Biomedical Materials
·
2024
·Vol. 19
·期 3
·035011
·
IF 3.9
Piaoyi Chen,Qinglin Xiao,Zhaoxiong Guo,Wei Liang,Ou Liu,Liteng Lin,Yugang Huang,Kangshun Zhu,Guodong Ye
Transcatheter arterial embolization plays a pivotal role in treating various diseases. However, the efficacy of embolization therapy in cancer treatment can be limited by several factors, such as inevitable incomplete or non-target embolization, and the tumor recurrence and metastasis caused by the hypoxic microenvironment. Moreover, it is essential to explore simpler, more economical, and efficient methods for microsphere synthesis. Herein, we achieved one-step photocatalytic synthesis of lipiodol-doped Fe3O4@Poly (diallyl iso-phthalate) multifunctional microspheres (IFeD MS) for arterial embolization, chemotherapy, and imaging. The prepared microspheres are in the shape of dried plums, with a particle size of 100–300 μm. Lipiodol demonstrates a certain degree of chemotherapeutic activity, and the incorporation of Fe3O4 enables the microspheres to exhibit magnetothermal response and magnetic resonance imaging capabilities. Furthermore, the radiopaque characteristics of both agents provide the microspheres with promising potential for computed tomography and digital radiography imaging. The renal embolization experiment in rabbits demonstrated that IFeD MS achieved significant embolization and chemotherapeutic effects. Biocompatibility experiments revealed that this embolic agent did not induce tissue damage or inflammation beyond the treatment area. Additionally, IFeD MS exhibited promising imaging potential. The results of this study imply that the developed multifunctional embolic agent IFeD MS may have significant potential in transforming tumors previously only suitable for palliative cares into resectable radical treatments.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2025
·Vol. 15
·期 7
·5117-5123
·
IF 4.6
Huizhou Ye,Jiayin Cai,Zhihao Shen,Qiuping Qian,Chunxia Zhang
Polyphenols exhibit strong antioxidant, and anti-inflammatory but are limited by chemical instability and low bioavailability. To address these challenges, we developed polyphenol–amino acid conjugates that self-assemble into stable nanospheres, enhancing their stability and bioavailability. These nanoparticles demonstrate significantly improved ROS scavenging efficiency and promote cell proliferation in vitro. The incorporation of amino acids enhances biocompatibility and facilitates effective ROS elimination. The polyphenol–amino acid nanoparticles offer a multifaceted therapeutic strategy to mitigate oxidative stress, overcoming traditional antioxidant limitations through advanced nanotechnology. This approach contributes to the development of next-generation wound care solutions with enhanced efficacy and safety profiles.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POWER SOURCES
·
2025
·
IF 7.9
Jingbo Xie,Ping Zhang,Zeyu Jiang,Qiying Zhang,Jiaxin Lv,Zhaoye Wu,Meng Yin,Yancheng Wu,Liyong Tian,Ningbo Yi,Yangfan Zhang
Fiber supercapacitors (FSCs) show high potential to integrate into wearable electronic textiles but still suffer from inadequate deformation durability due to physical assembly configuration. Chemical bonding of all-in-one configurations promises new perspectives for mechanically durable FSCs, however, which have been rarely reported so far. In this work, a universal prototype of all-in-one FSCs is proposed based on monolithic crosslinking of homogeneous matrices PVA in electrolyte and wet-spun fiber electrodes. Chemical crosslinking of homogeneous matrices converts separated fiber electrodes and electrolyte into a monolith with seamlessly integrated interface structures and all-in-one configurations, distinctly different from physical assembly and distinct interface structures of conventional FSCs. Compared with conventional FSCs, all-in-one FSCs achieve not only good electrochemical performances including high linear or volumetric capacitance (2.49 mF cm −1 or 1147 mF cm −3 ), volumetric energy density (2.93 mWh cm −3 @ 0.075 mW cm −3 ), and long cyclic life (capacitance retention of 97.9 % after 10000 cycles), but also outstanding deformation durability with high capacitance retention after long-term bending (91.1 %), twisting (91.7 %), knotting (81.2 %), folding (72.8 %) and stretching (72.1 %) deformations, thereby demonstrating reliable applications in powering electronic devices. Those findings should offer a facile and scalable design philosophy to develop mechanically durable all-in-one FSCs toward electronic textile applications.
✓ 已验证
产品关联
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2024
·Vol. 7
·期 6
·1-18
·
IF 23.2
Zhao Kui,Qi Luming,Li Qi,Wang Yin,Qian Cheng,Shi Zhengjun
Biocompatible and mechanically stable porous hydrogels are promising materials for artificial skin in wound healing. The rigid PVA phase was selected to make the scaffold, and a dense and uniform porous phase was formed in both transverse and longitudinal phases by freezing casting technology. The names PVA and PVA + PNS2A were used in in vitro activity tests using polymer solutions that had not been molded before. The crosslinked materials were named Base, CP1 (0.1% PNS2A), and CP2 (0.5% PNS2A). HUVEC and HaCat cell proliferation experiments proved to be safe and non-toxic and significantly promoted proliferation activity after 48 h. The cell model with Raw 264.7 proved anti-inflammatory effect by mixed polymer solution. The scratch test showed that the CP2 promotes the migration of HaCat cells more effectively at 48 h. The cell adhesion experiment showed that the skin-like composite material grew rapidly along the void direction. Animal experiments showed that the multi-layer skin-like CP2 increased the mechanical properties, gelation, and hemostasis (58.8% reduction) and inhibits inflammation through active polysaccharide in the early stage of wound healing. It promoted collagen formation in the late stages of the healing process. Upon contact with the wound, the material undergoes gelation to isolate the wound and completely healed the hurt after 12 days. Stent disintegration and 48-h absorption time provide support for implant material development. Graphical
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Xiaoxiao Chen,Feng Zhang,Chenying Lu,Ronghua Wu,Baozhu Yang,Tingting Liao,Baojie Du,Fazong Wu,Jiayi Ding,Shiji Fang,Zhongwei Zhao,Minjiang Chen,Gaofeng Shu,Weiqian Chen,Jiansong Ji
Treatment for hepatocellular carcinoma (HCC) may be improved with ferroptosis, a regulated form of cell death. However, the sensitivity of HCC to ferroptosis was strongly limited by lactic acid. In this study, a platelet membrane (PM)-engineered nanoparticle loaded with erastin, superparamagnetic iron oxide nanoparticles (SPIO) and lactate oxidase (LOX) (termed PM@ESL NPs) was designed for magnetic resonance imaging (MRI)-guided enhanced ferroptosis-immunotherapy of HCC. It was found that PM@ESL NPs could actively accumulate into the tumor due to the tumor-homing ability of PM. Subsequently, PM@ESL NPs could effectively enhance the sensitivity of HCC to ferroptosis by removing the lactic acid in the tumor. The removal of lactic acid also produces hydrogen peroxide (H2O2), which therefore converted into the cytotoxic hydroxyl radicals by the reaction of H2O2 with Fe2+/Fe3+ released from SPIO. Due to the combined ferroptosis and chemodynamic therapy (CDT), PM@ESL NPS showed a strong ability to induce immunogenic cell death (ICD), which could effectively suppress the growth and metastasis of HCC when combined with αPD-L1 immunotherapy. Furthermore, the incorporation of SPIO endows PM@ESL NPs with an outstanding MRI-T2 monitoring capability for HCC treatment. In conclusion, this study introduces a pioneering MRI-guided approach that enhances ferroptosis in tumors and synergistically improves immunotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2025
·
IF 16
Qian Yang,Yali Miao,Jinshui Luo,Chunhui Li,Xining Li,Yunhua Chen,Yingjun Wang
Granular hydrogel matrices have shown significant advantages in mesenchymal stem cell (MSC) delivery and tissue ingrowth due to their minimally invasive injection capabilities and porous structures. However, creating granular hydrogels that simultaneously mimic the nanofilamentous architecture of the natural extracellular matrix (ECM) and enhance stem cell retention and in vivo immunoregulation in a diabetic microenvironment remains challenging. In this study, we present a nanoengineered supramolecular granular hydrogel with a nanofibrillar structure designed to improve stem cell retention and regulate immune responses under diabetic conditions. The granular hydrogel matrix is assembled based on multiple hydrogen bonding and hydrophobic interactions, exhibiting a range of tunable features, including shear-thinning, injectability, self-healing, and 3D printability. Furthermore, enriched with manganese dioxide (MnO2)-amyloid fibril (AF) nanohybrids, the granular hydrogel supports MSC adhesion and stemness maintenance and can modulate the reactive oxygen species microenvironment by converting H2O2 into oxygen, thereby promoting cell viability and osteogenic differentiation of MSCs with the sustained release of Mn2+. In a two-week diabetic rat model study, the granular hydrogel demonstrates enhanced in vivo cell retention and anti-inflammatory immunomodulation properties, underscoring its potential as a promising matrix for stem cell therapy and immune regulation in diabetic conditions.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Research and Technology-JMR&T
·
2026
·
IF 7.3
Xuefei Li,Lingyun Qin,Zumin Wu,Qiren Huang,Zhiwei Guo,Xiuqin Bai,Chengqing Yuan
To address severe friction and wear of water lubricated bearings under boundary lubrication caused by the low viscosity of water, a functional composite was developed by grafting a hydrophilic layer onto Si 3 N 4 /PU and incorporating load bearing hydrogel particles. The design utilizes the hydration lubrication of the surface hydrophilic layer in the initial friction stage and the sustained hydration lubrication of exposed hydrogel particles after wear, thereby maintaining an improved hydration lubrication state throughout the entire friction process. Systematic materials tests (contact angle, compression, and reciprocating friction) were conducted to investigate the effects of hydrogel content, while bearing-level bench tests under various specific pressures were carried out with pure PU bearings as a reference to verify the practical tribological performance. The composite with 0.5 wt% hydrogel showed optimal performance. Under 40 N, its friction coefficient (0.23) and wear rate (8.5 × 10 −6 mm 3 /(N·m)) were reduced by 19% and 53.1% compared with the hydrogel-free composite. Under 0.3 MPa, the composite bearing reduced friction coefficient and wear volume by 12.1% and 65% relative to pure PU (0.19 and 0.8 mm 3 ). Notably, when specific pressure increased from 0.3 to 0.7 MPa, the composite's average friction coefficient further decreased by 59.9%, showing a continuous declining trend with increasing load, indicating excellent load-adaptive capacity. This study provides an effective approach for improving the tribological performance of water-lubricated bearing materials under boundary lubrication.
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Chemistry
·
2026
·
IF 7.4
Xuan Yue,Feibo Li,Xiying Fu,Yanming Wang,Nan Yan
Binary colloidosomes with periodic cubic symmetry are fabricated from anisotropic gold nanocubes and isotropic gold nanospheres. • The spatial arrangement of AuNPs within the colloidosomes is predominantly governed by entropic effects between the two components. • This study provides a general and efficient route to precisely engineer of binary colloidosomes from geometrically distinct nanocrystals. Binary colloidosomes constructed from polymer-grafted inorganic nanocrystals have recently garnered significant attention for their potential in constructing multifunctional materials. However, the fabrication of well-defined binary colloidosomes with tailored internal architectures using geometrically distinct nanoparticles remains challenging. In this study, we demonstrate the preparation of binary colloidosomes with periodic cubic symmetry via emulsion interfacial co-assembly of polystyrene-tethered anisotropic gold nanocubes (AuNCs@PS) and isotropic gold nanospheres (AuNPs@PS). The spatial distribution of AuNPs@PS within the resulting colloidosomes is predominantly governed by entropic effects between the two components, which are quantitatively characterized using the proposed effective size ratio parameter ( λ eff ). Furthermore, by tailoring the core size of AuNPs@PS and the molecular weight of the grafted polymer, the λ eff value and the resulting configuration of the colloidosomes can be precisely controlled. This strategy provides a versatile pathway for constructing binary colloidosomes with tailored internal structures, facilitating the rational design of advanced functional materials for applications in catalysis, optoelectronics, and photothermal therapy. Well-defined binary colloidosomes with periodic cubic symmetry self-assembled from anisotropic AuNCs@PS and isotropic AuNPs@PS building blocks are constructed through emulsion interface co-assembly strategy. The spatial distribution of AuNPs@PS within the resulting colloidosomes is predominantly governed by entropic effects between the two components. Download: Download high-res image (297KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2026
·
IF 6.7
Zi-Huang Yuan,Jingshuai Chen,Yupeng Yuan,Chang-Jie Mao
Highly integrated and power-dense electronic systems require materials that can simultaneously dissipate heat and mitigate electromagnetic interference, as both thermal hotspots and electromagnetic radiation compromise device stability and lifetime. Thermally conductive polymer composites are attractive for electronic packaging, but their performance is limited by discontinuous phonon-transport networks, filler restacking, and interfacial thermal resistance. Herein, a multiscale interfacial and architectural engineering strategy is developed to construct multifunctional polydopamine-coated exfoliated graphene/poly (vinyl alcohol) (fGNs@PDA/PVA) composite films. Commercial graphene nanosheets were first treated by CTAB-assisted exfoliation to reduce restacking and improve surface accessibility. A PDA interfacial layer was introduced as a noncovalent molecular bridge to improve graphene dispersion and interfacial coupling with PVA, while vacuum-assisted filtration and hot pressing assembled the fillers into a highly oriented layered architecture for in-plane phonon transport. The fGNs@PDA/PVA film achieved an in-plane thermal conductivity of 12.73 W m −1 K −1 at 40 wt%, corresponding to a 38.78-fold enhancement over pristine PVA and 2.8 times that of GNs/PVA. Theoretical calculations show that PDA increases the filler–matrix binding energy from 0.512 to 1.637 eV and strengthens interfacial interactions. The composite also delivered an EMI shielding effectiveness of 32 dB in the X-band and a tensile strength of 43.21 MPa, 74.1% higher than that of pure PVA. LED cooling tests further confirmed faster heat spreading and accelerated cooling of the 40 wt% fGNs@PDA/PVA film compared with pristine PVA. This work demonstrates a practical and scalable approach for designing multifunctional polymer composites capable of addressing the dual challenges of thermal management and EMI shielding in advanced electronic systems.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Min Kang,Haiyan Ma,Weiying Zhang,Xiaoguang Ying,Shulu Mao,Qiaoqin Zhou,Jianshun He,Xiao Li
With the burgeoning rise of the intelligent era, the flexible wearable strain sensors capable of being affixed to human skin for real-time monitoring of motion and physiological signals have garnered significant attention. In this study, polyvinyl alcohol (PVA) was selected as the substrate, polyaniline as the conductive filler, and the bio-based raw materials such as glycerol (Gly) and sodium carboxymethyl cellulose (CMC) were introduced. An environmentally friendly conductive composite fiber membrane (PPGC) flexible sensing material with good toughness and high sensitivity was fabricated by PVA/Gly/CMC electrospun nanofiber membrane in situ coated with polyaniline. The strain sensitivity (gauge factor, GF) of PPGC conductive composite fiber membrane can reach 9.7 within the strain range of 0%–40%. Its electrical conductivity is 2.37 mS/m, and its tensile strength and elongation at break are 6.0 MPa and 48%, respectively. PPGC can accurately detect the movements of different parts of the human body, demonstrating a promising application prospect in wearable monitoring systems.
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yongbo Yu,Qian Fei,Kailing Zhou,Jingbing Liu,Ziwei Ma,Hao Wang,Hui Yan
A dual-ion (H + /Cl − ) electrochemical polarization strategy dynamically tunes EMW shielding in flexible CNTs@PANI composites. • Dual-ion intercalation restructures PANI to optimize its band gap, sheet resistance, and reflective EMW shielding. • Uneven ion accumulation enlarges dipole moment and dielectric constant, significantly boosting EMW absorption shielding efficiency. • Synergistic reflection-absorption modulation achieves an ultrahigh specific shielding effectiveness variation of 289.44 dB·mm −1 . • A flexible sandwich device offers tunable X-band EMW shielding (26.29–42.06 dB) and robust bending/cycling stability. Dynamic manipulation of electromagnetic waves (EMWs) represents an indispensable cornerstone for next-generation intelligent stealth and adaptive communication systems. Nevertheless, the practical implementation of state-of-the-art electromagnetic materials remains severely constrained by insufficient modulation capabilities arising from single regulatory mechanisms, along with compromised operational flexibility and reliability. Herein, we report a dual-ion-mediated electrochemical polarization strategy in a flexible carbon nanotube@polyaniline (CNTs@PANI)-based device, which enables precise dynamic regulation of EMWs via the synergistic modulation of electromagnetic reflection and absorption. In-situ structural characterizations coupled with theoretical simulations demonstrate that electric-field-triggered H + /Cl − dual-ion intercalation drives the structural rearrangement of PANI from a non-polarized quinoid state to a polarized benzenoid structure. This transformation increases the content of protonated imine groups from 33.01% to 60.97%, narrows the band gap from 2.62 eV to 0.99 eV, and lowers the sheet resistance by 82.4% (from 47.99 to 8.43 Ω·sq. −1 ), thereby tailoring the EMW reflection shielding effectiveness (SE R ) from 4.71 dB to 8.84 dB. Furthermore, the asymmetric electrostatic potential distribution induced by H + /Cl − dual-ion intercalation and accumulation in PANI backbone amplifies the dipole moment by 118% (from 4.02 to 8.77 Debye), generating a pronounced dielectric polarization effect accompanied by maximum enhancement ratios of 172% and 6300% for the real (ε’) and imaginary (ε”) parts of the permittivity, respectively, which boosts the absorption shielding effectiveness (SE A ) from 11.12 to 17.75 dB. Consequently, the synergistic modulation of reflection and absorption contributes to thickness-normalized specific shielding effectiveness variation amplitude (ΔSSE) of 289.44 dB·mm −1 for the CNTs@PANI within the X-band (8.2–12.4 GHz), surpassing previously reported systems. This work establishes a novel paradigm for designing high-performance adaptive EMW protection systems through dual-ion electrochemical engineering.
✓ 已验证
产品关联
DOI
高影响因子
Crystals
·
2026
·Vol. 16
·期 8
·477
·
IF 2.9
Heng Qi,Jie Chen,Jiancheng Yan,Yao Wang,Weihao Gao,Zhenfei Lv
Large-scale high-value utilization of industrial solid waste is urgently required worldwide. Porous ceramics prepared from single-type solid waste face great limitations in balancing mechanical properties and thermal insulation performance. In this work, various types of industrial solid wastes—red mud, waste electric porcelain, and coal gangue—were fully adopted as primary raw materials, while SiC was employed as a foaming agent to prepare porous ceramics. Results show that at 3% SiC addition and 1140 °C sintering temperature, the apparent porosity of the ceramics reaches to 21.8%, with thermal conductivity of 0.08 W/(m·K). Moreover, favorable pore-size distribution and desirable crystalline phases (Mg–Fe–Al spinel and sodium calcium feldspar) are obtained under this optimal condition, accompanied by a favorable compressive strength of 2.91 MPa, making it a promising low-cost, high-performance high-temperature insulation material.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）