ACTA MATERIALIA
·
2023
·
IF 9.4
Xudong Rong,Dongdong Zhao,Xiaofeng Chen,Xiang Zhang,Di Wan,Chunsheng Shi,Chunnian He,Naiqin Zhao
Dense intragranular distribution of nanoscale reinforcements is highly desirable since it is effective in reconciling the strength-ductility trade-off in Al matrix composites (AMCs). Herein, we report a systematic investigation on the work hardening and strain delocalization in Al-5 wt.% CuO (Al-5CuO) composite with strength-ductility synergy contributed by in-situ dense intragranular nanoscale Al 2 O 3 . Results reveal that Al-5CuO exhibits prominent hetero-deformation induced (HDI) strengthening as indicated by its larger HDI stress than effective stress. We showcase that the notable pile-ups of geometrically necessary dislocations (GNDs) at intragranular Al 2 O 3 result in the prevailing kinematic hardening. While the plastic relaxation dislocations (PRDs) around Al 2 O 3 generated by the release of GND-induced internal stress produce isotropic hardening. Both contribute to the pronounced work hardening of Al-5CuO. Comprehensive characterizations suggest the GND distribution with marked intragranular feature in Al-5CuO during straining, which implies the effective provoking of grain interior rather than grain boundary (GB)/interfacial zone to take plastic strain. On basis of the well-described storage and annihilation of GNDs and PRDs at the intragranular Al 2 O 3 , the microstructure-based strain-hardening model enables an in-depth understanding of the kinematic and isotropic hardening contributions by Al 2 O 3 in Al-5CuO. Systematic analysis further confirms the important roles of intragranular Al 2 O 3 in improving the strain partitioning, strain/stress transfer and strength matching across different domains of Al-5CuO, which significantly contributes to strain delocalization and hence strength-ductility synergy. This work sheds important insights on the innovative design of strong and ductile AMCs with intragranular nanoscale reinforcements for structural applications.
研究领域:
材料科学
·
机械工程
·
冶金学
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2024
·
IF 8.3
Tianyu Zhang,Yang Hong,Jingyang Li,Yang Li,Huiyang Zhao,Kai Cui,Wenjing Wei,Hongjun Kang,Jinzhu Wu,Wei Qin,Xiaohong Wu
The radiation resistance of Metal-Oxide-Semiconductor Field-Effect Transistors (MOSFETs) is of great significance when applied in aerospace. However, it is still challenging to obtain MOSFETs with excellent radiation resistance. In this work, the radiation hardened MOSFETs were realized by GdF 3 -Al 2 O 3 @Bi-Ti 3 C 2 T x /epoxy (MBAG/EP) polymer-based composite coating with function of trapped interfacial electrons. The radiation resistance of resultant packed MOSFET is significantly improved, showing the lower threshold voltage negative drift value (0.41 V) than the bare MOSFET (7.89 V). This is mainly attributed to the introduction of ultra-thin Al 2 O 3 intermediate layer between Bi and GdF 3 , which effectively tailor electron dense and distribution for an effective electron attenuation, and thus improve the radiation resistance of the MOSFET. Theoretical calculations further reveal that the packed MOSFETs present the less shifted voltage and trapped charges compared with the pristine one. This work provides an interface engineering strategy for developing radiation hardened MOSFETs.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 100
·56791-56797
·
IF 3.708
Yulin Cui,Mei Tan,Aidi Zhu,Mingyu Guo
Strain hardening and high resilience are two unique mechanical characteristics of many soft biological hydrogels. However, these properties, especially the strain hardening behaviour, are generally not seen in synthetic polymer hydrogels. Here, hydrogels are prepared by free-radical copolymerization of acrylamide and chain-extended vinyl-modified pseudo-polyrotaxane, which acts as a multifunctional crosslinker. The reactive pseudo-polyrotaxane is based on a β-cyclodextrin monomer and amine-terminated PEG–PPG–PEG (Pluronic F127). The obtained hydrogels can be stretched from 10 to more than 26 times their original length before breaking and withstand a compression strain of 95% and even 98% without fracture. Tensile stretching tests show obvious strain hardening behaviours in high stretching and compression deformation regimes. The strain hardening behaviour in stretching deformation is considered to be the orientation and aggregation of the movable crosslinkers along the axial polymer backbone. Moreover, the formation of a second supramolecular network due to the chain-extension effect may also be responsible for it. Highly resilient behaviours with almost no hysteresis and residual strains are also observed even with a maximum strain of λ = 12 because of the inherent freely movable character of the crosslinkers.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
MOLECULAR MEDICINE
·
2023
·Vol. 29
·期 1
·1-19
·
IF 5.7
Han Zhiyang,Hu Haidi,Yin MingZhu,Lin Yu,Yan Yan,Han Peng,Liu Bing,Jing Bao
Background Macrophage-like transformation of vascular smooth muscle cells (VSMCs) is a risk factor of atherosclerosis (AS) progression. Transcription factor homeobox A1 (HOXA1) plays functional roles in differentiation and development. This study aims to explore the role of HOXA1 in VSMC transformation, thereby providing evidence for the potential mechanism of AS pathogenesis.Methods High fat diet (HFD)-fed apolipoprotein E knockout (ApoE−/−) mice were applied as an in vivo model to imitate AS, while 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphocholine (POV-PC)-treated VSMCs were applied as an in vitro model. Recombinant adeno-associated-virus-1 (AAV-1) vectors that express short-hairpin RNAs targeting HOXA1, herein referred as AAV1-shHOXA1, were generated for the loss-of-function experiments throughout the study.Results In the aortic root of AS mice, lipid deposition was severer and HOXA1 expression was higher than the wide-type mice fed with normal diet or HFD. Silencing of HOXA1 inhibited the AS-induced weight gain, inflammatory response, serum and liver lipid metabolism disorder and atherosclerotic plaque formation. Besides, lesions from AS mice with HOXA1 knockdown showed less trans-differentiation of VSMCs to macrophage-like cells, along with a suppression of krüppel-like factor 4 (KLF4) and nuclear factor (NF)-κB RelA (p65) expression. In vitro experiments consistently confirmed that HOXA1 knockdown suppressed lipid accumulation, VSMC-to-macrophage phenotypic switch and inflammation in POV-PC-treated VSMCs. Mechanism investigations further illustrated that HOXA1 transcriptionally activated RelA and KLF4 to participate in the pathological manifestations of VSMCs.Conclusion sHOXA1 participates in AS progression by regulating VSMCs plasticity via regulation of NF-κB p65 and KLF4. HOXA1 has the potential to be a biomarker or therapeutic target for AS.
研究领域:
心血管疾病
·
分子生物学
·
病理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2020
·Vol. 12
·期 12
·2880
·
IF 3.426
Huifeng Zhang,Lu Zhang,Xu Chen,Yueqiong Wang,Fuchun Zhao,Mingchao Luo,Shuangquan Liao
Though the non-rubber components have long been recognized to be a vital factor affecting the network of natural rubber (NR), the authentic role of non-rubber components on the network during accelerated storage has not been fully illuminated. This work attempts to clarify the impact of non-rubber components on the network for NR during accelerated storage. A natural network model for NR was proposed based on the gel content, crosslinking density, and the non-rubber components distribution for NR before and after centrifugation. Furthermore, the effect of non-rubber components on the network was investigated during accelerated storage. The results show that terminal crosslinking induced by non-rubber components and entanglements are primary factors affecting the network formation during accelerated storage. By applying the tube model to analyze the stress-strain curves of NR, we found that the contribution of the entanglements to the network formation is larger than that of terminal crosslinking during accelerated storage. The work highlights the role of non-rubber components on the network during accelerated storage, which is essential for understanding the storage hardening mechanism of NR.Keywords:natural rubber;non-rubber components;network;storage hardening
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2024
·Vol. 16
·期 15
·2248-2255
·
IF 2.7
Xiaoling Fu,Fan Zhang,Fangda Zhen,Lian Duan,Jian Zhou,Jianguo Ma
Herein, a magnetic bead-based chemiluminescence assay is reported to detect type IV collagen (col-IV) in serum samples. Magnetic beads (MBs) exhibit biocompatibility. Taking advantage of this property, they were conjugated with the col-IV antibody. For the determination of col-IV, the interaction of the col-IV sample, anti-(col-IV)-alkaline phosphatase (anti-(col-IV)-ALP) and anti-col-IV-magnetic beads (anti-(col-IV)-MBs) was performed to generate chemiluminescence. Under the optimized conditions, the developed method displayed good linearity in the concentration range of 20–2000 ng mL−1 with the limit of 0.79 ng mL−1. The repeatability coefficient of variation (CV) for col-IV detection ranged from 3.16% to 7.50%. The col-IV level in samples collected from a hospital was assessed by the chemiluminescence assay. Satisfactory recoveries were obtained ranging from 93.30% to 100.14%. In conclusion, the magnetic bead-based chemiluminescence assay may be used as a routine and efficient tool to detect type IV collagen in clinical diagnosis.
研究领域:
医学诊断
·
免疫学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
·
2025
·
IF 3.3
Xiaoyu Wu,Chuanbo Ding,Xinglong Liu,Qiteng Ding,Shuai Zhang,Yue Wang,Ting Zhao,Wencong Liu
Carotid atherosclerosis (CAS) is a complex cardiovascular disease linked to inflammatory response and oxidative stress. This study aimed to develop and assess the therapeutic efficacy of Phlorizin liposomes (Phlorizin-Lips) in repairing CAS in rats. Phlorizin-Lips were prepared using the film dispersion method and evaluated for controlled release, antioxidant properties, and biocompatibility. The methodology included preparing Phlorizin-Lips, conducting in vitro and in vivo experiments, observing histopathological changes in carotid arteries in a rat model, and detecting inflammatory markers and antioxidant gene expression in arterial endothelial cells using immunoblotting and ELISA. Results showed that Phlorizin-Lips significantly lowered inflammatory markers TNF-α and IL-1β in endothelial cells while upregulating Nrf2 and its downstream antioxidant genes, enhancing the cells' antioxidant capacity and reducing oxidative damage by activating the Nrf2 signaling pathway. Additionally, Phlorizin-Lips reduced carotid plaque formation, improved vascular endothelial function, and promoted CAS repair. This study underscores Phlorizin's potential as a therapeutic agent for CAS and highlights the Nrf2 pathway's role in regulating inflammation and oxidative stress. Future research will explore the clinical potential of Phlorizin-Lips.
研究领域:
药理学
·
心血管病学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials
·
2024
·Vol. 17
·期 21
·5364
·
IF 3.1
Lihui Li,Kaiming Niu,Jianrui Ji,Panpan Zhang,Jilin Zhang
In order to impart the properties of cementitious material to the Tibetan Agar soil, two high-temperature activation mechanisms (HTMA, HTMB) were designed in this study, and the products and hydration-hardening properties of Tibetan Agar soil high-temperature activation mechanism were analyzed by means of SEM, XRD, and XRF. The results show that the main components of Tibetan Aga soil are calcite and quartz; Aga soil is activated by HTMA high-temperature activation, forming the main products of CaO, C2S, CaSiO3, and CaAl2Si2O8, and its products have both air-hardening and water-hardening characteristics; Aga soil is activated by HTMB high-temperature activation, and when the temperature reaches 1250 °C when the clinker is not found in the CaO, the generation of C2S, C3S, C3A, C4AF, and Mg2SiO4minerals with good water-hardening cementitious properties occurs when the temperature rises to 1350 °C, although the formation of some inert minerals that do not have the cementitious properties, but this temperature activation products of the thermodynamic properties of the best; Enhancing the value of lime saturation degree (KH) and silicon rate (SM) can promote the formation of the products of the C2S and C3S, increase the reactivity of the Aga soil activation products, and increase the hydration heat as well as compressive and flexural strength, combined with the results of the hydration heat and mechanical test, KH is recommended to be 0.9~0.94, SM is recommended to be 1.8~2.4, and alumina ratio (IM) is recommended to be 1.8~2.4 when Aga soil is used with raw materials.
研究领域:
材料科学
·
土木工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Research
·
2023
·
IF 9.9
Wu Guanghao,Mu Changwen,Zhao Qianru,Lei Yao,Cheng Ran,Nie Weidong,Qu Jiamin,Dong Yuping,Yang Ruili,Xie Haiyan
Atherosclerosis is the most common cause of cardiovascular diseases that contribute to the major morbidity worldwide, but still lacking of effective treatment strategy. Here, a hybrid cell is constructed for the sonodynamic effect promoted cell therapy of early atherosclerosis by fusing M2 macrophages with thylakoid (TK) membranes. After systemic administration, the obtained TK-M2 actively accumulates in the early atherosclerotic plaques, wherein M2 macrophages relieve the cholesterol accumulation and the inflammation in the foam cells. Meanwhile, the TK membranes decorated on the M2 macrophages exhibit both type I and type II sonodynamic effects under ultrasound (US) activation, inducing the direct apoptosis of foam cells. The cooperation of M2 and TK leads to significant outcome in eliminating atherosclerotic plaques without obvious side-effects, providing a new avenue for atherosclerosis treatment.
研究领域:
心血管疾病
·
细胞治疗
·
生物医学工程
·
超声治疗
✓ 已验证
DOI
高影响因子
Insect Science
·
2025
·
IF 3
Yi Ding,Yuntian Cui,Huijie Xie,Jinhui Liang,Huan Liu,Fenghou Yuan,Tian Liu
The mode of action of botanical pesticides is often complex. In this study, camptothecin (CPT), a plant-derived compound, was found to alter the mechanical properties of the cuticle in the lepidopteran pest, Ostrinia furnacalis . CPT treatment resulted in a thinner, distorted cuticle with significantly reduced pigmentation. Fourier transformed infrared spectroscopy indicated decreased tyrosine-mediated crosslinking and melanin formation, while metabolomics showed a significant reduction in N -acetyldopamine content, with no reduction in dopamine or related precursors. Despite a slight increase in laccase 2 transcript levels, laccase activity was significantly reduced in CPT-fed larvae, suggesting that CPT may inhibit laccase translation or zymogen activation. This reduction in laccase activity led to impaired sclerotization and pigmentation, producing a disordered cuticle with weakened mechanical properties. These findings provide new insights into the mode of action of botanical pesticides and their potential to regulate insect cuticle formation.
研究领域:
昆虫学
·
植物化学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Energy Materials
·
2025
·
IF 26
Shaowu Huang,Jiazhuan Qin,Xinmin Yu,Qiao Li,Jiahui Yu,Limin Wu,Chunfu Lin,Renchao Che
Doping/substitution, which leads to an increase in configurational entropy, is a widely used approach to strengthen the electrochemical properties of energy-storage materials. Nevertheless, the key factor behind the enhanced cycling stability after the entropy increase remains elusive. Herein, via selective dopings of TiNb 2 O 7 (TNO), an entropy-increased Ti 0.95 V 0.05 Zr 0.05 Nb 1.9 Ta 0.05 O 7 (TNO-0.05) anode material is exploited, and an intrinsic link between the entropy increase and capacity-retention enhancement is revealed through a systematical study of this new material. As the dopant amount increases, the full-width at half-maximum of the X-ray diffraction (XRD) peaks of doped TNO monotonically widens, and thus the lattice distortion becomes severe. Significant lattice distortion with up to 427% larger lattice strain is introduced in TNO-0.05. Although the unit-cell-volume expansion of TNO-0.05 after lithiation is not reduced, the increased particle hardness, which originates from the increased lattice strain, effectively hinders particle breakage during repeated lithiation–delithiation. Consequently, TNO-0.05 delivers significantly improved cycling stability, showing approximately twice the capacity retention of TNO with a large active-material loading of 4.5 mg cm −2 after 500 cycles at 1250 mA g −1 . Clearly, the material hardening caused by the lattice distortion can solve the structure-degradation problem in intercalation electrodes, undoubtedly promoting the exploitation of long-life energy-storage materials.
研究领域:
材料科学
·
电化学
·
能源存储
✓ 已验证
产品关联
DOI
高影响因子
Lipids in Health and Disease
·
2025
·Vol. 24
·期 1
·1-15
·
IF 4.2
An He,Cheng Dong-liang,Xia Xian-ru,Li Xian-dong,Ruan Zhi-hua,Peng Chun-yan
Background Dyslipidemia has been extensively documented as a key driver of cardiovascular pathology. Regulating lipid homeostasis holds promise for treating atherosclerosis (AS). Although the protein phosphatase 2 catalytic subunit beta (PPP2CB) is involved in post-transcriptional gene regulation, its role in AS-associated dyslipidemia is not well understood. Methods The study included both human participants and animal models. The following techniques were employed: cell culture, extraction of exosomes, preparation of pooled hyperlipidemic serum (HS), transfection, western blotting, immunofluorescence staining, quantitative reverse transcription polymerase chain reaction (qRT-PCR), co-immunoprecipitation, low-density lipoprotein cholesterol (LDL-C) uptake assay, biochemical assays, assessment of aortic atherosclerotic lesions, as well as statistical analysis. Results This study identified a marked upregulation of PPP2CB expression in peripheral blood leukocytes of AS patients, artery plaque of ApoE −/− mice given a high-fat diet, and hepatic cells exposed to hyperlipidemic stimuli. Overexpression of PPP2CB in hepatic cells exacerbated lipid accumulation and low-density lipoprotein uptake, whereas silencing PPP2CB mitigated this effect. Immunofluorescence co-localization and co-immunoprecipitation analysis confirmed a direct interaction between PPP2CB and lectin-like oxidized LDL receptor-1 (LOX-1). Notably, PPP2CB manipulation disrupted hyperlipidemia-induced LOX-1 expression. Additionally, PPP2CB-mediated lipid dysregulation was linked to the activation of the LOX-1/ mitogen-activated protein kinase (MAPK)/ extracellular signal-regulated kinase (ERK) signaling cascade. Conclusions These results unveil PPP2CB as a novel lipid regulator in the progression of pathological AS and highlight its involvement in signaling regulation during abnormal lipid metabolism. PPP2CB could be considered a promising candidate for biomarker development and therapeutic intervention in AS.
研究领域:
生物学
·
医学
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）