INDUSTRIAL CROPS AND PRODUCTS
·
2019
·
IF 4.191
Wenqian Luo,Zhiyun Du,Yating Zheng,Xiaoxin Liang,Guomeng Huang,Qianhua Zhang,Zexuan Liu,Kun Zhang,Xi Zheng,Li Lin,Lanyue Zhang
Essential oils isolated from the Lamiaceae species are attracting increasing interest because of their applications in natural food preservation and pharmaceutics. The aim of this study was to systematically investigate the composition and biological effects of six Lamiaceae essential oils. Approximately 106 components were identified by gas chromatography-mass spectrometry (GC–MS), and the predominant compounds were linalool (0.05–46.55%), α-pinene (0.12–45.35%), o- cymene (0.91–41.20%), patchouli alcohol (28.27%), dl -menthol (21.12%), isobornyl acetate (22.52%), d -limonene (0.01–18.42%), α-terpineol (0.07–4.88%), and β-pinene (0.08–2.03%). Most of these essential oils were found to have effective antioxidant activities (IC 50 ; 1.07–18.77%), as estimated by 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assays. The essential oils not only had antibacterial activities (6.5–12.3 mm diameter inhibition zones), but also had antifungal activities (6.5–19.0 mm diameter inhibition zones). The essential oils exhibited strong anti-inflammatory activities and markedly decreased the production of tumor necrosis factor (TNF-α), nuclear factor-kappa B (NF-κB), interleukin 6 (IL-6), and cyclooxygenase 2 (COX-2). The most abundant compounds in the essential oils isolated from the six Lamiaceae species have potential applications in the scavenging of free radicals, inhibition of bacterial and fungal growth, and relief from inflammation.
研究领域:
植物化学
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药理学
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食品科学
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DOI
高影响因子
ChemMedChem
·
2018
·Vol. 13
·期 20
·2202-2207
·
IF 3.009
Rong Zhou,Yueguang Sun,Hangbin Li,Weili Long,Xiaojian Liao,Pengju Feng,Shihai Xu
Graphical Sponging up SAR data : The marine sponge Reniochalina stalagmitis is the source of a set of cyclic peptides known as reniochalistatins. Herein we report the total synthesis of reniochalistatins A–E, along with evaluations of their anticancer and antitubercular activities. Our results pave the way for further investigations into the structure–activity relationships of this class of cyclic peptide. The total synthesis of reniochalistatins A–E, along with a reniochalistatin E analogue (inverso-E) was successfully achieved through Fmoc-based solid-phase peptide synthesis and subsequent macrolactamization with PyBOP and DIEA. The biological activities of these reniochalistatins and a key linear peptide intermediate were systematically evaluated. Among these seven synthesized compounds, linear reniochalistatin B was found to have potent activity against several cancer cell lines not shown by the cyclic reniochalistatin B counterpart. In addition, linear reniochalistatin B was found to have antitubercular activity (IC 50 =1.4 μ m ). Inverso-E possesses increasing cytotoxicity against the HeLa and LNCaP cell lines after simple alternation of the sequence of amino acids in reniochalistatin E. The results of these studies provide a feasible method to further investigate the structure–activity relationships (SARs) of reniochalistatins A–E.
研究领域:
有机化学
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药物化学
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生物化学
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DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 11
·期 21
·2201397
·
IF 11.092
Shixiong Yi,Ying Zhou,Jiamei Zhang,Min Wang,Shaohui Zheng,Xiao Yang,Lian Duan,Rui L. Reis,Fangyin Dai,Subhas C. Kundu,Bo Xiao
One of the leading causes of death globally, especially in underdeveloped countries, is bacterial infection. Recently, the prevalence of infections from antibiotic-resistant bacteria has been increasing, which makes the need for innovative antibacterial wound dressings urgent. It is reported that g-C 3 N 4 -based flat silk cocoons (FSCs) with rechargeable antibacterial activity can efficiently generate reactive oxygen species (ROS) under daylight irradiation. The photoactive FSCs store the ROS and then release them in the dark. The engineered FSCs exhibit integrated properties of good biocompatibility, strong mechanical characteristics, robust photoactivity with photostorability, and excellent bactericidal efficiency (99.9% contact killing). In a rat model of infected wounds, the photoactive FSCs induce faster healing and reduce bacterial infections. The successful application of these FSC materials as wound dressings may provide a versatile platform for exploring the use of green photoactive antibacterial materials for accelerated wound healing and prevention of infections.
研究领域:
生物材料学
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医学
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抗菌技术
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产品关联
DOI
PubMed
高影响因子
CHEMISTRY & BIODIVERSITY
·
2024
·
IF 2.3
Zhiping Che,Ruiguang Wang,Yuanhao Li,Wanying Yin,Huilu Sun,Shaobin Xu,Shaoyan Shuang,Yuee Tian,Xiaobo Huang,Genqiang Chen
Oleanolic acid is a pentacyclic triterpenoid extracted and isolated from the fruit of plants in the Ligustrum lucidum Ait. in the family Oleaceae. To discover biorational natural product-based pesticides, a series of oleanolic acid derivatives containing anhydride active skeletons were prepared by ingeniously introducing an active acyloxy group at its C-28 carboxyl position, and their structures were well characterized by 1H NMR, 13C NMR, HRMS, and m.p.. The stereochemical configuration of compound 8e was confirmed using single-crystal X-ray diffraction. Furthermore, bioactivities of these compounds as anti-oomycete and anti-fungal agents against two serious agricultural pests, Phytophthora capsici and Fusarium graminearum we assessed. Amongst evaluated compounds, 1) Compounds 8h and 8j displayed significant anti-oomycete against P. capsici, with EC50 values of 54.73 and 65.15 mg/L, respectively. 2) The target compounds have obvious selectivity, and their anti-oomycete activity is significantly better than their anti-fungal activity. 3) Interestingly, there are significant differences in the structure-activity relationship of different substituents or the same substituent at different positions anti-oomycete and anti-fungal against P. capsici and F. graminearum, respectively. The study provides an idea for further exploring the bioactivities of 28-acyloxyoleanolic acid derivatives, and develops the application of 28-acyloxyoleanolic acid derivatives containing anhydride in agriculture.
研究领域:
植物化学
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农药学
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农业科学
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产品关联
DOI
PubMed
高影响因子
POLYHEDRON
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2019
·
IF 2.284
Yi-Chun Chu,Tian-Tian Wang,Lin-Jian Wang,Qing-Yang Luo,Ru Jia,Tao-Cheng Hong,Xiao-Ming Wang,Hai-Liang Zhu
A novel Zn(II)-Naproxen complex [Zn(nap) 2 (dap)] containing 1,3-diaminopropane ligand was synthesized and characterized by FT-IR, UV–Vis, elemental analysis and 1 H NMR spectroscopy, its single crystal structure was confirmed by X-ray crystallography. The new Zn(II)-Naproxen complex was evaluated in vivo for its anti-inflammatory, ulcerogenic and analgesic activities, in vitro for antibacterial and antioxidant activities, which showed superior biological properties compared with Naproxen. The edema inhibition rate for the complex reached 57.8% after 3 h, pain inhibition value was 71%, and ulcer index was 8 ± 1. Furthermore, the antibacterial and antioxidant activities of Zn(II)-Naproxen complex were tested showing better effects than Naproxen.
研究领域:
药理学
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生物化学
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金属有机化学
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DOI
高影响因子
Journal of Essential Oil Bearing Plants
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2022
·
IF 1.971
Jialun Zhong,Nadeem Muhammad,Xiaoying Yang,Jiasheng Li
Atractylodes chinensis (DC.) Koidz., Magnolia officinalis Rehd. et Wils., Citrus reticulata Blanco, Amomum villosum Lour., Pogostemon cablin (Blanco) Benth., Mosla chinensis Maxim., Zingiber officinale Rosc., and Artemisia argyi Lévl. et Vant are eight of the extensively used herbs among Traditional Chinese Medicines (TCM) with a long history. The essential oil (EO) extracts of the eight TCMs were obtained using supercritical fluid extraction coupled with molecular distillation to investigate the chemical composition, antimicrobial, antioxidant activities, and anti-inflammatory activity for further exploration of the underlying mechanism of the various biological activities. The chemical components of the EO were analyzed by GC-MS. The antimicrobial activity was evaluated by the agar-well diffusion assay and the minimum inhibitory concentration assay. The antioxidant activity of the EO was evaluated by 1, 1-diphenyl-2-picrylhydrazyl radical and 2, 2’-azinobis (3-ethylbenzothiazoline-6-sulfonic acid ammonium salt assays. The anti-inflammatory activity of a recipe named “Shenshusan” was evaluated by the xylene-induce ear vasodilatation assay and the acetic acid-induce capillary permeability enhancement assay. Chemical constituents of the EO varied markedly among the eight species of TCMs. The EOs from Mosla chinensis and Artemisia argyi exhibited strong antimicrobial activity while the EOs from Magnolia officinalis, Mosla chinensis and Zingiber officinale exhibited strong antioxidant activity. The recipe “Shenshusan” showed significant anti-inflammatory activity (340 mg/kg for mice). This study contributes to what is known about the eight kinds of TCM possesses the potent antimicrobial, antioxidant, and anti-inflammatory activity which held great potential and can help guide future recommendations and interventions for food, medicine, and cosmetics application.
研究领域:
药理学
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植物化学
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中医药学
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2025
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IF 6.5
Yong Lian,Ning Ma,Qianying Cheng,Mingquan Luo,Zhen Xu,Fei He,Xiaomei Zhou,Ying Zhang,Dejun Jin,Yidan Kong,Yong Wang,Na Wei
Purpose Study aims to optimize the synthesis conditions for silver nanoparticle composites [ALP(D)-AgNPs] using a rapid and environmentally friendly method and investigate the antioxidant, antibacterial, and anticancer activities of the fabricated composite.Methods The polysaccharide component ALP-D was extracted and purified from the fruits of Amomum longiligulare and subsequently used for further experiments. The structure of ALP-D was characterized by FT-IR, monosaccharide composition and molecular weight.The optimal conditions for the green synthesis of silver nanoparticles using ALP-D were determined through single-factor experiments. The synthesized silver nanoparticles were characterized by UV-Vis spectroscopy, FT-IR, DLS, HRTEM and XRD. Finally, the in vitro antioxidant activity, antibacterial activity and anticancer activity of the nano-silver composite were evaluated.Results Single-factor experiments identified the optimal synthesis conditions for ALP(D)-AgNPs as a reaction time of 180 min, a temperature of 100 °C, and a 10:1 volume ratio of silver nitrate to ALP-D. The free radical scavenging activity of ALP(D)-AgNPs against DPPH and ABTS was significantly enhanced compared with that of ALP-D. The minimum inhibitory concentration (MIC) values of ALP(D)-AgNPs against E coli and B subtilis were 31.25 μg/mL, while the MIC value against S aureus was 62.5 μg/mL. The minimum bactericidal concentration (MBC) values of ALP(D)-AgNPs were 125 μg/mL for E coli, B subtilis, and S aureus. The IC50 values of ALP(D)-AgNPs on the MDA-MB-231, HepG2, Caco-2, and C6 cancer cell lines were 14.72 ± 0.23, 8.19 ± 0.65, 22.73 ± 3.01, and 15.77 ± 2.91 μg/mL, respectively.Conclusion In summary, we have identified a novel material for the green synthesis of silver nanoparticles. The results show the ALP(D)-AgNPs synthesized using the new material ALP-D exhibit excellent stability and dispersibility. Furthermore, the biological activity reveals that ALP(D)-AgNPs possess notable antioxidant, antibacterial, and cancer-suppressing activities.
研究领域:
材料科学
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生物化学
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药理学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 15
·4974
·
IF 4.927
Xingan Cheng,Huiqing He,Fangyun Dong,Chunbao Charles Xu,Hanhui Zhang,Zhanmei Liu,Xiaojing Lv,Yuehua Wu,Xuhong Jiang,Xiangjing Qin
Matrine is a traditional botanical pesticide with a broad-spectrum biological activity that is widely applied in agriculture. Halopyrazole groups are successfully introduced to the C13 of matrine to synthesize eight new derivatives with a yield of 78–87%. The insecticidal activity results show that the introduction of halopyrazole groups can significantly improve the insecticidal activity of matrine onPlutella xylostella,Mythimna separataandSpodoptera frugiperdawith a corrected mortality rate of 100%, which is 25–65% higher than matrine. The fungicidal activity results indicate that derivatives have a high inhibitory effect onCeratobasidium cornigerum,Cibberella sanbinetti,Gibberrlla zeaeandCollectot tichum gloeosporioides. Thereinto, 4-Cl-Pyr-Mat has the best result, with an inhibition rate of 23–33% higher than that of matrine. Therefore, the introduction of halogenated pyrazole groups can improve the agricultural activity of matrine.
研究领域:
植物化学
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农药科学
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有机合成
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DOI
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 2
·356
·
IF 3.098
Yanqing Gao,Jingjing Li,Jian Li,Zhanqian Song,Shibin Shang,Xiaoping Rao
Turpentine is a volatile component of resin, which is an abundant forest resource in Southern China. As one of the most important components, the integrated application of β-pinene has been studied. The broad-spectrum evaluation of β-pinene and its analogues has, therefore, been necessary. In an attempt to expand the scope of agro-activity trials, the preparation and the evaluation of the herbicidal activity of a series of β-pinene analogues against three agricultural herbs were carried out. In accordance with the overall herbicidal activity, it is noteworthy that compounds6k,6l, and6mdemonstrated extreme activity with IC50values of 0.065, 0.065, and 0.052 mol active ingredients/hectare againstE. crus-galli. The preliminary structure–activity relationship (SAR) was analyzed and the compounds with the appropriate volatility and substituent type that had beneficial herbicidal activity were analyzed. Simultaneously, the quantitative structure–activity relationship (QSAR) model was built and the most important structural features were indicated, which was, to a certain extent, in line with the SAR study. The study aimed to study the application of the forest resource turpentine in agriculture as a potential and alternative approach for comprehensive utilization.Keywords:turpentine;herbicidal activity;SAR;QSAR
研究领域:
农学
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化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Jialin Xie,Wentao Xu,Hongjian Song,Yuxiu Liu,Jingjing Zhang,Qingmin Wang
On the basis of the mechanism of acylhydrazone compounds inhibiting the assembly of TMV CP and the unique structural characteristics of diketopiperazine ring, a series of optically pure indole diketopiperazine acylhydrazone were designed and synthesized. In order to systematically study the effect of the spatial configuration of the compounds on the antiviral activity, four compounds with different spatial configurations at C6 and C12a were also prepared. The bioassay results indicated that most of these new compounds displayed moderate to good antiviral activity, among which compounds 23, 25, 27, 28, 31, and 5d showed a significantly higher activity than that of commercial ribavirin. An in-depth structure–activity relationship investigation showed that the spatial conformation was one of the most important factors in adjusting antiviral activity; the research results provided information about the possible optimum configuration for interaction of this molecular with its target protein. At the same time, these new compounds also exhibited broad-spectrum fungicidal activities against 14 kinds of phytopathogenic fungi. What’s more, some of these compounds exhibited good insecticidal activity to Plutella xylostella and Culex pipiens pallens.
研究领域:
有机化学
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植物保护
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药理学
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2021
·
IF 5.645
Hai-bo Wu,Peng-xin Guo,Lin-hui Ma,Xi-meng Li,Ting-ting Liu
The present study evaluates the nematicidal, antifungal and insecticidal effects of extracts from different organs (leaves, stems and roots) of Artemisia halodendron Turcz. ex Bess. Correlative analysis revealed that polyacetylenes were the main contributors to biological activities. Furthermore, five extraction techniques were compared and evaluated based on the yield of polyacetylenes and their activities. It was found that microwave-assisted extraction (MAE) was the best extracting approach. Additionally, two new polyacetylenes ( 1 – 2 ) and four known polyacetylenes ( 3 – 6 ) were isolated from the MAE extract. All polyacetylenes showed remarkable nematicidal effect against Meloidogyne incognita (Kofoid & White) Chitwood (50 % lethal concentration, LC 50 , 0.21–9.46 mg/L) compared with abamectin (LC 50 , 9.98 mg/L). In particular, nematicidal activity of the new compound 1 was 48-times higher than that of abamectin. Also, these polyacetylenes exhibited antifungal effects against five fungi (minimum inhibitory concentration, MIC, 4–128 mg/L). Moreover, polyacetylenes 1 – 4 showed remarkable insecticidal activity against Bradysia odoriphaga Yang & Zhang (50 % lethal dose, LD 50 , 19.31–36.51 mg/L), stronger than the azadirachtin (LD 50 , 39.30 mg/L). Together, the results gained from this study suggest that A. halodendron and the isolated polyacetylenes have great potential application in nematicide, fungicide and insecticide agent industry.
研究领域:
植物化学
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植物学
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农业科学
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产品关联
DOI
高影响因子
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2015
·Vol. 96
·期 7
·2462-2471
·
IF 1.714
Qian Li,Jun Chen,Ti Li,Chengmei Liu,Wei Liu,Jiyan Liu
BACKGROUND Choerospondias axillaris is both an edible and medicinal fruit. It has a growing popularity and economic importance due to its nutritive value and medicinal effects, but comprehensive information on the chemical composition and bioactivity of its fruits is still lacking. Therefore the aim of this study was to investigate the antioxidant, antimicrobial and antiproliferative effects and chemical composition of peel polyphenolic (PP) and flesh polyphenolic (FP) extracts from C. axillaris . RESULTS The phenolics and flavonoids of peel were significantly higher than those of flesh. Ultra-performance liquid chromatography (UPLC) and ultra-performance liquid chromatography/electrospray ionization quadrupole time-of-flight-mass spectrometry (UPLC/ESI-QTOF-MS 2 ) analysis revealed that (+)-catechin and oligomeric procyanidins were the most abundant compounds in PP and FP. Both extracts exhibited strong ferric-reducing antioxidant power, total antioxidant activity and 2,2-diphenyl-1-picrylhydrazyl radical (DPPH • )-scavenging ability. PP showed a significantly higher antimicrobial effect against tested strains than that of FP, in a dose-dependent manner. Furthermore, both extracts inhibited the growth of HepG2 and Caco-2 cells in a dose- and time-dependent manner, with IC 50 values of 39.31 and 47.49 µg mL −1 to HepG2 cells and 101.90 and 102.61 µg mL −1 to Caco-2 cells respectively. CONCLUSION This is the first detailed report on the chemical composition and bioactivities of C. axillaris fruits. © 2015 Society of Chemical Industry
研究领域:
植物化学
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药理学
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食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）