JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Yaozhen Yi,Rujian Jiang,Ziting Liu,Haixu Dou,Lingjie Song,Limei Tian,Weihua Ming,Luquan Ren,Jie Zhao
Constructing safe and effective antibacterial surfaces has continuously received great attention, especially in healthcare-related fields. Bioinspired mechano-bactericidal nanostructure surfaces could serve as a promising strategy to reduce surface bacterial contamination while avoiding the development of antibiotic resistance. Although effective, these nanostructure surfaces are prone to be contaminated by the accumulation of dead bacteria, inevitably compromising their long-term antibacterial activity. Herein, a bioinspired nanopillar surface with both mechano-bactericidal and releasing actions is developed, via grafting zwitterionic polymer (poly(sulfobetaine methacrylate) (PSBMA)) on ZnO nanopillars. Under dry conditions, this nanopillar surface displays remarkable mechano-bactericidal activity, because the collapsed zwitterionic polymer layer makes no essential influence on nanopillar structure. Once being incubated with aqueous solution, the surface could readily detach the killed bacteria and debris, owing to the swelling of the zwitterionic layer. Consequentially, the surface antibacterial performances can be rapidly and controllably switched between mechano-bactericidal action and bacteria-releasing activity, guaranteeing a long-lasting antibacterial performance. Notably, these collaborative antibacterial behaviors are solely based on physical actions, avoiding the risk of triggering bacteria resistance. The resultant nanopillar surface also enjoys the advantages of substrate-independency and good biocompatibility, offering potential antibacterial applications for biomedical devices and hospital surfaces.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
表面科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Wenjun Wang,Jiang Li,Rongheng Li,Benqiang Li,Xuesong Mei,Xuefeng Sun
Fabrication of a hierarchical macro-/micro-/nano compound eye is presented in this paper. This bioinspired compound (BIC) eye is obtained by an integrated manufacturing technology that combines (i) nanoimprinting, (ii) picosecond laser swelling, and (iii) air-assisted deformation. The diameter and height of nanopillars, microlens, and macrobase can be controlled precisely by fine-tuning the process parameters. The multifunctional properties of the BIC eye, such as superhydrophobicity, antireflection, and other optical characteristics, are investigated. It is found that the microlens with nanopillars can effectively improve the surface wettability with a contact angle of 152° and contact angle hysteresis of 12°, and enhance transmittance by 2% over the wavelength range of 200–1200 nm. Moreover, the final hierarchical compound eye exhibits the excellent imaging properties and a wide field-of-view of 120° without distortion. These multifunctional properties will enable the widespread application of the compound eye in diverse real-time environmental conditions.
研究领域:
材料科学
·
光学工程
·
生物仿生学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Xiang Zhang,Yurui Xu,Wanyao Chen,Laiyou Wang,Xinghai Ning,Haixiong Ge
UV-nanoimprint lithography (UV-NIL) has been proved to be an efficient method for preparing nanodrug delivery systems. Herein, we used UV-NIL associated with the glancing angle deposition (GLAD) process of electron beam evaporation to prepare Au-coated PLGA nanocylinders loaded with PTX (PTX-PLGA-Au NCs) to enhance anticancer efficacy by the cooperative treatment of photothermal-chemotherapy. PTX-PLGA-Au NCs with different length-to-diameter ratios can be prepared by controlling the concentration of PLGA and regulating the angle of GLAD. Upon 808 nm near-infrared (NIR) irradiation, PTX-PLGA-Au NCs exhibit a stable and repeatable photothermal effect. Besides, hyperthermia generated by the Au layer on the surface of PTX-PLGA-Au NCs under laser irradiation promoted the rapid release of PTX. The in vitro studies demonstrated that PTX-PLGA-Au NCs can achieve the synergistic effect of photothermal-chemotherapy, leading to increased cell cytotoxicity. Therefore, UV-NIL combined with the GLAD process produced a promising nanofabrication method for efficiently developing a multifunctional nanoplatform for cancer treatment.
研究领域:
纳米医学
·
肿瘤学
·
药剂学
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Xin Zhang,Jiteng Zhang,Xiaoli Han,Shengnan Wang,Lingwan Hao,Chengchun Zhang,Yong Fan,Jie Zhao,Rujian Jiang,Luquan Ren
Polymeric materials that have been extensively applied in medical devices, wearable electronics, and food packaging are readily contaminated by bothersome pathogenic bacteria. Bioinspired mechano-bactericidal surfaces can deliver lethal rupture for contacted bacterial cells through mechanical stress. However, the mechano-bactericidal activity based only on polymeric nanostructures is not satisfactory, especially for the Gram-positive strain which is generally more resistant to mechanical lysis. Here, we show that the mechanical bactericidal performance of polymeric nanopillars can be significantly enhanced by the combination of photothermal therapy. We fabricated the nanopillars through the combination of low-cost anodized aluminum oxide (AAO) template-assisted method with an environment-friendly Layer-by-Layer (LbL) assembly technique of tannic acid (TA) and iron ion (Fe 3+ ). The fabricated hybrid nanopillar exhibited remarkable bactericidal performances (more than 99%) toward both Gram-negative Pseudomonas aeruginosa ( P. aeruginosa ) and stubborn Gram-positive Staphylococcus aureus (S. aureus) bacteria. Notably, this hybrid nanostructured surface displayed excellent biocompatibility for murine L929 fibroblast cells, indicating a selective biocidal activity between bacterial cells and mammalian cells. Thus, the concept and antibacterial system described here present a low-cost, scalable, and highly repeatable strategy for the construction of physical bactericidal nanopillars on polymeric films with high performance and biosafety, but without any risks of causing antibacterial resistance.
研究领域:
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2024
·
IF 3.7
Yuanjian Xie,Pingxiong Cai,Xiaofeng Cao,Bo Chen,Yuanfeng Pan
To solve the problems that poly(vinyl alcohol) (PVA) easily breeds bacteria and swells in a humid environment, PVA and ZnO nanopillar (ZnO NP) components were composed to generate PVA/ZnO NP composite films via a simple combination process of blending and heat treatment in this study. Here, ZnO NPs endowed composite films with good antibacterial properties, and the etherification and dehydration of hydroxyl groups between PVA molecular chains induced by heat treatment resulted in the composite films having excellent water-swelling resistance. Most importantly, PVA/ZnO NP composite films revealed excellent tensile strength in both humid (52.85 MPa) and dry (74.63 MPa) environments. In addition, PVA/ZnO NP composite films showed good antibacterial and antisepsis abilities as well as preservation functions in the packaging test of half-cut apples. The current work disclosed an easy strategy for producing a PVA-based antibacterial film for packaging materials that are water-resistant and highly strong, making them suitable for applications in humid environments.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2020
·
IF 3.784
Xiaofan Zhai,Peng Ju,Fang Guan,Yadong Ren,Xin Liu,Nan Wang,Yimeng Zhang,Jizhou Duan,Chuanxing Wang,Baorong Hou
Zinc oxide with the morphology of nanopillar is promising marine antifouling materials as they can kill adhered bacteria and fungi. The zinc oxide with the morphology of nanopillar has shown super-antibacterial properties on galvanized steel , which makes ZnO/Zn nanopillar films promising in marine antifouling and antimicrobial corrosion. Thus, an efficient approach to coat ZnO/Zn nanopillar films on steel is of great significance. The electrodeposition method is a universal method for both ZnO crystals and galvanized coatings, and it can control the morphologies and structures of the resultant films. Therefore, in this study, capsaicin was added into an alkaline electrolyte to induce the formation of ZnO nanopillars. Due to capsaicin addition to the electrolyte, ZnO/Zn nanopillar films were obtained in a single cathodic electrodeposition. The added capsaicin in the electrolyte was absorbed on the electrodepositing surface by the functional –NH– groups in amide bond. The Zn(OH) 4 2− diffusion was promoted by negatively shifted electrodepositing potential. The scanning electron microscopy (SEM) and X-ray diffraction (XRD) results illustrate that regular ZnO nanopillars were obtained when the capsaicin concentration was 0.6 g L −1 in the electrolyte. The resultant ZnO/Zn nanopillar films showed high antibacterial properties in Escherichia coli suspended solutions and relatively low living bacterial coverage, indicating promising application in marine antifouling. Electrochemical evaluation revealed that the obtained capsaicin-induced ZnO/Zn nanopillar films exhibited significantly enhanced corrosion resistance in a sulfate-reducing bacteria (SRB) medium. Moreover, the results illustrate that adding 0.6 g L −1 concentration of capsaicin in the electrolyte yielded the best films, which featured the lowest bacterial coverage and highest corrosion resistance.
研究领域:
材料科学
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生物学
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DOI
高影响因子
POWDER DIFFRACTION
·
2018
·Vol. 33
·期 2
·115-120
·
IF 0.519
Jing Wu,Jikang Jian,Shufang Wang,Shuang Guo,Renbo Lei,Haitao Liu
The Bi4Te3 films with well-ordered orientation and microstructure were successfully prepared on SiO2 substrate by a vacuum thermal evaporation deposition technique for the first time. We discussed the effects of evaporation temperature and substrate temperature on the phase and its well-ordered growth of Bi4Te3 films. The formation of Bi4Te3 phase is owing to the differences of the saturated vapor pressure. The thermoelectric transport properties of the Bi4Te3 films were investigated and the (00l)-oriented nanopillars array film has a better electrical transport performance, whose value of PF is 0.032 mWm−1 K−2 at 339 K, approaching twice that of the non-oriented ordinary film. The enhanced electrical properties of Bi4Te3 films could be achieved via the high-crystallinity well-controlled (00l)-oriented nanopillars array.
研究领域:
材料科学
·
热电材料
·
薄膜制备技术
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2024
·
IF 4.9
Fangbin Wang,Jing Qi,Liang Zhu
Bacterial infection and contamination is a tough problem that generates numerous hazardous factors in areas ranging from human health, clinical to industrial manufacture. Here, an Ag/MoS 2 nanozyme-modified ZnO nanopillar surface was designed and assembled. This nanopillar surface can achieve remarkable antibacterial effects against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli . The obtained nanozyme-modified nanopillar surface demonstrated mechanical antibacterial property with a killing rate of 69.6% and 70.4% to Staphylococcus aureus and Escherichia coli , respectively. Moreover, the surface disables bacteria under H 2 O 2 efficiently, reaching a lethality rate of 89.7% and 98.4% in 30 min, respectively. The superiorities of fast and high lethality rate are owed to a synergistic antibacterial functions consisted of mechanical rupture, enormous ROS generation and silver ions release. Meanwhile, the nanozyme-modified nanopillar surface also shows the surface superhydrophobic property with an antibacterial adhesion rate of over 99.9%. Therefore, the scheme pdresented in this study can provide a potential perspective to solve bacterial infection and contamination in the fields of daily life, clinical and industrial manufacture.
研究领域:
生物材料学
·
微生物学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2022
·
IF 12.545
Fajun Li,Jiaqing Shen,Chaoheng Guan,Yinong Xie,Zhenbiao Wang,Shaowei Lin,Junjie Chen,Jinfeng Zhu
Plasmonic metasurface biosensors have great potential on label-free high-throughput clinical detection of human tumor markers. In the past decades, nanopillar and nanohole metasurfaces have become the common choices for plasmonic biosensing, because they typically enable universal simple large-area nanopatterns via a low-cost reproducible fabrication manner. The two kinds of metasurfaces have the complementary shapes and are used to be assumed as the same type of two-dimensional plasmonic nanograting for biosensing. Up to date, there is still a lack of comparison study on their biosensing performance, which is critical to guide their better applications on tumor marker detection. In this study, we compare the bulk/surface refractive index and sensitivity of plasmonic nanopillar (PNP) and plasmonic nanohole (PNH) metasurfaces in order to evaluate their biosensing capabilities. The sensing physics about their space near-field utilization is systematically revealed. The PNH metasurface demonstrates a higher biomolecule sensitivity versus the complementary PNP metasurface, and its limit of detection for bovine serum albumin reaches ∼0.078 ng/mL, which implies a greater potential of detecting cancer biomarkers. We further adopt the PNH metasurfaces for immunoassay of three typical tumor markers by testing clinical human serum samples. The results imply that the immunodetection of alpha-fetoprotein has the most optimal sensing efficiency with the lowest detection concentration (<5 IU/mL), which is much lower than its clinical diagnosis threshold of ∼16.5 IU/mL for medical examination. Our work has not only illuminated the distinct biosensing properties of complementary metasurfaces, but also provided a promising way to boost plasmonic biosensing for point-of-care testing.
研究领域:
生物医学工程
·
临床检验
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2025
·
IF 14.3
Muqiu Xia,Li Lai,Mengyu Fu,Yuxin Wu,Shiqiang Chen,Guangzhou Liu
Copper materials have emerged as the preferred choice for marine heat exchangers owing to their exceptional thermal conductivity. The enhancement of surface performance can be significantly achieved by engineering micro-nano structures on the material's surface, thereby attaining improved corrosion resistance and antibacterial properties in complex marine environments. In this study, we directly fabricated a copper nanopillar array structure on the substrate via template-assisted electrodeposition. Subsequently, passivation of the pillar-structured copper surface was achieved through a formate & dodecanethiol-assisted solvothermal process (Cu/FA-DT). The results indicate that the nanopillar structure effectively eliminates bacteria through physical rupture upon contact, leading to an 85.47% reduction in P. aeruginosa adhesion compared to untreated samples after 72 h of immersion in seawater. Furthermore, corrosion resistance is significantly enhanced, with inhibition rates of approximately 95.27% and 90.50% in natural and P. aeruginosa containing seawater, respectively. Notably, the thermal conductivity of copper is well preserved, ensuring its functional integrity in marine heat exchange environments. After 7 days of immersion in natural and P. aeruginosa containing seawater, the thermal conductivity of Cu/FA-DT decreased by only 15.41% and 2.78%, respectively, demonstrating superior thermal conductivity retention compared to untreated bare copper. This study provides valuable insights into the potential application of traditional copper in marine heat exchange environments.
研究领域:
材料科学
·
表面工程
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Bingsheng Du,Jing Wu,Xiaofang Lai,Yuan Deng,Shufang Wang,Haitao Liu,Jiao Liu,Jikang Jian
Highly oriented Bi 2-x Sb x Te 3 (x = 0, 0.7, 1.1, 1.5, 2) ternary nanocrystalline films were fabricated using vacuum thermal evaporation method. Microstructures and morphologies indicate that Bi 2-x Sb x Te 3 films have pure rhombohedral phase with well-ordered nanopillars array. Bi, Sb and Te atoms uniformly distributed throughtout films with no precipitation. Electrical conductivity of Bi 2-x Sb x Te 3 films transforms from n-type to p-type when x > 1.1. Metal-insulator transition was observed due to the incorporation of Sb in Bi 2 Te 3 . Bi 2-x Sb x Te 3 film with x = 1.5 exhibits optimized electrical properties with maximum electrical conductivity σ of 2.95 × 10 5 S m −1 at T = 300 K, which is approximately ten times higher than that of the undoped Bi 2 Te 3 film, and three times higher than previous report for Bi 0.5 Sb 1.5 Te 3 films and bulk materials. The maximum power factor PF of Bi 0.5 Sb 1.5 Te 3 nanopillars array film is about 3.83 μW cm −1 K −2 at T = 475 K. Highly oriented (Bi,Sb) 2 Te 3 nanocrystalline films with tuned electronic transport properties have potentials in thermoelectric devices.
研究领域:
材料科学
·
凝聚态物理
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Shujin Wang,Ziting Liu,Li Wang,Jianing Xu,Ru Mo,Yue Jiang,Cuie Wen,Zhihui Zhang,Luquan Ren
Bacterial invasion and proliferation on various surfaces pose a serious threat to public health worldwide. Conventional antibacterial strategies that mainly rely on bactericides exhibit high bacteria-killing efficiency but might trigger the well-known risk of antibiotic resistance. Here, we report a superhydrophobic mechano-bactericidal surface with photodynamically enhanced antibacterial capability. First, bioinspired nanopillars with polycarbonate as the bulk material were replicated from anodized alumina oxide templates via a simple hot-pressing molding method. Subsequently, a facile bovine serum albumin phase-transition method was used to introduce chlorin e6 onto the nanopillar-patterned surface, which was then perfluorinated to render the surface superhydrophobic. Benefiting from its strong liquid super-repellency and photodynamically enhanced mechano-bactericidal properties, the superhydrophobic nanopillar-patterned surface exhibits 100% antibacterial efficiency after 30 min visible light irradiation (650 nm, 20 mW cm–2). More strikingly, the surface exhibited impressive long-lasting antimicrobial performance, maintaining a very high bactericidal efficiency (≥99%) even after 10 cycles of bacterial contamination tests. Also, the superhydrophobic nanopillar-patterned surface displays good hemocompatibility with a much lower than the 5% hemolysis rate. Overall, this work offers a new method for significantly enhancing the antibacterial efficiency of structural antimicrobial surfaces without involving any bactericidal agents, and this functional surface shows great potential in the field of advanced medical materials and hospital surfaces.
研究领域:
生物医学工程
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）