EUROPEAN POLYMER JOURNAL
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2024
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IF 5.8
Shi-Si Li,Jun-Lin Pan,Xi-Long Chen,Jing Xu,Zi-Long Li,Chunzu Cheng
Long-chain aliphatic polyesters are recognized as the most promising polyethylene mimics in that these materials show comparative physicochemical properties to polyolefins and own the unique merits of degradability and/or recyclability. Nevertheless, the application scenarios of these polymers are rather limited owing to the lack of functional groups. Herein, sulfur atoms are incorporated into the microstructures of long-chain aliphatic polyesters to decipher the variations of physicochemical properties upon replacing specific methylene units by thioether moieties and simultaneously impart polyethylene-like materials with functionalities. First of all, high molecular weight polyesters P1 - P4 and poly(β-thioester)s P5 - P8 were obtained via condensation polymerization and thiol-Michael polyaddition, respectively. As for phase transition behaviors, poly(β-thioester)s show inferior crystallization/melting temperatures and the corresponding enthalpy changes than their polyester counterparts, and a loosely packed crystalline structure should be responsible for such thermal property degradation. It is reasonable that replacing specific methylene units of long-chain aliphatic polyesters by sulfur atoms, the much bulkier functional entities, will definitely cause great disturbance to the regular arrangement of polymer chains. The rapid hydrolytic degradation of poly(β-thioester)s in acidic and alkaline media can be ascribed to the easy penetration of water molecules into their incompact amorphous/crystalline regions. In the meantime, these poly(β-thioester)s exhibit great prospects in noble metal recovery and information encryption (optical anticounterfeiting). For instance, poly(β-thioester) P5 is an excellent adsorbent to abstract gold ions from water due to its outstanding metal coordination capability. Moreover, poly(β-thioester) P5 emits bright blue photoluminescence in concentrated solution and solid state upon UV irradiation as a result of the clustering-triggered through space electron delocalization and rigidified polymer chain conformation.
研究领域:
材料科学
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环境科学
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化学工程
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产品关联
DOI
高影响因子
SYNTHESIS-STUTTGART
·
2024
·
IF 2.2
Taijie Guo,Wei Wang,Long Xu,Jiajia Dong
Here we report the utilization of NH-sulfamoyl fluorides (RNHSO2F) as reliable SuFEx synthons for the construction of various sulfamate esters. By using potassium fluoride as base, we are able to convert RNHSO2F to azasulfene intermediates under mild conditions and guarantee their further efficent ligation with phenols and alcohols.
研究领域:
有机化学
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合成化学
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DOI
高影响因子
NUCLEIC ACIDS RESEARCH
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2019
·Vol. 47
·期 22
·11514-11526
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IF 11.147
Jie Jialong,Xia Ye,Huang Chun-Hua,Zhao Hongmei,Yang Chunfan,Liu Kunhui,Song Di,Zhu Ben-Zhan,Su Hongmei
Phosphorothioate (PS) modifications naturally appear in bacteria and archaea genome and are widely used as antisense strategy in gene therapy. But the chemical effects of PS introduction as a redox active site into DNA (S-DNA) is still poorly understood. Herein, we perform time-resolved spectroscopy to examine the underlying mechanisms and dynamics of the PS oxidation by potent radicals in free model, in dinucleotide, and in S-oligomer. The crucial sulphur-centered hemi-bonded intermediates -P–S∴S–P- were observed and found to play critical roles leading to the stable adducts of -P–S–S–P-, which are backbone DNA lesion products. Moreover, the oxidation of the PS moiety in dinucleotides d[GPSG], d[APSA], d[GPSA], d[APSG] and in S-oligomers was monitored in real-time, showing that PS oxidation can compete with adenine but not with guanine. Significantly, hole transfer process from A+• to PS and concomitant -P–S∴S–P- formation was observed, demonstrating the base-to-backbone hole transfer unique to S-DNA, which is different from the normally adopted backbone-to-base hole transfer in native DNA. These findings reveal the distinct backbone lesion pathway brought by the PS modification and also imply an alternative -P–S∴S–P-/-P–S–S–P- pathway accounting for the interesting protective role of PS as an oxidation sacrifice in bacterial genome.
研究领域:
生物化学
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分子生物学
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基因治疗
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DOI
PubMed
高影响因子
ACS Sensors
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2024
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IF 8.2
Jiping Ni,Huan Wei,Wenliang Ji,Yifei Xue,Fenghui Zhu,Chunxia Wang,Ying Jiang,Lanqun Mao
Selective and nondisruptive in vivo neurochemical monitoring within the central nervous system has long been a challenging endeavor. We introduce a new sensing approach that integrates neurocompatible galvanic redox potentiometry (GRP) with customizable phosphorothioate aptamers to specifically probe dopamine (DA) dynamics in live rat brains. The aptamer-functionalized GRP (aptGRP) sensor demonstrates nanomolar sensitivity and over a 10-fold selectivity for DA, even amidst physiological levels of major interfering species. Notably, conventional sensors without the aptamer modification exhibit negligible reactivity to DA concentrations exceeding 20 μM. Critically, the aptGRP sensor operates without altering neuronal activity, thereby permitting real-time, concurrent recordings of both DA flux and electrical signaling in vivo. This breakthrough establishes aptGRP as a viable and promising framework for the development of high-fidelity sensors, offering novel insights into neurotransmission dynamics in a live setting.
研究领域:
神经科学
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生物医学工程
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分析化学
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生物技术
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）