JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·Vol. 74
·期 31
·24277-24291
·
IF 6.7
Wu Yuwei,Zhao Meiqi,Zhang Peng,Ho Chi-Tang
Asiaticoside,
a triterpenoid saponin abundant in Centella asiatica , exhibits notable anti-inflammatory
activity but suffers from poor oral bioavailability. Here, we reveal
a gut microbiota-dependent mechanism underlying its therapeutic efficacy
against chronic intestinal inflammation. Using a DSS-induced mouse
model and antibiotic-mediated microbiota depletion, we demonstrate
that asiaticoside requires microbial metabolism to alleviate epithelial
injury, oxidative stress, and inflammatory cytokine production. HPLC
analysis showed that asiaticoside is hydrolyzed by gut microbes into
asiatic acid, which accumulates in colonic tissues and suppresses
IL-17 signaling, NF-κB, and JAK2/STAT3 activation while restoring
Nrf2-mediated antioxidant responses. The released glycosides are further
fermented into butyrate and other short-chain fatty acids, supporting
colonocyte metabolism and intestinal barrier function. Antibiotic
treatment abolishes asiaticoside conversion, SCFA production, and
therapeutic efficacy. These findings establish microbial biotransformation
as a critical determinant of asiaticoside activity and a key mechanism
governing natural glycoside pharmacology.
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高影响因子
Materials Today Bio
·
2025
·
IF 10.2
Shanguo Zhang,Tianyi Jiang,Depeng Yang,Liangyu Cao,Ming Li,Jiachao Tang,Qi Gu,Aitong Xu,Yu Li,Hongyuan Jiang
Bacterial infection and persistent inflammation severely hinder tissue regeneration; therefore, a synergistic therapeutic strategy that combines antibacterial and pro-healing functions is crucial for the effective treatment of infected wounds. In this study, we construct a self-powered microneedle drug delivery platform based on a Dual-domain engineered exosome (D 2 -Exo) that integrates antimicrobial and healing-promoting capabilities. The exosome is internally loaded with asiaticoside and surface-modified with an antimicrobial peptide. The self-powered microneedle delivery platform, driven by a triboelectric nanogenerator, enables precise and efficient release of the D 2 -Exo. In vitro and in vivo experiments show that electrical stimulation significantly enhances exosome release and cellular uptake. The D 2 -Exo-loaded platform effectively reduces inflammation, inhibits bacterial infection, and promotes granulation tissue formation and collagen deposition, thereby accelerating the healing of infected wounds. This study presents a promising strategy for the intelligent treatment of infected wounds.
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高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-14
·
IF 9.429
Wang Pei,Wang Yun,Yi Yang,Gong Yan,Ji Haoran,Gan Yuci,Xie Fei,Fan Jinchen,Wang Xiansong
Patients with diabetic foot ulcers usually suffer from inefficient epithelisation and angiogenesis accompanied by chronic wound healing. Diabetic foot ulcers remain a major challenge in clinical medicine; however, traditional treatments are incapable of transdermal drug delivery, resulting in a low drug delivery rate. We report the development of Ti 2 C 3 MXenes-integrated poly-γ-glutamic acid (γ-PGA) hydrogel microneedles to release asiaticoside (MN-MXenes-AS). Asiaticoside was loaded into PGA-MXenes hydrogel to facilitate cell proliferation while regulating angiogenesis. The characterisation and mechanical strength of the microneedles were investigated in vitro, and the wound-healing efficacy of the microneedles was confirmed in diabetic mice. MXenes significantly improved the mechanical strength of microneedles, while γ-PGA hydrogels provided a moist microenvironment for wound healing. Mice treated with MN-MXenes-AS demonstrated obvious improvements in wound healing process. We successfully fabricated an MXenes-integrated microneedle that possesses sufficient rigidity to penetrate the cuticle for subcutaneous drug delivery, thereby accelerating diabetic wound healing. We demonstrated that MN-MXenes-AS is effective in promoting growth both in vivo and in vitro. Collectively, our data show that MN-MXenes-AS accelerated the healing of diabetic foot ulcers, supporting the use of these microneedles in the treatment of chronic wounds. Graphical Abstract
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高影响因子
MOLECULAR IMMUNOLOGY
·
2020
·
IF 3.641
Keyan Wu,Guanghuai Yao,Xiaolei Shi,Huan Zhang,Qingtian Zhu,Xinnong Liu,Guotao Lu,Lianghao Hu,Weijuan Gong,Qi Yang,Yanbing Ding
Acinar cell necrosis is one of the most prominent pathophysiological changes of acute pancreatitis (AP). Asiaticoside (AS) is a triterpene compound with confirmed apoptosis-and necrosis-related activities. However, the specific effects of AS on AP have not been determined. In this study, we aimed to investigate the protective effect of AS on AP using two mouse models. In the caerulein-induced mild acute pancreatitis (MAP) model, We found that AS administration reduced serum amylase levels and alleviated the histopathological manifestations of pancreatic tissue in a dose-dependent manner. And the levels of toll-like receptor 4 (TLR4) and necrotic related proteins (RIP3 and p-MLKL) of pancreatic tissue were reduced after AS administration. In addition, TLR4 deficiency eliminated the protective effect of AS on AP induced by caerulein in mice. Correspondingly, we elucidated the effect of AS in vitro and found that AS protected against pancreatic acinar cells necrosis and TAK-242 counteracted this protective effect. Meanwhile, we found that AS ameliorated the severity of pancreatic tissue injury and pancreatitis-associated lung injury in a severe acute pancreatitis model induced by l -arginine. Furthermore, Molecular docking results revealed interaction between AS and TLR4. Taken together, our data for the first time confirmed the protective effects of AS on AP in mice via TLR4 pathway.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Heng Li,Deguang Wang,Zixun Wang,Wenjie Chen,Yuxin Guo,Han Liang,Yanqiu Zhao,Qi Wang,Yiqian Huang,Wei Jing,Pengfei Wei,Bo Zhao,Binbin Guan,Min Zhang,Jing Yu,Xudong Xiang
Postoperative complications, such as air leakage, inflammation, and pleural adhesion, present considerable clinical challenges following lung resection procedures. These complications critically affect pulmonary recovery. In this study, we report a novel multifunctional self-adhesive bio-patch SIS-PEG-AC, which synergistically combines the biological activity of small intestinal submucosa (SIS), the effective sealing air leaks provided by polyethylene glycol (PEG) coating, and the anti-inflammatory effects of asiaticoside (AC). Compared to SIS, which exhibited limited tissue adhesion (0.73 kPa), the SIS-PEG-AC patch demonstrated a 30-fold increase in adhesiveness, achieving robust tissue adhesion (23.31 kPa) and significantly enhanced reparative capacity. AC delivered from the PEG hydrogel coating in a sustained manner, promoting the polarization of macrophages to M2 phenotype, to suppressing pro-inflammatory cytokine expression, thereby establishing a pro-regenerative ecological environment. The results of 28-day implantation on rat lung injury and 70-day implantation on pig lung wedge resection showed, the SIS-PEG-AC achieved excellent wound sealing, minimized postoperative pleural adhesions and significantly accelerated lung tissue regeneration. Compared with traditional synthetic polymers, the SIS-PEG-AC patch exhibited reduced adverse reactions, superior host tissue integration, and heightened control of the regenerative microenvironment, providing a promising approach to mitigate postoperative complications. Overall, this multifunctional patch demonstrates considerable clinical potential in lung repair, offering an effective strategy for thoracic surgical interventions.
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高影响因子
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