JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Danni Wu,Haonan Wu,Yan Lyu,Huiying Zhang,Jiade Wang,Xiang Li,Xiaobing Pang
Atmospheric particulate matter (PM) poses adverse effects on human via producing reactive oxygen species (ROS). Oxidative potential (OP, ability to generate ROS) can be induced by various chemicals in PM, while their interplay remains poorly characterized. Here, we systematically assessed influences of Cu 2+ on OP of Brown carbon (BrC) (e.g., imidazoles) using dithiothreitol (DTT) assay. Results showed DTT consumption rate exhibited an initial rise and later decline (0.25 −0.56 µM/min) along with increase of BrC concentration (0.1 − 2 µM), while no general trend was observed for • OH formation. Although Cu 2+ showed either antagonism or synergism with BrC against DTT consumption, Cu 2+ displayed antagonism with most BrC against • OH generation. Fluorescence quenching experiments provided evidence of complexation between Cu 2+ and water-soluble organic compounds (WSOCs, from ambient PM 2.5 ), which was influenced by Cu 2+ concentration. Further parallel factor analysis of spectra showed that polycarboxylate-type humic acid-like substances (complexation site number ( n ): 0.46, complexation equilibrium constant ( k ): 0.51) and fulvic acid-like compounds ( n : 0.42, k : 0.62) were the main components in WSOCs that complexed with Cu 2+ . Our results suggest the interactions of BrC and copper play a crucial role in PM OP and highlight complexation in evaluation of PM OP.
研究领域:
环境科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2015
·
IF 3.391
Lu Zhang,Zong-cai Tu,Hui Wang,Zhi-feng Fu,Qing-hui Wen,Dan Fan
This study aimed to evaluate the antioxidant potential of Artemisia selengensis Turcz (AST) leaves, a byproduct when processing AST stalk, and identify the antioxidant constituents by using HPLC-QTOF-MS 2 . The total phenolics content (TPC), total flavonoids content (TFC) and antioxidant abilities of fractions resulted from the successively partition of chloroform, ethyl acetate and n -butanol were compared. Ethyl acetate fraction (EAF) exhibited the highest TFC (65.44 mg QuE/g fraction), n -butanol fraction ( n BuF) showed the highest TPC (384.78 mg GAE/g fraction) and the best DPPH scavenging ability, ABTS + scavenging ability and reducing power. Totally, 57 compounds were identified or tentatively identified in n BuF and EAF, 40 of them were reported in AST for the first time. The major constituents in EAF were flavonoids, and the major constituents in n BuF were phenolic acids and organic acids. Thus, AST leaves might be a potential low-cost resource of natural antioxidants .
研究领域:
植物化学
·
药用植物学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2019
·
IF 7.149
Haotian Jiang,Yongchun Liu,Yun Xie,Jun Liu,Tianzeng Chen,Qingxin Ma,Hong He
Carbon nanomaterials from various sources are the important component of PM2.5 and have many adverse effects on human health. They are prone to interact with other pollutants and subsequently age, defined here as changes in chemical properties. In this work, we investigated the aging process of various carbon nanoparticle samples such as Special Black 4A, Printex U, single-walled carbon nanotubes, and hexane flame soot by ambient air and studied the evolution of their oxidation potential. We found that coatings of inorganic and organic species dominated the aging process of carbonaceous particles by ambient air. The amounts of disordered carbon and C–H functional groups of aged carbonaceous particles decreased during the aging process; meanwhile, the contents of sulfate and nitrate showed significant increases. In addition, the oxidation potential measured by the dithiothreitol assay remarkably declined as a function of aging time with ambient air evidently because of heterogeneous reactions between SO2 and NO2, as well as the coating with organic vapors. This work is important for understanding the oxidation potential changes of carbonaceous particles during atmospheric transport.
研究领域:
环境科学
·
材料科学
·
公共卫生
✓ 已验证
DOI
高影响因子
Environmental Science-Processes & Impacts
·
2022
·Vol. 24
·期 4
·525-546
·
IF 5.334
Yangyang Liu,Chak K. Chan
Elemental carbon is often found in ambient particulate matter (PM), and it contributes to the PM's oxidative potential (OP) and thus poses great health concerns. Previous review articles mainly focused on the methodologies in evaluating OP in PM and its relationship with selected chemical constituents, including metal ions, PAHs, and inorganic species. In recent years, growing attention has been paid to the effect of atmospheric aging processes on the OP of EC-containing airborne particles (ECCAPs). This review investigates more than 150 studies concerning the OP measurements and physico-chemical properties of both fresh and aged ECCAPs such as laboratory-generated elemental carbon (LGEC), carbon black (CB), soot (black carbon), and engineered carbon-containing nanomaterials (ECCBNs). Specifically, we summarize the characteristics of water-soluble and insoluble organic species, PAHs, quinone, and oxygen-containing functional groups (OFGs), and EC crystallinity. Both water-soluble organic carbon (WSOC) and water-insoluble organic carbon (WIOC) contribute to the OP. Low molecular weight (MW) PAHs show a higher correlation with OP than high MW PAHs. Furthermore, oxidative aging processes introduce OFGs, where quinone (CO) and epoxide (O–C–O) increase the OP of ECCAPs. In contrast, carboxyl (–COOH) and hydroxyl (–OH) slightly change the OP. The low crystallinity of EC favors the oxygen addition and forms active OFG quinone, thus increasing the OP. More detailed analyses for the EC microstructures and the organic coatings are needed to predict the OP of ECCAPs.
研究领域:
环境科学
·
公共卫生
✓ 已验证
DOI
PubMed
高影响因子
Eco-Environment & Health
·
2025
·
IF 17.6
Chunmei Ran,Meiqi Guo,Yuan Wang,Ye Li,Jiao Wang,Yinqing Zhang,Chunguang Liu,Bridget A. Bergquist,Chu Peng
Evaluating the plant risk of soil pollution by plant physiological indices usually requires a long cycle and has significant uncertainty. In this study, oxidative potential (OP) of the in situ heavy metal contaminated soils was measured by the dithiothreitol method. The oxidative stress response of the model plant ryegrass ( Lolium perenne L. ) induced by heavy metal contaminated soil was evaluated by the biomarkers, including superoxide dismutase and total antioxidant capacity. The comprehensive biomarker response index has a significant exponential correlation with the OP of soil ( r = 0.923, p < 0.01) in ryegrass. Metabolomics analysis also showed a significant relationship of the metabolic effect level index of amino acids and sugars with OP. Random forest was selected from four machine learning models to screen the metabolites most relevant to OP, and Shapley additive explanations analysis was used to explain the contribution and the influence direction of the features on the model. Based on the selected 20 metabolites, the metabolic pathways most related to OP in plants, including alkaloid synthesis and amino acids metabolism, were identified. Compared to the plant physiological indices, OP is a more stable and faster indicator for the plant risk assessment of heavy metals contaminated soil.
研究领域:
植物生理学
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环境毒理学
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分析化学
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生物信息学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Environmental Sciences
·
2019
·
IF 3.556
Haotian Jiang,Yun Xie,Yanli Ge,Hong He,Yongchun Liu
The dithiothreitol (DTT) assay is the most commonly used method to quantify the oxidative potential of fine particles. However, the reported DTT decay rates of carbon black (CB) materials vary greatly among different researchers. This might have resulted from either the intrinsic toxicity of CB or the unsuitability of the DTT assay protocol for CB particles. In the current study, the protocol of the DTT assay for CB materials has been carefully evaluated. It was found that the dispersion degree of CB particles in water has a great influence on the DTT decay rate of CB materials. For CB particles (special black 4A (SB4A) and Printex U) and single-walled carbon nanotube tube (SWCNT), the DTT decay rate after sonication for 10 min became 4.2, 4.6 and 1.7 times higher than that without sonication. The rate continued to grow as a function of ultrasound time up to 30 min of sonication. Although the concentration of soluble transition metals and surface oxygen-containing species such as carbonyls increased slightly with sonication, they had no significant effects on the measured DTT activity, while the increase in the dispersion degree of aggregates was found to play a vital role in the observed enhancement of the DTT decay rates for different CB materials. Based on our results, 30 min of sonication is recommended for sample dispersion when measuring the DTT decay rate of CB materials.
研究领域:
环境科学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2024
·
IF 7.6
Jiali Zhu,Shuang Wu,Hongxing Yue,Erhao Gao,Wei Wang,Jing Li,Zuliang Wu,Shuiliang Yao
Photochemistry plays a significant role in the atmospheric aging processes of soot. However, the physicochemical properties and changes in environmental and health effects of soot particles from sacrificial sources after photochemical aging remain unclear. The reaction mechanisms of soot under different irradiation wavelengths require further investigation. In this study, candle soot from sacrificial sources was subjected to photochemical aging using ultraviolet (UV) and visible light. The experimental results of oxidation potential (OP) and heterogeneous oxidation of sulfur dioxide (SO 2 ) indicated that both UV and visible light promoted the photooxidation of candle soot, leading to significant increases in oxygen-containing functional groups, environmentally persistent free radicals, and negative charges on soot surfaces. After photochemical aging, candle soot exhibited higher OP values and enhanced SO 2 oxidation and sulfate formation. UV light had a stronger photooxidation ability on candle soot than visible light. Mechanistic analysis revealed that the photochemical aging mechanisms driven by reactive oxygen species were different under these two wavelengths. Photosensitive aging induced by organic carbon under UV light was stronger than the photocatalytic oxidation induced by element carbon under visible light. Our research findings provided new insights into the photochemical aging mechanisms and health impacts of soot.
研究领域:
大气科学
·
环境健康
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
·
2024
·
IF 2.7
Iqra Saleem Naz Babari,Muhammad Islam,Hamid Saeed,Humaira Nadeem,Fariha Imtiaz,Awais Ali,Nusrat Shafiq,Abdulaziz Alamri,Rabia Zahid,Imran Ahmad
Heterocyclic compounds with oxazole and imidazole rings in their structure have disclosed momentous biological aptitudes. Taking into account their superlative attributes, the present study was designed to introduce a new synthetic scheme to make new derivatives with tremendous futuristic pharmacological potentialities. Series of Oxazolones were synthesized by using substituted benzaldehyde with benzyl halides to produce respective benzaldehyde derivatives 1 (a–d) which further reacted with hippuric acid to yield oxazolones 2 (a–e). Newly synthesized oxazolones then reacted with 4-chloroaniline to yield corresponding imidazolones 3 (a–e). All the compounds were characterized by using FTIR and NMR spectroscopic techniques. Docking studies of Compounds were conducted using AutoDock Vina and analyzed with PYMOL. All synthesized oxazolone and imidazolone derivatives exhibited antioxidant potential, demonstrated by their IC50 values compared to ascorbic acid standard. Oxazolone derivatives (2a–2e) exhibited good acetyl cholinesterase inhibitory potential whereas Imidazolone series did not show significant inhibition as shown by their IC50 values compared to donepezil as a standard. Docking studies of all compounds against acetylcholinesterase demonstrated favorable binding affinity, indicating their potential for further in-vivo studies. It is notable that novel compounds of both oxazolones and Imidazolone series exhibited antioxidant potential with maximum percentage inhibition of 75.9 (IC50 12.9 ± 0.0573 µM/mL) by compound 2d while compound 2a showed AChE inhibitory potential with maximum %age inhibition of 75.49 (IC50 7.8 ± 0.0218 µM/mL).Communicated by Ramaswamy H. Sarma
研究领域:
药物化学
·
药理学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Antioxidants
·
2021
·Vol. 10
·期 8
·1317
·
IF 6.313
Ji-Min Lv,Mostafa Gouda,Yan-Yun Zhu,Xing-Qian Ye,Jian-Chu Chen
Using ultrasound (US) in proanthocyanidin (PA) extraction has become one of the important emerging technologies. It could be the next generation for studying the US mechnophore impact on the bioactive compound’s functionality. The objective of this study was to demonstrate the potential of US treatment on PAs extracted from kiwifruit (Actinidia chinensis) leaves, and to provide a comprehensive chemical composition and bioactivity relationship of the purified kiwifruit leaves PAs (PKLPs). Several methods like single-factor experiments and response surface methodology (RSM) for the four affected factors on US extraction efficiency were constructed. HPLC-QTOF-MS/MS, cytotoxicity analysis, and antioxidant activity were also demonstrated. In the results, the modeling of PA affected factors showed that 40% US-amplitude, 30 mL/g dry weight (DW) solvent to solid ration (S/S), and 70 °C for 15 min were the optimum conditions for the extraction of PAs. Furthermore, PKLPs exhibited significant radical scavenging and cellular antioxidant activity (p< 0.05). In conclusion, this study’s novelty comes from the broad prospects of using US in PKLP green extraction that could play an important role in maximizing this phytochemical functionality in drug discovery and food science fields.Keywords:proanthocyanidins;ultrasound-assisted extraction;kiwifruit leaves;extraction optimization;HPLC-QTOF-MS/MS;antioxidant potential
研究领域:
植物化学
·
食品科学
·
药物发现
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2017
·Vol. 97
·期 14
·4760-4769
·
IF 2.463
Weisu Huang,Shuqin Mao,Liuquan Zhang,Baiyi Lu,Lufei Zheng,Fei Zhou,Yajing Zhao,Maiquan Li
BACKGROUND Phenolic compounds could be sensitive to digestive conditions, thus a simulated in vitro digestion–dialysis process and cellular assays was used to determine phenolic compounds and antioxidant and antiproliferative potentials of 10 common edible flowers from China and their functional components. RESULTS Gallic acid, ferulic acid, and rutin were widely present in these flowers, which demonstrated various antioxidant capacities (DPPH, ABTS, FRAP and CAA values) and antiproliferative potentials measured by the MTT method. Rosa rugosa , Paeonia suffruticosa and Osmanthus fragrans exhibited the best antioxidant and antiproliferative potentials against HepG2, A549 and SGC-7901 cell lines, except that Osmanthus fragrans was not the best against SGC-7901 cells. The in vitro digestion–dialysis process decreased the antioxidant potential by 33.95–90.72% and the antiproliferative potential by 13.22–87.15%. Following the in vitro digestion–dialysis process, phenolics were probably responsible for antioxidant ( R 2 = 0.794–0.924, P < 0.01) and antiproliferative ( R 2 = 0.408–0.623, P < 0.05) potential. Moreover, gallic acid may be responsible for the antioxidant potential of seven flowers rich in edible flowers. CONCLUSION The antioxidant and antiproliferative potential of 10 edible flowers revealed a clear decrease after digestion and dialysis along with the reduction of phenolics. Nevertheless, they still had considerable antioxidant and antiproliferative potential, which merited further investigation in in vivo studies. © 2017 Society of Chemical Industry
研究领域:
食品科学
·
植物化学
·
药理学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
·
2023
·
IF 8.9
Chunmei Ran,Chunguang Liu,Chu Peng,Xinxin Li,Yu Liu,Ye Li,Wenjun Zhang,Hongming Cai,Lei Wang
The ecological risk of heavy metal-contaminated soil is usually evaluated by its oxidative stress on terrestrial animals , which are vulnerable to the impact of individual differences of animals and environmental conditions. Oxidative potential (OP) is the potential of particles to induce the formation of reactive oxygen species (ROS). In this study, OP of the in situ contaminated soils collected from an industrial site (i.e., 64.5–7783 mg/kg of Cu, 54.9–397 mg/kg of Pb, 278–2085 mg/kg of Zn and 0.615–121 mg/kg of Cd) were measured as 38.0–60.1 pmol/min/mg, and the water extractable Cu, Pb, Zn, and Cd in soils have been proved to contribute 89%–98% to OP. Oxidative stress in earthworms ( Eisenia fetida ) caused by the industrial contaminated soils can be reflected by the biomarkers such as 8-hydroxy-2′-deoxyguanosine, metallothionein , and antioxidant enzymes, and a negative correlation presents between the comprehensive biomarker response index and the OP of soils ( r = −0.979, p < 0.01). This is the first time to propose a dose-response relationship between OP and oxidative stress. Metabolomic analysis also verified that the regulation of four ROS-related metabolites (i.e., l-pipecolate, 1-methylhistidine, 5-methoxytryptamine, and xanthosine) in earthworms treated with contaminated soil were directly correlated with OP values. These results indicate that OP can be used as an indicator for ecological risk assessment of heavy metal-contaminated soil, which provides a fast, stable and easily testable chemical method.
研究领域:
环境科学
·
生态毒理学
·
土壤学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Functional Foods
·
2020
·
IF 3.701
Vemana Gowd,Lianghua Xie,Chongde Sun,Wei Chen
Bayberry (BB) fruits contain high levels of polyphenols and possess good bioactivities. However, there are no specific studies to illustrate the impact of human gut microbiota fermentation (HGMF) on BB polyphenols subjected to gastrointestinal digestion (GID). Therefore, in this study, BB was subjected to simulated GID and HGMF (0–48 h) in order to study the fate of BB bioactive components. Phenolic gut metabolites were identified and quantified by relevant standards using HPLC. Cyanidin-3- O -glucoside was the only anthocyanin in BB and could be detected in its free form even after gut fermentation for 24 h. Gut metabolites of BB showed better hypoglycemic activity by improving hepatic glucose consumption and glycogen content. Furthermore, gut metabolites significantly ameliorated glucolipotoxicity induced oxidative stress. Since BB gut metabolites showed good hypoglycemic and antioxidant activities, BB can be considered as a functional food and dietary supplementation of BB could help in maintenance of good health.
研究领域:
食品科学
·
营养学
·
药理学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）