Journal of Materials Chemistry C
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2017
·Vol. 5
·期 12
·3065-3071
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IF 5.256
Linzhong Wu,Jiaqi Yu,Lei Chen,Di Yang,Shumin Zhang,Lu Han,Muyang Ban,Le He,Yong Xu,Qiao Zhang
We report a general and fast approach that can transfer any hydrophobic nanocrystals into water within several seconds without vigorous stirring or ultrasonication treatment at room temperature. The key factor is to find a suitable solvent that can be soluble in both organic solvent and water using the classical “like dissolves like” rule. Hydrophobic nanocrystals covered with oleic acid, oleylamine, and TOPO have been successfully transferred into water. The second ligand could be any amphiphilic ligands, such as sodium oleate, decanoate, dopamine, CTAB, and so on. The surface charge could be tuned to negatively or positively charged by using different ligands. After phase transfer, the original properties, including the plasmonic, magnetic, catalytic, and fluorescence properties, of the nanocrystals are well retained.
研究领域:
纳米技术
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材料科学
·
化学
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Drug Design Development and Therapy
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2019
·
IF 3.208
Mahmoud M Omar,Nermin E Eleraky,Amani M El Sisi,Omiya Ali Hasan
Background Sumatriptan succinate (SUT) is a potent drug used for relieving or ending migraine and cluster headaches. SUT bioavailability is low (15%) when it is taken orally owing to its gastric breakdown and bloodstream before reaching the target arteries. Aim The aim of the study was to enhance SUT bioavailability through developing an intranasal transferosomal mucoadhesive gel. Methods SUT-loaded nanotransferosomes were prepared by thin film hydration method and characterized for various parameters such as vesicle diameter, percent entrapment efficiency (%EE), in vitro release and ex vivo permeation studies. The in-situ gels were prepared using various ratios of poloxamer 407, poloxamer 188, and carrageenan and characterized for gelation temperature, mucoadhesive strength, and rheological properties. Results The prepared transferosomes exhibited percent entrapment efficiencies (%EE) of 40.41±3.02 to 77.47±2.85%, mean diameters of 97.25 to 245.01 nm, sustained drug release over 6 hours, and acceptable ex vivo permeation findings. The optimum formulae were incorporated into poloxamer 407 and poloxamer 188-based thermosensitive in-situ gel using carrageenan as a mucoadhesive polymer. Pharmacokinetic evaluation showed that the prepared in-situ gel of SUT-loaded nano-transferosomes gave enhanced bioavailability, 4.09-fold, as compared to oral drug solution. Conclusion Based on enhancing the bioavailability and sustaining the drug release, it can be concluded that the in-situ gel of SUT-loaded nano-transferosomes were developed as a promising non-invasive drug delivery system for treating migraine.
研究领域:
药物学
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药物递送系统
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纳米技术
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药代动力学
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INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
·
2016
·
IF 1.451
Baogui Wang,Jing Fu,Lumin Li,Deming Gong,Xuefang Wen,Ping Yu,Zheling Zeng
Accumulation of lipids in the liver can lead to cell dysfunction and steatosis, an important factor in pathogenesis causing non-alcoholic fatty liver disease. The mechanisms related to lipid deposition in the liver, however, remain poorly understood. This study was aimed to investigate the effects of medium-chain fatty acid (MCFA) on the lipolysis and expression of lipid-sensing genes in human liver cells with steatosis. A cellular steatosis model, which is suitable to experimentally investigate the impact of fat accumulation in the liver, was established in human normal liver cells (LO2 cells) with a mixture of free fatty acids (oleate/palmitate, 2:1) at 200 μm for 24 h incubation. MCFA was found to down-regulate expression of liver X receptor-α, sterol regulatory element binding protein-1, acetyl-CoA carboxylase, fatty acid synthase, CD 36 and lipoprotein lipase in this cellular model, and have positive effects on adipose triglyceride lipase and hormone-sensitive lipase. These results suggest that MCFA may reduce lipid accumulation by regulating key lipid-sensing genes in human liver cells with steatosis.
研究领域:
肝病学
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分子生物学
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细胞生物学
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Food & Function
·
2025
·
IF 5.4
Yumeng Yang,Songyi Lin,Xinqi Du,Yuhao Qiu,Chunqing Ai,Yue Tang
This study introduced a novel physical strategy to reduce the digestibility and glycemic index of starch-based foods by modifying waxy corn flour (WC) with sodium fatty acids (NaFAs) of varying carbon chain lengths. The aim was to elucidate the impact of these modifications on the structural and digestive properties of WC. The synthesis of WC–NaFA complexes revealed a pronounced relationship between WC digestibility and NaFA carbon chain length. Specifically, the incorporation of sodium oleate (SO, C18) fostered robust intermolecular interactions, forming complex and ordered structures (B + V-type) through hydrogen bonding and hydrophobic forces. This modification increased the complexity index by 24.28% and branching degree by 12.03%, resulting in a substantial reduction in digestibility from 83.66% to 47.48%. To evaluate the physiological implications, the hypoglycemic and intestinal-microbiota-modulating impacts of WC modified by SO (WCO) were assessed in streptozotocin-induced C57BL/6J mice. The results showed significant improvements in type II diabetes symptoms, including reduced blood glucose levels, enhanced glucose tolerance, and decreased liver and pancreas inflammation. Additionally, WCO promoted the growth of beneficial bacteria, enhancing gut microbiota regulation. Collectively, these findings highlight the potential of WCO as a functional food ingredient for diabetes management and prevention.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
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2023
·
IF 4.3
Huihui Wang,Xiaojiao Zheng,Jiadong Wang,Shu Qin,Jindong Li,Yanli Qi,Xiaowen Wang,Xu Jing
The risk of the hazardous pesticide dichlorvos (DDVP) entering the human body through aquatic products is causing concern as global demand for aquatic products increases. Herein, a novel approach ground on switchable hydrophilicity solvent-based microextraction coupled with fluorescent detection of DDVP in aquatic products was established. Sodium nonanoate , a switchable hydrophilic solvent, was converted into nonanoic acid in-situ for use as an extractant under acidic conditions to extract DDVP from aquatic products. Thereafter, DDVP was hydrolyzed to dichloroacetaldehyde (DCA) by adjusting the extraction solution to an alkaline condition. The fluorescent substances were generated due to the condensation reaction of DCA and resorcinol which can achieve the quantification of DDVP. The assay had a linear relationship between 40 and 280 μg kg −1 , with a limit of detection of 2.4 μg kg −1 . The assay has been used to determine the residual content of DDVP in grass carp, sea cucumber, and abalone samples. The recoveries ranged from 93.8% to 106%. The strategy integrating microextraction and detection offers insight into monitoring pesticides in food products.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2022
·
IF 4.52
Haoyue Xue,Liyan Jia,Haijuan Jiang,Shu Qin,Yukun Yang,Junxue Wu,Xu Jing
A simple, efficient, and environmentally friendly method for the determination of pyrethroids and cadmium in drink samples was developed by successive homogeneous liquid-liquid microextraction (SHLLME) based on switchable hydrophilicity solvents and ionic liquids coupled with high-performance liquid chromatography-diode array detector (HPLC-DAD) and graphite furnace atomic absorption spectrometry (GFAAS) detection. The extraction of pyrethroids needs to be conducted under acidic conditions, while cadmium needs to be extracted under neutral or slightly alkaline conditions. In SHLLME, hydrophobic fatty acids and ionic liquids were generated in situ as extraction solvents for pyrethroids and cadmium, respectively. Acidic ionic liquids and sodium carbonate were successively applied to adjust the pH value of the sample solution. The SHLLME procedure was optimized by univariate analysis and the Box-Behnken response surface methodology . Optimum conditions were as follows: 105 mg of sodium decanoate , 246 mg of [Emim][HSO 4 ], 131 mg of sodium fluoroborate amount, and 128 mg of sodium carbonate. Under optimized conditions, the extraction recovery varied from 77.0% to 97.2%, and relative standard deviations varied from 0.5% to 4.5%. The limits of detection were 0.6 μg L −1 and 0.006 μg L −1 for pyrethroids and cadmium, respectively. This established method has the potential to continuously extract compounds with different physical and chemical properties.
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JOURNAL OF FOOD SCIENCE
·
2016
·Vol. 81
·期 3
·H794
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IF 1.649
Baogui Wang,Lumin Li,Jing Fu,Ping Yu,Deming Gong,Cheng Zeng,Zheling Zeng
Nonalcoholic fatty liver disease (NAFLD) is closely associated with obesity-related metabolic complications, which caused by excess energy intake and physical inactivity apart from genetic defects. The mechanisms that promote disease progression from NAFLD to further liver injury are still unclear. We hypothesize that the progression involved “2nd hit” is strongly influenced by the type of fatty acids in diets. Flow cytometric analysis showed that medium-chain fatty acid (MCFA) markedly decreased the percentage of late apoptotic and necrotic cells compared with long-chain fatty acid (LCFA), and MCFA inhibited the activities of caspase-3 and -9 in human liver cells with steatosis. Western blot analysis found that the levels of inflammatory markers (interleukin [IL]-6, IL-1-β, and tumor necrosis factor-α) were substantially reduced by MCFA compared with LCFA. Proteomic analysis further showed that LCFA inhibited the expression of antioxidant enzymes, and increased the expression of proteins associated with oxidative stress. It was found that LCFA (palmitate), not MCFA induced apoptosis, oxidative stress and chronic inflammatory responses in the hepatic cells with steatosis. In conclusion, reasonable selection of dietary fats has potential to translate therapeutically by ameliorating disease progression in patients with NAFLD.
研究领域:
肝病学
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营养学
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细胞生物学
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分子生物学
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Journal of Natural Gas Science and Engineering
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2021
·
IF 4.965
Xuejian Liu,Quan Cao,Dongyan Xu,Shengjun Luo,Rongbo Guo
The maximum methane storage capacity (MSC) is of critical importance of methane hydrate to store methane. This paper reports the effects of vesicle solutions, formed through combination of carboxylate surfactants with cationic quaternary ammonium salt including hydroxypropyl trimethyl ammonium chloride chitosan (HACC) or dodecyl trimethyl ammonium chloride (DTAC), on the formation of methane hydrate. It was found that vesicles could raise the maximum MSC of hydrate by about 10 (V/V, the volume of methane stored by one volume of hydrate) at appropriate anion and cation concentrations. For example, at 800 ppm (parts per million) of sodium laurate (SL) and 600 ppm of HACC concentrations, the formed vesicles could elevate the maximum capacity to 151 V/V, 5.3% higher than that of sodium laurate alone. The vesicles formed could increase the maximum MSC, from 136 V/V to 147 V/V by sodium oleate (SO) and HACC, 145 V/V to 153 V/V by sodium decanoate (SD) and HACC and 137 V/V to 149 V/V by SO and DTAC. The reason for the enhancement is that the large hydrophobic space of the vesicles could solubilize methane molecules and facilitate them to contact with water molecules.
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CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
·
2021
·
IF 1.134
Xu JING,Hao-Yue XUE,Xin HUANG,Hui-Yuan LI,Xiao-Wen WANG,Li-Yan JIA
A simple, efficient and environmentally-friendly pretreatment technique was proposed for determination of alkylphenols (4- tert -octylphenol, nonylphenol and octylphenol) in drink samples using high performance liquid chromatography-fluorescence detection. In this approach, the extractants in the form of (green) medium-chain fatty acids were generated in situ in the Pasteur pipette and extractant droplets dispersed by CO 2 generated by an effervescent reaction. A demulsifier was then used to break up the emulsion and induce phase separation, thus avoiding the need for a time-consuming centrifugation step. Finally, the floating extractant droplets were collected through solidification. Under optimal conditions, a good linearity was obtained in the concentration range from 0.1 μg/mL to 10 μg/mL, with determination coefficients ranging from 0.997 to 0.999. The extraction recoveries varied from 75.8% to 94.4% and the limits of quantification were in the range of 1.55–2.30 μg/L. The developed approach had good prospects in detection of alkylphenols in mineral water, tea drink, carbonated drink and Baijiu.
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JOURNAL OF MOLECULAR LIQUIDS
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2020
·
IF 5.065
Xu Jing,Xiaoyu Cheng,Wenfei Zhao,Huihui Wang,Xiaowen Wang
A method for the determination of triazine herbicides in water samples was established by magnetic effervescence tablet-assisted switchable hydrophilicity solvent-based liquid phase microextraction procedure (META-SHS-LPME) coupled with high-performance liquid chromatography with diode array detection. The magnetic effervescence tablet, composed of citric acid , sodium hexanoate, sodium bicarbonate, and Fe 3 O 4 nanoparticles , combined extractant generation, dispersion, and magnetic recovery into one step. Citric acid could react with sodium hexanoate and sodium bicarbonate to generate hexanoic acid and carbon dioxide in situ , respectively. Carbon dioxide bubbles assisted the eco-friendly extractant hexanoic acid to fully contact with target compounds. Fe 3 O 4 nanoparticles containing extractant and triazine herbicides were isolated from the sample solution using an external magnet. Good linearity was achieved in the range of 50–5000 ng mL −1 with a correlation coefficient greater than 0.997. The limit of detection was within 0.10–0.13 ng mL −1 . The extraction recovery of triazine herbicides were 81.4–96.7% in well, pond, and river waters. Overall, the proposed method was a simple, efficient, and eco-friendly analytical approach for determining triazine herbicide residues in water samples.
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Food Science & Nutrition
·
2020
·Vol. 8
·期 7
·3590-3601
·
IF 1.797
Jun Yang,Ting Peng,Jiyong Huang,Guohua Zhang,Jiaheng Xia,Maomao Ma,Danwen Deng,Deming Gong,Zheling Zeng
Drug-induced liver injury (DILI) is one of the common adverse effects of drug therapy, which is closely associated with oxidative stress, apoptosis, and inflammation response. Medium-chain fatty acids (MCFA) were reported to relieve inflammation and attenuate oxidative stress. However, little has been known about the hepatoprotective effects of MCFA in DILI. In the present study, acetaminophen (AP) and rifampicin (RFP) were used to establish DILI models in LO2 cells, and the cytoprotective effects of MCFA on hepatocellular injury were investigated. Results showed that the optimal condition for the DILI model was treatment with 10 mM AP or 600 µM RFP for 24 hr. LCFA treatment markedly reduced the cell viability and increased the activities of alanine aminotransferase, aspartate aminotransferase, and lactate dehydrogenase. Meanwhile, LCFA treatment aggravated cell apoptosis, mitochondrial dysfunction, and oxidative stress. The mRNA and protein expression levels of inflammatory cytokines (IL-1β and TNF-α) were significantly elevated by LCFA. In contrast, MCFA treatment did not significantly affect cell viability, apoptosis, oxidative, stress and inflammation, and it did not produce the detrimental effects on DILI models. Therefore, we proposed that MCFA may be more safe and suitable than LCFA as nutrition support or the selection of daily dietary oil and fat for the patients with DILI.
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