FOOD CHEMISTRY
·
2021
·
IF 7.514
Hongxia Tan,Hongyuan Zhou,Ting Guo,Yuhao Zhang,Jiaxin Li,Chi Zhang,Liang Ma
Food processing might induce the transformation of hidden ZEN (zein-bound ZEN) in maize. The objective of this study was to assess the effect of processing factors on free ZEN and hidden ZEN. After zein was treated under different temperature and pH, ZEN was quantified in samples before and after in vitro digestion. The ratios of hidden to total ZEN in zein are decreased from 54.25% to 40.74% after thermal treatment and from 54.25% to 0 after alkaline treatment, respectively. Conversely, acid treatment increased the ratio of hidden to total ZEN from 54.25% to 100%. Thus, it can be concluded that thermal or alkaline condition induced the conversion of hidden ZEN to free ZEN while acid condition promoted the ZEN-zein interactions to form the hidden ZEN. Overall, temperature and pH values played a vital role in the conversion of hidden ZEN during food processing.
研究领域:
食品科学
·
毒理学
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产品关联
DOI
PubMed
高影响因子
Nature Communications
·
2025
·Vol. 16
·期 1
·1-19
·
IF 15.7
Wang Xiaojuan,Zhang Guohui,Bian Zhiwei,Chow Vimanda,Grimaldi Marina,Carivenc Coralie,Sirounian Savannah,Li Hao,Sladekova Lucia,Mott Stefano,Luperi Yulia,Gong Yufeng,Costello Cait,Li Linhao,Jachimowicz Matthew,Guo Miao,Hu Shian,Wilson Derek,Balaguer Patrick,Bourguet William,Mani Sridhar,Bonati Laura,Peng Hui,March John,Wang Hongbing,Wang Shengpeng,Krause Henry M.,Liu Jiabao
The literature documenting the value of drug-like molecules found in natural products is vast. Although many dietary and herbal remedies have been found to be effective for treating intestinal inflammation, the identification of their active components has lagged behind. In this study, we find that a major ginger component, furanodienone (FDN), is a selective pregnane X receptor (PXR) ligand with agonistic transcriptional outcomes. We show that FDN binds within a sub-pocket of the PXR ligand binding domain (LBD), with subsequent alterations in LBD structure. Using male mice, we show that orally provided FDN has potent PXR-dependant anti-inflammatory outcomes that are colon-specific. Increased affinity and target gene activation in the presence of synergistically acting agonists indicates further opportunities for augmenting FDN activity, efficacy and safety. Collectively, these results support the translational potential of FDN as a therapeutic agent for the treatment and prevention of colonic diseases.
研究领域:
药理学
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分子生物学
·
天然产物研究
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产品关联
DOI
PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2016
·
IF 4.012
Mazloom Shah,Fan Zhang,Ashfaq Ahmad
The catalytic conversion of substituted and unsubstituted cyclohexanones to the corresponding enones and aromatic alcohol catalyzed by Pd, Pd-1, Pd-cube, Cu, Ni, Ag@Pd and Ni-Sn nanocatalysts has been studied in the presence of O 2 as the oxidant without using any additives i.e. acid or base or ligand. The optimization of experimental parameters for dehydrogenation of cyclohexanones was established to achieve maximum yield of the product by using Pd nanocatalyst. The conversion of cyclohexanone, cyclohexenone, 3-methyl cyclohexanone and 3-methyl cyclohexenone catalyzed by Pd nanocatalyst at 80 °C, 10 atm O 2 pressure after 24 h, led to a 79%, 49%, 62% and 25% yields of desired products, respectively. Then, the conversion of substituted and unsubstituted cyclohexanones investigated in the presence of various nanocatalysts i.e., Pd-1, Pd-cube, Cu, Ni, Ag@Pd and Ni-Sn nanoparticles and was compared their percentage yields.
研究领域:
化学
·
催化科学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL POLLUTION
·
2020
·
IF 6.793
Ye Tian,Dianzhen Yu,Na Liu,Yan Tang,Zheng Yan,Aibo Wu
Mycotoxins are toxic fungal metabolites, contaminating cereal grains in field or during processing and storage periods. These environmental contaminants pose great threats to humans and animals’ health due to their toxic effects. Type A trichothecenes, fumonisins and fusaric acid (FA) are commonly detected mycotoxins produced by various Fusarium species. Trichoderma spp. are promising antagonists in agriculture for their activities against plant pathogens , and also regarded as potential candidates for bioremediation of environmental contaminants. Managing toxigenic fungi by antagonistic Trichoderma is regarded as a sustainable and eco-friendly strategy for mycotoxin control. However, the metabolic activities of Trichoderma on natural occurring mycotoxins were less investigated. Our current work comprehensively explored the activities of Trichoderma against type A trichothecenes, fumonisins and FA producing Fusarium species via co-culture competition and indirect volatile assays. Furthermore, we investigated metabolism of type A trichothecenes and FA in Trichoderma isolates. Results indicated that Trichoderma were capable of bio-transforming T-2 toxin, HT-2 toxin, diacetoxyscirpenol and neosolaniol into their glycosylated forms and one Trichoderma strain could bio transform FA into low toxic fusarinol. These findings proved that Trichoderma isolates could manage toxigenic Fusarium via direct competition and volatile-mediated indirect inhibition. In addition, these antagonists possess defensive systems against mycotoxins for self-protection, which enriches our understanding on the interaction mechanism of Trichoderma spp. on toxigenic fungus.
研究领域:
微生物学
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食品安全
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植物病理学
✓ 已验证
DOI
PubMed
高影响因子
MOLECULES
·
2018
·Vol. 23
·期 4
·818
·
IF 3.098
Siyan Zheng,Yingpeng Zhu,Chunyan Jiao,Mengyao Shi,Lianping Wei,Yang Zhou,Qing Jin,Yongping Cai
In order to optimize the extraction of gigantol fromDendrobium officinale, the influence of methanol concentration, ultrasonic temperature, and liquid ratio on extraction efficiency was analysed by the response surface analysis method. The results show that the extraction rate reached a maximum when the methanol concentration was 92.98%, the solid-liquid ratio was 27.2 mL/g, and the extraction temperature was 41.41 °C. The content of gigantol ofDendrobium officinalein leaves was significantly higher than that in stems, reaching 4.7942 μg/g. The content of gigantol inDendrobium huoshanensisFengdou was significantly higher than that of other species of Fengdou. This experiment has practical significance for improving the utilization rate ofDendrobium officinale, and provides a reference for the study of the pharmacological and biological activity of gigantol.Keywords:Dendrobium officinale;gigantol;response surface methodology;ultrasonic-assisted extraction
研究领域:
植物化学
·
药用植物学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CATALYSIS
·
2018
·
IF 6.759
Weiwei Yu,Xinwen Guo,Chunshan Song,Zhongkui Zhao
The controlled visible-light mediated conversion of nitroaromatics to versatile nitrogen-containing intermediates is of great significance but still remains a challenge. Herein, we report for the first time a facile visible-light-initiated one-pot strategy for clean and efficient synthesis of nitrone from nitrobenzene and benzyl alcohol. It integrates the controlled photocatalytic reduction of nitrobenzene to phenylhydroxylamine by photogenerated electrons with the selective photocatalytic oxidation of benzyl alcohol to benzaldehyde by photoinduced holes over a low-cost CdS photocatalyst with a suitable reduction capability, followed by spontaneous condensation of the as-formed hydroxylamine and aldehyde at ambient pressure and room temperature. Furthermore, by modulating cocatalyst and illumination time, for the conversion of the same reactants, the other two useful nitrogen-containing compounds, imine and secondary amine, were also successfully synthesized. The reaction mechanisms for flexible synthesis of the three target products are proposed.
研究领域:
化学合成
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光催化反应
✓ 已验证
产品关联
DOI
高影响因子
RENEWABLE ENERGY
·
2024
·
IF 9
Cuicui Wu,Meng Wang,Yunming Fang
The productive motivation of high-energy-density fuels from sustainable feedstocks has been prompted by environmental concerns and resource scarcities. To address this demand, here, the energy-rich C10 cycloalkanes were first afforded with biomass-derived 2-cyclopentenone (2CPE). Initially, bio-based 2CPE can be converted to tricyclo-diketones by (2 + 2) cycloaddition under UV irradiation or zeolite catalysis. The UV-light photocatalysis for dimerization of 2CPE to diketol-cycloadducts disclosed outstanding advantages of cost-effectiveness and feasibility than traditional zeolite-catalyzed manner, with a yield of 53.61 % at ambient temperature for 2 h. Despite the potential for high dimer yield (77.28 %) under thermo-catalysis of H-ZSM-5 zeolite, the reaction conditions (120 °C, 18 h) were found to be suboptimal. Subsequently, diketol-cycloadducts were selectively and efficiently hydrodeoxygenated to provide cyclopentane-based hydrocarbons using a Huang-Minlon methodology with a yield of 97.04 %, where the target components were directly distilled during the reaction. Specifically, the as-synthesized C10 cycloalkane mixture originated from 2CPE possess high density of 0.96 g mL −1 , large volumetric heat net of combustion (NHOC) of 40.02 MJ L −1 , along with low freezing point of −49 °C. These properties suggest that the bio-liquid cycloalkanes can be used as a standalone high-energy fuel or as a blending agent to enhance the performance of conventional jet fuels.
研究领域:
生物化学
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能源科学
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产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL THERMODYNAMICS
·
2023
·
IF 2.6
Zhenghui Li,Ziwen Dong,Huijun He,Ganbing Yao,Renjie Xu
The equilibrium solubility of sulfenone in various aqueous cosolvent systems was determined by isothermal saturation method at 278.15–323.15 K under 101.2 kPa. Four cosolvents (methanol, ethanol, isopropanol and n -propanol) exhibited different power in dissolving. The specific performance was that in the saturated state, the content of sulfenone in n -propanol + water was the most and in methanol + water was the least. The Jouyban-Acree (J-A), van’t Hoff-Jouyban-Acree (V-J-A) and Apelblat-Jouyban-Acree (A-J-A) models were utilized to correlate the obtained solubility data of sulfenone. The maximum of relative average deviation ( RAD ) and root-mean-square deviation ( RMSD ) were 1.47 × 10 −2 (from A-J-A) and 6.07 × 10 −5 (from V-J-A). In addition, the difference in dissolution was explained from a microscopic point of view through the acquisition of hansen solubility parameters (HSPs). The preferential solvation parameter δx 1,3 was calculated by Inverse Kirkwood-Buff Integrals (IKBI) method, the change trend of δx 1,3 presented in the entire concentration range was non-linear. The apparent thermodynamic parameters were calculated by van’t Hoff plots and the results indicated that the dissolution process of sulfenone is an endothermic and entropy increment process.
研究领域:
化学
·
物理化学
✓ 已验证
DOI
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Zhilei Zhao,Yu Li,Wenlei Zhai,Liuqing Wang,Qianqian Li,Yudan Wang,Meng Wang
The contamination of highly toxic zearalenone (ZEN) in food and the environment poses a serious threat to human safety. However, it is still challenging to establish an efficient, inexpensive and stable ZEN degradation technology. In this study, a Fe single-atom nitrogen-doped porous carbon (Fe-N-PC) was synthesized by high-temperature pyrolysis and used for efficient adsorption and degradation of ZEN. Fe-N-PC showed a high adsorption capacity (q m = 78.2 mg/g) for ZEN, and the Fe-N-PC/peroxymonosulfate (PMS) system could remove 99.39 % of ZEN, in which 1 O 2 played a major role in ZEN degradation. Furthermore, four degradation products of ZEN were identified and possible degradation pathways were hypothesized. For practical applications, Fe-N-PC was applied to remove ZEN from Coix seed extracts, and the results showed that Fe-N-PC was able to detoxify ZEN from Coix seed (92.32 %). Additionally, Fe-N-PC and ZEN degradation products showed low biological toxicity. In a word, the Fe-N-PC/PMS system was used for efficient adsorption and degradation of ZEN, and has been practically applied in complex food matrices, demonstrating Fe-N-PC may be a promising material for the removal of ZEN in the food field.
研究领域:
食品安全
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环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
FOLIA MICROBIOLOGICA
·
2022
·Vol. 67
·期 4
·633-640
·
IF 2.629
Gao Huihui,Lu Dan,Xing Mingyan,Xu Qing,Xue Feng
Zearalenone (ZEN) is a toxic secondary metabolite of Fusarium sp. commonly found in wheat, corn, and other crops. In addition to economic losses, ZEN can seriously endanger the health of both humans and livestock, thus presenting an urgent need for ZEN-detoxifying enzymes that function in the extreme heat or pH conditions of industrial fermenters. Here, we identify and characterize the activity of the ZEN-degrading enzyme from Exophiala spinifera , ZHD_LD, which shares 60.15% amino acid identity and a conserved catalytic triad with the well-characterized ZEN-detoxifying protein ZHD101 from Clonostachys rosea . Biochemical activity and stability assays indicated that purified recombinant ZHD_LD exhibited high activity against ZEN with optimal reaction conditions of 50 ℃ and pH 7.0–10.0. Structural modeling of the ZHD_LD active site and comparison with ZHD101 revealed its likely mechanism of ZEN degradation. This research provides an industrially valuable candidate enzyme for ZEN detoxification in food and livestock feed.
研究领域:
微生物学
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食品安全
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Toxins
·
2023
·Vol. 15
·期 8
·488
·
IF 4.2
Xue Liu,Na Wu,Mingyu Zhang,Feng Xue,Qing Xu
Zearalenone (ZEN) is a widespread mycotoxin found in grain and feed, presenting a serious threat to animal and human health. This study investigated the ability of the novel strain B73, isolated from petroleum-contaminated soil, to detoxify ZEN. B73 was identified asBacillus spizizeniithrough physiological and biochemical tests, and further confirmed based on the 16S rRNA gene sequence and the complete genome sequence.B. spizizeniiB73 was capable of degrading up to 99.3% of ZEN at a concentration of 10 μg/mL in a minimal medium (pH = 7.0) within 8 h at 37 °C via HPLC-UV. In addition,B. spizizeniiB73 was used to treat ZEN-contaminated wheat bran, dried distillers grains (DDGS), and corn meal, whereby the respective degradation rates reached 96.32%, 98.73%, and 80.31% after 36 h of treatment. HPLC-Q-Exactive-MS/MS analysis revealed one of the degradation products to have the formula C17H24O4.B. spizizeniiB73 is a novel strain isolated from petroleum-contaminated soil, and the extracellular enzymes secreted by this strain show a remarkable ability to degrade ZEN.Keywords:zearalenone;Bacillus spizizenii;detoxification;cell extract;enzymeKey Contribution:Our study demonstrates thatBacillus spizizeniiB73 is capable of optimally degrading ZEN at 37 °C, pH 7.0, and with a 4% inoculation amount. After 36 h of degradation, ZEN degradation rates in wheat bran, corn meal, and DDGS were found to be 96.32%, 98.73%, and 80.31%, respectively, when the medium contained 50% grain content.
研究领域:
微生物学
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毒理学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
Foods
·
2023
·Vol. 12
·期 6
·1129
·
IF 5.2
Zhe Zheng,Liyang Niu,Wencheng Yang,Yi Chen,Yousheng Huang,Chang Li
In this study, a dielectric barrier discharge (DBD) cold plasma was used to degrade zearalenone, and the degradation efficiency and the quality of maize were evaluated. The results showed that the zearalenone degradation rates increased with the increase in voltage and time. When it was treated at 50 KV for 120 s, the degradation percentage of the zearalenone in maize could reach 56.57%. The kinetics’ analysis showed that the degradation followed a first-order reaction. The crude fiber of the maize reduced after the cold plasma treatment. In addition, cold plasma treatment did not significantly change the crude protein content, but slightly changed the fatty acid and color. The changes in maize quality are generally acceptable. DBD cold plasma may be a promising approach to reducing zearalenone in maize.Keywords:cold plasma;zearalenone;degradation;maize;quality;food safety
研究领域:
食品科学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）