Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Tingyue Gong,Minghuo Wu,Shuo Liu,Yufeng Hu,Yiwen Zhang,Hao Zhou
The generation of high-valent cobalt-oxo species Co(IV)=O for the removal of organic pollutants has been challenging due to the low conversion efficiency of Co(III)/Co(II) and the high activation energy barrier of Co(II)-oxidant complexes. Here, we introduced oxygen vacancies into the material by incorporating Co(OH) 2 with chitosan to achieve a nano-complex Co(OH) 2 @CS, which was applied in the activation of peracetic acid (PAA) as oxygen vacancies could optimize the Co 3d orbital, improve the electron distribution in Co(OH) 2 , and accelerate activation of PAA. The reactive species were characterized by reactive oxygen species quenching, phenylmethylsulfoxide probing, and electron paramagnetic resonance (EPR), and the results confirmed that the Co(IV)=O was the predominant substance for the degradation process. After a systematical investigation of the reaction conditions, complete degradation of 4 typical SAs (10 mg/L) was achieved in 8 min. In addition, the system showed remarkable resistance towards inorganic (Cl - , H 2 PO 4 - and NO 3 - ) and organic compounds (humic acid) in real water (pond water and seawater). The degradation products/intermediates from sulfamethoxazole (SMX) were identified using liquid chromatography-high resolution tandem mass spectrometry, and the toxicity of these products was investigated by computational toxicology. It was found that the toxicity of most products was lower than their precursor SMX in terms of acute (all) and chronic toxicity (6 out of 7), indicating that this Co(OH) 2 @CS/PAA system was an environment-friendly approach for the treatment of SAs-containing wastewater.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Zhihui Wu,Xiangzhi Li,Yucong Ma,Fangze Qin,Haoyang He,Hongbin Pu,Shi Gang Liu
Aflatoxin B1 (AFB1) contamination in foods threatens human health worldwide, and accurate and rapid detection of AFB1 is essential. Herein, a surface-enhanced Raman scattering (SERS) and fluorescence dual-mode aptasensor is constructed for sensitive detection of AFB1 based on ZnFe 2 O 4 magnetic nanoparticle@gold nanoparticles-silver shell nanostructures (MNP@AuNPs-Ag) and fluorescent N-doped carbon dots (N-CDs). Specifically, Raman beacon molecule cyanine 3-modified aptamer (Apt-Cy3) is coupled on the MNP@AuNPs-Ag surface, and complementary DNA (cDNA) is modified on the N-CDs surface (N-CDs-cDNA). In the absence of AFB1, thanks to the DNA hybridization, low fluorescence for the supernatant and low SERS for the precipitate appear after magnetic separation. However, in the presence of AFB1, most of N-CDs-cDNA are free as the aptamer preferentially binds to AFB1, resulting in a strong fluorescent signal in the supernatant, while the change in the secondary structure of the aptamer shortens the spatial distance between Cy3 and MNP@AuNPs-Ag, producing a strong SERS signal. Based on the principle, the dual-mode aptasensor is developed and quantifies AFB1 using SERS and fluorescence signals with the low detection limits of 0.88 and 9.74 pg/mL, respectively. What's more, the dual-mode aptasensor is applied to the detection of AFB1 in real food samples successfully. This work exploits magnetic plasmonic core-shell nanostructures and fluorescent N-CDs to obtain fluorescence and SERS signals from the supernatant and the precipitate respectively after magnetic separation. The strategy not only provides a robust method for detection of AFB1 but also offers new insights for the design of dual-mode aptasensor.
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JOURNAL OF FLUORESCENCE
·
2024
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IF 2.6
Wang Xuefeng,Mejia Esteban,Zuo Yujing,Lv Zhiyan,Wang Zonghua
The development of fluorescent probes for H 2 S detection especially in living cells is of great significance due to its fundamental role as signal molecule. A promising scaffold for the development of such probes is polydimethylsiloxanes (PDMS), which is cost-effectiveness, non-toxicity, flexibility, and biocompatibility and easy to post-functionalize. Surprisingly, fluorescent probes for H 2 S detection based on PDMS have not been investigated. Moreover, 4-nitro − 2,1,3-benzoxadiazole (NBD) derivates provides high fluorescence quantum yield, a large molar absorption coefficient, and sensitivity to environmental changes. Through reasonable design and adjustment of substituents on the NBD group, precise control of its fluorescence properties can be achieved. Herein, a novel H 2 S fluorescent probe, P-NBD, was designed and synthesized by a one-step aromatic ring nucleophilic substitution of Cl-NBD with a PDMS derivative. Due to the occurrence of the cleavage reaction strategy and the intramolecular charge transfer process, P-NBD can detect H 2 S via a colorimetric method. The limit of detection is down to 93 nM. P-NBD demonstrated considerable detection capability comparable to other reported types of H 2 S probes. Moreover, the probe can also be utilized for H 2 S imaging in HeLa cells. This work provides new insights into the design and synthesis of novel H 2 S probes while also offering experimental evidence for the application of PDMS in cellular imaging.
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Nature Communications
·
2026
·
IF 18.1
Wu Jing,Yang Jingying,Liu Qisijing,Zhang Pixian,Zheng Bowen,Liu Linyuan,An Tingtao,Wang Hao,Xu Fupei,Shen Yudi,Wang Shuo
Characterizing exercise-induced fatigue is challenging due to difficulties in monitoring biochemical and electrophysiological signals consistently. While wearable sensors able to monitor both signals are available, they struggle to maintain stable signal acquisition across exercise-rest scenarios because of significant sweat variation. Here we describe the development of a system, FatigueVisual, combining an adaptive sweat-regulating hybrid electronic textile (e-ASRHT) patch with artificial intelligence (AI) analytics to improve fatigue management. The key innovation lies in the precise regulation of the breakthrough pressure of micropores in fabric electrodes and sweat-excreting areas, allowing for accurate sweat management. This design enables efficient enrichment at an ultralow sweat rate (5.0×10 −4 ml cm −2 min −1 ) while rapidly transporting excess sweat at a rate 2533 times the human physiological limit, ensuring stable chemical-electrophysiological sensing from exercise to rest. A cloud-connected AI model, trained on over 200,000 time-resolved observations collected from 10 participants, recognizes six fatigue-related states and provides personalized exercise management via a mobile app. Validation in three participants showed 87.3% agreement with clinical assessments. The system reduced exercise fatigue by 51.8% and accelerated recovery by 48 h compared with the control group. In practice, FatigueVisual may enable intelligent sports health management.
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TALANTA
·
2026
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IF 6.7
Ximing Zeng,Shaohua He,Hua Nian,Ming Zong,Duo Lin
Influenza is currently one of the most prevalent respiratory diseases in humans, with outbreaks typically occurring during the winter months. Its impact is particularly pronounced among vulnerable populations, such as the elderly, infants, and individuals with chronic illnesses. Common methods including reverse transcription polymerase chain reaction (RT-PCR), rapid influenza diagnostic tests (RIDTs), and direct fluorescent antibody (DFA) assays for detecting influenza viruses have their own limitations and struggle to meet the point-of-care testing (POCT) demands during influenza pandemics. In this study, a surface-enhanced Raman spectroscopy (SERS) sensor chip based on the immunosandwich principle was developed for the rapid detection of influenza A and B viruses. Using a portable Raman spectrometer, viral antigen detection can be completed within 20 min, with a detection limit as low as 0.69 ng/mL. This provides a new approach for the rapid screening and dynamic monitoring of influenza viruses.
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ACS Applied Polymer Materials
·
2026
·Vol. 8
·期 14
·11602-11617
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IF 5.2
Xu Yue,Du Yanwei,Liang Jingshi,Ding Xiaochu,Zhang Chunling,Zhang Zhihui,Liu Bo
Endogenous signaling molecules are essential for coordinated
wound
healing, yet current donor-based dressings typically provide only
single-mediator delivery with limited release duration. Here, a multifunctional
hydrogel dressing, HEVCTM, is developed by free radical copolymerization
of N -hydroxyethyl acrylamide (HEAA) with a hydrogen
peroxide (H 2 O 2 ) releasing donor (VIM-CAT) and
a hydrogen sulfide (H 2 S) releasing donor (TBA-MA). The
hydrogel enables temporally programmed release, with rapid H 2 O 2 delivery within 24 h for early stage antibacterial
action and sustained H 2 S release for up to 7 days to alleviate
inflammation and promote angiogenesis during later healing stages.
HEVCTM exhibits potent antibacterial activity against Escherichia coli (99.6%) and Staphylococcus aureus (99.97%), significantly enhances macrophage
M2 polarization (52.4%), and shows favorable antioxidant, hemostatic,
adhesive, and pro-angiogenic properties. Moreover, in an infected
mouse wound model, HEVCTM significantly accelerated wound healing
and promoted tissue regeneration. This work provides a bioactive hydrogel
platform that matches the dynamic requirements of wound healing and
effectively accelerates tissue repair.
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Journal of Bioresources and Bioproducts
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2026
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IF 19.9
Yusi Bu,Guoxi Xia,Minglei Zhang,Jiabo Wang,Qiuhua Chen,Guoxiang Wang,Xiaolian Shi,Fang Sui
The development of robust biomimetic interfaces remains challenging due to the inherent instability of native cell membranes when integrated into functional devices. Herein, we reported a bio-based functional composite in which a chitosan-derived conductive hydrogel served as a multifunctional matrix to achieve unprecedented stabilization of red blood cell membranes (RBCMs). Leveraging the three-dimensional polycationic network and abundant amino groups of this natural polysaccharide, the hydrogel electrostatically anchored RBCMs while preserving their native fluidity and membrane-bound acetylcholinesterase conformation-overcoming a long-standing bottleneck in biomembrane-based material engineering. Integration of carboxylated multi-walled carbon nanotubes endowed the composite with efficient electron transfer capability without compromising biocompatibility. The resulting biomimetic interface retained 85.8% of its initial electrochemical response after 7 days of continuous operation and enabled sensitive detection of organophosphate pesticides in real agricultural samples (apples, oranges, and tomatoes). This work established chitosan hydrogel as a versatile bio-based platform for constructing stable biomembrane composites, expanding the application scope of natural polysaccharides in functional material design for environmental monitoring.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2026
·
IF 3.1
Jing Chen,Shuman Zhang,Youliang Cheng,Changqing Fang,Yang Wang,Jinyang Chen,Yiting Han,Xiaoqian Yan
Antibacterial packaging is crucial for food safety. Polylactic acid (PLA) lacks antimicrobial activity, and the use of additives like imidazolium salts is constrained by the conflict between efficacy requiring migration and safety risks from excess migration. This study developed PLA films functionalized with 1-allyl-3-alkylimidazolium ionic liquids (AIMC, C8-C16). Alkyl chain length of C12 combined with a loading not exceeding 15 wt% is identified as the optimal formulation strategy that simultaneously achieves mechanical integrity, antibacterial efficacy, and biological safety. At this formulation, the composite film exhibits balanced tensile properties (36.68 MPa at 10 wt% AIMC12) and cell viability above the 70% cytotoxicity threshold (up to 78.59% at 10 wt% and 70.94% at 15 wt%). Antibacterial activity is dose-dependent, with higher loadings producing larger inhibition zones against E. coli (4.260 cm at 20 wt%) and S. aureus (2.660 cm at 20 wt%), but the 20 wt% loading compromises biocompatibility (cell viability = 43.29%). AIMC migration into food simulants was temperature- and polarity-dependent, with the fastest release in the initial 4 h (83.98%–87.58% of total). This work establishes a design principle for PLA-based active packaging, where a C12 chain with controlled loading (≤ 15 wt%) enables effective antimicrobial function, mechanical performance, and biological safety.
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TALANTA
·
2026
·
IF 6.7
Zifeng Wang,Cong Dai
The dual-channel fluorescent sensing of hydroxyl radicals (·OH) is of great importance for environment and life. Organic cage for fluorescence sensing suffers from short excitation/emission wavelength and poor water solubility, while the application of carbon quantum dots is also hindered by the time-consuming preparation in high pressure and temperature conditions. Herein, we report a red emitted carbon dots derived from cationic organic cage for dual-channel fluorescent sensing of ·OH. The abundant flexible methylene within the cationic organic cage leads to remarkable collapse of intrinsic cavity. The ring-opening of imidazole structure occurs via redox reaction at acidic condition, resulting in the simple formation of carbon dots with the emission at 640 nm. Under acidic conditions, the ·OH generated via Fenton reaction exhibits strong affinity toward the prepared carbon dots. The mild oxidation at pH 1 significantly enhances the fluorescence, whereas the severe oxidative degradation at pH 6 leads to obvious fluorescence quenching. Based on the mutual verification of dual signals, a dual-channel fluorescent sensing method is established for ·OH in environmental samples and biological fluids. The sensing at pH 6 and 1 respectively achieves the linearity range of 1-50 and 5-50 μM, the limit of detection of 7.3 and 11.8 nM, and the relative standard deviation of 0.76% and 0.83% for 10 replicate analysis. The proposed method gives the recoveries of spiked ·OH ranged from 97.3% to 103.4% in real samples, demonstrating excellent accuracy and reliability. This study underscores the promising application potential of organic cage and carbon dots in fluorescent sensing. Furthermore, combined with Fenton reaction, the proposed dual-channel sensing platform can also be utilized to the detection of hazardous substances or biomarkers capable of H 2 O 2 generation.
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TALANTA
·
2026
·
IF 6.7
Wangyu Nan,Qingdan Ye,Jie huang,Pei Liang,Qianmin Dong,Kun Pang,Zihong Ye,Kai Sun,Yufeng Wang
In this study, we developed an aptamer-mediated surface-enhanced Raman scattering (SERS)-coupled immunochromatographic assay (ICA) for the quantitative detection of pyrethroids. For this approach, core-shell gold nanoparticles (Au@Au NPs) were used as SERS probes by conjugating with aptamers, and fluorescent Raman reporter molecules (MPBN) were incorporated to yield stable, reproducible spectral signals. Leveraging the aptamers' specific recognition of the target analyte, Raman-labeled Au@Au NPs could be effectively captured by the test line of the immunochromatographic strip, thereby enabling the quantitative analysis of fenvalerate-with a limit of detection (LOD) as low as 0.4 ppb. Comparative experiments revealed that the detection sensitivity of this SERS-ICA method was 476 times higher than that of conventional lateral flow assays (LFA), showcasing a remarkable sensitivity advantage. To validate its practicality, spiked recovery experiments were conducted on three real samples, namely welsh onions, cowpeas, and kidney beans. The results showed that the spiked recoveries ranged from 78.3% to 112.5%, with relative standard deviations (RSD) between 1.7% and 20.1%. This fully confirms that the method possesses favorable specificity and accuracy, making it suitable for real-sample detection. This detection platform offers a new technical route for the rapid on-site monitoring of trace contaminants in food safety and environmental surveillance, holding broad application prospects.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Ziyi Yang,Yihang Li,Guanxia Qiu,Qi Xu,Zhen Wu,Xiuhua Zhang,Shengfu Wang,Wei Wen
An antifouling nanosensor was constructed with a thin-layer hydrogel interface for effectively resisting non-specific adsorption. • Gel/Pt/CFE achieved ultrasensitive and accurate detection of H 2 O 2 with a low LOD of 1.093 μM. • The nanosensing platform enabled spatiotemporal-resolution monitoring of H 2 O 2 levels in PC-12 cells at the single-cell level. Accurate detection of endogenous hydrogen peroxide (H 2 O 2 ) at the single-cell level is crucial for elucidating its important roles in cellular signaling and oxidative stress. However, the accuracy of nanoelectrochemical sensors is severely hindered by non-specific adsorption at the sensing interface in complex cellular environments. The adsorption of proteins and other biomolecules can significantly passivate the electrode interface, leading to signal shifts and unreliable monitoring. Herein, an innovative implantable nanosensor with robust antifouling interface was developed by electrodepositing platinum nanoparticles onto a carbon fiber electrode, followed by the in-situ synthesis of hydrophilic poly(ethylene glycol) diacrylate hydrogel layer. The hydrogel layer served as a highly effective diffusion barrier against non-specific adsorption of proteins and other interferents while remaining permeable to H 2 O 2 molecules. The results demonstrated that the proposed nanosensor had excellent sensitivity and stability for H 2 O 2 detection ranging from 10 to 1000 μM, with a detection limit of 1.093 μM (S/N = 3), enabling in-situ monitoring of intracellular H 2 O 2 fluctuations in single cells with high accuracy. This work provides a reliable platform for nanoelectrochemical sensing toward small biomolecules in complex biological matrices. Download: Download high-res image (209KB) Download: Download full-size image
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Bao Jiang,Yanhui Niu,Xiuxin Jin,Yuntao Huang,Qin Hu,Yaxin Luo,Jialing Hua
Rational Interface Engineering: We successfully synthesized a GO/MoS 2 /TiO 2 ternary nanocomposite with carefully engineered heterojunction interfaces. This structure not only prevents the restacking of MoS 2 and aggregation of TiO 2 but also facilitates efficient charge separation and accelerates electron transfer rates compared to single or binary counterparts. • Significant Synergistic Enhancement: Rather than simply mixing components, our design yields a substantial improvement in electrochemical performance. The sensor exhibits a 2-fold increase in current response and a significantly lower detection limit compared to the individual MoS 2 electrodes. This result strongly validates the effectiveness of our interface engineering strategy in overcoming the intrinsic limitations of single-component materials. • Self-Cleaning and Anti-Fouling Capability: A distinct advantage of our ternary system is its excellent anti-fouling property. The incorporation of TiO 2 endows the sensor with self-cleaning capabilities (attributed to its photocatalytic activity/surface properties), effectively mitigating electrode passivation caused by the adsorption of oxidation products. This ensures superior operational stability and reproducibility, addressing a common bottleneck in APAP detection. • Practical Robustness: We successfully applied the sensor to the determination of acetaminophen in real pharmaceutical tablets and water samples with satisfactory recovery rates, proving its potential for practical applications in complex matrices. Efficient detection of acetaminophen (APAP) is critical for public health and environmental safety, but traditional electrochemical sensors often suffer from severe electrode passivation and ambiguous interfacial sensing mechanisms.To address these challenges, To address these fundamental challenges, this study constructs a novel photo-assisted electrochemical platform based on a GO/MoS 2 /TiO 2 ternary heterojunction, systematically characterized via XRD, TEM, FTIR, and XPS. Explicitly shifting the focus from conventional metric-chasing (e.g., pursuing extreme detection limits) to rational material design, this work thoroughly elucidates the structure–activity relationship and underlying synergistic mechanisms through comprehensive kinetic investigations (e.g., CV, EIS, and DPV). Experimental results demonstrate that the strategically designed cascaded band structure significantly boosts electrocatalytic activity and interfacial charge transfer. Furthermore, by leveraging the distinct structural advantages of the distinct structural advantages of GO/MoS 2 alongside the photo-assisted properties of TiO 2 , the sensor achieves a dual-mode “anti-fouling and self-cleaning” capability that effectively resolves surface fouling caused by oxidation products. Consequently, the sensor exhibits robust performance with a detection limit of 0.07 µM (S/N = 3) and three wide linear response ranges (7.865∼12.155 µM, 12.155∼71.5 µM and 71.5∼715 µM). Ultimately, this systematic study provides not only a robust platform for real-world APAP monitoring but also a theoretical blueprint for designing next-generation, passivation-resistant sensing interfaces. A photo-assisted GO/MoS 2 /TiO 2 ternary heterojunction sensor was constructed for ultrasensitive electrochemical detection of acetaminophen with enhanced charge transfer and excellent anti-fouling performance.(This graphical abstract was generated using AI tools) Download: Download high-res image (252KB) Download: Download full-size image
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危险品化学品经营许可证（带存储）