Advanced Healthcare Materials
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2024
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IF 10
Ziheng Chen,Hui Chen,Kaiwen Fang,Na Liu,Jiangfan Yu
Magnetic microswarms capable of performing navigation to targeted lesions show great potential for in vivo medical applications. However, using the swarms for lesion cavity filling encounters challenges from precise delivery and sealing. Herein, this work develops a magneto-thermal hydrogel swarm consisting of magnetic hydrogel particles, which can perform phase transition induced by temperature change. The particles are prepared using a temperature-responsive hydrogel matrix, tissue adhesive monomers, and magnetic microparticles. The swarms can be remolded to various shapes, and it can be used to seal perforation in phantom and gastric tissue. The swarms can also serve as drug carriers, and their drug release profiles induced by temperature changes are characterized. Finally, the targeted delivery, adaptive filling, and sealing of a gastric ulcer using the swarms are achieved in ex vivo and in vivo environments.
研究领域:
生物医学工程
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材料科学
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医疗机器人
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组织工程
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DOI
高影响因子
JOURNAL OF DRUG TARGETING
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2025
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IF 3.9
Jinmei Ren,Shuxia Wang,Zhaoli Wu,Chenghao Zhang,Qing Zhang,Xinran Cui,Jiaxin Liu,Jingling Tang
Objective Sildenafil citrate (SC) could promote uterine lining development, leading to successful embryo implantation. Due to the low oral bioavailability of the first-pass elimination of SC, it is necessary to develop a gel for vaginal administration to improve the efficacy.Methods A vaginal gel was prepared using the cold method to increase the retention of SC in the uterus, which allows for prolonged contact between SC and the vaginal mucosa. A poloxamer-based thermosensitive in situ gel containing SC (SC-Tsgel) and an HPMC-based standard gel containing SC (SC-Cogel) were prepared. The rheological properties, in vitro drug release, and in vivo retention in the uterus of SC-Tsgel and SC-Cogel were compared.Results The gel formulations significantly prolonged the time it took for drugs to be released following a release study. SC-Tsgel and SC-Cogel administered vaginally increased the duration of drug administration compared to SC solutions injected through the tail vein. Nevertheless, compared with tail vein injection of SC solutions or vaginal administration of the SC-Cogel, the retention of SC in the uterus was increased significantly after vaginal administration of the SC-Tsgel.Conclusions Novel formulations of SC prepared with poloxamer 407 show promise as vaginal medication preparations for the management of a thin endometrium.
研究领域:
药剂学
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药物递送
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妇科学
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生物利用度
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产品关联
DOI
PubMed
高影响因子
Regenerative Engineering and Translational Medicine
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2025
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IF 1.9
Pradana F. Josse Pasca,Handayani Salsabila Dwi,Phalosa Ghani,Salsabila Mirza,Wicaksono Ikhsan Adil,Al-Ghifary M. Raafi,Putri Dita Sheilla,Arsyadi,Tuba Syahrul
Background Uncontrolled hemorrhage is a leading cause of preventable mortality in trauma cases, necessitating rapid and effective hemostatic interventions. Conventional methods such as gauze dressings and tourniquets have limitations, including delayed clot formation, bacterial contamination, and potential tissue damage. Recent advancements in biomaterials have highlighted chitosan/β-glycerophosphate (CS/β-GP) hydrogels as promising thermosensitive agents for emergency hemostasis. Objective This literature review explores the potential of chitosan/β-glycerophosphate (CS/β-GP) thermosensitive aerosol hydrogel as a novel hemostatic agent, emphasizing its physicochemical properties, gelation mechanisms, delivery innovations, and strategies to enhance its mechanical strength. Methods Relevant scientific literature was collected from Scopus, PubMed, CrossRef, and Semantic Scholar databases using targeted
研究领域:
生物材料
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生物医学工程
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急诊医学
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高分子科学
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药剂技术
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产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
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2025
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IF 2.3
Yang Jing,Wang Xin,Xiang Xu
This work reports on a highly sensitive and temperature-adaptive gellan gum/sodium lignosulfonate-modified hydrogel (PGL hydrogel) aimed at developing materials suitable for wearable sensors. By introducing gellan gum into the polyacrylamide (PAM) matrix, an interpenetrating network structure was formed, significantly enhancing the mechanical properties of the hydrogel. Subsequent post-treatment with a sodium lignosulfonate solution further improved the conductivity of the hydrogel to 0.48 S/m. As the core functional material for wearable sensors, this hydrogel exhibits a wide strain detection capability of approximately 400%, with a gauge factor ( GF ) of 3.79 in the 0–200% strain range and 5.16 in the 200–400% range. Notably, the material maintains synergistic stability in mechanical properties, conductivity, sensitivity, and response time across a wide temperature range of –20–60 ℃. It provides robust support for its use as a stable and sensitive strain sensor. Graphical
研究领域:
材料科学
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高分子科学
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传感器技术
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生物医学工程
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产品关联
DOI
高影响因子
Journal of Macromolecular Science Part A-Pure and Applied Chemistry
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2025
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IF 2.4
Wenna Dong,Long Fang,Jinhai Ma
As a drug delivery system with vast potential applications, hydrogels have garnered significant attention due to their unique drug loading mechanisms and effectiveness. In this paper, a novel reversible thermosensitive hydrogel polymer, synthesized through copolymerization of mono-6-allyl-β-cyclodextrin, N-isopropylacrylamide, and acrylamide, is introduced. This hydrogel polymer formed a three-dimensional network structure in water, featuring β-cyclodextrin hydrophobic cavities. The encapsulated drug molecules could be slowly and progressively released from both the three-dimensional network and the β-cyclodextrin hydrophobic cavities. IR and XRD analysis confirmed the successful encapsulation of the target drug molecules, sodium salicylate and naproxen sodium, within the β-cyclodextrin cavity of the hydrogel polymer and its three-dimensional network space. Specifically, when the mass ratio of N-isopropylacrylamide/acrylamide/mono-6-allyl-β-cyclodextrin was 9.8/0.2/0.5, the polymer hydrogel demonstrated an initial gelation temperature of 34.9 °C and a final gelation temperature of 37 °C. The expansion rate of the blank hydrogel was slightly higher than that of the drug-loaded hydrogel. Both drugs undergo sustained release through the hydrogel, adhering to Fick’s diffusion law, ensuring consistent drug release within 8 h and maintaining this release for over 24 h, regardless of the drug loading rate. Within 30 days, the degradation rate of the drug-loaded hydrogels in PBS exceeded 15%, while the degradation rate in the presence of lysozyme was more than 40%. These properties render the hydrogel a versatile candidate for targeted drug delivery and biomedical applications, offering novel strategies for treating chronic diseases and other conditions.
研究领域:
生物医学工程
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高分子科学
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药剂学
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材料科学
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药物传递系统
✓ 已验证
产品关联
DOI
高影响因子
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