CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xiaoqing Yuan,Ju Liu,Yanlei Wang,Xingming Jie,Jingyu Qin,Hongyan He
Knoevenagel condensation reaction is important for generating C C double bonds and providing various valuable intermediates in organic chemistry, which always need harsh conditions including high reaction temperature, difficult catalyst recovery, difficult product separation, etc. In this work, a novel class of dual-responsive emulsion reactor was prepared for the Knoevenagel condensation reaction between malononitrile and aromatic aldehyde, where the temperature and CO 2 -responsive ionic liquids (ILs) were used as an emulsifier, responder, and catalyst simultaneously. Driven by temperature or CO 2 , the emulsion reactor undergoes reversible and controllable transformations between emulsification and demulsification, where efficient catalytic reactions, product separation, and reactor recovery are all achieved. The isolated product yield of 2-(4-chlorobenzylidene)-malononitrile remained above 90% after 5 cycles of the emulsion reactor. NMR and molecular dynamics simulations showed that the temperature drives the reversible stretching and curling of the polyether chain on the cation, while CO 2 reacts with the –COO - group on the anion to form carbonates and carboxylic acids in water, leading to changes in the surface activity of ILs, thereby reversibly regulating the demulsification and emulsification of the emulsion. Hence, through the dual stimuli-responsive ILs, the efficient reaction can be performed in the homogeneous phase, and the products and catalysts can be easily separated in the heterogeneous phase. These results on the revisable microreactor can not only help to design the smart and efficient “homogeneous reaction-heterogeneous separation” systems but also support the development of green sustainable chemistry.
研究领域:
有机化学
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绿色化学
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催化科学
✓ 已验证
产品关联
DOI
高影响因子
LETTERS IN ORGANIC CHEMISTRY
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2023
·Vol. 20
·期 11
·1004-1009
·
IF 0.8
Li Qinsheng,Xiong Junhao,Liao Jiahao,Huang Qinghua,Hu Zhongyu,Yang Yuping,Xiong Zhenhua,Cheng Chuanjie
Irritant, expensive, or toxic desulfurating agents are usually used in the synthesis of isothiocyanates from amines, CS2, and appropriate bases, accompanied by a tedious workup. A more practical and green method has been developed. Cheap and non-toxic CaO was used as both
a base and a desulfurating agent in the synthesis of isothiocyanates. Both alkyl and aryl isothiocyanates are easily synthesized in moderate to high yield from amines, CS2, and CaO under mild conditions. A simple and practical synthetic approach for isothiocyanates from amines,
CS2, and CaO was developed. CaO acts as both a base and a desulfurating agent in the reactions, simplifying the reaction system and reducing cost as well as side products. Moderate to high yields were obtained at room temperature in 48 hours which included alkyl and aryl isothiocyanates.
研究领域:
有机化学
·
绿色化学
✓ 已验证
DOI
高影响因子
CATALYSIS COMMUNICATIONS
·
2014
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IF 3.32
Qian Han,Xingquan Xiong,Sizhong Li
An efficient, green and scale-up synthesis of amides from esters and amines has been developed using Ru-MACHO as a readily available catalyst. A diverse range of amides were obtained in moderate to excellent yields (55–98%). Furthermore, when the scale of the amidation reaction was increased to 240.0 mmol, the desired amide still could be obtained in high yield (48.2 g of N -benzylbenzamide, 95%).
研究领域:
有机化学
·
催化化学
✓ 已验证
DOI
高影响因子
npj Science of Food
·
2025
·Vol. 9
·期 1
·1-10
·
IF 7.8
Sun Zhi,Wang Fangfang,Zhou Peipei,Chen Di,Zuo Lihua
5-Hydroxymethylfurfural (HMF), a product of the Maillard reaction and caramelization in honey, serves as a crucial marker of food quality and thermal processing, underscoring the importance of regulatory surveillance for consumer safety. This study introduces a method for rapid, high throughput and eco-friendly detection of HMF, using derivatization in matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS). 5,10,15,20-Tetrakis-(4-aminophenyl)-porphyrin was employed for in-situ derivatization of aldehydes after extraction by ethyl acetate, enhancing detection sensitivity by shifting low-molecular-weight aldehydes to higher regions. The calibration curves for HMF determination exhibited outstanding linearity. The detection limit reached 0.347 mg/kg with good accuracy and precision. Variations in the content of HMF in honey during heating were also assessed, revealing the increased formation of HMF under high temperature and prolonged heating. The method’s proficiency was evidenced through the detection of various aldehydes. This method represents an advance in rapid analysis for food safety, aligning with green chemistry principles.
研究领域:
食品科学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2023
·Vol. 47
·期 44
·20316-20321
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IF 3.3
Yong Tang,Kaifu Zhang,Yuelin Xu,Jinglin Ma,Hanqing Xie,Hongquan Zhang,Yanmin Jiang,Rui Zhao,Lei Wang
A green and efficient method for the construction of functionalized 2,3-dihydrothiophene derivatives in water was reported. In this work, Novozym 435 acted as a remarkable biocatalyst in catalyzing the four-component reaction of aldehydes, malonitrile or ethyl cyanoacetate, 1,3-thiazolidinedione, and amines under mild conditions. Excellent yields (85–95%) of all the corresponding products could be obtained in reasonable reaction time. Moreover, Novozym 435 could be reused for six cycles with a yield of at least 80%. The rationality of this multicomponent reaction mechanism was also verified via control experiments.
研究领域:
有机化学
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生物催化
·
绿色化学
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2021
·
IF 8.198
Qianqian Xu,Xueru Sheng,Na Li,Jian Zhang,Haiqiang Shi,Meihong Niu,Qingwei Ping,Ning Li
For the first time, ball-milling was introduced as an efficient process for the condensation of biomass-derived cyclopentanone using commercial CaO as a catalyst. Compared with traditional magnetic stirring methods (“heat input” methods), ball-milling is an alternative “energy input” method. CaO dosage, rotation speed, and reaction time were investigated for optimal condition screening, and the ball-milling method could achieve a high yield (98.9%) and a high selectivity (99.2%) under lower energy demand conditions at mild temperature (∼40 °C). Moreover, the power hypothetically needed for dimer per mole (E2) of the ball-milling method was comparable or even lower than that for the magnetic stirring method after our assessment. In addition, we also explored the applicability of the ball-milling method for the condensation of other biomass-derived aldehydes and ketones. Competitive yield was obtained using heterogeneous CaO as a catalyst. Due to the intense stirring in ball-milling, the CaO catalyst was mixed uniformly with reactants, and higher surface area was also obtained due to the decrease of the particle size during the ball-milling method, which may also benefit the reaction and increase the catalytic activity. This way would tally with the concept of green chemistry and economic efficiency, which has the potential for industrial applications.
研究领域:
化学工程
·
绿色化学
✓ 已验证
产品关联
DOI
高影响因子
Sustainable Chemistry and Pharmacy
·
2025
·
IF 5.8
Qianwei Li,Bowen Deng,Ru Feng,Di Chen,Linlin Hua
Extracting antidepressants from biological samples is challenging due to their low concentrations and complex matrices. Pipette-tip solid-phase microextraction (PT-μSPE) simplifies the process, reducing solvent use and enabling automation, but challenges like custom adsorbents and toxic solvents limit its broader application. Melt-blown polypropylene nonwoven, sourced from the middle layer of 3-ply disposable non-woven face masks, was employed as the sorbent material. The extraction tip was easily assembled by combining a 200 μL pipette tip, the melt-blown polypropylene nonwoven, and a 1 mL pipette tip. This method provides a cost-effective and sustainable alternative to conventional adsorbents. A 90% ethanol solution was selected as the desorption solvent to comply with green chemistry principles, with the volume minimized to 100 μL to reduce waste. The pH adjustment was achieved using low-toxicity sodium carbonate (Na₂CO₃). The developed PT-μSPE method proved excellent linearity, sensitivity, accuracy, precision, and robustness, making it suitable for routine antidepressant monitoring in plasma and urine. It offers a practical, scalable, and environmentally friendly solution for therapeutic drug monitoring.
研究领域:
分析化学
·
药物分析
✓ 已验证
产品关联
DOI
高影响因子
GREEN CHEMISTRY
·
2025
·
IF 9.2
Jia Bao Zhang,Wei Chen,Yong Jun Yang,Zhen Zhen Liu
Genistein, a plant-derived isoflavone with pharmaceutical value, is conventionally obtained through ecologically detrimental extraction processes that rely on large-scale plant harvesting and hazardous solvents. Here, we report the discovery of native genistein biosynthesis in the Paenibacillus jilinensis, which inherently produces 5.7 mg L−1 genistein via the phenylalanine branch of the phenylpropanoid pathway. This pathway mirrors plant flavonoid synthesis but operates through seven bacterial enzymes (PjPAL, PjC4H, Pj4CL, PjCHS, PjCHI, PjIFS, and PjHID) with about 30% sequence homology to the corresponding protein sequences in plants, suggesting evolutionary convergence. To leverage this native capability for sustainable production, we constructed a genome-scale metabolic model (GSMM YPG26) with 1636 reactions and 717 genes to rationally optimize carbon flux. Metabolic engineering elevated genistein titers by 9.3-fold to 52.8 mg L−1 without introducing heterologous plant genes. Green-chemistry analysis further showed that P. jilinensis-ΔGLN achieves 92% less waste than soybean extraction and up to one order of magnitude better than state-of-the-art E. coli and yeast systems. It is crucial that this bacterial platform requires only a basic culture medium for sustained production, and eliminates dependence on medicinal plants. Our findings reveal P. jilinensis as a naturally gifted genistein producer and a green chassis for industrial isoflavone synthesis, aligning with green chemistry goals of waste prevention and bio-based process innovation.
研究领域:
生物化学
·
微生物学
·
合成生物学
✓ 已验证
DOI
高影响因子
ChemSusChem
·
2018
·Vol. 12
·期 2
·495-502
·
IF 7.411
Yunchao Feng,Mengzhu Li,Zhebang Gao,Xin Zhang,Xianhai Zeng,Yong Sun,Xing Tang,Tingzhou Lei,Lu Lin
Graphical Biomass valorization with bioderived catalysts ! Renewable and sustainable betaine-based catalysts (BX) are prepared for the production of 5-hydroxymethylfurfural (HMF) from various carbohydrates and biomass in satisfactory yields. The introduction of choline chloride (ChCl) significantly improves the HMF yield, and the catalytic activity of ChCl-derived choline-O-sulfate (ChOS) is also demonstrated. This work introduces a promising approach for the use of biomass-derived catalysts for effective valorization of biomass. Renewable and sustainable betaine-based catalysts (BX) derived from the betaine sugar industry or ChCl were developed for the production of 5-hydroxymethylfurfural (HMF) from various carbohydrates. The HMF yields in the BX-based media reached up to 88 %, 66 %, 37 % and 53 %, for the conversion of fructose, glucose, cellulose, and lignocellulosic biomass, respectively. In addition, choline-O-sulfate was synthesized and demonstrated to be an efficient catalyst for the conversion of fructose to HMF. From the perspective of green and sustainable chemistry, this work demonstrates benefits not only in the preparation of sustainable catalysts but also the green production of HMF from biomass.
研究领域:
生物化学
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催化化学
·
可再生资源
✓ 已验证
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 13
·5032-5038
·
IF 3.069
Yihan Sun,Jinxia Huang,Siyang Zhao,Zhiguang Guo
Herein, a simple, facile and versatile protocol was presented to fabricate water-resistant fabrics based on an in situ bio-silicification strategy and fluorinate-free modification. The whole fabrication procedure is green and avoids the need for any fluorinate-containing compounds, environmentally harmful organic solvents and high preparation temperature. The produced fabrics maintained robust lyophobic properties after multiple machine laundry cycles, repeated abrasion cycles, UV irradiation, and organic solvent and strong acid/base attacks. The obtained superhydrophobic fabrics exhibited repeatable self-repairing behaviour against repeated washing and oxygen plasma etching cycles. Our in situ biomimetic silicification strategy for developing robust self-repairing superhydrophobic fabrics using a waterborne fluorinate-free coating system well fits the motifs of green chemistry and will lead to the development of green preparation of other superwetting surfaces.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Yongrong Jiang,Xuezhi Dong,Yuzhe Li,Yan Li,Ying Liang,Min Zhang
This work presents a lab-made automatic flow-batch system for headspace single-drop microextraction and on-drop conductometric sensing ammonium. Sample and NaOH solution are simultaneously pumped into a reaction chamber (RC), where ammonium is converted to ammonia by raising pH. The converted ammonia then diffuses into the headspace of the RC, and reacts with a 100 mM boric acid drop. The conductivity of the drop is measured by an on-drop conductivity probe, which is made by two stainless-steel contacting electrodes. The result shows that the increasing rate of conductivity has a linear relationship to the ammonium concentration in sample (R 2 = 0.9945). This method has a linear range up to 400 μM, a limit of detection 2.8 μM, a relative standard deviation of 3.0% (200 μM, n = 10) and carryover coefficient 0.028. Measurements of river waters, lake waters and wastewaters have been demonstrated. The recoveries have achieved from 99.0 to 114%. This method avoids using of harmful or odorous reagents and follows the concept of green chemistry.
研究领域:
分析化学
·
环境科学
✓ 已验证
DOI
PubMed
高影响因子
HYDROMETALLURGY
·
2019
·
IF 3.465
Shuainan Ni,Caibin Wu,Yanliang Wang,Xiangguang Guo,Zeyuan Zhao,Xiaoqi Sun
Softening ammonia sulfate wastewater is one of the vital issues in the rare earth industry. In this article, a novel softening process using [4,4′-isopropylidenebis (phenoxyacetate)] (H 2 IPOAA) for Ca 2+ and Mg 2+ (M 2+ ) is developed. The effect factors, i.e., equilibrium time, pH value of aqueous phase and saponification degree are investigated. The extraction mechanism is proposed to be cation exchange. With a saponification degree of 85%, H 2 IPOAA is successfully used for the precipitation of Ca 2+ and Mg 2+ from ammonia sulfate wastewater within 10 min. The process can form precipitated particles with an average size of 35 μm, which are much larger than the precipitates formed by H 2 C 2 O 4 , Na 2 C 2 O 4 and Na 2 CO 3 . The precipitated particles can be easily separated from the raffinate. In addition, H 2 IPOAA is repeatedly used for five times with a little loss. To a considerable extent, the reuse of H 2 IPOAA contributes to lowering the cost and reducing the pollution. The concentrations of Ca 2+ and Mg 2+ in the raffinate extracted by H 2 IPOAA are up to the MVR standard for wastewater treatment . The economical and efficient softening process meets the need of green chemistry, which is expected to replace traditional industrial processes for water softening based on H 2 C 2 O 4 , Na 2 C 2 O 4 and Na 2 CO 3 .
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）