MICROCHEMICAL JOURNAL
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2025
·
IF 5.1
Wangui Peng,Minmin Gao,Wanzhen Xu,Weihong Huang,Wenming Yang
The widespread use of antibiotics in agriculture and livestock has resulted in the accumulation of environmental residues, raising significant global concerns. Consequently, the development of efficient and selective methods for detecting and isolating these compounds has become a major area of scientific focus. In response to this challenge, we present a photo-magnetic dual responsive molecularly imprinted polymer (DR-MIPs) as a novel and effective solution for the selective detection of sulfamerazine (SMZ). By utilizing the photoisomerization reaction, DR-MIPs enable reversible adsorption and release of SMZ under alternating irradiation of 365 nm and 430 nm, exhibiting excellent adsorption capacity (0.094 mmolL −1 ), high selectivity, and repeatability. Characterization using BET, FTIR, and other techniques confirmed the favorable physicochemical properties of the material, such as its microporous structure and photoresponsive behavior. This work offers a practical technical approach for the efficient separation and detection of SMZ, paving the way for broader applications of modern analytical chemistry techniques.
研究领域:
环境科学
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分析化学
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Jilan Long,Guangliang Zhou,Xiaomeng Yu,Jiayun Xu,Liqiu Hu,Andrey Pranovich,Qiwen Yong,Zhi-Hui Xie,Chunlin Xu
This study reports a pH/magnetic dual-responsive hemicellulose-based nanocomposite hydrogel with nearly 100 % carbohydrate polymer-based and biodegradable polymer compositions for drug delivery. We synthesized pure Fe 3 O 4 magnetic nanoparticles (Fe 3 O 4 MNPs) using a co-precipitation method, then engineering xylan hemicellulose (XH), acrylic acid, poly(ethylene glycol) diacrylate, and Fe 3 O 4 to synthesize the pH/magnetic dual-responsive hydrogel (Fe 3 O 4 @XH-Gel), through graft polymerization on XH with in - situ doping Fe 3 O 4 MNPs initiated by the ammonium persulfate/tetramethylethylenediamine redox system. Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance ( 1 H NMR), X-ray diffractometry (XRD), scanning electron microscopy and energy dispersive spectrometer (SEM-EDS), high-resolution transmission electron microscopy (HRTEM), Brunauer-Emmett-Teller (BET), swelling gravimetric analysis, vibrating sample magnetometer (VSM) were employed to analyze the hydrogel's chemical structures, morphologies, pH-responsive behaviors, and magnetic responsiveness characteristics, mechanical and rheological properties, as well as cytotoxicity and biodegradability. The results indicate that the Fe 3 O 4 @XH-Gel exhibited excellent dual responsiveness to pH and magnetism. Furthermore, an emphasis was placed on the in-depth analysis of the pH response mechanism. Finally, we utilized this cutting-edge hydrogel to investigate the controlled-release behavior of two model drugs, Acetylsalicylic acid and Theophylline . The hydrogel demonstrated exceptional controlled release attributes, positioning it as a potential carrier for targeted drug delivery, particularly to the gastrointestinal conditions.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2019
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IF 8.355
Xiaoyu Xie,Qi Hu,Ruifang Ke,Xueyan Zhen,Yusi Bu,Sicen Wang
Stimulated response molecularly imprinted polymers (MIPs) have attracted wide attention not only because of their intriguing response to external stimuli, but also due to the desired molecular recognition ability. Herein, a novel dual responsive proteins MIPs with both photonic and magnetic stimuli has been developed by surface imprinting polymerization, where double bonds modified Fe 3 O 4 nanoparticles, a water-soluble azobenzene containing 4-[(4-methacryloyloxy)phenylazo]benzenesulfonic acid and bovine hemoglobin (BHb) were used as magnetic core, photoswitchable functional monomer and template protein, respectively. The resultant MIPs possessed a typical spherical structure with a relative rough imprinted layer of 15 nm thickness. Moreover, the MIPs had good binding behavior toward BHb with fast binding kinetics, high adsorption capacity and satisfactory selectivity. The MIPs were proved to be well photo-controlled toward the template protein BHb under the alternating irradiation of 365 and 440 nm: 31.4% BHb was released from the MIPs at 365 nm and 67.2% BHb was bound into the MIPs at 440 nm. As a result, the MIPs were successfully applied to specifically extract template protein from actual biological sample. As a consequence, combining photocontrolled release and uptake, rapidly magnetic separation and specific recognition, the resultant MIPs with photonic and magnetic dual responsive abilities show significant advantages in the enrichment of trace protein in biological samples.
研究领域:
纳米技术
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生物材料
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分析化学
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生物技术
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DOI
高影响因子
ADVANCED MATERIALS
·
2024
·Vol. 36
·期 31
·2405547
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IF 27.4
Jiangnan Hu,Zhenglong Lian,Zhenzhen Weng,Zihao Xu,Jie Gao,Yuanyuan Liu,Tao Luo,Xiaolei Wang
Restricted by synaptic plasticity, dopamine receptor (DR) upregulation takes a long time to work. Moreover, the impact of the blood–brain barrier (BBB) on delivery efficiency restricts the development of drugs. Taking inspiration from snuff bottles, a convenient, fast-acting, and nonaddictive nasal drug delivery system has been developed to rapidly reshape the balance of synaptic transmitters. This optical and magnetic response system called CFs@DP, comprised of carbonized MIL-100 (Fe) frameworks (CFs) and domperidone (DP), which can enter the brain via nasal administration. Under dual stimulation of near-infrared (NIR) irradiation and catecholamine-induced complexation, CFs@DP disintegrates to release iron ions and DP, causing upregulation of the dopamine type 1 (D 1 ), type 2 (D 2 ) receptors, and brain-derived neurotrophic factor (BDNF) to achieve a therapeutic effect. In vivo experiments demonstrate that the DR density of mice (postnatal day 50–60) increased in the prefrontal cortex (PFC) and the hippocampus (HPC) after 10 days of therapy, resulting in antidepressant-like and cognitive enhancement effects. Interestingly, the cognitive enhancement effect of CFs@DP is even working in noniron deficiency (normal fed) mice, making it a promising candidate for application in enhancing learning ability.
研究领域:
神经科学
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药学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
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