Scientific Reports
·
2024
·Vol. 14
·期 1
·1-14
·
IF 3.8
Ye Jian,Shi Chenyang,Lan Jian,Chen Qingqing,Si Qin,Xu Panpan,Zhang Xijiang,Zheng Cheng
Rapid and safe hemostasis is crucial for the survival of bleeding patients in prehospital care. It is urgent to develop high performance hemostatic material to control the massive hemorrhage in the military field and accidental trauma. In this work, an efficient protein hemostat of thrombin was immobilized onto commercial gauze, which was mediated by self-polymerization and anchoring of tannic acid (TA). Through TA treatment, the efficient immobilization of thrombin was achieved, preserving both the biological activity of thrombin and the physical properties of the dressing, including absorbency, breathability, and mechanical performance. Moreover, in the presence of TA coating and thrombin, Gau@TA/Thr could obviously shortened clotting time and enriched blood components such as plasma proteins, platelets, and red blood cells, thereby exhibiting an enhanced in vitro coagulation effect. In SD rat liver volume defect and artery transection hemorrhage models, Gau@TA/Thr still had outstanding hemostatic performance. Besides, the Gau@TA/Thr gauze had inherent antibacterial property and demonstrated excellent biocompatibility. All results suggested that Gau@TA/Thr would be a potential candidate for treating uncontrollable hemorrhage in prehospital care.
研究领域:
生物医学工程
·
创伤护理
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2020
·
IF 3.784
Weishi Zheng,Chuntao Chen,Xujun Zhang,Xiaodong Wen,Yuanxiang Xiao,Lin Li,Qingbo Xu,Feiya Fu,Hongyan Diao,Xiangdong Liu
We developed a hemostatic material able to quickly stop wound bleeding by successively constructing carboxymethyl chitosan (CMC), gelatin, and alginate onto a cotton gauze surface through a simple layer-by-layer (LbL) process. Briefly, we grafted CMC onto the cotton fibers through an esterification reaction with the hydroxyl groups of the cellulose chains, and then built a gelatin layer on the CMC layer by the ionic reactions with CMC. Finally, we integrated alginate by the lamellar structure through the cross-linking reactions caused by the Ca 2+ ions permeated from the gelatin layer. Characterization analyses demonstrated that the resulting composite dressing possessed high fluid absorption, excellent biocompatibility, and hemocompatibility. A better hemostatic performance was also revealed in animal tests compared with cotton gauze, and it showed a short hemostasis time and a small amount of blood loss in the mouse liver injury model and mouse-tail amputation model. Moreover, the composite dressing also exhibited a significant promotion effect of wound healing in a mouse defect wound model. This new composite dressing, which was prepared by natural raw materials, is a promising candidate for wound dressing and demonstrated great potential in medical applications.
研究领域:
生物医学工程
·
材料科学
·
医学
✓ 已验证
DOI
高影响因子
CELLULOSE
·
2018
·Vol. 26
·期 2
·1383-1397
·
IF 3.809
Liu Gongyan,Xiang Jun,Xia Qiongfen,Li Kaijun,Lan Tianxiang,Yu Ling
Abstract Common cotton gauze was endowed with both superhydrophobic and antibacterial properties by a dip-coating method that involved sequential deposition of positively charged chitosan (CS), negatively charged gallic acid modified silver nanoparticles (GA@AgNPs) and 1H,1H,2H,2H-perfluorodecanethiol (PFDT) with low surface energy on cotton fabrics. After such surface coating, the wettability of gauze surface was converted from superhydrophilic to superhydrophobic with a water contact angle (CA) of 158 ± 2.2° and sliding angle (SA) of 5.2 ± 1.8°, exhibiting water repellency, antifouling ability as well as bacterially antiadhesive activity. Moreover, such PFDT/GA@AgNPs/CS-coated cotton fabrics showed efficiently antibacterial activities against Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ), which was mainly attributed to the synergistic effect of contact-killing of CS and continuous release of Ag + . In addition, it was found that the outer PFDT deposition could act as a barrier to prevent leaching of the AgNPs during laundry, enhancing the antibacterial durability. Graphical abstract
研究领域:
材料科学
·
生物医学工程
·
纺织科学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Advances
·
2024
·
IF 5.5
Qingheng Wu,Yimeng Cai,Ke Xu,Dan Wu,Xuan Li,Yi Zhao,Denghao Huang,Shuqin Cao,Malcolm Xing,Leixiao Yu,Quan Yuan
Hemorrhage caused by trauma is a global public health issue. While traditional cotton gauze compression is commonly used for hemostasis, its efficacy is limited in severe hemorrhage cases. Herein, we developed a gauze with Janus wettability (JW-G). Its surface was sequentially dip-coated with hydrophilic polydopamine and then spray-coated with hydrophobic silicon dioxide nanoparticles. Benefiting from the asymmetric surface wettability, the obtained JW-G could control blood flow direction and permeation speed. JW-G's hydrophobic surface concentrates blood cells and facilitate faster clot formation in vitro. Meanwhile, the silicon dioxide nanoparticles could also activate coagulation factor XII. Therefore, the JW-G greatly accelerates the hemostasis. In vivo bleeding model further demonstrated JW-G's good performance in reducing bleeding time and blood loss compared with commercial hemostatic gauze. The present strategy to develop hemostatic gauze offers a promising solution for reversing the adverse outcomes of severe traumatic hemorrhage.
研究领域:
生物材料学
·
创伤医学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Wei Zhang,Qiang Niu,Yuyang Cheng,Hengguo Zhang,Kelong Fan,Xianwen Wang
Traditional medical gauze can only partially isolate bacteria and cannot effectively address the persistent problem of antibiotic resistance. In this study, persistent antibacterial gauze modified with zinc oxide and manganese oxide (MG@ZnO) was developed for antibacterial treatment and the promotion of wound healing via the inhibition of bacterial invasion, disruption of bacterial protein metabolic processes, and stimulation of the host immune response. Notably, MG@ZnO was fabricated via simple potassium permanganate oxidation followed by wet chemical processing, resulting in excellent physical stability and significant clinical translational potential. Moreover, MG@ZnO exerts bactericidal effects through a variety of antibacterial mechanisms, including physical, Zn 2+ , and peroxidase pathways, thereby circumventing the issue of bacterial resistance. In vitro antibacterial experiments demonstrated that MG@ZnO can effectively eliminate both Escherichia coli ( E. coli ) and methicillin-resistant Staphylococcus aureus ( MRSA ). Notably, a concentration of only 100 μg/mL was sufficient to achieve complete bactericidal activity against both strains (1 × 10 6 colony-forming units/mL). The RNA-sequencing findings of MRSA indicate that ZnO disrupts the bacterial ribosome, thereby impacting the metabolic processes of bacterial peptides and proteins. Furthermore, ZnO has the capacity to prevent MRSA infiltration of epithelial cells by dismantling fibrinogen-binding proteins A and B (FnBPA and FnBPB) located on the surface of MRSA . Animal experiments have demonstrated that MG@ZnO has the ability to eliminate MRSA by stimulating the host immune response and facilitating the recovery of infected bacterial wounds. Red blood cell hemolysis, cell toxicity, and routine blood and blood biochemistry results revealed that ZnO and MG@ZnO have good biocompatibility. This low-cost, versatile and flexible synthesis process can be used to manufacture a variety of functional gauzes, making it useful in a variety of medical applications.
研究领域:
医学材料学
·
生物医学工程
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Functional Biomaterials
·
2024
·Vol. 15
·期 6
·152
·
IF 5
Junnan Cui,Haobo Shu,Panpan Zhu,Zhimin Cao,Shuilin Wang,Pan Cao
Silver nanoparticles (AgNPs) are known for their antibacterial properties and their ability to promote wound healing. By incorporating silver nanoparticles into medical gauze, the resulting composite material shows promise as an advanced wound dressing. However, clinical applications are hindered by challenges related to the stability of silver nanoparticle loading on the gauze as nanoparticle leaching can compromise antibacterial efficacy. In this study, silver nanoparticles were immobilized onto polydopamine (PDA) submicron particles, which were then used to modify medical gauze. Energy dispersive spectroscopy (EDS) was employed to analyze the elemental distribution on the modified gauze, confirming successful surface modification. The antibacterial properties of the modified gauze were assessed using a laser scanning confocal microscope (CLSM). The results demonstrated a significant reduction in the adhesion rates ofEscherichia coli(E. coli) andStaphylococcus aureus(S. aureus) by 99.1% and 63%, respectively, on the PDA–Ag-modified gauze. Optical density (OD) measurements at 590 nm indicated that the modified gauze effectively inhibited biofilm formation, underscoring its potent antimicrobial capabilities. Further antibacterial efficacy was evaluated by diluting and plating co-cultured bacterial solutions with the modified dressing, followed by 24 h incubation and colony counting. The gauze exhibited an antibacterial efficiency of 99.99% againstE. coliand 99.8% againstS. aureus. Additionally, cell compatibility tests, involving the co-culture of PDA–Ag composites with human cells, demonstrated excellent biocompatibility. These findings suggest that PDA–Ag-modified medical gauze holds significant potential for the treatment of infected wounds, offering a promising solution to improve wound care through enhanced antimicrobial activity and biocompatibility.
研究领域:
材料科学
·
医学
·
生物工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2021
·Vol. 56
·期 12
·7598-7612
·
IF 4.22
Fang Huan,Li Dongrun,Xu Longquan,Wang Yi,Fei Xu,Tian Jing,Li Yao
Abstract Rapid and convenient treatment of wounds is urgently needed in daily life. It is very essential to finish the dressing and antibacterial treatment in one step. In this study, we developed a reusable ionic liquid-grafted antibacterial cotton gauze wound dressing using 1-vinyl-3-butylimidazolium bromide, 3-aminopropyltriethoxysilane, glycidyl methacrylate and butyl acrylate. The ionic liquid was grafted onto the surface of the cotton gauze through covalent bond to obtain antibacterial properties. The successful grafting was confirmed by Fourier transform infrared spectroscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy. The biocompatibility, antibacterial ability and wound healing properties of antibacterial cotton gauze were evaluated. The antibacterial cotton gauze exhibited effective antibacterial ability against Escherichia coli ( E. coli ), Staphylococcus aureus ( S. aureus ) and Candida albicans ( C. albicans ), and they were not cytotoxic to L929 mouse fibroblasts. The reusability experiment showed that the antibacterial cotton gauze had good antibacterial activity even after three repeated antibacterial tests. In addition, the antibacterial cotton gauze effectively promoted skin wound recovery in a rat model. These results indicated that the antibacterial cotton gauze could be used in the biomedical field, especially as an antibacterial wound dressing. Graphical abstract
研究领域:
生物医学工程
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 18
·6098-6107
·
IF 6.843
Yuting Shi,Xiaoquan Ding,Yufei Cao,Haicun Zhou,Wenwen Yu,Mingsheng Liu,Juanjuan Yin,Hongbin Liu,Jingjing Wang,Congshu Huang,Chenliang Gong,Hua Wei,Guanghui Zhao
Thrombin is a serine protease known as activated coagulation factor II and is primarily applied as an effective local hemostatic agent. However, its clinical application is hindered by drawbacks, such as high sensitivity to the surrounding environment, instability and poor storage stability, easy inactivation, and low bioavailability. The biological functions of biomacromolecules in harsh environments can be preserved through biomineralization. Despite the success of biomimetic mineralization, limited consideration has been given to the mineral-based methods and the effect of various metal ions on enzyme activity. To explore an efficient technique for biomimetic mineralized thrombin, six kinds of ion/thrombin hybrid microflowers and two kinds of thrombin/MOF were synthesized in this work. The results showed that Zn-HNFs-G exhibits good hemostatic effect and maintains high enzymatic activity when exposed to high-temperature conditions. Meanwhile, Fe-HNFs-G, Thrombin@ZIF-8-G and Thrombin@MAF-7-G possess negligible enzyme protection.
研究领域:
生物医学工程
·
材料科学
·
止血
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 12
·期 1
·2201591
·
IF 11.092
Xiaoxu Yang,Nan Shi,Jian Liu,Qingqing Cheng,Guangyong Li,Jing Lyu,Fengguo Ma,Xuetong Zhang
Hemostatic materials have played a significant role in mitigating traumatic injury by controlling bleeding, however, the fabrication of the desirable material's structure to enhance the accumulation of blood cells and platelets for highly efficient hemostasis is still a great challenge. In this work, directed assembly of poly(vinyl alcohol) (PVA) macromolecules covering the rigid Kevlar nanofiber (KNF) network during 3D printing process is utilized to fabricate hydrophilic, biocompatible, and mechanically stable KNF-PVA aerogel filaments for effective enriching blood components by fast water absorption. As such, KNF-PVA aerogel gauzes demonstrate remarkable water permeability (338 mL cm −2 s −1 bar −1 ), water absorption speed (as high as 9.64 g g −1 min −1 ) and capacity (more than ten times of self-weight), and ability to enrich micron-sized particles when contacting aqueous solution. All these properties favor efficient hemostasis and the resulting KNF-PVA aerogel gauzes significantly outperform the commercial product Quikclot Gauze (Z-Medica) during in vivo experiments with the rat liver laceration model, reducing the hemostasis time by half (60 ± 4 s) and the blood loss by two thirds (0.07 ± 0.01 g). These results demonstrate a robust strategy to design various aerogel gauzes for hemostasis applications.
研究领域:
生物医学工程
·
材料科学
·
创伤护理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Biomaterials Science & Engineering
·
2020
·
IF 4.152
Bai-Yi Yan,Bai-Lu Liu,Ling-Yu Yi,Gui-Ling Wang,Bai-Zhong Xue,Ying Xie
Biodegradable hemostatic gauze used for surgical hemostasis has attracted great interest due to its excellent compliance and local anti-inflammatory and therapeutic effects when combined with drugs. Herein, we demonstrate the successful fabrication of water-soluble absorbed cellulose hemostatic material by introducing a biocompatible hydroxyethyl cellulose (HEC) hemostasis gauze into doxorubicin-loaded in situ gel (GEL(DOX)) for the prevention of breast cancer recurrence after surgical tumor resection. The present results show that HEC has a shorter metabolic period, no anaphylaxis and peripheral nerve toxicity, and possesses more advantages than oxidative regenerated cellulose hemostasis gauze, a commercially available product in market. HEC is of the physical hemostasis in mechanism, which does not induce physiological hemostasis and hemolysis. In addition, the combination of HEC with GEL(DOX) not only stops the bleeding efficiently, but also effectively reduces the proliferation of tumor with no cardiac toxic and bone marrow suppression. After treatment, the tumor inhibition rate is up to 90%, resulting in prolonged survival time to 58 days. In conclusion, HEC hemostatic gauze has a broad prospect in clinical application due to its perfect biocompatibility, and we envision that it is a new strategy for the prevention of breast cancer to implant HEC hemostatic gauze containing GEL(DOX) at the postoperative site after surgery.
研究领域:
肿瘤学
·
药剂学
·
生物材料学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2021
·Vol. 11
·期 42
·25976-25982
·
IF 3.361
Fengyi Cao,Changmin Wei,Gangqing Ma,Like Hou,Rencong Zhang,Lin Mei,Qi Qin
Cotton gauze has been used as a wound dressing since the 19th century, and still plays an important role in current clinical therapies. However, the antimicrobial ability of cotton gauze is limited. In this work, gold nanoparticles (AuNPs) were used as photothermal transduction agents to synthesize modified photothermal antimicrobial cotton gauze. The modified cotton gauze was synthesized by immersing and heating the clinical cotton gauze with AuNPs solution. XPS, ICP-OES, FTIR, XRD and SEM characterizations confirmed that AuNPs were successfully decorated on the surface of cotton gauzes. Besides, the mechanical properties, air and water vapour permeability performance of cotton gauze were not changed after modification. Photothermal antimicrobial experiments confirmed that AuNPs modified on the cotton gauze could convert light to heat, inducing rapid temperature increase of the cotton gauze. And the heat could kill microbial cells permeated in the modified cotton gauze, giving it the potential of being used for photothermal antimicrobial therapy.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Mengdi Xu,Hermela Ejegu Feysa,Xiaoqing Ni,Guangbiao Xu,Qingshuai Yan,Hua Shen,Yueqi Zhong,Xingjie Wang
Optimized management of wound exudate is pivotal in modulating the wound healing microenvironment and facilitating tissue regeneration. Conventional dressings, however, are constrained by limited absorption capacity and a slow drainage rate, frequently resulting in excessive exudate accumulation that hinders the healing process. In this study, we developed hydrophilic kapok fiber gauze (H-KG) and Janus kapok fiber gauze (J-KG) through a sustainable and scalable hydroentanglement forming process combined with chemical modification, leveraging the unique hollow tubular structure of kapok fibers. H-KG and J-KG achieved rapid absorption, high capacity storage, and efficient evaporation through synergistic wettability modulation and capillary action-enhanced liquid transport within the hollow structure. The kapok fiber-based gauze demonstrated remarkable sustainable liquid self-pumping capabilities, exhibiting a saturation absorption rate of approximately 1346% with complete liquid evaporation achieved within 1 h. In vivo experiments revealed that both H-KG and J-KG significantly mitigated wound exudate accumulation compared with cotton gauze (CG), thereby accelerating wound healing. Quantitative analysis showed that on day 12 post-treatment, the H-KG and J-KG exhibited residual wound areas measuring 48.23% and 34.41%, respectively, of CG. This work elucidated the mechanistic role of hollow fiber in exudate management while proposing an innovative wound dressing with dynamic fluid regulation capabilities.
研究领域:
生物材料
·
生物医学工程
·
组织工程
·
伤口愈合
·
流体传输材料
·
纤维科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）