method offers a rapid, sensitive and efficient approach for monitoring quinolone antibiotics in aquatic environments. Its innovative design not only enables effective determination of quinolones but also holds considerable promise for developing novel in-situ DES enrichment strategies aimed at detecting other emerging environmental pollutants in complex matrices, thereby offering substantial potential for environmental monitoring and risk assessment. Download: Download high-res image (133KB) Download: Download full-size image
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FOOD CHEMISTRY
·
2025
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IF 9.8
Guangxin Yang,Jingru Zhang,Junyu Zhang,Peng Wang,Wei Xia,Jun Wang,Xiaosheng Shen,Cong Kong
Antibiotic use in aquaculture leads residues in aquatic products, contributing to antimicrobial resistance and potential human toxicity. Complex sample matrices hinder detection. This study uses wolfberry biomass waste-derived biochar as a novel solid-phase extraction (SPE) sorbent to detect 26 antibiotic residues (14 fluoroquinolones, 12 sulfonamides) in aquatic products, effectively repurposing agricultural waste into a high-performance, eco-friendly material. The mesoporous structure of the biochar enables rapid diffusion of antibiotics into its interior, facilitating highly efficient adsorption. Adsorption kinetics follow a pseudo-first-order model, reaching equilibrium in 60 min. The superior adsorption performance enables the prepared biochar to serve as an SPE sorbent for drug residue analysis with stable performance over at least three reuse cycles. The SPE was used for real samples analysis based on HPLC-HRMS, and the detection limits was 1–4.5 μg·kg −1 , recoveries was 75–119 %. Validation against the national standard GB 31658.17–2021 confirms method practicality and reliability.
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PubMed
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2025
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IF 4.6
Nanke Ma,Anqi Wei,Yajie Wang,Yafeng Zhang,Yuan Jin,Guangli Li,Xuliang He
The abuse and misuse of fleroxacin (FLE) has led to its concerning accumulation in food and environment, posing potential health risks that demand a rapid, reliable, and sensitive determination method for FLE in complex matrices. Herein, a novel electrochemical sensing platform based on α-zirconium phosphate/reduced graphene oxide (α-ZrP/rGO) nanocomposites was firstly established for sensitive detection of trace FLE residues in tap water and honey. The synergistic interaction between α-ZrP and rGO significantly enhanced the system's electrochemical performance through both enlarged electroactive surface area and accelerated electron transfer kinetics. As a result, the optimized ZrP/rGO modified glassy carbon electrode (GCE) exhibited excellent sensing performance for FLE, with a wide linear response range (0.1 – 10 μM) and a low limit of detection (0.02 μM). In addition, the α-ZrP/rGO/GCE demonstrated high selectivity against potential interferents, and showed good reproducibility and stability (92.12 % response retention after 15 days). Finally, practical applications in real samples yielded satisfactory recoveries of 98.1 % − 103.4 % in tap water and 98.8 % − 104.3 % in honey. These results highlight the potential of α-ZrP/GO nanocomposite as an efficient, reliable platform for real-time, on-site detection of FLE residues in food and environmental matrices.
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FOOD CHEMISTRY
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2023
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IF 8.8
Changxing Wang,Feifei Qin,Siyuan Tang,Xiameng Li,Tingting Li,Guoqiang Guo,Chenjie Gu,Xu Wang,Da Chen
The design of intelligent and real-time sensing devices is significant in the medical drug monitoring field, but it is still highly challenging. Here, ratiometric fluorescent detections of ofloxacin (OFL) and its L-isomer levofloxacin (LEV) constructed from tri-doped graphene quantum dots (T-GQDs) are reported, and the detection limits reach as low as 46/67 nM toward OFL/LEV due to the intermolecular electron transfer (intermolecular ET) effect. After adding OFL/LEV, the generation of electrostatic bond provides a channel for the intermolecular ET from the edge of T-GQDs to OFL/LEV, resulting in the fluorescence quenching at 414 nm and the fluorescence promoting at 498 nm. Furthermore, a smartphone can be used for the visual and quantitative detection of OFL and LEV by identifying the RGB values of test paper and drink samples. This work not only reveals the physics mechanism of ratiometric detection, but also develops a convenient smartphone diagnostic for OFL and LEV .
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PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 40
·19153-19160
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IF 3.925
Zhenyu Lu,Gongke Li,Yufei Hu
A Tb3+ functionalized triazine-porous organic framework (Tb3+/TAPOF) was prepared by introducing Tb3+ into a triazine-porous organic framework through a coordination bond. Combining the advantages of both Tb3+ and TAPOF, Tb3+/TAPOF showed good thermal stability, a high specific surface area, and excellent fluorescence performance. As the concentration of ciprofloxacin became higher, the intensity of the peak at 544 nm increased, while that of the peak at 440 nm did not change. Thus, a ratiometric fluorescent sensor based on Tb3+/TAPOF for selective ciprofloxacin determination was constructed, and the mechanism of ciprofloxacin determination was studied using the UV-vis and phosphorescence spectra and fluorescence lifetime. A good linear relationship, under the optimized conditions, was obtained between the I544/I440 value and the ciprofloxacin concentration in the range of 0.06 μmol L−1 to 5.0 μmol L−1, and the limit of detection (LOD, S/N = 3) was 19 nmol L−1. Moreover, the ratiometric fluorescent sensor based on Tb3+/TAPOF was applied to the determination of ciprofloxacin in aquatic products with recoveries in the range of 96.1–108.6%. These results obtained by the ratiometric fluorescence method and the high-performance liquid chromatography (HPLC) method are consistent for determination of aquatic products, which further proves that this method based on Tb3+/TAPOF is accurate. Generally, these results demonstrate that the Tb3+/TAPOF based ratiometric fluorescent sensor has an extensive application prospect in ciprofloxacin determination in the aquatic product industry.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2022
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IF 24.319
Boqiang Gao,Yu Pan,Hu Yang
A constructed MoS 2 /Bi 2 S 3 /BiVO 4 ternary photocatalyst(MBB) mainly with a S-scheme heterostructure was loaded on a 3D lignosulfonate modified poly(vinyl formal) sponge to obtain a novel composite sponge(PLS-MBB) with an enhanced performance in synergistic adsorption and photo-Fenton degradation of various fluoroquinolones(FQs) in water. The synergistic adsorption and photocatalysis of PLS-MBB notably improved the applicable pH from 2.0 to 9.0 and reduced the dosage of Fe 2+ to 0.014 mmol/L in Fenton reaction , which could achieve the degradation efficiency of 92.8 % for FQs within 60.0 min at pH 6.0. The photo-generated electrons by MBB and the redox transformation of Mo(IV)/Mo(VI) and Bi(III)/Bi(V) accelerated the conversion of Fe 3+ to Fe 2+ ; besides, the efficient adsorption of FQs on the sponge carrier promoted the surface degradation in solution, thereby causing an enhanced photo-Fenton reaction. This work provided a novel strategy to improve photo-Fenton reaction and accordingly fabricated a talented material for effective removal of organic contaminants in water.
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CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Boqiang Gao,Koukou Tao,Zhonghua Xi,Mayyada M.H. El-Sayed,Tamer Shoeib,Hu Yang
In this work, a 3D lignosulfonate composited poly(vinyl formal) (PVF) sponge impregnated by BiVO 4 /polyaniline (PANI)/Ag ternary photocatalyst (PLS-BiVO 4 /PANI/Ag) was designed and fabricated. The synergistic adsorption-photodegradation of five fluoroquinolones (FQs) antibiotics onto PLS-BiVO 4 /PANI/Ag was investigated. Incorporating lignosulfonate as a carrier on PVF sponge improved its structural properties and enhanced its adsorption performance toward FQs. The BiVO 4 /PANI/Ag ternary photocatalyst was well-dispersed and tightly bound to the composited sponge, thus it efficiently degraded the adsorbed FQs through surface photodegradation. PLS-BiVO 4 /PANI/Ag achieved >90% removal efficiency for all examined FQs within 2.0 h in a batch system, while it maintained a steady 80% removal efficiency for 30.0 h in a continuous dynamic treatment system. Photoelectric characterizations and ESR results showed that BiVO 4 /PANI/Ag was consistent with the type II heterostructure and effectively improved the utilization of visible light and the separation of photogenerated electron-hole pairs. The hole was the dominant active species in the degradation of FQs, while the main degradation pathways included defluorination, decarboxylation and destruction of piperazine ring. The prepared composited sponge is thus characterized by its high performance, convenient operation, eco-friendliness, and practicality in real water treatment systems since it undergoes self-purification and is easily recovered from water without mass loss.
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FOOD CHEMISTRY
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2022
·
IF 9.231
Jin'ai Chen,Yuting Jin,Taotao Ren,Shuo Wang,Xianghong Wang,Fuyuan Zhang,Yiwei Tang
Fluoroquinolones, a family of synthetic broad-spectrum antibiotics, are widely used in clinical medicine, farm animals and aquaculture. Residues of fluoroquinolones in samples have attracted much attention because of growing food safety and public health concerns. Here, a novel Tb 3+ ion-enrofloxacin aptamer coordination probe was prepared to develop a sensitive and rapid label-free fluorescence assay for specific detection three fluoroquinolones. In presence of the target, Tb 3+ ion- enrofloxacin aptamer probe specifically bound with enrofloxacin, norfloxacin and ciprofloxacin , leading to a sharp increase in fluorescence emission of the probe. Under the optimized conditions, fluorescence increased linearly in the 1.0–100.0 ng/mL range for the three fluoroquinolones, with 0.053 ng/mL limit of detection for ciprofloxacin, 0.020 ng/mL limit of detection for norfloxacin and 0.061 ng/mL limit of detection for enrofloxacin. Satisfactory recovery (80.10–102.48%) in spiked honey and water samples were obtained for the three fluoroquinolones with relative standard deviations between 0.21% and 5.44% (n = 3).
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DYES AND PIGMENTS
·
2023
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IF 4.5
Qi Pu,Lu Zhang,Nengsheng Ye,Yuhong Xiang
The residues of norfloxacin in milk and other foods cause serious harm to human health. Compared with the other ratiometric fluorescence sensors formed by lanthanide hybridized carbon quantum dots , the synthesized carbon quantum dot of this sensor used citric acid as the carbon precursor. It could act as an internal standard signal (λ em = 460 nm) and form ratiometric fluorescence with a Tb 3+ characteristic emission peak (λ em = 545 nm). More importantly, this carbon quantum dot could sensitize Tb 3+ to promote the f-f transition of Tb 3+ and enhance its characteristic fluorescence. In addition, the antenna effect between norfloxacin and Tb 3+ could further enhance the fluorescence signal at 545 nm. Under the optimal detection conditions, the limit of detection was down to 3.20 nM, and the recovery rate in milk was 94.60–97.00 %. The sensor platform showed a rapid and sensitive response to norfloxacin, providing a simple and effective strategy for the detection of antibiotics in food.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Guangli Li,Xuan Wan,Yonghui Xia,Du Tuo,Xiaoman Qi,Tianyu Wang,Mohammad Mehmandoust,Nevin Erk,Quanguo He,Qing Li
The excessive use of levofloxacin (LEV) can lead to significant environmental pollution, while also damaging human health. The accurate detection of its concentration is therefore essential to protect both the environment and human health. Herein, we report the simple synthesis of α-zirconium phosphate supported on nitrogen-doped graphene nanosheets (α-ZrP/NG) and its application in the voltammetric determination of trace LEV in real samples. The surface morphology, microstructure, and electrochemical properties of α-ZrP/NG were investigated by microscopic and spectroscopic techniques. The analytical parameters, including the accumulation potential, accumulation time, loading volume, and buffer pH, were optimized to improve the electrocatalytic sensing performance of α-ZrP/NG. Owing to the synergetic interaction between α-ZrP and NG, the proposed sensor exhibited an excellent electrocatalytic activity for the electrical oxidation of LEV. In the range of 0.01–5.0 μM, the anodic peak current of LEV increased linearly with an increase in the LEV concentration, and the limit of detection was 2.6 nmol L–1. Finally, the LEV levels in wastewater, human serum, milk, and eye drop samples were determined by using the α-ZrP/NG system combined with a glassy carbon electrode to give satisfactory recoveries (98.48–103.2%), indicating that the prepared sensor demonstrates promise for use in environmental, food, and drug monitoring applications.
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