CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2021
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IF 1.134
Xiu QIN,Chun-Ling YUAN,Rui SHI,Shu-Zheng WANG,Yi-Lin WANG
A colorimetric analytical method, with wavelength change as a response, was developed for highly sensitive determination of dopamine (DA) based on gold nanorods (AuNRs). Even though AuNRs were unable to be etched by KIO 3 , however, they surrendered to I 2 generated from IO 3 - in the presence of DA. This could result in a blue shift of their absorption peak of longitudinal localized surface plasma resonance (LSPR), accompanied by obvious color change of solution from wine red to blue. Under the optimum conditions such as KIO 3 concentration of 0.7 mmol/L, reaction temperature at 50 °C, pH 2.6 and incubation time of 6 min, the amount of blue shift of AuNRs absorption wavelength was linear to DA concentration in the range of 0.80–60.0 μmol/L and the detection limit was 0.62 μmol/L (3σ/k). Furthermore, the common substances in urine did not interfere in the determination and the DA recovery rate in actual urine samples ranged from 103.0% to 110.8%.
研究领域:
分析化学
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纳米医学
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生物传感
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DOI
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2025
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IF 4.7
Bei Jiang,Jintao Jiang,Xinrui He,Yilei Zhu,Chao Guo
Accurate quantification of total antioxidant capacity (TAC) is crucial for evaluating the overall antioxidant activity in biological systems and food products. This is of growing importance in diverse applications such as health risk assessment and nutritional recommendations. Here, we introduce a novel Förster resonance energy transfer (FRET)-based sensor for the determination of TAC. The sensor utilizes an iodine-mediated FRET mechanism, employing BODIPY as the donor and Nile Red as the acceptor, both encapsulated within polystyrene (PS) microspheres. In the presence of iodine, its lipophilicity facilitates adsorption into the PS microspheres, resulting in fluorescence quenching due to the heavy-atom effect. This quenching results in an increased distance between the unquenched donors and acceptors, thereby decreasing FRET efficiency. Conversely, the presence of antioxidants reduces iodine concentration, which increases FRET efficiency. This dynamic allows for the development of a ratiometric fluorescence method for TAC determination. Critically, the sensor demonstrates exceptional photostability and resilience to variations in pH and ionic strength, contributing to its analytical robustness. The proposed method exhibits a linear response to ascorbic acid concentrations ranging from 0 to 50 μM, exhibiting good sensitivity (LOD = 2.5 μM) and selectivity. Additionally, the method has been successfully applied to evaluate TAC in ascorbic acid chewable tablets and lemon juice, demonstrating its potential as a robust and efficient tool for TAC determination.
研究领域:
分析化学
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生物医学工程
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DOI
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2020
·Vol. 412
·期 29
·8051-8059
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IF 3.637
Liu Bo-Wen,Huang Peng-Cheng,Wu Fang-Ying
A simple but efficient colorimetric assay was developed for the detection and quantification of acid phosphatase (ACP) using a smartphone. This strategy is based on target-controlled iodine-mediated etching of gold nanorods (AuNRs). Due to effective hydrolysis of the substrate pyrophosphate (PPi) by ACP, chelated Cu 2+ with PPi was released, which promoted the redox reaction with an iodide ion (I − ), leading to the formation of I 3 − . As the etching agent of AuNRs, I 3 − caused a blueshift of the localized surface plasmon resonance peak and, more importantly, an observable color change. The vivid colors were recorded with a smartphone camera and directly analyzed using an image-processing app. On the basis of the direct correlation between ACP concentration and the etching degree of AuNRs as well as color change, this smartphone nanocolorimetry technique showed a good linear response toward ACP over the range of 0–15.0 U/L, with a detection limit of 0.97 U/L. Using the standard addition method, the practical applicability of the proposed smartphone-based assay was successfully demonstrated by determining ACP in human serum samples, with results consistent with those obtained by UV-Vis spectrophotometry.
研究领域:
生物化学
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医学检验
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纳米技术
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2018
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IF 5.667
Xin Cheng,Yan Huang,Chao Yuan,Ke Dai,Hong Jiang,Jimei Ma
An ultrasensitive colorimetric method for α-glucosidase sensing based on iodine-mediated etching of gold nanorods (AuNRs) was developed. In this method, 2- O -α- d -glucopyranosyl- l -ascorbic acid (AA-2G) was used as an enzymatic substrate. The hydrolysate ascorbic acid in situ reduced KIO 3 to I 2 , which subsequently etched the AuNRs. A blue-shift of the localized surface plasmon resonance (LSPR) absorption of AuNRs was clearly observed by UV–vis spectroscopy and reflected with visual color changes. The shift showed a good linear relationship with the concentration of α-glucosidase during 2.5–45 U/L and a low α-glucosidase detection limit of 0.5 U/L was provided. This strategy was featured with low cost, simplicity, excellent sensitivity, high selectivity and successfully applied in the α-glucosidase inhibitor screening with Chinese Wolfberries as candidates.
研究领域:
生物化学
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医学诊断
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药物筛选
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DOI
高影响因子
ADVANCED SYNTHESIS & CATALYSIS
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2016
·Vol. 358
·期 17
·2759-2766
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IF 6.453
Zhigang Lv,Jing Liu,Wei Wei,Jie Wu,Wenquan Yu,Junbiao Chang
An intramolecular aryl C−H amination reaction has been achieved using molecular iodine as the sole oxidant for the synthesis of benzimidazole derivatives. The required substrates were readily prepared by addition or coupling of arylamines with the corresponding nitriles or aryl iodides. Iodine-mediated oxidative cyclization of these substrates in the presence of potassium carbonate (K 2 CO 3 ) as base afforded the corresponding products in moderate to good yields. The transition metal-free protocol presented here is insensitive to air and operationally simple. This versatile and eco-friendly synthetic methodology is broadly applicable to a variety of N -aryl-substituted amidines and pyridin-2-amines, and provides direct access to both 1 H -benzo[ d ]imidazole and pyrido[1,2- a ]benzimidazole derivatives from the corresponding precursors.
研究领域:
有机化学
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药物化学
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DOI
高影响因子
CHEMISTRY & BIODIVERSITY
·
2019
·Vol. 17
·期 2
·e1900570
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IF 1.449
Hongyu Xu,Ao Jia,Enhua Hou,Zhiyan Liu,Rui Yang,Ruige Yang,Yong Guo
A series of sarisan analogs containing 1,3,4-oxadiazole moieties were synthesized by iodine-mediated oxidative cyclization and screened in vitro for their antifungal activities at 50 μg/mL against five phytopathogenic fungi such as Valsa mali , Curvularia lunata , Alternaria alternate , Fusarium solani and Fusarium graminearum . 1,3,4-Oxadiazole derivatives 7e , 7p , 7r , 7t and 7u exhibited potent and a broad spectrum of antifungal activities against at least three phytopathogenic fungi at the concentration of 50 μg/mL. Especially, compound 7r displayed more potent antifungal activities against five phytopathogenic fungi than the positive control hymexazol. The EC 50 of 7r against V. mali , C. lunata and A. alternate were 12.6, 14.5 and 17.0 μg/mL, respectively. Additionally, some interesting results of structure-activity relationships (SARs) were also observed.
研究领域:
药物化学
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植物病理学
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有机合成
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL SCIENCES
·
2023
·Vol. 39
·期 6
·935-943
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IF 1.6
Wang Jingyu,Cui Yunyi,Lin Ying,He Yi
Abstract A long-standing challenge in colorimetric detection of triacetone triperoxide (TATP) explosive is low sensitivity. We herein developed an iodine-mediated photoinduced auto-inductive tandem chromogenic system to achieve exponential signal amplification. The strategy employs the KI-TATP reaction and photo-induced autocatalytical oxidation of o-phenylenediamine (OPD) that work in tandem. The resulting I 3 − from the KI-TATP reaction oxidizes OPD to yellow 2,3-diaminophenazine (DAP) that is further excited by blue light illumination to produce reactive oxygen species (ROS). The obtained ROS, in turn, promotes the oxidation of OPD to gain more DAP, causing the auto-inductive chromogenic reaction processes. This tandem chromogenic system is applied for visual colorimetric detection of TATP, allowing the selective and sensitive detection of TATP down to 42.8 μM. Moreover, analyses of TATP in real samples are performed, and the satisfactory recovery results are achieved. Furthermore, a field detection kit is also developed. Graphical abstract
研究领域:
分析化学
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爆炸物检测
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光化学
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比色传感器
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产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
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2020
·Vol. 11
·期 47
·7497-7505
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IF 5.342
Jiannan Cheng,Kai Tu,Enjie He,Jinying Wang,Lifen Zhang,Zhenping Cheng,Xiulin Zhu
A new photocontrolled iodine-mediated reversible-deactivation radical polymerization (RDRP) strategy to facilely prepare main-chain-type semifluorinated alternating block copolymers was successfully established under irradiation with blue LED light at room temperature, by using a semifluorinated alternating copolymer ((AB)n, where A represents α,ω-diiodoperfluoroalkane and B represents α,ω-unconjugated diene) as a macroinitiator and chain-transfer agent, and methacrylates, acrylates and styrene as the monomers. The end group of (AB)n terminated with perfluoroalkyl iodide –(CF2)n–I can be activated by Ru(bpy)3Cl2/AsAc-Na reducing quenching catalytic cycle which generates initial carbon centered radicals (–(CF2)n˙) to initiate the polymerization under blue LED light irradiation. The polymerization can reach a reversible equilibrium through effective oxygen–iodine halogen bonding in acetone and undergo a photocontrolled iodine-mediated RDRP process. In addition, the “living” features of this photocontrolled iodine-mediated RDRP system were confirmed by polymerization kinetics and controlled “on–off” light switching cycle regulation. What's more, different types of fluoropolymers can be introduced on the copolymer chains due to the powerful designability of (AB)n. Therefore, this strategy can provide a facile and highly efficient approach to the precision synthesis of main-chain-type semifluorinated alternating di/triblock polymers under visible light irradiation.
研究领域:
高分子化学
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材料科学
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光化学
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有机化学
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DOI
高影响因子
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