COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Xieyu Yan,Quanjin Li,Shuai Xiao,Junjie Chen,Wei Song
Promoting ferroptosis in tumor cells has emerged as a promising strategy for cancer therapy. Nonetheless, the heightened antioxidant activity within tumor cells hampers this approach, diminishing its effectiveness and fostering drug resistance. In this study, a new type of sulfasalazine (SAS) loaded nanoframe self-etched Pt-Co nanodendrites (Pt/Co-BNN@SAS) was developed, presenting a novel avenue for inducing ferroptosis in tumor cells by depleting glutathione (GSH) for cancer treatment. Pt/Co-BNN exhibits notable peroxidase (POD) activity, catalyzing the production of abundant oxygen radicals through the consumption of hydrogen peroxide (H 2 O 2 ) and the concurrent depletion of GSH. Simultaneously, the liberated sulfasalazine (SAS) from Pt/Co-BNN@SAS effectively obstructs system xc - , impeding the absorption of cystine by tumor cells and thereby expediting GSH depletion. The expeditious reduction of GSH markedly stimulates the accumulation of lipid peroxides (LPO) and suppresses glutathione peroxidase 4 (GPX4), consequently triggering ferroptosis in bladder cancer cells and inhibiting the migration ability of bladder cancer cells effectively. This research contributes to a more profound comprehension of nano-drug-biological interactions and provides a prospective outlook on treating bladder cancer by instigating ferroptosis in tumor cells through GSH depletion.
研究领域:
肿瘤学
·
药理学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2019
·
IF 1.918
Jing Deng,Huadan Wu,Sujuan Wang,Yibing Liu,Hongyu Wang
The removal of sulfapyridine (SPY) by ferrate(VI) in aqueous solutions under a broad range of reaction conditions, including ferrate(VI) dosage, solution pH, natural organic matter and coexisting inorganic ions, was systematically investigated and the oxidation pathway of SPY by ferrate(VI) was deeply explored. Results showed that 500 µg/L of SPY was efficiently decomposed (86%) within 1 min by 5 mg/L ferrate(VI) at pH 5.6. The increment in ferrate(VI) dosage was surely favorable for SPY removal. The best SPY degradation was achieved at pH 5.6, under or above which the removal decreased. The introduction of inorganic ions in solutions retarded SPY removal. Ten oxidation intermediates were identified and the cleavages of C–S and S–N bonds might be the primary ways of SPY oxidation by ferrate(VI).
研究领域:
环境科学
·
化学
✓ 已验证
DOI
PubMed
高影响因子
SENSORS
·
2019
·Vol. 19
·期 19
·4223
·
IF 3.031
Weiming Ji,Zumei Zhu,Shunni Dong,Jingjing Nie,Binyang Du
A highly selective and sensitive optical sensor was developed to colorimetric detect trace Fe3+ions in aqueous solution. The sensor was the sulfasalazine (SSZ) functionalized microgels (SSZ-MGs), which were fabricated via in-situ quaternization reaction. The obtained SSZ-MGs had hydrodynamic radius of about 259 ± 24 nm with uniform size distribution at 25 °C. The SSZ-MG aqueous suspensions can selectively and sensitively response to Fe3+ions in aqueous solution at 25 °C and pH of 5.6, which can be quantified by UV-visible spectroscopy and also easily distinguished by the naked eye. Job’s plot indicated that the molar binding ratio of SSZ moiety in SSZ-MGs to Fe3+was close to 1:1 with an apparent association constant of 1.72 × 104M−1. A linear range of 0–12 μM with the detection limit of 0.110 μM (0.006 mg/L) was found. The obtained detection limit was much lower than the maximum allowance level of Fe3+ions in drinking water (0.3 mg/L) regulated by the Environmental Protection Agency (EPA) of the United States. The existence of 19 other species of metal ions, namely, Ag+, Li+, Na+, K+, Ca2+, Ba2+, Cu2+, Ni2+, Mn2+, Pb2+, Zn2+, Cd2+, Co2+, Cr3+, Yb3+, La3+, Gd3+, Ce3+, and Bi3+, did not interfere with the detection of Fe3+ions.Keywords:functional microgels;sulfasalazine;Fe3+detection;optical response
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2025
·
IF 2
Xu Gao,Yuanwei Zhang,Mengxi Ren,Junjie Wang,Yunhong Song,Junchao Ma
The widespread existence of sulfapyridine (SPD, a typical representative of sulfonamide) in natural environment has raised increasing interest because its potential to cause antibiotic-resistant genes. In this work, the degradation of SPD during heat-activated peroxodisulfate (heat/PDS) oxidation process was explored. The pseudo-first-order rate constant (kobs) of SPD was 0.0149 min−1 with 0.5 mM PDS at pH 7. The kobs values were increased obviously with increasing PDS concentration. Such degradation was ascribed to the oxidation of sulfate radical (SO4•−) primarily according to radical quenching test. A total of 16 transformation products derived from hydroxylation, aniline moiety oxidation, and SO2 extrusion & rearrangement pathways were identified by high-resolution mass spectrometry (HRMS) and theoretical calculations. Of which, the production of nitrated byproducts was attributed to the oxidation of aniline moiety in SPD molecule. The existence of natural organic matter (NOM) obviously reduced the degradation efficiency of SPD, while the effects of coexisting anions (i.e., NO3−, CO32−, and Cl−) were negligible. These findings illustrated that SPD can be effectively degraded but cause the nitrated byproducts generation during the heat/PDS oxidation process, which should be paid attention to when SR-AOPs is applied.
研究领域:
环境科学
·
化学工程
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL LETTERS
·
2020
·
IF 1.467
Xu Ning,Liu Mu-Hua,Yuan Hai-Chao,Huang Shuang-Gen,Wang Xiao,Zhao Jin-Hui,Chen Jian,Wang Ting,Hu Wei,Song Yi-Xin
In order to meet the growing demand for food safety, the rapid classification of sulfadimidine and sulfapyridine in duck meat based on surface-enhanced Raman spectroscopy (SERS) was investigated using gold nanoparticles (Au NPs) and NaCl solution as the active substrate and active agent, respectively. The results showed that the Raman characteristic peaks at 557 and 573 cm−1 were used to determine whether sulfadimidine and sulfapyridine remained in duck meat. A single factor experimental method was used to optimize the conditions. Three pretreatment methods were employed to optimize the raw measurements. According to the classification accuracies, adaptive iterative reweighted penalty least squares and second derivative were selected to be the optimal pretreatment method. Next, principal component analysis (PCA) was performed to extract the characteristic variables. The first four score values of PCA were selected to be the input values of support vector machine (SVM) classification model, which classified duck meat samples into four categories. Nu-support vector classification and radial basis function were selected to be the employed SVM classification model and the Kernel type, respectively. The gamma and nu values were 0.25 and 0.255, respectively. The classification accuracy for the test set was 90.44%. The sensitivities and specificities of test set were calculated, and the highest sensitivity and specificity values were 96.97% and 100%, respectively. The experimental results showed that this classification model provides favorable classification results. Therefore, the adopted method may be used for the rapid classification of sulfadimidine and sulfapyridine residues in duck meat.
研究领域:
食品安全
·
光谱学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
·
2022
·Vol. 39
·期 10
·2685-2690
·
IF 3.146
Wu Kang,Zhang Zhongliang,Hua Fei,Ye Zhou,Li Chao,Yao Youzhi
Sewage containing antibiotics is harmful to the water environment. Here, a newly prepared iron manganese binary oxide (FMBO) activated persulfate (PDS) has excellent performance for the degradation of sulfapyridine (SPY) in an aqueous environment. The effects of initial pH, SPY, PDS concentration and FMBO dosage on the degradation ability of SPY were investigated. When the pH of FMBO/PDS was 4.0 and the initial concentration of PDS was 2.0 mmol/L, the degradation ratio of SPY could reach 94.4%. In the system of removing organic pollutants by transition metal activated PDS, SO
−• 4
and •OH radicals are generally generated, and •OH radical plays a major role. Through the identification of SPY intermediate products by LC/MS, the degradation mechanism was explored. The degradation pathway showed that the strong oxidation of FMBO and the activity of PDS promoted the production of hydroxyl radical and contributed to the degradation and transformation of antibiotics. This study shows that FMBO/PDS has high degradation efficiency in the degradation of SPY.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2021
·
IF 6.291
Jiahong He,Taiping Xie,Tianhong Luo,Qiang Xu,Feng Ye,Jibin An,Jun Yang,Jiankang Wang
The largest source of resistant bacteria or viruses is the overuse and misuse of antibiotics in humans and animals. These resistant bacteria or viruses may evolve into superbacteria or superviruses, which causes global plague. Therefore, it is significant to find a highly efficiency and low-cost method to eliminate antibiotics in water environment from inappropriate discharge. Here, a highly active and highly stable heterogeneous catalyst, Cu 0.76 Co 2.24 O 4 /SBA-15 (CCS) was prepared for peroxymonosulfate (PMS) activation in aim of decomposing persistent sulfapyridine (SPD). The reaction mechanism was thoroughly investigated via in situ quenching test and in situ electron paramagnetic resonance. Four reactive species, SO 4 · − , O 2 · − , 1 O 2 and ·OH were generated in Cu 0.76 Co 2.24 O 4 /SBA-15/PMS (CCSP) system. The SO 4 · − and O 2 · − were dominant active species responsible for SPD degradation. Co(Ⅱ)↔Co(Ⅲ)↔Co(Ⅱ) redox reaction cycle was constructed due to the different redox potential of Co(Ⅱ)/Co(Ⅲ), HSO 5 - /SO 4 ∙ - , and HSO 5 - /SO 5 ∙ - . Interestingly, Cu(Ⅰ) could urge the redox reaction cycle for PMS activation to be more thermodynamically feasible. Therefore, CCS possessed a highly catalytic activity and excellent stability. Meanwhile, the anions interference test indicated Cl - , NO 3 - , HCO 3 - , and H 2 PO 4 - had almost no inhibitory effect on SPD degradation over this catalytic system. We sincerely expected that this catalyst system would be applied extensively into antibiotics degradation in real water bodies.
研究领域:
环境科学
·
化学工程
·
生物学
✓ 已验证
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Qinchao Shao,Xiubin Zhang,Pei Liang,Qiang Chen,Xiaohua Qi,Mingqiang Zou
Fabrication of a magnetic substrate based on metal–organic frameworks (MOFs) with high sensitivity and stability for surface-enhanced Raman scattering (SERS) analysis were reported in this paper. MIL-101(Cr) nanoparticle prepared via a traditional hydrothermal reaction, which was combined with Fe 3 O 4 to synthesize the Fe 3 O 4 /MIL-101(Cr) composites. Then, the concentration of chloroauric acid and the time of reduction reaction were adjusted to acquire the optimal Au/Fe 3 O 4 /MIL-101(Cr) (AF-MIL) SERS substrate. The detection ability of the substrate can down to 10 -8 mol/L for Rhodamine 6G (R6G) as probe molecule, and the relative standard deviation (RSD) is only about 4.48 %, which indicates that it possesses wonderful SERS performance and uniformity. Finally, the as-synthesized substrate has been adopted to test the trace level sulfapyridine, with its desirable detection ability can down to 10 -6 mol/L. Such desirable SERS substrate with facile and effective operation holds great promise in the fast sensitive detection of the antibiotic residue and some other pollutants in environment.
研究领域:
材料科学
·
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Environmental Science-Water Research & Technology
·
2022
·Vol. 8
·期 10
·2207-2215
·
IF 5.819
Jie Ji,Changjie Shi,Luo Xu,Kai Zhang,YunShu Zhang,Cong Li,Eric Lichtfouse
Sulfonamides (SAs) have been proved to damage organisms if the contact time last over the long term. Therefore, sulfapyridine (SPD), as typical one, was chosen as a target to be investigated. For the study, the degradation kinetic of SPD in the chlorination stage of a pilot-scale water distribution system (WDS) was studied. The result showed that the degradation of SPD simultaneously followed the first-order and pseudo second-order kinetic model. In the beakers tests or WDS, the reaction rate reaches maximum value when the pH is about 7. The degradation rate of SPD would be higher with the increase of water velocity in the WDS. Different pipe materials were studied and the degradation effect of SPD was in the following order: stainless-steel pipe > ductile iron pipe > polyethylene (PE) pipe. There was a significant increase in the content of trihalomethanes (THMs) when chlorination of tap water containing SPD in both the WDS and the beakers system were performed. The mechanism of this process was analyzed in combination with the intermediate products degraded by SPD in the process. In addition, density functional theory (DFT) calculations were performed to assist in the identification of 6 intermediates and possible degradation pathways.
研究领域:
环境科学
·
化学
·
生物学
✓ 已验证
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2019
·
IF 3.206
Jiahui Yan,Yongli Yu,Baoying Kong,Shuang Zhao
In the current study, a method for the determination of sulfasalazine (SSZ) based on the fluorescence quenching of Tb-2,6-pyridinedicarboxylic acid (Tb-DPA) complex probe in the presence of sodium dodecylbenzene sulfonate (SDBS) was established. Moreover, the mechanism of fluorescence quenching was studied and it was concluded that the process is static quenching and involved the formation of the SSZ-Tb-DPA ternary complex. Under the optimum conditions, the linear range of the method was 8.0 × 10 −8 –1.00 × 10 −6 M and 1.00 × 10 −6 –1.00 × 10 −4 M with the detection limit of 60 nM. The approach was successfully applied for the detection of SSZ in pharmaceutical preparations, urine, and human serum samples with recoveries between 98% and 106%.
研究领域:
分析化学
·
药学
·
生物医学
✓ 已验证
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2020
·
IF 3.573
Huaying Liu,Biaojun Zhang,Yingjie Li,Qi Fang,Zhichao Hou,Senlin Tian,Junjie Gu
Degradation of sulfapyridine as a representative sulfonamide by the UV/chlorine process was investigated. Kinetic experiments revealed that aniline and sulfonamide moieties were sulfapyridine’s main reaction sites with •OH, and the aniline moiety was the preferable site for Cl• attack. Effects of four influence factors (pH; humic acid, HA; HCO3–; Cl–) on the degradation kinetics were explored by response surface methodology, and it was found that pH and HA have the highest level influence (81%) among all influence variables (linear, quadratic, and interactive terms), and low pH and concentrations of HA were beneficial for degradation. Approximately 70% of sulfapyridine degradation was observed within 60 min in the UV/chlorine system (pH = 5) without HA. A kinetic model considering steady-state concentrations of reactive radicals and their second-order rate constants is suitable for predicting sulfapyridine degradation, elucidating that •OH and Cl• are major radicals for sulfapyridine degradation in freshwater, and •OH and Cl2•– are responsible for the degradation in coastal seawater.
研究领域:
环境科学
·
水处理工程
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Chao Li,Juan Lu,Yanjia Guo,Jing Wang,Yujia Song,Ruidan Li,Li Tian,Xuwen Li
In this study, a solid-state electrochemiluminescence (ECL) sensor was developed for ultrasensitive and specific detection of sulfapyridine (SPY) using graphitic carbon nitride (g-C 3 N 4 ) as a luminescent reagent. The sensor was fabricated by sequentially coating composite material g-C 3 N 4 @ZIF-8 and Nafion onto the electrode surface. The g-C 3 N 4 , synthesized through high-temperature pyrolysis of melamine, generated a sensitive ECL signal in K 2 S 2 O 8 solution. And g-C 3 N 4 served as a carrier for ZIF-8, with the latter acting as a co-reaction promoter within the g-C 3 N 4 -K 2 S 2 O 8 system, leading to a significant enhancement of the ECL signal. Additionally, molecularly imprinted polymers (MIPs) with SPY were introduced to further enhance the performance of the sensor by specifically recognizing SPY. Under optimal conditions, the prepared ECL sensor showed sensitive measurement of SPY in the linear range of 5.0 × 10 −13 ∼ 5.0 × 10 −8 mol/L, with a detection limit (LOD) of 1.67 × 10 −13 (S/N = 3). The developed MIP-ECL sensor demonstrated good stability, high sensitivity, and reliable reproducibility, thus making it suitable for detecting SPY in real samples.
研究领域:
分析化学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）