MOLECULES
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2018
·Vol. 23
·期 7
·1821
·
IF 3.098
Yejing Wang,Rui Cai,Gang Tao,Peng Wang,Hua Zuo,Ping Zhao,Ahmad Umar,Huawei He
Silk sericin is a protein from a silkworm’s cocoon. It has good biocompatibility, hydrophilicity, bioactivity, and biodegradability. However, sericin could not be used in biomedical materials directly because of its frangible characteristic. To develop multifunctional sericin-based materials for biomedical purposes, we prepared a sericin/agar (SS/agar) composite film through the blending of sericin and agar and repetitive freeze-thawing. Then, we synthesized silver nanoparticles (AgNPs) in situ on the surface of the composite film to endow it with antibacterial activity. Water contact angle, swelling and losing ratio, and mechanical properties analysis indicated that the composite film had excellent mechanical property, hydrophilicity, hygroscopicity, and stability. Scanning electron microscopy and X-ray photoelectron spectroscopy analysis confirmed the successful modification of AgNPs on the composite film. X-ray powder diffraction showed the face-centered cubic structures of the AgNPs. This AgNPs modified composite film exhibited an excellent antibacterial capability againstEscherichia coliandStaphylococcus aureus. Our study develops a novel AgNPs/sericin/agar composite film with enhanced mechanical performance and an antimicrobial property for potential biomedical applications.Keywords:silk sericin;agar;silver nanoparticles;antimicrobial activity
研究领域:
生物材料学
·
医学材料
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DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2017
·
IF 4.164
Yahui Song,Jianping Gao,Xiaoyang Xu,Huilin Zhao,Ruinan Xue,Jingkuo Zhou,Wei Hong,Haixia Qiu
Thermal sensitive supramolecular hybrid gels for injectable drug release were prepared by adding different amounts of agar into folic acid (FA) gelator. The gelation temperature was modulated in order to form injectable gel with body temperature (37 °C). Such kind of folic acid-agar (FAG) hybrid gel makes it possible to use supramolecular gel as injectable drug loaded gels for drug release. FT-IR and UV–vis spectra indicate that agar macromolecules involve in the self-assembly process through intermolecular H-bonding and π-π stacking interactions with FA molecules. The SEM and TEM images demonstrate that the fiber diameter of FAG hybrid gel is about 20 nm, much smaller than that of FA gel (40 nm). However, FAG hybrid has a denser nano-fibrous network structure than FA gels. Moreover, FAG hybrid gel is endowed with a more ordered network structure and a little better crystallization capability by adding agar. FAG hybrid gel also shows a shear-thinning behavior but the shear viscosity is about 2 times higher than that of FA gel. Compared with FA gel, the storage (G′) and loss (G″) moduli of the FAG gel are higher, which implies an enhanced gel strength. At the same time, both FA and FAG gels are facilely affected by some external factors such as acid, base and salts. In acidic or basic conditions, the strength became weak and the gelation temperature (Tg) decreased. While, within certain concentrations, the salt (NaCl) increased the gel strength and Tg. FAG gel suffered lower mass loss and owned better stability in different pH solutions compared with pure FA gel. The release behavior of the FA and injectable FAG gels was investigated by using Rhodamine B as a mimic model drug. FAG hybrid gel shows a long release profile and the release time is 3 times longer than that of FA gel, up to 30 h, and the accumulative release amount reaches about 86%. So it is a potential injectable gel for sustained release drug delivery system.
研究领域:
材料科学
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药学
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DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2021
·
IF 6.953
Lu Cao,Jian Zhu,Na Li
Selenium (Se) is an essential trace element for human beings and animals. Traditional plant Se enrichment technology suffers from selenium pollution. Herein, environmentally friendly Se-agarose (Se-Agar) hybrid hydrogels are prepared by simply mixing agar with different Se species including selenocarrageenan (SeCA), selenite and Se yeast under heating and stirring for 0.5 h without any other reagent. Such Se-Agar hybrid hydrogels with excellent biocompatibility were used as natural substrates for the cultivation of Se-enriched mung bean sprouts. Compared with Se yeast, SeCA and selenite show a better Se enrichment effect on mung bean sprouts. Furthermore, the growth indices including plant weight and plant height of mung bean sprouts were investigated with different concentrations and sources of Se. Notably, the Se-Agar hybrid hydrogels could be easily regenerated and reused for multiple cycles. The results indicated that Se-Agar hybrid hydrogels as recyclable natural substrates offer a simple, sustainable and affordable strategy for plant Se enrichment.
研究领域:
植物学
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环境科学
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食品科学
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DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
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2020
·Vol. 221
·期 22
·2000237
·
IF 2.335
Xin Han,Mengyu Li,Zewen Fan,Yu Zhang,Huihui Zhang,Qiaoling Li
Traditional self-healing hydrogels have great application prospects in biological engineering because of their extremely high water content, but their durability cannot be easily guaranteed. Therefore, developing a rapid self-healing hydrogel with long-lasting water retention capacity is still a significant challenge. A high-strength and fast self-healing hydrogel with an interpenetrating double network based on polyvinyl alcohol/agar-ethylene glycol (PVA/agar-EG) is proposed. Polyvinyl alcohol (PVA) and agar are designed for the construction of the interpenetrating network. Furthermore, the introduction of a borate-bonding dynamic action mode affords the hydrogel with extraordinary mechanical strength and rapid self-healing. The addition of EG as a traveling solvent enables the sample to retain water and prevents freezing in harsh environments, including at high temperatures of 80 °C and extremely low temperatures of −40 °C. Additionally, owing to the intelligent remolding ability of the PVA/agar-EG hydrogel, the material can be recycled to prolong the service life of the hydrogel. Overall, the PVA/agar-EG hydrogel developed in this study can provide a new general strategy for the development of intelligent self-healing devices, and hydrogels can be applied in complex environmental engineering.
研究领域:
生物工程
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材料科学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Zhen Nie,Kelin Peng,Lizhi Lin,Jueying Yang,Zhekun Cheng,Qiang Gan,Yu Chen,Changgen Feng
Conductive hydrogels (CHs) have drawn wide attention from the field of flexible sensor for their similarities to tissues, excellent flexibility and good electrical conductivity. However, most of the reported hydrogel-based flexible sensors display the disadvantages of poor tensile strength, low sensitivity and insufficient stability, and most of them are prepared with non-degradable synthetic polymers, which have greatly limited their application. To solve these problems, in this work, we have constructed an agar-based dynamic double cross-linked CH by the dynamic crosslinking between agar and borax via borate bonds and the hydrogen bonds between agar chains. The CH exhibits excellent electrical conductivities, tensile properties and self-healing abilities. A novel two-dimensional material, MXene nanosheet, was introduced to further improve the mechanical properties and ionic conductivity of the CH with its high ionic conductivity and ability to form hydrogen bonds with agar. The obtained Agar/Borax/MXene CH displays the excellent strength and elongation of 129 kPa and 105.1 % and the satisfying ionic conductivity of 8.14 × 10 −2 S/cm. The flexible sensor assembled with Agar/Borax hydrogel with 0.15 wt% MXene exhibits a wide strain detection range from 0 to 100 %, high sensitivity (GF≈1.520) and good stability. Our work has provided a novel strategy for the construction of green flexible sensors with good mechanical properties and high sensitivity.
研究领域:
材料科学
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生物医学工程
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DOI
高影响因子
JOURNAL OF CHROMATOGRAPHY A
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2023
·
IF 4.1
Hao Chi,Sheng Tian,Xiu Li,Yuchu Chen,Qiumin Xu,Qixiao Wang,Wenwan Shi,Michael Adu-Frimpong,Shanshan Tong
In order to improve the separation process of affinity chromatography that has silica as the main carrier material, we sought to construct Lipid [email protected] 4B affinity chromatography model. We extracted the lipid rafts from U251 cells with a descaler method and sucrose density gradient centrifugation. Afterwards, it was discovered via immunofluorescence that the lipid rafts contain a large amount of tropomyosin-related kinase A (TrkA) protein. Also, agarose powder in the lyophilised state was pretreated, before the lipid rafts were coupled to the agarose gel in a coupling buffer of alkaline pH. CNBr-Sepharose 4B affinity gel packing was characterised using UV spectrophotometric, immunofluorescence and scanning electron microscopic techniques, wherein and the results showed that the lipid rafts were successfully coupled to the agarose gels. Three compounds were used to verify the specific sorption of Sepharose 4B and CNBr-Sepharose 4B, which showed no specific sorption on the materials. Of note, the prepared Lipid [email protected] 4B agarose gels packed with TrkA-rich target proteins could be successfully validated for the active drug gefitinib with high affinity sorption efficiency and eluted with good recovery and reproducibility. This study broadens the range of affinity chromatography carrier materials and provides a reference for research in active drug screening.
研究领域:
生物化学
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药学
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生物技术
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分析化学
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
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2023
·
IF 7.7
Chen Shao,Jian Zhang,Yuqing Liu,Yuting Jiang,Yanping Jia,Guomin Li,Zhong Sun
The presence of antibiotics such as Tetracycline (TC) in the water environment poses new challenges to traditional water treatment technologies . Simple and clean electrocatalytic technology has been widely used in the degradation of antibiotic-based wastewater. In this study, agarose (AG) was loaded onto ITO using an impregnation method, and Pd was deposited onto the AG/ITO electrode by electrodeposition , the Pd/AG/ITO composite electrode was prepared. The electrode was then observed and analyzed using SEM , XRD , FT-IR, and XPS . The optimal conditions for the electrocatalytic reaction were explored as follows: PdCl 2 concentration of 0.20 mmol/L, PdCl 2 deposition current of 3 mA, deposition time of 10 min, and degradation current of 8 mA. Under these optimal working conditions, the Pd/AG/ITO composite electrode achieved a degradation efficiency of 85.21% within 120 min. Through five replications, the degradation efficiency of the electrodes decreased by less than 3.50%, which indicated its good reusability and stability. Based on the generation of active substances during degradation and the analysis of LC-MS, potential degradation products , and degradation pathways were deduced, and it was proposed that the degradation of TC was completed by a synchronous redox reaction co-led by·OH and H*. Toxicity analysis of TC and its degradation products was performed using ECOSAR software. This study will promise to provide an effective method of degrading TC wastewater.
研究领域:
环境科学
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化学工程
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材料科学
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产品关联
DOI
高影响因子
CHEMICAL PHYSICS LETTERS
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2023
·
IF 2.8
Bo Li,Mohib Ullah Khan,Cheng Qv,Lin Chen,Ying Xiong,Lixin Zhang,Mingzai Wu
Conventional flexible zinc-air batteries (ZABs) electrolytes are mainly made of hydrogels, and thus can freeze at low temperatures and cause cell failure. Here, we report a gel electrolyte consisting of agar, polyacrylamide and dimethyl sulfoxide with high ionic conductivity (24 mS cm −1 ) at −30 °C. The flexible ZABs based on this gel electrolyte showed good cycling stability (45 h) at −30 °C, which provides a new idea for the development of low-temperature resistant flexible ZABs.
研究领域:
能源材料
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电化学
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产品关联
DOI
高影响因子
Polymers
·
2021
·Vol. 13
·期 22
·4028
·
IF 4.329
Chi Gong,Zhiyuan Kong,Xiaohong Wang
In three-dimensional (3D) bioprinting, the accuracy, stability, and mechanical properties of the formed structure are very important to the overall composition and internal structure of the complex organ. In traditional 3D bioprinting, low-temperature gelatinization of gelatin is often used to construct complex tissues and organs. However, the hydrosol relies too much on the concentration of gelatin and has limited formation accuracy and stability. In this study, we take advantage of the physical crosslinking of agarose at 35–40 °C to replace the single pregelatinization effect of gelatin in 3D bioprinting, and printing composite gelatin/alginate/agarose hydrogels at two temperatures, i.e., 10 °C and 24 °C, respectively. After in-depth research, we find that the structures manufactured by the pregelatinization method of agarose are significantly more accurate, more stable, and harder than those pregelatined by gelatin. We believe that this research holds the potential to be widely used in the future organ manufacturing fields with high structural accuracy and stability.Keywords:3D bioprinting;agarose;pregelatinization;organ manufacturing
研究领域:
生物工程
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再生医学
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DOI
PubMed
高影响因子
Food Packaging and Shelf Life
·
2023
·
IF 8
Liling Fu,Yi Ru,Qinglin Hong,Yonghui Zhang,Huifen Weng,Qiuming Yang,Qiong Xiao,Anfeng Xiao
Caffeic acid was grafted to agarose by a nonradical synthesis method to improve the functional properties of agarose and its application value in food preservation. Structural characterization showed that the carboxyl group of caffeic acid was successfully grafted to the C6-OH of D -galactose in agarose, and the highest grafting ratio could reach 12.18 %. Incorporating caffeic acid significantly increased the antioxidant and bacteriostatic activities. With the increase in grafting ratio from 0 % to 12.18 %, the scavenging ratio of DPPH increased from 0 % to 50.09 %, and the inhibition ratio of β -carotene bleaching increased from 7.49 % to 72.21 %. The bacteriostatic ratio of agarose caffeate (Cf-Ag) against Escherichia coli and Staphylococcus aureus could reach 100 %. The fish preservation test indicated that Cf-Ag had positive effects on inhibiting bacterial growth and fat oxidation , reducing the water loss, and prolonging the overall quality of grass carp fillet during refrigeration, which was more effective than native agarose in extending the shelf life of fish.
研究领域:
食品科学
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生物化学
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DOI
高影响因子
RARE METALS
·
2019
·Vol. 39
·期 4
·375-382
·
IF 1.785
Yazdan Ali,Wang Ji-Zhe,Hu Bing-Kun,Xie Wen-Sheng,Zhao Ling-Yun,Nan Ce-Wen,Li Liang-Liang
Abstract Hydrogels are cross-linked polymers suitable for various applications, but the thermal conductivities of hydrogel-based composites have not been thoroughly investigated. In this study, agarose hydrogel-based composites with various boron nitride (BN) fillers were synthesized and their thermal conductivities were systematically investigated. With the increase in the agarose content from 1.5 wt% to 3.0 wt%, the thermal conductivity of the composite decreased. The composites with BN micropowder had larger thermal conductivities than those of the composites with BN nanopowder at the same filler loading, as the BN micropowder provided better thermal conduction pathways in the hydrogel matrix than those provided by the nanopowder. The maximum thermal conductivity of 2.69 W·m −1 ·K −1 was achieved when 15 wt% microscale BN fillers were added into 1.5 wt% agarose hydrogel, which was 3.5 times larger than that of the pure agarose hydrogel. Additionally, a theoretical model was used to calculate the thermal conductivities of the BN/agarose hydrogel composites; a good agreement was achieved between the experimental and fitting ones. This study demonstrated that the thermal conductivities of hydrogel-based materials can be efficiently and significantly enhanced using BN fillers. Graphic Abstract
研究领域:
材料科学
·
热传导研究
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DOI
高影响因子
Gels
·
2024
·Vol. 10
·期 4
·266
·
IF 5
Yuxiang Du,Pengjie Jiang,Xin Yang,Rui Fu,Lipeng Liu,Changqing Miao,Yaxiong Wang,Huazheng Sai
Aerogel fibers, characterized by their ultra-low density and ultra-low thermal conductivity, are an ideal candidate for personal thermal management as they hold the potential to effectively reduce the energy consumption of room heating and significantly contribute to energy conservation. However, most aerogel fibers have weak mechanical properties or require complex manufacturing processes. In this study, simple continuous silk fibroin–agarose composite aerogel fibers (SCAFs) were prepared by mixing agarose with silk fibroin through wet spinning and rapid gelation, followed by solvent replacement and supercritical carbon dioxide treatment. Among them, the rapid gelation of the SCAFs was achieved using agarose physical methods with heat-reversible gel properties, simplifying the preparation process. Hydrophobic silk fibroin–agarose composite aerogel fibers (HSCAFs) were prepared using a simple chemical vapor deposition (CVD) method. After CVD, the HSCAFs’ gel skeletons were uniformly coated with a silica layer containing methyl groups, endowing them with outstanding radial elasticity. Moreover, the HSCAFs exhibited low density (≤0.153 g/cm3), a large specific surface area (≥254.0 m2/g), high porosity (91.1–94.7%), and excellent hydrophobicity (a water contact angle of 136.8°). More importantly, they showed excellent thermal insulation performance in low-temperature (−60 °C) or high-temperature (140 °C) environments. The designed HSCAFs may provide a new approach for the preparation of high-performance aerogel fibers for personal thermal management.
研究领域:
材料科学
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生物工程
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）