CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Meng Zeng,Ping Deng,Qin Li,Qi Tang,Jixiang Li,Liangke Zhang
Psoriasis, an immune-mediated disease, commonly utilizes topical drug administration in clinical treatments, yet the thickening of skin presents a challenge to conventional topical drug delivery methods. In this study, we have successfully developed a multifunctional composite ionic liquid (CIL) that enhances the local delivery of melittin (CIL@Mel) by modifying the fluidity of the stratum corneum and the structure of keratin. In addition, CIL@Mel can transport H 2 S to the psoriatic microenvironment, effectively regulating the redox imbalance within it. The in vivo experimental results demonstrated that CIL@Mel effectively mitigates the progression of psoriasis, provides relief from oxidative stress, reduces the production of inflammatory factors, and promotes the repolarization of macrophages. Computational simulations and experimental validation revealed that CIL@Mel exerts its effects by inhibiting the expression of EGFR, STAT3, IL-6, SRC, and HSP90AA1. In conclusion, this study unveils the transdermal promotion mechanism of CIL@Mel and validates its efficacy in psoriasis.
研究领域:
药理学
·
皮肤病学
·
生物化学
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产品关联
DOI
高影响因子
Journal of Cleaner Production
·
2019
·
IF 6.395
Hui Liu,Zhenhua Yin,Qian Zhang,Xiumin Li,Keyong Tang,Jie Liu,Ying Pei,Xuejing Zheng,Cem Emre Ferah
Excessive utilization of such sulfides as sodium sulfide always results in serious wastewater pollution in the liming processing of leather manufacture, and thus the critical or optimal consumption of sodium sulfide is necessary. In this work, it was found that the swelling behavior of bovine hides is highly dependent on the liming time as well as temperature and the sodium sulfide concentration. In order to understand the swelling mechanism and optimize the swelling condition, a mathematical model was built based on the response surface methodology (RSM). As a result, the predicted values (Pva) were in good agreement with the experimental values (Eva) by analyzing the absolute as well as relative errors, and the optimized operation conditions were found to be performed in 0.85 wt% Na 2 S solution at 25 °C for 895 min, by which the polysaccharides in hair follicle are dissolve completely and meanwhile the collagen fiber bundles are swollen and disperse very well.
研究领域:
环境科学
·
皮革化学与工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
·
2022
·Vol. 147
·期 23
·13217-13229
·
IF 4.755
Yang Guochao,Zhang Qiuhui,Li Yan,Ouyang Yunshu
The microencapsulation of flame retardants can avoid the problems of water absorption and loss. In this paper, hydrophobic microcapsule-encapsulated ammonium polyphosphate (HMAPP) was prepared by ion exchange and Stöber method and applied to the preparation of hydrophobic flame-retardant kraft paper by impregnation. The microscopic morphology and element analysis of the hydrophobic microcapsules tested by TEM and SEM showed that nano-scale particles with a size of about 100 nm have been successfully prepared, and the core–shell structure has been formed. HMAPP constructed a rough structure with low surface energy on the surface of kraft paper and provided the kraft paper with hydrophobic property. The water contact angle of kraft paper reached 122.7 ° after treated by HMAPP, while it also enhanced the physical strength of the paper. Kraft had the self-extinguishing phenomenon after treated by HMAPP, which attached to the surface of kraft paper were heated and melted to release ammonia to dilute combustible gas and oxygen, and formed a flame-retardant layer containing SiO 2 particles, phosphoric acid, metaphosphoric acid, pyrophosphoric acid, and carbon flakes on the fiber surface. There were C–C, C–O–C bonds in the carbon layer after flame-retardant treatment, indicating that the pentose contained in fiber has not been completely destroyed. In addition, the presence of Si and P elements in the residual carbon indicates that the decomposed flame retardant adheres to the surface of the fiber to block the heat transfer and flame spread.
研究领域:
材料科学
·
林业工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 53
·34548-34556
·
IF 4.036
Youdan Duan,Haiming Cheng
In the extraction of collagens from mammalian tissues, the free pepsin used in the acid–pepsin extraction system is hard to recycle, and there is a risk of enzyme protein contamination in the extracted collagen products, which limits their applications. To solve this problem, an immobilized pepsin was successfully prepared via the covalent crosslinking of glutaraldehyde using a 3-aminopropyltriethoxysilane (APTES) surface modified silica clay as the support. The immobilized pepsin was applied for the extraction of collagen from bovine hide. The optimal immobilization process involves incubating pepsin with an initial concentration of 35 mg mL−1 and glutaraldehyde with 5% activated APTES modified silica clay at 25 °C for 60 min, by which the loading amount of pepsin was 220 mg g−1 and the activity of the immobilized pepsin was 4.2 U mg−1. The collagen extracted using acetic acid and the immobilized pepsin method retained its complete triple helix structure. This research thus details an effective separation method using pepsin for extraction of collagen via an acetic acid–enzyme method, where the extracted collagen may be a candidate for use in biomaterial applications.
研究领域:
生物化学
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材料科学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 54
·期 2
·1884-1897
·
IF 2.993
Xu Fang,Zhong Ling,Xu Yuan,Feng Shaoyang,Zhang Cheng,Zhang Fengxiu,Zhang Guangxian
The flame resistance of kraft paper was greatly modified by an eco-friendly, phosphorus-containing and reactive flame retardant, ammonium phosphite, which was grafted on kraft paper via pad-bake method. The results showed that the limiting oxygen index of treated kraft paper could increase from 19.1 to 48.2%. The results of vertical flammability tests imply that the char length of treated sample decreased from 210 to 45 mm. Thermogravimetry analysis showed that treated kraft paper had the lower initial decomposition temperature and more residues than control sample. Thermogravimetry analysis/infrared spectrometry indicated that the flammable volatile species of treated kraft paper reduced obviously compared with that of control sample. Fourier transform infrared spectroscopy suggested that ammonium phosphite was grafted on the cellulose molecules by P–O–C covalent bonds and the flame retardant is reactive in condensed phase. Scanning electron microscopy showed that the modification had little effect on the surface of kraft paper and the residual carbonized frame of treated kraft paper retained the fiber shape after combustion. EDX results showed that the flame retardant introduced a large amount of phosphorus and nitrogen into kraft paper. X-ray diffraction indicated that the modification did not significantly affect the crystal structure of kraft paper. And the strength of kraft papers slightly declined after the modification, but it still remained well.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Tong Hao,Rongrong Chen,Yingfeng Lu,Zainab Rasheed,Jing Yan,Suqing Li,Wen Qin,Mingrui Chen,Yaowen Liu
Yellow peach slices are popular for their nutritional value and portability, but they tend to absorb moisture and lose nutrients during storage. In this study, a biodegradable, superhydrophobic, and moisture-resistant paper-based packaging material was developed by coating kraft paper (KP) with a composite formulation of pea starch (PS), shellac (SH), zein (ZE), and stearic acid (SA). The selection of this composite system was based on the complementary functional properties of its components: PS provided a biodegradable matrix with good film-forming ability, SH contributed moisture resistance and adhesion, ZE enhanced mechanical strength and hydrophobicity, while SA further lowered surface energy to achieve superhydrophobicity. The coatings were applied through hydrogen bonding and electrostatic interactions, creating a robust barrier on the paper surface. The coated papers were evaluated for oxygen permeability (OP), water vapor transmission rate (WVTR), water contact angle (WCA), and rolling angle (RA). Results demonstrated that the PS/SH/ZE/SA-coated KP exhibited an 83.1 % reduction in WVTR and a 79.8 % decrease in OP compared to unmodified KP. The optimal formulation (KP/PS/SH/ZE/SA-3 %) displayed the lowest moisture content (MC) and achieved a WCA exceeding 150°, confirming superhydrophobicity. Additionally, the coatings significantly improved thermodynamic stability and imparted self-cleaning properties to the paper. These findings suggest that the developed composite coating can effectively modify paper-based packaging for moisture-sensitive applications, such as dehydrated yellow peach slices and other dry foods, offering a sustainable alternative to conventional plastic-based packaging.
研究领域:
食品科学
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材料科学
·
包装技术
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食品保鲜
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高分子科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Chemistry-X
·
2024
·
IF 6.5
Lin Zhu,Yijun Liu,Jiameng Liu,Xunxia Qiu,Lijing Lin
We prepared tea tree essential oil microcapsules, and the microcapsules and pullulan were coated on kraft paper to prepare an antibacterial paper. The antibacterial activity, structural characterization, and thermal stability of the prepared microcapsules and packaging paper were then tested. We found that the retention rate of microcapsules reached 87.1% after a 70 min of high-temperature treatment. The minimum inhibitory concentrations of microcapsules to S. aureus and E. coli were 112 mg/mL and 224 mg/mL, and the bacteriostatic zones of the packaging paper to E. coli and S. aureus were 17.49 mm and 22.75 mm, respectively. The prepared microcapsules were irregular. The paper coating was formed via hydrogen bonding, which filled the pores of paper fibers. When compared with the base paper, the roughness of the paper was reduced to 7.16 nm (Rq) and 5.61 nm (Ra), and no thermal decomposition occurred at <288 °C, which together implies a good application prospect.
研究领域:
材料科学
·
化学工程
·
食品科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food & Function
·
2019
·Vol. 10
·期 6
·3379-3385
·
IF 3.241
Qi Chen,Hongxia Yang,Yan Li,Xiaoxi Wang,Lixin Wei,Yuzhi Du
Studies have shown that gelatin is not only a good hemostatic material, but also a food additive with potentially broad use. Yak skin gelatin is a new gelatin resource, but its oral coagulant effects have not been studied. Given the central role of platelets in hemostasis, in this study we examined the pharmacodynamical differences between different molecular Yak skin gelatins on platelet activation. The hemostatic effects of Yak skin gelatins with different molecular weight distributions were evaluated for bleeding time (BT), clotting time (CT), and platelet activity by measuring the contents of P-selectin, platelet membrane glycoprotein Ia/IIa (GP Ia/IIa), platelet membrane glycoprotein IIb/IIIa (GP IIb/IIIa), and platelet membrane glycoprotein IV (GP IV). Intragastric administration of Yak skin gelatin resulted in a significant reduction in CT and BT, and an increase in the contents of P-selectin, GP Ia/IIa, GP IIb/IIIa, and GP IV in all groups in comparison with the control group. The strongest activation of platelets by Yak skin gelatin was observed with size between 0.1 μm and 0.22 μm, and activation may have been in response to improving GP IIb/IIIa and GP IV levels. When measuring the levels of an established indicator of platelet activation, platelet activation-dependent granule membrane protein (CD62P), its promotion was observed for all molecular weight ranges of Yak skin gelatins. In brief, Yak skin gelatin has hemostatic effects, and Yak skin gelatin fractions between 0.1 μm and 0.22 μm are the primary effectors of hemostasis via promoting platelet membrane glycoprotein activities and strengthening platelet function.
研究领域:
药理学
·
止血
·
血小板功能
✓ 已验证
DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Xuanying Xin,Sungkwon Park,Wen Zhang,Jia Yu,Sun Jin Hur,Xiangzi Li,Seong-Ho Choi
Conventional identification methods for antioxidant peptides from bovine hide collagen suffer from poor specificity and high costs. This study employed an integrated approach combining peptidomics, molecular simulation, and quantum chemical calculations to identify ten highly active antioxidant peptides from 6006 candidates. Molecular docking revealed that the peptides bound strongly to the Keap1 protein (binding energies: −7.19 to −12.26 kcal/mol) Quantum chemical calculations demonstrated superior electron-donating capacity, while Fukui function analysis identified key active sites. Cellular assays showed all ten synthetic peptides (1 mg/mL) significantly reduced H₂O₂-induced ROS levels in RAW264.7 cells, enhanced SOD/GSH-Px activities, inhibited MDA accumulation, and upregulated the expression of genes in the Nrf2 signaling pathway, which was further confirmed by Western Blot analysis of key proteins in the Keap1-Nrf2 axis. Computational parameters strongly correlated with cellular antioxidant efficacy, with SGPOGPOGP showing optimal protective effects. This tripartite validation strategy provides an innovative paradigm for efficient discovery of bovine hide-derived antioxidant peptides.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE ENERGY INSTITUTE
·
2025
·
IF 6.2
Wenyuan Duan,Shaoquan Chen,Jiale Lu,Yutong Li,Miaomiao Li,Jianjing Gao,Yuzhen Zhao
Lignin, an abundant byproduct of lignocellulosic biorefineries, exhibits significant potential as a renewable feedstock for the production of value-added aromatic chemicals and high-energy-density biofuels due to its complex, highly aromatic polymeric structure. In this study, we investigated the effect of a Co-loaded HZSM-5 (50) (HZ) catalyst on oxidative valorization of kraft lignin under mild conditions of air. The bio-oil yield was increased with the increasing loading of Co, and was obtained to be 45.3 wt.% at 140°C/ 30 min. The desilication of zeolite exhibited a promising impact on the depolymerization of lignin, and the bio-oil was significantly enhanced to 51.8 wt.% with 10Co/HZ-n catalyst. Herein. The effect of metal promoters (Zn, Fe, and Nb) were also comprehensively determined by their successive loading on 10Co/HZ-n catalyst. The maximum bio-oil yield (67.3 wt.%) was evaluated with 10Co-3Nb/HZ-n catalyst at 120°C/ 30 min, reaction conditions. Additionally, the reusability performance of the 10Co-3Nb/HZ-n catalyst was examined for up to four catalytic cycles. The elemental analysis of bio-oils showed a significant improvement in the quality in terms of high calorific value (36.8 MJ/kg) for the 10Co-3Nb/HZ-n. Additionally, vanillin (68.2%) was observed as the main selective catalytic product, and its maximum selectivity was also determined for the optimum 10Co-3Nb/HZ-n bio-oil. The study emphasises the role of high metal valent ions in the selective fractionation of lignin into valuable phenolic compounds.
研究领域:
催化
·
生物质转化
·
绿色化学
·
可再生能源
·
高分子降解
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Hui Liu,Mengya Li,Keyong Tang,Jie Liu,Xiumin Li,Xueping Meng
Conformations of secondary and super secondary structure from bovine hides collagen are very important for constructing collagen molecular space structure, and directly related to its properties. In this work, the evolutional mechanism of the collagen conformation in the environment of sodium sulphide (Na 2 S) solution is periodically studied by FT-IR spectroscopy, the Gaussian peak fitting of secondary derivative, and auxiliary methods such as SDS-PAGE, SEM and TG. As a result, the three polypeptide chains structure of bovine hide collagen was hardly affected by the ions of OH − , HS − and S 2− . The conformation of collagen molecules such as β-turn, triple helix and β-strand were gradually evolved into unordered structure and α-helix with the sequential addition of OH − , HS − and S 2− , which is because the hydrogen bond inside collagen molecular is extended or opened with the increase of the synergistic effect of pH and reducibility of HS − and S 2− in the solution. The bound water content and thermal properties of the treated collagen molecules are decreased. Finally, the order of the hydrolysis ability to collagen is NaOH < NaHS < Na 2 S at the same condition, which was confirmed by measuring the content of hydroxyproline from their solutions after treating the collagen. This work provides very important information for understanding the evolutional mechanism of bovine hide collagen conformation in the Na 2 S solution, developing the alternatives of sulfide, extraction of collagen, tanning, and application of collagen in biological and material science.
研究领域:
材料科学
·
生物化学
·
胶原蛋白研究
·
鞣制技术
·
生化研究
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）