JOM
·
2026
·
IF 2.3
Deng Chuheng,Qin Yufeng,Shen Yi,Rao Longshi,Wang Shuangxi
Metallized ceramic substrates are essential for power electronics, offering superior thermal and electrical conductivity. However, traditional metallization techniques, such as thick printed copper (TPC), face significant challenges, including weak bonding strength, high sintering temperatures, and complications associated with glass frit, which ultimately compromise device reliability and performance. To address these issues, this study presents an efficient method for fabricating high-performance copper (Cu) films on Al 2 O 3 ceramic substrates using low-temperature, pressureless sintering. By incorporating a magnetron-sputtered copper interlayer combined with printed copper paste, we eliminate the need for glass frit, a conventional component that often introduces defects. Through careful optimization of copper powder synthesis and paste formulation, we achieved dense, low-porosity Cu films sintered at just 300°C, which demonstrate exceptional electrical conductivity (1.7 × 10 7 S m −1 ) and shear strength (31.5 MPa). The sputtered copper interlayer significantly enhances the adhesion between the copper film and the ceramic substrate, minimizing delamination and improving mechanical integrity when compared to traditional sintering methods. This approach addresses key challenges in power device packaging, providing a cost-effective, reliable solution for low-temperature, high-performance interconnections. The results have wide-reaching implications for advancing electronic packaging, especially in power electronics, by enabling durable, efficient, and scalable manufacturing processes.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2025
·
IF 6.2
Chun Zhang,Kunhong Zhao,Zilin Wu,Na Tao,Weijia Yang,Zhaojia Li,Moxian Chen,Xiangyang Li
Bacterial canker caused by Pseudomonas syringae pv. actinidiae (Psa) severely impacts global kiwifruit production. This study shows that 5-fluoroindole exerts significant bactericidal activity against Psa, with a half-maximal effective concentration (EC50) of 15.34 μg/mL, demonstrating a higher efficacy than the positive control copper hydroxide (EC50 = 58.65 μg/mL). 5-Fluoroindole disrupts membrane integrity, induces oxygen species (ROS) accumulation, and triggers apoptosis in Psa. Transcriptome analysis reveals that 5-fluoroindole treatment increased the expression of the methionine synthase II (MetE) gene by 6.28 fold compared with the expression of this gene in the control (CK) group. Microscale thermophoresis and isothermal titration calorimetry show that the dissociation constants of the binding of 5-fluoroindole to MetE protein are 0.33 and 8.55 μM, respectively. Molecular docking experiments indicate that Asp693 is a key binding site and that there is no specific binding between 5-fluoroindole and the Psa MetED693A mutant. This study provides valuable insights for developing effective agents to control kiwifruit bacterial canker.
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ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Juan Huang,Mingjing Yang,Xingyu Zhou,Jigang Luo,Xiaoxia Yan,Guanghui Lin,Shijie Li,Shihui Liu,Zhuoyue Song,Chunzhi Tang,Nenggui Xu,Tao Liu,Jian Liang
Drug repurposing has received increasing attention in the field of oncology drug development as an alternative strategy to de novo drug synthesis. Disulfiram (DSF) has a long history of clinical application in alcohol withdrawal, and recent studies have revealed that its metabolite diethyldithiocarbamate (DDTC) can be coordinated with copper ions in vivo to form Cu-DDTC complexes with anticancer activity. However, the insufficient in vivo stability of DSF remains a challenge. In this study, the nanomedicine Cu-BTC@DDTC with DDTC-Cu(I) chemical valence and polycrystalline structure was prepared by incorporation of DDTC into the nanosized metal–organic framework (MOF) Cu-BTC. The in vitro cellular evaluation results showed that Cu-BTC@DDTC exhibited high inhibition of tumor cell growth, migration, and invasion. Animal experiments on the xenograft tumor model further demonstrated the excellent antitumor activity and biosafety of Cu-BTC@DDTC, and the antitumor activity was found to be closely related to the regulation of the SLC7A11/GPX4 signaling pathway to induce ferroptosis. This study provides a feasible option for antitumor drug development based on a drug repurposing strategy.
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2023
·
IF 5.8
Chan Li,Sheng Zhou,Chuncheng Chen,Lijun Zhu,Shijie Li,Zhuoyue Song,Jian Liang,Chunzhi Tang,Nenggui Xu,Tao Liu,Shihui Liu
Disulfiram (DSF), a drug for alcohol withdrawal , has attracted extensive scientific attention due to its potential to treat cancer. The metabolite of DSF, diethyl dithiocarbamate (DDTC), forms a Cu-DDTC complex in vivo with copper ions , which has been shown to be a proteasome inhibitor with high antitumor activity . However, the in vivo stability of Cu-DDTC complexes remains a challenge. In this study, the nanomedicine [email protected] with high antitumor activity was prepared by using the nanoscale metal-organic framework (MOF) Cu-BTC as a carrier and loading diethyldithiocarbamate (DDTC) through coordination interaction. The results showed that [email protected] had high drug loading and adequate stability, and exhibited DDTC-Cu(I) chemical valence characteristics and polycrystalline structure features. In vitro cytocompatibility investigation and animal xenograft tumor model evaluation demonstrated the anti-cancer potential of [email protected] , especially the combination of [email protected] with low-dose cisplatin showed significant antitumor effect and biosafety. This study provides a feasible protocol for developing antitumor drugs based on the drug repurposing strategy.
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Arabian Journal of Chemistry
·
2022
·
IF 6.212
Lusheng Shi,Pengquan Yan,Zhihua Gao,Wei Huang
Due to the complexity of the structure–activity relationship of the CuAl 2 O 4 spinel catalyst, optimization of the catalyst structure is a great challenge. In this paper, three different CuAl 2 O 4 spinel catalysts were prepared by the solid-phase method using copper hydroxide, copper nitrate, and copper oxide as the copper source, respectively, to study the difference in the structure of CuAl 2 O 4 spinel catalysts induced by the raw materials and the catalytic behavior for CO hydrogenation. The structure of CuAl 2 O 4 spinel catalyst was characterized by XRD, BET, SEM, TEM, H 2 -TPR and XPS. The activity of CO hydrogenation over the CuAl 2 O 4 spinel catalyst without pre-reduction was evaluated in the slurry reactor. The results demonstrated that different copper sources had obvious influence on the CuAl 2 O 4 spinel texture properties, surface enrichment degree, as well as decomposition and reduction ability, which further regulated the ratio of Cu + /Cu 0 and thus affected the catalytic performance, especially the alcohol distribution. The CuAl 2 O 4 spinel, employing copper hydroxide as the copper source, showed better selectivity of C 2+ OH, which was assigned to a higher ratio of Cu + /Cu 0 , along with larger pore size and pore volume. Moreover, the synergistic effect between Cu 0 and γ-Al 2 O 3 improved the selectivity of dimethyl ether.
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Chemical Biology & Drug Design
·
2023
·
IF 3
Jie Li,Xiuheng Liu
This work is performed to investigate the effect of coptisine (COP) on the malignant biological behaviors of bladder carcinoma cells and its underlying mechanism. Bladder carcinoma cell lines were treated with different concentrations of COP in vitro. Cell counting kit-8 (CCK-8), scratch healing assay, Transwell assay, and flow cytometry were used to detect cell growth, migration, invasion, and cell cycle progression. Bioinformatics analysis was performed to predict the molecular targets of COP. Quantitative real-time PCR and western blot were adopted to determine the expression levels of exportin 1 (XPO1) mRNA and protein, respectively. Gene set enrichment analysis was applied to predict the signaling pathways related to XPO1. This study showed that COP treatment markedly suppressed the malignant biological behaviors of bladder carcinoma cells. XPO1 was identified as a downstream molecular target of COP in bladder carcinoma, and COP treatment inhibited the expression of XPO1 in bladder carcinoma cell lines. Overexpression of XPO1 reversed the impacts of COP on the malignant biological behaviors of bladder carcinoma cells. COP treatment modulated the expression level of cyclin D1 and CYP450 via XPO1. In summary, COP represses the malignant biological behaviors of bladder carcinoma cells and regulates XPO1 expression, which is promising to be a complementary drug for bladder carcinoma treatment.
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Micromachines
·
2023
·Vol. 14
·期 7
·1318
·
IF 3.4
Gang Li,Xuecheng Yu,Ruoyu Zhang,Qionglin Ouyang,Rong Sun,Liqiang Cao,Pengli Zhu
Copper-based nanoinks are emerging as promising low-cost alternatives to widely used silver nanoinks in electronic printing. However, the spontaneous oxidation of copper under ambient conditions poses significant challenges to its broader application. To address this issue, this paper presents an economical, large-scale, and environmentally friendly method for fabricating Cu@Ag nanoparticles (Cu@Ag NPs). The as-prepared nanoparticles exhibit a narrow size distribution of approximately 100 nm and can withstand ambient exposure for at least 60 days without significant oxidation. The Cu@Ag-based ink, with a 60 wt% loading, was screen-printed onto a flexible polyimide substrate and subsequently heat-treated at 290 °C for 15 minutes under a nitrogen atmosphere. The sintered pattern displayed a low electrical resistivity of 25.5 μΩ·cm (approximately 15 times the resistivity of bulk copper) along with excellent reliability and mechanical fatigue strength. The innovative Cu@Ag NPs fabrication method holds considerable potential for advancing large-scale applications of copper-based inks in flexible electronics.Keywords:core–shell nanoparticles;antioxidation;conductive ink;printing electronics
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APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Wanwan Li,Jiao Liu,Chao Chen,Yidong Zhu,Nan Liu,Yuman Zhou,Siru Chen
It is urgent to develop highly active catalysts toward hydrogen peroxide (H 2 O 2 ) sensor in many industrial and biological processes, which usually is limited by high cost of instrumentation requirements and low-accuracy detection at low level. Herein, Cu 2 O@Cu 9 S 5 yolk-shell nanospheres has been synthesized via a facial wet chemical method and applied as electrocatalyst for non-enzymatic H 2 O 2 sensor. These Cu 2 O@Cu 9 S 5 yolk-shell nanospheres with mean sizes of 230 nm consisting of Cu 2 O conductive core and Cu 9 S 5 shell show numerous advantageous characteristics of well-sustained structural integrity, the homogeneous particle size distribution and visible mesoporosity morphology. The significantly improved electrocatalytic activity by catalyzing H 2 O 2 of the Cu 2 O@Cu 9 S 5 yolk-shell nanospheres as a sensor has been obtained by comparing with those neat Cu 2 O nanospheres and Cu 9 S 5 hollow nanospheres. This noticeable property is largely due to the synergistic catalysis effect of the contribution of the Cu 2 O and Cu 9 S 5 . Cu 2 O@Cu 9 S 5 yolk-shell nanospheres based non-enzymatic H 2 O 2 sensor displays the relatively wide linear range from 0.1 μM to 3.5 mM with a high sensitivity of 299.74 μA mM −1 cm −2 but low detection limit of 28.83 nM (S/N ≥ 3) for electrochemical detection of H 2 O 2 , which is potentially superior to other similar Cu 2 O-based sensors that has been reported in the literatures. Additionally, this sensor also demonstrates excellent selectivity of H 2 O 2 in the presence of various coactive interferences. This novel Cu 2 O@Cu 9 S 5 yolk-shell nanospheres electrocatalyst provides a broad application prospect for H 2 O 2 sensing.
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Journal of Experimental Nanoscience
·
2021
·
IF 3.075
Ying Zhang,Yangmei Li,Qiang Tan,Song Hong,Zhenyu Sun
Electrochemical CO2 reduction (ECR) powered by renewable electricity is reckoned to provide an effective strategy to alleviate environmental issues and energy crisis, enabling a potential carbon neutral economy. To boost the ECR to fuels and value-added chemicals, the design of highly active and selective catalysts is important. In this study, we demonstrate facile ultrasonication-facilitated synthesis of two-dimensional copper terephthalate for efficient ECR. High faradaic efficiencies (FEs) of up to 72.9% for hydrocarbons are achieved at a mild overpotential in an H-type cell. In particular, the FE for ethylene (C2H4) formation approaches 50.0% at an applied potential of −1.1 V (vs. the reversible hydrogen electrode), outperforming commercial Cu, Cu2O, CuO, Cu(OH)2 and many recently reported Cu-based materials. The C2H4 partial geometric current density is as high as ∼6.0 mA·cm−2. This work offers a simple avenue to developing advanced electrocatalysts for converting CO2 into high-value hydrocarbons.
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JOURNAL OF SOLID STATE CHEMISTRY
·
2021
·
IF 3.498
Lei Chen,Huan Wang,Xiaohong Cao,Yue Feng,Zhibing Zhang,Youqun Wang,Yunhai Liu
A simple hydrothermal method was adopted to synthesize different inorganic-organic hybrid materials (Zr -x ), including zirconium ethylenediamine tetramethylene phosphine (Zr-EDTMP), 2-phosphobutane-1,2,4-zirconium tricarboxylate (Zr-PBTC), odium creatine phosphate zirconium phosphate (Zr-CP), and creatinol zirconium phosphate (Zr–COP). Various characterizations were utilized to explore the physical and chemical properties of materials. The applications of Zr -x in removing U(Ⅵ) were studied comprehensively. The effects of solution's pH value, contact time, initial concentration of U(Ⅵ), and temperature on adsorption were examined. Besides, the desorption, reusability, as well as adsorptive selectivity were investigated. The present study revealed that the U(Ⅵ) adsorption on Zr-EDTMP was in accordance with Sips isothermal model with the greatest adsorption capacity (317.4 mg/g) and the superior adsorptive selectivity for U(Ⅵ). Zr-EDTMP is a potentially high-efficient adsorbent for extracting U(Ⅵ) from radioactive wastewater .
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ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Yu Zhang,Pengli Zhu,Gang Li,Zhen Cui,Chengqiang Cui,Kai Zhang,Jian Gao,Xin Chen,Guoqi Zhang,Rong Sun,Chingping Wong
Elliptic Cu–Ag nanoflakes were syntheszied via facile in situ galvanic replacement between prepared Cu particles and Ag ions. Alloy nanoflakes with high purity and uniformity present a size of 700 × 500 nm, with a thinness of 30 nm. Nontoxic and low-cost polyvinyl pyrrolidone was used as a dispersant and structure-directing agent, promoting the formation of the remarkable structure. Synthesized nanoflakes were utilized as a filler for conductive paste in an epoxy resin matrix. Conductive patterns on flexible substrates with a resistivity of 3.75 × 10–5 Ω·cm could be achieved after curing at 150 °C for 2 h. Compared with traditional silver microflakes, smart alloy nanoflakes provide much improved conductive interconnection, whose advantage could be attributed to their nanoscale thicknesses. It is also noteworthy that the conductive patterns are able to tolerate multiple bendings at different angles, having good conductivity even after 200 repeated bendings. Therefore, alloy nanoflakes could be a promising candidate conductive filler for flexible printing electronics, electronic packaging, and other conductive applications.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 30
·期 21
·19598-19608
·
IF 2.195
Li Pengfei,Zhang Hong,Gao Caiyun,Jiang Guoxiang,Li Zhicheng
N egative temperature coefficient (NTC) ceramics based on simple ZnO were prepared and investigated in present work, where slight amount of Al- and La- ions were added as semiconductor dopants, and Cu-ions were selected as the sintering agent and property modificator. All the prepared ZnO-based ceramics have a wurtzite structure and show typical NTC characteristic. For various contents of Al-, La- and Cu- ions in ZnO-based ceramics, ρ 25 can be adjusted from 0.65 kΩ cm to 3.28 MΩ cm, and B values were obtained in range of 2500 K to 5850 K. The ageing treatment at 125 °C for 600 h in air revealed that the ZnO-based ceramics have high thermal stability with the resistance shift < 2%. The complex impedance spectra were applied to analyze the electrical performance.
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