SENSORS AND ACTUATORS B-CHEMICAL
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2022
·
IF 9.221
Mingzhu Yan,Jinming Chen,Bo Wang,Bin Li,Huan Liu,Wei Xu,Huimin Cao,Yanyan Fu,Qingguo He,Jiangong Cheng
Aqueous organic amines are threatening to organisms and ecosystem balance. Although many techniques have been used for detection, the simultaneous identification of both its type and concentration is still challenging due to its structural similarity and low environmental concentration. Sensor array is a powerful sensing technology to identify analytes via unique fingerprint patterns. However, the information from general sensor array based on the weak interaction limited its discernibility ability to similar substances. Here, we propose to design molecules with various sensing units based on strong interactions and hence rich spectral change, then construct a tri-probe sensor array for efficient fluorescent differentiation of aqueous organic amine. Different fluorescence responses to different concentrations and types of organic amines were produced by this array. Varied interaction between the probes and the amines was proved by NMR spectra analysis. The combination of probes can produce rich and complementary fluorescence changes. These unique fluorescence response patterns can be well identified and processed using hierarchical analysis (HCA) and linear discriminant analysis (LDA), enabling the 99.35% accurate differentiation of 5 concentration orders (1 μM ~ 10 mM) of 6 kinds of amines. Blind detections for samples of diethylamine , diisopropylamine in tap water and propylamine , hexylamine, trimethylamine , triethylamine in other five domestic wastewater all can be classified and distinguished successfully. The influence of temperature, pH and mental ions are also considered. This sensing method, with the feature of facile preparation, fast response, and excellent discrimination accuracy, can provide a potential option for fast quality test of water.
研究领域:
分析化学
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环境科学
·
生物传感技术
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DOI
高影响因子
ANALYST
·
2018
·Vol. 143
·期 8
·1899-1905
·
IF 3.864
Wei Ji,Xue Zhang,Jianzhang Zhao,Ye Gao,Wei Song,Yukihiro Ozaki
A simple and ultrasensitive surface-enhanced Raman scattering (SERS) assay for heparin detection has been demonstrated based on an in situ hot spot assembly method using N,N′-bis[3,3′-(trimethylammonium)propylamine]-3,4,9,10-perylenediimide (bis-quaternized perylene dye, abbreviated as BQPER). In this assay, a BQPER probe with two positive charges is employed as both Raman reporter and electrostatic bridge to cause the aggregation of citrate-capped Ag nanoparticles (Ag NPs), resulting in a strong SERS signal due to the formation of numerous hot spots in the gaps of the aggregates. The SERS intensity of BQPER decreases in the presence of heparin, because BQPER binds primarily to heparin due to its high anionic charge to mass ratio compared to that of Ag NPs. Accordingly, a novel method for the detection of heparin has been developed based on SERS of the unbound BQPER probe. Two obvious advantages of the proposed heparin assay over other reported methods are: its much wider linear concentration range (10−5–10−10 g mL−1) and lower limit of detection (0.08 ng mL−1). Besides, our proposed heparin assay has been successfully applied to the detection of heparin in serum samples, indicating its great potential in the diagnosis of heparin-related diseases. This work provides a new Raman probe for the SERS analysis of heparin and opens a different perspective for SERS-based transducer design in charged analytes.
研究领域:
生物医学分析
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纳米技术
·
药物检测
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2019
·
IF 6.35
Libin Wan,Bin Lin,Ruiqin Zhu,Chuixiu Huang,Stig Pedersen-Bjergaard,Xiantao Shen
Isolation of substances by liquid-phase microextraction (LPME) or electromembrane extraction (EME) is becoming more and more important in analytical chemistry. However, the understanding of the mass transfer in LPME and EME is limited, especially for highly concentrated samples. In this work, the mass transfer in LPME and EME from aqueous samples (0.5–200 mg L–1) was studied in terms of recovery, equilibrium time, flux, and mass transfer capacity. In both EME and LPME, high recoveries were achieved at low analyte concentration, and the recoveries decreased at high analyte concentration. For EME, the loss in recovery was partly compensated by increasing the extraction voltage (from 50 to 200 V), while the LPME recovery at high analyte concentration was improved by increasing the extraction time (from 30 to 180 min). EME was superior in terms of equilibrium time and flux, while LPME provided much higher mass transfer capacity especially for highly concentrated samples. Moreover, the recovery was much more sensitive to high analyte concentrations in EME than in LPME, and the EME recovery decreased significantly above 50 mg L–1, indicating that LPME could be used to isolate analytes in a wider concentration range than EME. We believe that this fundamental study will be of great importance for the selection of a suitable membrane-based microextraction technique.
研究领域:
分析化学
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分离科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Jun Wang,Yining Pan,Liangxing Jiang,Min Liu,Fangyang Liu,Ming Jia,Jie Li,Yanqing Lai
Copper ions are not only physiologically essential for life but also hazardous materials causing a series of neurodegenerative diseases. Photoelectrochemical (PEC) detection has attracted a large amount of focus as a potential strategy to develop Cu2+ ion sensors. However, relatively low photocurrent signals with poor antidisturbance ability and the limited concentration range have prevented its practical applications. Here, we designed a WO3/CdS heterojunction photoanode for the PEC determination of Cu2+ in aqueous solution through a simple two-step chemical bath deposition method. The obtained WO3/CdS photoanode had a nanoplate morphology and showed an enhanced photoresponsivity with a photocurrent density of 1.5 mA/cm2 at 1.23 V versus RHE under illumination. Naturally, it exhibited a low detection limit (0.06 μM) and wider range (0.5 μM to 1 mM) for Cu2+ PEC detection first, suggesting that the WO3/CdS heterojunction photoanode is a promising tool to monitor copper pollution in natural environments.
研究领域:
环境科学
·
分析化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Lei Sun,Hao Guo,Zhilan Pan,Bingqing Liu,Ning Wu,Yinsheng Liu,Zongyan Lu,Xiaoqin Wei,Wu Yang
Owing to the high toxicity of acetaminophen (ACOP) and 4-aminophenol (4-AP) when they are overused, the simultaneous determination of ACOP and 4-AP is crucial. In this present paper, an electrochemical sensor based on the nanocomposite of sulfurbridged covalent triazine frameworks (S-CTFs) and in situ formed nickel cobaltite (NiCo 2 O 4 ) nanoflowers on S-CTFs, denoted as S-CTFs@NiCo 2 O 4 , was fabricated for the first time for sensitive detection of ACOP and 4-AP. S-CTFs@NiCo 2 O 4 modified electrode exhibited the outstanding synergetic effects of S-CTFs (prominent enrichment ability and large surface area) and NiCo 2 O 4 (excellent electrocatalytic activity). The developed electrode had the advantages of high reproducibility, repeatability, anti-interference and stability, and it exhibited a wide linear concentration range (2 ∼ 360 μM) and a low limit of detection (0.18 μM and 0.35 μM) for ACOP and 4-AP, respectively. In addition, the designed electrochemical sensor was evaluated towards the detecting ACOP and 4-AP in real samples with satisfactory recovery, illustrating that electrode has a broad prospect in the clinical application.
研究领域:
分析化学
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电化学
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纳米材料
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药物分析
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产品关联
DOI
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Su-Juan Li,Zhen-Zhen Qi,Zhi-Wen Luo,Shuang Miao
Solvothermal method was used to synthesize a unique nanostructure with hedgehog shaped microspheres assembled by ordered Mn 2 CuO 4 nanobelts, which was characterized by SEM, TEM and XRD. These Mn 2 CuO 4 microspheres were loaded on graphene oxide (GO) support to form Mn 2 CuO 4 /GO nanocomposites, and its application for highly efficient sensing of hydrogen peroxide (H 2 O 2 ) was demonstrated. The CV and amperometry results indicated that Mn 2 CuO 4 /GO nanocomposites exhibited superior electrocatalytic performance over Mn 2 CuO 4 for H 2 O 2 detection. The developed sensor shows a high detection sensitivity (838.9 μA mM cm -2 ), a wide linear concentration range (0.5-2352 μM), and a low limit of detection (20 nM). In addition, the Mn 2 CuO 4 /GO based H 2 O 2 sensor possesses good reproducibility, stability, selectivity and effective sample application.
研究领域:
材料科学
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纳米技术
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分析化学
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电化学
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2014
·Vol. 181
·期 11
·1361-1367
·
IF 3.719
Luo Xubiao,Wu Wenbin,Deng Fang,Chen Dezhi,Luo Shenglian,Au Chaktong
Silica-coated, thiol-enriched and zinc-doped CdS quantum dots (SiO 2 -S-Zn-CdS QDs) were fabricated by a sol–gel process and used as fluorescent probe for imaging and monitoring of intracellular Cd(II) and Zn(II) in endophytes in the “turn-on” mode. There is a linear relationship between fluorescence intensity and the concentration of Zn(II) in the 3.5 – 23.2 μM concentration range and with a detection limit of 2.0 μM. The probe also responds well to Cd(II) in the 0.3 – 26 μM concentration range and the detection limit is 0.1 μM. Due to its negligible cytotoxicity, fair sensitivity and good photostability, the quantum dot probe presented here is a promising tool for fluorescent imaging of intracellular Zn(II) or Cd(II).
The SiO 2 -S-Zn-CdS QDs “turn-on” fluorescent probe shows superior selectivity for Zn 2+ and Cd 2+
研究领域:
材料科学
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纳米技术
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分析化学
·
生物成像
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产品关联
DOI
高影响因子
Analytical Methods
·
2020
·Vol. 12
·期 15
·1988-1994
·
IF 2.596
Chaoqun Huang,Fengling Zhang,Qingshui Wang,Yao Lin,Jiyi Huang
A new enzyme-free conductometric immunoassay based on bimetallic PtPd hybrid nanostructures was developed for the sensitive determination of lipocalin-2 in renal cell carcinoma. An immunosensor was prepared by immobilizing the capture antibody on an interdigitated micro-comb electrode, whereas bimetallic PtPd hybrid nanostructures were utilized for the conjugation of the detection antibody. Initially, a sandwich immunoreaction was carried out between the capture antibody and detection antibody in the presence of lipocalin-2 on the functional interdigitated micro-comb electrode. Thereafter, the immobilized PtPd bimetallic nanostructures could be used as enzymatic mimics to catalyze the reaction of hydrogen peroxide (H2O2) in 0.01 M phosphate buffer solution (pH 7.4) containing KI, thereby resulting in the local variation in the conductivity of the modified electrode. Several labeling strategies using Pt nanoparticles, Pd nanoparticles and bimetallic PtPd hybrid nanostructures were investigated for the detection of lipocalin-2, and improved analytical features were acquired with PtPd bimetallic nanostructures. With the PtPd labeling method, the factors influencing the analytical performance of the conductometric immunoassay were studied in detail. The strong attachment of biomolecules to the interdigitated micro-comb electrode and PtPd bimetallic nanostructures enabled a good repeatability and intermediate precision down to 10.4%. The dynamic concentration range spanned from 10 pg mL−1 to 30 ng mL−1 with a low detection limit of 5.9 pg mL−1 lipocalin-2 under optimum conditions. The reliability of the conductometric immunoassay was verified for the detection of lipocalin-2 in 4 blood serum and 4 urine samples and matched well with that obtained from the commercial lipocalin-2 enzyme-linked immunosorbant assay kit.
研究领域:
生物传感器
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纳米技术
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癌症诊断
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电化学
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产品关联
DOI
高影响因子
ANALYST
·
2019
·Vol. 145
·期 2
·619-625
·
IF 4.019
Nuo Zhang,Yaoguang Wang,Guanhui Zhao,Chao Wang,Yueyuan Li,Yong Zhang,Huan Wang,Qin Wei
An ultrasensitive label-free photoelectrochemical (PEC) immunosensor was developed to detect amyloid β-protein (Aβ) based on CdS/CdTe-cosensitized SnO2 nanoflowers. Specifically, SnO2 with a flower-like porous nanostructure was utilized as a perfect substrate for the construction of PEC immunosensors, and the SnO2-modified electrode was first coated with CdTe quantum dots (QDs) and then further deposited with CdS by successive ionic layer adsorption and reaction techniques. The formed SnO2/CdS/CdTe-cosensitized structure exhibited excellent photocurrent intensity and was employed as an excellent photoactive matrix to immobilize Aβ antibody to further construct the immunosensor. Under optimal conditions, the as-constructed PEC immunosensor was used to detect Aβ and exhibited a wide linear concentration range from 0.5 pg mL−1 to 10 ng mL−1, with a low limit of detection (LOD, 0.18 pg mL−1, S/N = 3). Meanwhile, it also presented good reproducibility, specificity, and stability and may open a new promising platform for the clinical detection of Aβ or other biomarkers.
研究领域:
生物传感器
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纳米技术
·
光电化学
·
分析化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Lisi Wang,Xiaoqing Li,Yijing Ai,Xiao Han,Mansoor Ahmad,Xiaoping Zhang,Amir Badshah,Wei Sun,Hongji Li
A novel electrochemical method for sensitive detection quercetin (QU) was constructed with graphitic carbon nitride (g-C 3 N 4 ) and black phosphorene (BP) composite (g-C 3 N 4 @BP) modified carbon ionic liquid electrode (CILE) as signal amplified interface. g-C 3 N 4 @BP was synthesized by a hydrothermal method with the characteristics investigated by SEM, XPS, FT-IR, XRD and electrochemical methods. Electrochemical behaviors of QU on the modified electrode (g-C 3 N 4 @BP/CILE) was investigated with the electrochemical parameters calculated and the experimental conditions optimized. The excellent electroanalytical result of QU was realized with the linear concentration range from 5.0 nmol/L to 90.0 µmol/L and a lower detection limit of 1.7 nmol/L (3σ). It was proved that the composite exhibited the synergistic effect of BP and g-C 3 N 4 with more active sites, porous structure, large specific surface area, good electrical conductivity and strong electrocatalytic activity. The g-C 3 N 4 @BP/CILE was successfully used to detect the practical drug and food samples with satisfactory recoveries.
研究领域:
分析化学
·
材料科学
·
电化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
Analytical Methods
·
2023
·Vol. 15
·期 30
·3642-3649
·
IF 3.1
Kai Zhang,Xiaoyuan Zhang,Yanqin Rong,Qingfang Niu,Pengyue Jin,Xuewen Ma,Cheng Yang,Wenting Liang
Ractopamine (RAC) is universally known for improving lean meat percentage in livestock and thus is widely introduced as a feed additive. However, it is difficult to eliminate the RAC residue in animal tissues from the biological system and will inevitably harm human health. Hence, detecting RAC molecules in biological samples is extremely significant. Herein, a novel strategy of supramolecular recognition-enhanced electrochemical sensing is presented. This platform was constructed by coupling β-cyclodextrin (β-CD) with palladium nanoparticles (Pd NPs)-functionalized three-dimensional reduced graphene oxide (3D-rGO) to form a nanocomposite (3D-rGO/Pd/β-CD), which was further used to modify a glassy carbon electrode (GCE) for RAC detection. Benefiting from the attractive electrical conductivity and catalytic activity of 3D-rGO/Pd, as well as the unique small-molecule-recognition ability of β-CD demonstrated by 1H NMR spectrum, which revealed the 1 : 2 binding mode of RAC with β-CD, increased peak current signals of RAC were observed in the cyclic voltammetry (CV) test. Under optimized conditions, the wide linear concentration range spanned 1–95 μM, along with a relatively low detection limit of 0.12 μM (S/N = 3), as evidenced by the differential pulse voltammetry (DPV) approach. The platform also exhibited satisfactory stability and fine reproducibility, as well as high selectivity and good anti-interference capability. Moreover, this as-obtained sensor was efficiently applied in pork samples with a high recovery rate (96.44–103.99%), which provides a promising view of its electrochemical biosensing ability in practical applications.
研究领域:
分析化学
·
纳米技术
·
电化学
·
生物传感器
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产品关联
DOI
PubMed
高影响因子
ELECTROANALYSIS
·
2019
·Vol. 31
·期 7
·1390-1400
·
IF 2.691
Ying Wang,Xamxikamar Mamat,Yongtao Li,Xun Hu,Ping Wang,Yemin Dong,Guangzhi Hu
In this study, a molybdenum disulfide/multiwalled carbon nanotubes (MoS 2 @MWCNTs) nanocomposite was synthesized by employing a simple hydrothermal method. The flower-like structure of the MoS 2 @MWCNTs was characterized via scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and the load of crystalline MoS 2 was verified via X-ray diffraction (XRD) and energy-dispersive spectroscopy (EDS). The as-prepared MoS 2 @MWCNTs nanocomposite was used to modify glassy carbon electrode (GCE) as an electrochemical sensor for detecting aristolochic acids (AAs). With the optimized parameters, the proposed electrochemical sensor exhibited good sensitivity and a broad linear concentration range for detecting AAs from 0.2 to 10 μ mol/L and 10 to 100 μ mol/L, with the sensitivity of −3.10 μ A/( μ mol/L) and −0.91 μ A/( μ mol/L), respectively. The detection limit was also calculated as 0.06 μ mol/L (S/N=3) based on the low background signal. Furthermore, the modified electrochemical sensor exhibited good selectivity, repeatability, reproducibility, and stability, thus showing potential application for detecting AA in chinese herbs with good mean recovery and accuracy. In other words, the MoS 2 @MWCNTs/GCE can be used as an excellent platform to detect AAs.
研究领域:
分析化学
·
纳米材料
·
电化学
·
药物分析
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）