Extreme Mechanics Letters
·
2021
·
IF 4.567
Xueqi Zhao,Jingping Wu,Yifan Zhou,Yudong Pan,Tongqing Lu,Xiaoping Song,Jian Hu
Physical hydrogels, composed of non-covalently crosslinking three dimensional polymer networks and a large amount of water, have drawn much attention due to their excellent mechanical properties such as high toughness, self-healing, self-recovery, and shape-memory. But the fatigue behaviors of physical hydrogels, especially the role of non-covalent bonds in the fatigue process, have not been well studied. Here we study fatigue damage and fatigue fracture of two kinds of physical hydrogels based on hydrogen bonding (H-bonding): poly(vinyl alcohol)/poly(acrylic acid) (PVA/PAA) gels with weak H-bonding (weak gels) and PVA/PAA-LiCl gels with strong H-bonding (strong gels). For the fatigue damage of uncut samples, both the weak and strong gels are fatigue strengthened in small deformation by stretch-induced H-bonding rearrangement, but are fatigue damaged in large deformation by chain sliding. For the fatigue fracture of precut samples, both the weak and strong gels show no measurable fatigue threshold, but the strong gel can mitigate crack growth. These results reveal the intrinsically weak non-covalent bonds cannot effectively increase the fatigue resistance of physical hydrogels. This work provides a deep perspective for developing novel anti-fatigue hydrogels.
研究领域:
材料科学
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2023
·Vol. 16
·期 6
·2488
·
IF 3.4
Songtao Lv,Dongdong Ge,Ziyang Wang,Jinping Wang,Jing Liu,Zihao Ju,Xinghai Peng,Xiyan Fan,Shihao Cao,Dingyuan Liu,Wenhui Zhang,Milkos Borges Cabrera
Fatigue cracking is a common form of flexible pavement distress, which generally starts and spreads through bitumen. To address this issue, self-healing elastomer (SHE) modified bitumens were elaborated to assess whether these novel materials can overcome the neat asphalt (NA) fatigue performance and whether the current failure definition, failure criterion, and fatigue-restoration criteria can fit their performance. All bitumens were subjected to short-term and long-term aging. Linear amplitude sweep (LAS) test, LAS with rest period (LASH), and simplified viscoelastic-continuum-damage (S-VECD) model were utilized to appraise the behavior of the mentioned bitumens. The results showed that maximum stored pseudo-strain energy (PSE) and tau (τ) × N (number of loading cycles) failure definitions exhibited high efficiency to accommodate the fatigue life of NA and SHE-modified bitumens. Both failure criteria identified that SHE-modified bitumen (containing 1% of SHE) showed the highest increment of fatigue performance (67.1%) concerning NA. The failure criterion based on total released PSE, in terms of the area under the released PSE curve, was the only failure concept with high efficiency (R2up to 0.999) to predict asphalt binder fatigue life. As well, the current framework to evaluate bitumen self-restoration failed to fully accommodate asphalt binder behavior, because bitumen with higher restoration could not exhibit greater fatigue performance. Consequently, a new procedure to assess this property including fatigue behavior was proposed, showing consistent results, and confirming that SHE-modified bitumen (containing 1% of SHE) exhibited the highest increment of fatigue performance (154.02%) after application of the rest period. Hence, the optimum SHE content in NA was 1%. Furthermore, it was found that a greater number of loading cycles to failure (Nf) did not ensure better fatigue performance and stored PSE influenced the bitumen fatigue behavior.Keywords:bitumen fatigue performance;bitumen fatigue failure;failure definition;failure criterion;self-restoration;self-healing
研究领域:
土木工程
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Science & Nutrition
·
2025
·Vol. 13
·期 6
·e70304
·
IF 3.8
Yuening Li,Qinsheng Li,Wenxiu Xu,Ruiqing Liu,Yanling Gong,Ming Li
Resveratrol (trans-3,4′,5-trihydroxystilbene, RES) is a stilbenoid naturally present in a variety of plants. Although there are several reports about its anti-fatigue activity, its impact on intensive exercise-induced fatigue and the underlying mechanisms are yet not well understood. In the present study, we established a swimming exercise protocol in mice that is similar to the fatigue condition induced by a long period of intensive exercise and explored the effect of RES on fatigue and the mechanisms from the perspective of intestinal injury and gut microbiota. The results revealed that RES significantly prolonged exhaustive swimming time in fatigued mice and improved the serum indexes associated with fatigue, including serum glucose, lactic acid (LA), urea nitrogen (BUN), lactate dehydrogenase (LDH), creatine kinase (CK), catalase (CAT), glutathione peroxidase (GSH-Px), and glycogen storage in liver and muscle. Meanwhile, RES increased the expressions of ZO-1, Occludin, and Claudin-1, thereby enhancing intestinal barrier integrity and inhibiting mRNA expressions of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interleukin-1β (IL-1β) in the colon, thereby improving the pathological injury in the colon. Importantly, RES modified gut microbiota dysbiosis by increasing the diversity of gut microbiota, regulating microbiota associated with inflammation and fatty acid metabolism at the phylum ( Bacteroidetes and Firmicutes ), family ( Erysipelotrichaceae , Enterobacteriaceae, and Prevotellaceae ), and genus ( Brevundimonas diminuta , Coprobacillus , Megasphaera, and Lactobacillus ) levels, respectively. The results supplemented the anti-fatigue mechanism for RES from the perspective of intestinal injury and gut microbiota. The detailed mechanisms and associated metabonomics analysis remain for further study.
研究领域:
运动生理学
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营养学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYTOMEDICINE
·
2025
·
IF 8.3
Meng Zhang,Rui Liu,Ting Zhou,Yuxin Guo,Hui Li,Wei Wu
Background Chronic fatigue syndrome (CFS) is a crippling illness with limited effective treatment options. Recent findings have suggested that ginseng stem and leaf saponins (GSLS) possess anti-fatigue effects. However, the detailed mechanisms by which GSLS impact CFS have yet to be fully elucidated. Purpose This study aimed to explore the efficacy and underlying mechanisms of GSLS in the treatment of peripheral and central fatigue in mice with CFS. Methods A CFS model was established in male C57BL/6 mice, which were then subjected to prolonged swimming tests. The validity of this model and the efficacy of GSLS were verified using the forced exhaustion swimming test and the Morris water maze test. The anti-fatigue mechanism of GSLS was verified using pathological section observations, biochemical index tests, neurotransmitter analysis, and Ultra-high performance liquid chromatography–high-resolution mass spectrometry (UHPLC-MS) metabolomics analysis. Results GSLS prolonged the swim time-to-exhaustion in CFS mice and reduced escape latency in the water maze, revealing their anti-fatigue and memory-improving effects. GSLS significantly protected both peripheral (liver) and central (hippocampus) tissues, as shown in pathological sections. Biochemical indices suggested that GSLS mitigate peripheral fatigue by reducing energy expenditure and oxidative damage and inhibiting the production of harmful metabolites. Furthermore, GSLS altered the abnormal levels of 14 neurotransmitters in the brains of CFS mice, including seven upregulated and seven downregulated neurotransmitters, highlighting their role in mitigating central fatigue through neurotransmitter regulation. Serum metabolomics analysis identified alterations in 19 metabolites across 11 metabolic pathways, thereby elucidating the potential mechanisms by which GSLS treat CFS. Conclusion GSLS ameliorate damage caused by both peripheral and central fatigue. They also act on multiple pathogenic mechanisms by modulating neurotransmitters and serum biomarkers, making them a potential therapeutic agent for CFS.
研究领域:
药理学
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代谢组学
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神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Extreme Mechanics Letters
·
2022
·
IF 4.728
Yihang Xiao,Qi Li,Xi Yao,Ruobing Bai,Wei Hong,Canhui Yang
Hydrogels composed of amorphous polymer networks are widely used as soft and stretchable components in diverse devices and machines. However, existing amorphous hydrogels are susceptible to fatigue fracture. Here, we propose that amorphous hydrogels with dynamic covalent bonds can resist fatigue fracture, so long as the dynamics of bond recovery is faster than the rate of deformation. We examine this hypothesis by performing fatigue tests for polyacrylamide hydrogels crosslinked by covalent C–C bonds and by dynamic covalent siloxane bonds, using N, N’-methylenebis-acrylamide (MBAA) and silanes as the crosslinkers , respectively. Experiments show that the fatigue threshold of MBAA-crosslinked hydrogels is 12.7 J/m 2 , much lower than the toughness, 70.2 J/m 2 , and comparable to the Lake–Thomas prediction, 11.17 J/m 2 , while the silane-crosslinked hydrogels achieve a fatigue threshold of 68.7 J/m 2 , surprisingly close to the toughness, 86.2 J/m 2 , which is reported for the first time in hydrogels with dynamic covalent bonds. We trace the violation of the Lake–Thomas mechanism to the dynamic nature of siloxane bonds. We carry out self-healing tests, self-recovery tests, and fatigue tests for silane-crosslinked hydrogels with different pH values to examine the bond dynamics. We discuss the importance of dynamic covalent bonds in synthesizing fatigue-free hydrogels by constructing a fatigue threshold-toughness Ashby plot. The current work suggests that dynamic covalent bonds pave alternative avenues towards anti-fatigue soft materials with amorphous polymer networks.
研究领域:
材料科学
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生物工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2022
·
IF 10.319
Linjing Liu,Bin Yang,Rui Lv,Qiangwei Kou,Shuai Yang,Hang Xie,Yuan Sun,Yunfei Chang,Shan-Tao Zhang,Fei Li
Piezoceramics with high and fatigue-resisted piezoelectric properties are strongly desired for actuator applications. In this work, textured Pb(Mg 1/3 Nb 2/3 )O 3 -Pb(Zr, Ti)O 3 ceramics with Lotgering factor F 001 ∼98% were fabricated by templated grain growth technique. Strong [001] c -grain orientation ( f ∼90% and r ∼0.22) of the textured ceramics effectively produced about 230% enhanced piezoelectric coefficient d 33 * (i.e., S max / E max ) and substantially improved unipolar electrical fatigue resistance. Unipolar polarization P max and d 33 * of the textured ceramics were nearly maintained up to 10 6 unipolar cycles, while 19% and 14% degradations were respectively observed from randomly oriented counterparts. Especially, normalized d 33 * of the textured ceramics shows better unipolar fatigue resistance than those of piezoceramics reported previously. Much lower bipolar strain asymmetry γ s (∼4%) was observed from the textured samples fatigued after 10 6 unipolar cycles as compared to γ s ∼23% for randomly oriented counterparts. While charged defect accumulation model described the serious fatigue deteriorations in randomly oriented ceramics, the current work revealed that substantially enhanced unipolar fatigue resistance of the textured ceramics is mainly associated with the inherent fatigue anisotropy, weakened local bias fields owing to both enhanced domain mobility and lower defect density near grain boundaries/interfaces, and increased intrinsic contribution due to more tetragonal content. These superior characteristics suggest the great potential of textured ceramics for high-performance and robust actuator applications.
研究领域:
材料科学
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物理学
✓ 已验证
产品关联
DOI
高影响因子
Foodborne Pathogens and Disease
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2025
·
IF 1.9
Jinfeng Zhang,Wenkai Zhang,Longhui Yu,Qinru Yang,Wenjing Wang,Xinru Hu,Jingen Li,Guodong Zheng
This study aimed to explore the ameliorative effect of Millettia speciosa Champ. polysaccharides (MSP) on excessive exercise-induced fatigue (EF) mice. The physicochemical characterization and in vitro antioxidant activities were analyzed. The fatigue-related biochemical indexes were determined, and gut microbiota was analyzed by 16S rDNA sequencing. The results showed that MSP primarily consists of total carbohydrates, uronic acids, and proteins. It was mainly composed of glucose, arabinose, and galactose. Additionally, MSP showed good scavenging effects on free radicals. In the experiment of EF mice, MSP intervention effectively extended the pole-climbing and swimming time, significantly increased the levels of muscle and liver glycogen, blood glucose, adenosine triphosphate, glutathione peroxidase, and superoxide dismutase, while significantly decreased the levels of fatigue-related lactate dehydrogenase, creatine kinase, and urea nitrogen. Furthermore, MSP intervention reduced harmful bacteria (Helicobacter, Anaerotruncus, Erysipelatoclostridium, and Lachnospiraceae_FCS020_group), and enriched the beneficial bacteria (Lactobacillus, Alistipes, Ruminococcaceae, and Roseburia). Therefore, MSP may utilize the gut microbiota as a target to alleviate fatigue caused by excessive exercise.
研究领域:
植物学
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营养学
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微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Soft Matter
·
2013
·Vol. 9
·期 27
·6331-6337
·
IF 3.909
Jinlong Zhang,Ning Wang,Wenguang Liu,Xiaoli Zhao,William Lu
The need for high strength hydrogels in load bearing applications has motivated an effort to improve the mechanical properties of these soft and wet materials. However, hydrogels with high strength, excellent elasticity and fatigue resistance are rarely reported. In this study, we fabricated hydrogels with excellent comprehensive mechanical performances by copolymerization of 2-vinyl-4,6-diamino-1,3,5-triazine (VDT) and chain length modulable polyethylene glycol diacrylates (PEGDA). The intermolecular hydrogen bonding effects from diaminotriazine were shown to increase both the tensile and compressive strengths of the gels up to MPa levels, and longer PEG chains could increase the gel's elongation to over 700%. The stress-softening phenomenon did not appear until the VDT content in all the hydrogels was above 50 wt%. PEG35K-PVDT gel containing 93 wt% water was able to resist car pressing and retain excellent fatigue resistance during 20 000 cycles of compression due to hydrogen bonding reinforcing effect and effective energy dissipation of flexible polyethylene glycol chains. These high strength and elastic hydrogels with antifatigue ability may serve as soft tissue engineering scaffolds.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Weichen Wang,Yu Dai,Cuilin Cheng,Rongchun Wang,Jiapei Ma,Qiuju Jing
In this study, zein-gum Arabic (GA)-flaxseed gum (FG) nanoparticles (ZGF) were prepared using the anti-solvent and electrostatic deposition methods to overcome the hydrophobicity and instability of curcumin (CUR). Additionally, the optimal mass ratio of GA to FG (4:1) and CUR to zein (1:40) was determined. Additionally, the initial concentration of the polysaccharide (0.04 %) was determined and the ZGF nanoparticles encapsulated with CUR (CUR-ZGF) were optimized. The formed CUR-ZGF nanoparticles were spherical, with a particle size of 188 nm and an embedding rate of 96.8 %. Furthermore, the CUR-ZGF nanoparticles showed excellent pH, thermal, storage, and salt stability. The encapsulate CUR exhibited antioxidant capacity and controlled release rate in the gastrointestinal digestive system in vitro. Animal experiments showed CUR-ZGF nanoparticles significantly enhanced exercise capacity and anti-fatigue effects. High-dose CUR-ZGF nanoparticles doubled exhaustion running time versus the model group, improving exercise endurance. Fatigue-related biochemical parameters (serum urea nitrogen, serum lactate, and creatine kinase) were significantly reduced, indicating rapid fatigue elimination. Meanwhile, significantly increased lactate dehydrogenase and fasting glucose levels suggested efficient energy replenishment to mitigate fatigue damage. These results indicate CUR-ZGF nanoparticles may be a promising natural anti-fatigue healthcare product in the future.
研究领域:
食品科学
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生物医学工程
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营养学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2021
·Vol. 31
·期 10
·2009869
·
IF 18.808
Wu Bin Ying,Guyue Wang,Zhengyang Kong,Chen Kai Yao,Yubin Wang,Han Hu,Fenglong Li,Chao Chen,Ying Tian,Jiawei Zhang,Ruoyu Zhang,Jin Zhu
Polymeric elastomers play an increasingly important role in the development of stretchable electronics. A highly demanded elastic matrix is preferred to own not only excellent mechanical properties, but also additional features like high toughness and fast self-healing. Here, a polyurethane (DA-PU) is synthesized with donor and acceptor groups alternately distributed along the main chain to achieve both intra-chain and inter-chain donor-acceptor self-assembly, which endow the polyurethane with toughness, self-healing, and, more interestingly, thermal repair, like human muscle. In detail, DA-PU exhibits an amazing mechanical performance with elongation at break of 1900% and toughness of 175.9 MJ m −3 . Moreover, it shows remarkable anti-fatigue and anti-stress relaxation properties as manifested by cyclic tensile and stress relaxation tests, respectively. Even in case of large strain deformation or long-time stretch, it can almost completely restore to original length by thermal repair at 60 °C in 60 s. The self-healing speed of DA-PU is gradually enhanced with the increasing temperature, and can be 1.0–6.15 µm min −1 from 60 to 80 °C. At last, a stretchable and self-healable capacitive sensor is constructed and evaluated to prove that DA-PU matrix can ensure the stability of electronics even after critical deformation and cut off.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Ming Cai,Hua Zhu,Lei Xu,Jian Wang,Jing Xu,Zhenhao Li,Kai Yang,Jianyong Wu,Peilong Sun
This study was to investigate the antifatigue, prebiotic effects and their relationships to the structure properties of three ethanol precipitated polysaccharides from Dendrobium officinale (EPDO), as EPDO-40, EPDO-60 and EPDO-80. EPDOs with anti-fatigue activity were screened out by forced swimming test, and blood lactic acid (BLA), blood urea nitrogen (BUN), superoxide dismutase (SOD), liver glycogen, muscle glycogen, and intestinal microflora were investigated. Results showed that purified EPDO-60, 277.3 kDa, with a backbone consisted of 4-Man p and 4-Glc p . EPDO-60 had the best anti-fatigue activity, because it could significantly prolong the forced swimming time, as well as down-regulating the levels of BLA and BUN, increasing SOD. Proportions of Bacteroidetes and Firmicutes and abundance of Lactobacillus and Bifidobacterium in gut microflora increased after treated with EPDO-60. Accordingly, EPDO-60 could affect the community structure of gut microflora, leading to promote the balance of oxidation and antioxidation, and accelerated the fatigue metabolism in vivo .
研究领域:
食品科学
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营养学
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植物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
·
2021
·Vol. 57
·期 1
·78-91
·
IF 3.713
Xiangna Chang,Xuefeng Chen,Pin Gong,Wenjuan Yang,Lan Wang,Ning Liu,Yao Su,Yuanyuan Zhao
Summary The anti-fatigue effects and structure-activity relationship of apple polysaccharides (APPs), the active components in apple pomace, remain unknown. We examined the effects of different extraction methods on polysaccharide structures and anti-fatigue activities. Additionally, the structural and biochemical properties of APPs prepared under acidic (ACAPP) or alkaline (ALAPP) conditions, were characterised. ACAPP and ALAPP were acidic heteropolysaccharides primarily comprising arabinose, rhamnose, galactose, glucose, xylose and galacturonic acid. The molecular weights of ACAPP and ALAPP were 110 kDa and 89.6 kDa, respectively. ALAPP had more branched chains than ACAPP and showed stronger free radical-scavenging and anti-fatigue properties. The anti-fatigue properties of APPs correlated with their anti-oxidant activities and were exerted through eliminating free radicals and mediating an oxidative balance. The stronger anti-fatigue activity of ALAPP is probably related to its structural characteristics. Collectively, our study provides a fundamental basis for the development and use of APPs in medicine and functional foods.
研究领域:
食品科学
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生物化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）