INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
·
IF 6.953
Lu Cao,Jian Zhu,Na Li
Selenium (Se) is an essential trace element for human beings and animals. Traditional plant Se enrichment technology suffers from selenium pollution. Herein, environmentally friendly Se-agarose (Se-Agar) hybrid hydrogels are prepared by simply mixing agar with different Se species including selenocarrageenan (SeCA), selenite and Se yeast under heating and stirring for 0.5 h without any other reagent. Such Se-Agar hybrid hydrogels with excellent biocompatibility were used as natural substrates for the cultivation of Se-enriched mung bean sprouts. Compared with Se yeast, SeCA and selenite show a better Se enrichment effect on mung bean sprouts. Furthermore, the growth indices including plant weight and plant height of mung bean sprouts were investigated with different concentrations and sources of Se. Notably, the Se-Agar hybrid hydrogels could be easily regenerated and reused for multiple cycles. The results indicated that Se-Agar hybrid hydrogels as recyclable natural substrates offer a simple, sustainable and affordable strategy for plant Se enrichment.
研究领域:
植物学
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环境科学
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食品科学
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DOI
高影响因子
LANGMUIR
·
2022
·
IF 4.331
Rong Chang,Tao Wang,Qian Liu,Jun Tang,Dongling Wu
Flexible surface-enhanced Raman scattering (SERS) substrates have become one of the research hot spots due to the facile sampling by swabbing or wrapping on rough surfaces and the sensitive and nondestructive detection of contaminants. In this work, we proposed a simple and fast in situ reduction method to prepare Ag nanoparticles (Ag NPs) composited agar hydrogel (Ag NPs@Agar) flexible SERS substrate. Owing to the three-dimensional (3D) structure, good hydrophilicity and adsorption of the agar hydrogel, Ag NPs were grown uniformly in the 3D cross-linked structure. The distribution density of Ag NPs was further increased by the volume shrinkage when the hydrogel was dried in air. This high density and uniformly distribution of Ag NPs produced a large number of highly active SERS regions. In addition, the sensitivity of Ag NPs@Agar was further improved with the assistance of hydrophilic agar gel, which can trap the probe molecules into highly active SERS areas. The SERS results showed that the substrate can be used to detect dye molecules (rhodamine 6G), the minimum detectable concentration was 10–15 M, the relative standard deviation tested at 18 different positions was only 7.58%, and the intensity of the characteristic peak at 611 cm–1 decreased only about 10% after 49 days of storage, demonstrating the superior stability. Moreover, the Ag NPs@Agar substrate also could successfully achieve the micro-trace detection of melamine and sodium penicillin G in Xinjiang specialty camel milk powder. The above available results show that the prepared flexible Ag NPs@Agar SERS substrates possess potentials for the illegal additives and antibiotics in food safety analysis.
研究领域:
材料科学
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分析化学
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食品安全检测
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 13
·5788-5807
·
IF 4.5
Wen Zhijie,Fu Hudie,Ye Xuexin,Yang Xuedan,Zhu Shengpeng,Hu Jie,Kang Li,Li Xiaojun,Yang Xinzhou,Hu Yan
Currently, conventional chemotherapy for hepatocellular carcinoma is limited and has serious side effects due to premature release and limited lesion targeting recognition. In this study, to further address the challenges of drug delivery for liver cancer, a novel hybrid lipid–polymer nanocomposite, glycyrrhetinic acid-modified lipogel (GA-SS-LG), was designed to merge the beneficial features of both polymer-based and lipid-based delivery systems in a single nanocarrier, which was proposed as a liposome with a bifunctional ligand as well as a polymer gel core inside in the liposome. The inhibitory effect of the GA-SS-LG on HepG2 cells was studied in vitro by using curcumin (Cur) as a model drug. The experimental results show that the incorporation of the polymer gel core improved the stability of the liposomes and had the ability to enhance drug encapsulation and delay drug release. At the same time, the liposome outer membrane could be modified with functional ligands to deliver drugs accurately. Our system accurately delivers drugs to tumor cells and responds quickly to release the loaded drugs in large quantities. This study improves the antitumor activity of Cur by preparing a lipogel composite system and provides a new formulation that combines both the polymer-based and lipid-based delivery systems in a single nanocarrier for the clinical application of antitumor drugs. Graphical abstract
研究领域:
药学
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纳米技术
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肿瘤学
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产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2017
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IF 2.986
Lei Yuan,Beiyue Ma,Qiang Zhu,Xiaodong Zhang,Han Zhang,Jingkun Yu
Porous fibrous mullite ceramics with a narrow range of pore size distribution have been successfully prepared utilizing a near net-shape epoxy resin gel-casting process by using mullite fibers, Al 2 O 3 and SiC as raw materials. The effects of sintering temperatures , different amounts of fibers and Y 2 O 3 additive on the phase compositions, linear shrinkage, apparent porosity, bulk density, microstructure, compressive strength and thermal conductivity were investigated. The results indicated that mullite-bonded among fibers were formed in the porous fibrous mullite ceramics with a bird nest pore structure . After determining the sintering temperatures and the amount of fibers, the tailored porous fibrous mullite ceramics had a low linear shrinkage (1.36–3.08%), a high apparent porosity (61.1–71.7%), a relatively high compressive strength (4.4–7.6 MPa), a low thermal conductivity (0.378–0.467 W/m K) and a narrow range of pore size distribution (around 5 µm). The excellent properties will enable the porous ceramics as a promising candidate for the applications of hot gas filters, thermal insulation materials at high temperatures.
研究领域:
材料科学
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陶瓷工程
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 7
·1-9
·
IF 5.705
Da Qiang,Gu Yuanyuan,Peng Xiafeng,Zhang Liying,Du Shuhu
A colorimetric and visual method is described for the determination of mercury(II) ion. A gel consisting of agar-stabilized silver-coated gold nanoparticles (Au@Ag NPs) was prepared. The reaction with dithiothreitol (DTT) via thiol-Ag chemistry results in an orange to purple color change of the gel. However, in the presence of Hg(II), the reaction of DTT with the silver shells is suppressed due to the strong thiophilicity of Hg(II). The color of the gel changes from purple to red to orange in the presence of increasing concentrations of Hg(II). The Au@Ag NPs therefore are a viable optical probe for Hg(II) which can be detected in concentration as low as 78 nM via dual-wavelength ratiometric absorbance (A 390 /A 520 ), and at 1 μM levels with bare eyes. The use of agar as a support is mandatory to prevent the aggregation of the NPs and also improves selectivity. The method was applied to the analysis of spiked samples, and recoveries ranged between 96.3 and 104%. The assay is easy, inexpensive, and in our perception represents an attractive tool for on-site visual detection of Hg(II).
Schematic of the assay. With increasing concentrations of Hg(II), the oxidative etching of silver shells caused by dithiothreitol (DTT) is gradually inhibited, and the color of agar-stabilized Au@Ag NP gel varies from purple to red, and finally to orange. This can be used for visual detection of Hg(II).
研究领域:
分析化学
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环境科学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
Food & Function
·
2024
·
IF 5.1
Xin Wang,Jing Zhang,Ruimin Zhong,Gangchao Li,Hongjin Qi,Yong Cao,Yaqi Lan
This study investigated the effect of oleogel consumption on lipid metabolism, gut microbiota and low-grade inflammation in rats fed by high-fat diet. Male SD rats received a control diet or high-fat diets for six weeks. High-fat diets included regular high-fat diet, high-fat diet where lard was replaced by pure sunflower oil, un-gelled sunflower oil with dispersed gelator, and gelled sunflower oil with gelator (oleogel), respectively. Results showed that consumption of oleogel significantly suppressed the weight gain and the adipose tissue accumulation, as well as lipid accumulation in serum and liver caused by a high-fat diet compared to regular fat, pure sunflower oil and un-gelled sunflower oil. Microscopy observations suggested that the white adipose tissue and liver steatosis caused by high-fat diet were also alleviated. Results from ex vivo biodistribution in rats indicated that more TAG moved downwards to the large intestine for oleogel group. In the meantime, the dysregulation of gut microbiota was restored by reducing the Firmicutes/Bacteroidetes ratio and the relative abundance of Desulfobacterota and Proteobacteria. The LPS levels in oleogel group were reduced in faeces, serum and liver. Furthermore, consumption of oleogel alleviated the inflammation, including decreased gene expression level of pro-inflammation cytokines, i.e., IL-6 and TNF-α, as well as suppressed protein expression of TLR4 and NF-κB in the liver. These results provided theoretical guidance for regulation of oleogel properties and the application of oleogels as healthy fat replacers in high-fat diet.
研究领域:
营养学
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微生物学
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代谢学
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食品科学
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产品关联
DOI
PubMed
高影响因子
Energy Storage Materials
·
2020
·
IF 16.28
Pengfei Sun,Juntong Chen,Yuanlin Huang,Jing-Hua Tian,Sha Li,Gulian Wang,Qiaobao Zhang,Zhaowu Tian,Li Zhang
Al-air batteries (AABs) are a great option for outdoor wearable electronics due to their high theoretical energy density (8100 Wh kg −1 ), huge industrial reserves and easy recyclability of Al, but suffer from severe self-corrosion, low Al utilization and harmful liquid leakage. Herein, we first devise a high-strength agarose gel electrolyte (AGE) that combines high toughness and super solution carrying capacity, for the construction of wearable AABs with high energy density, safety, easy assembly and greatly suppressed self-corrosion. The rigid AGEs convert the traditional Al/liquid interface into an Al/quasi-solid interface, thus leading to the formation of a Sn-dominated passivation layer that drastically inhibits the self-corrosion of Al. The in-depth failure mechanism study of AGE-based AAB coin cells demonstrates that three most critical factors affecting the discharge behavior of Al anodes are in order: H 2 accumulation, working current density and OH − replenishment. On this basis, the optimized large-area soft-package AAB (10 cm 2 ) shows a 20.1-hour discharge duration and a specific capacity of 2148.5 mAh g −1 (2766.9 Wh kg −1 ), outperforming those of the state-of-the-art AABs based on other gel electrolytes. More impressively, a practically useful wearable AAB pack is further prepared to drive the LED array and a smart phone.
研究领域:
材料科学
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能源技术
·
电化学
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Yiwen Wu,Bo Sun,Xinyi Pan,Baolin Guo,Xiaokang Li,Wei Guo,Qing Yao
Long afterglow materials were widely used in road lighting and safety indication because they could continue to emit light even after the excitation source stops. Due to the high cost associated with preparing long afterglow phosphor in glass, in this study, the long afterglow material SrAl 2 O 4 :Eu 2+ , Dy 3+ was combined with glass powder and solid waste. A new type of epoxy resin gel casting system was adopted. The sintering system of debinding at 700 °C for 2 h and then sintering at 825 °C was confirmed. By adjusting the demolding, drying, and sintering processes of the green body, the performance of the composite material was enhanced. Finally, the glass-based long afterglow composite material with a smooth appearance and distinct interface was obtained. We conducted strength and corrosion resistance tests on the prepared samples. The results showed that the flexural strength of the sample was 46.3 MPa and it had good mechanical strength. The average coefficient of friction was approximately 0.24. It was not easy to wear out and had a long service life. The electrochemical experiments indicated that the Nyquist plot showed that the impedance value of the material in the high-frequency region exceeded 10 3 Ω, indicating good initial corrosion resistance. Meanwhile, the impedance value in the low-frequency region was still higher than 10 1 Ω, demonstrating excellent corrosion resistance. The slope of the Bode plot curve being close to 1 indicated that there was a diffusion control process on the electrode surface, with a low corrosion rate and strong corrosion resistance of the sample. Therefore, this experiment provided a new feasible approach for the preparation of long afterglow phosphor composite materials by solid waste recycling.
研究领域:
材料科学
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环境工程
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高分子科学
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固体物理
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化学工程
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产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2019
·
IF 4.561
Xiangrui Meng,Yijin Mi,Dongling Jia,Ning Guo,Yarui An,Yuqing Miao
Co hydroxide polymorphs (green α-Co(OH) 2 , red β-Co(OH) 2 and brown β-Co(OH) 3 ) formed at separate positions in a test-tube. Diffusion of hydrazine hydrate downward in agar gel facilitated the reaction between hydrazine and Co 2+ leading a dilatational wave of reactant concentration. The resulting periodic Liesegang bands of α-Co(OH) 2 were observed due to the diffusion hindrance of reactants. It can be deduced that the high concentration of Co 2+ causes formation of α-Co(OH) 2 while the low concentrations produce β-Co(OH) 2 . β-Co(OH) 2 is oxidized readily to form brown β-Co(OH) 3 at the upper area of agar gel with high alkali condition and O 2 distribution. This study is helpful to learn the formation of more than one product and prepare multiple materials in single chemical reaction system. In addition, the obtained α-Co(OH) 2 has been stabilized in the gel medium for at least 3 months. It may facilitate its application in many areas especially in electrochemical area since α-Co(OH) 2 typically exhibits higher conductivity and electrocatalysis than β-Co(OH) 2 while in the past its application often is limited by thermodynamically instability.
研究领域:
材料科学
·
化学
·
电化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Lu Gao,Lihua Jin,Shengnan Zhang,Han Zhang,Like Lin,Cong Li,Bang Chen,Yehua Shen
In this study, a novel camellia oil composite oleogel (SX@G-CO) was prepared by a combination of direct dispersion and emulsion-templated methods using polysaccharides (sodium alginate and xanthan gum, ratio in 4:6) as oleogelators and glycerol monolaurate (GML, 7 wt%) as gel-enhancer. The comparative experiments revealed that the polysaccharides could effectively enhance the densification of the three-dimensional network structure of the oleogel through hydrogen bonding and electrostatic interactions, and significantly improve its thermal stability, rheological properties (adhesive strength 49,243.6 mPa•s, viscosity recovery rate 94.6 %) and oil binding capacity (80.6 %). The introduction of GML further enriched the crystal diversity of the oleogel and imparted excellent antimicrobial ability (nearly 100 % inhibition effect on E.coli ). Furthermore, the in vitro experiments demonstrated that the synergistic effect of polysaccharides and GML significantly enhanced the anti-inflammatory, antioxidant, cell migration and proliferation abilities of SX@G-CO oleogel compared with GML-CO and SX-CO oleogels. In addition, SX@G-CO oleogel has also been demonstrated to effectively promote full-thickness burn healing in mice by reducing bacterial infection and inflammatory response, regulating free radical levels, and promoting neovascularization in vivo, with effects comparable to marketed ointment. SX@G-CO oleogel as a bioactive molecule-polysaccharides composite has potential clinical application in burn wound repair.
研究领域:
材料科学
·
药剂学
·
生物医学工程
·
伤口愈合
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产品关联
DOI
PubMed
高影响因子
Materials Today Bio
·
2023
·
IF 8.2
Jun Tao,Peng Yang,Mingying Gao,Fan Zhang,Yongzhong Wu,Yan Jiang,Yunxuan Ning,Zhenglin Li,Fanrong Ai
Rheumatoid arthritis (RA) is a common chronic disease dominated by inflammatory synovitis, which is characterized with hyperplastic synovium, up-regulated matrix metalloproteinase (MMP) expression, hypoxic joint cavity and excessive reactive oxygen species (ROS) accumulation. Such local adverse microenvironment in RA joints further exacerbates the infiltration of synovial inflammatory cells, especially M1-type macrophages. Regulating intra-articular pathological conditions, eliminating excess M1 macrophages or converting them to an anti-inflammatory M2 phenotype may break the vicious progression circle. Herein, we develop a multi-stimulus responsive lipogel as effective platform to relieve RA symptoms and promote articular cartilage recovery via reversing its inflammatory microenvironment. The injectable lipogel is fabricated by loading polydopamine nanoparticles and methotrexate into a thermosensitive gel, and intra-articularly injected to form the therapeutic depot (PDA/ [email protected] ) in situ . The gel degrades slowly under esterase hydrolysis, and maintains sustained drug release in physiological conditions. Meanwhile, it can 1) induce a reversible gel-sol phase transition upon mild photothermal treatment (external NIR light control), and 2) specifically respond to MMP-rich RA microenvironment (internal enzymatic hydrolysis effect). Such stimulus-responsive system can deliver therapeutic components in a controllable manner, and significantly reverse adverse inflammatory microenvironment of RA joints through ROS eliminating, hypoxia alleviating, and M1-M2 macrophage polarization effects. Animal experiments indicate that observable RA relief and joint repair are realized after a single lipogel injection combined with NIR irradiation. Our study highlights the importance of altering local RA microenvironment via anti-inflammatory macrophage polarization, and therefore presents a potent therapeutic strategy for RA treatment in clinical intervention.
研究领域:
药理学
·
生物医学工程
·
免疫学
·
风湿病学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Guihua Fang,Qiuxiang Wang,Xuewen Yang,Yu Qian,Guowei Zhang,Qiang Zhu,Bo Tang
In this paper, we developed a vesicular phospholipid gels (VPGs) for topical ocular delivery of flurbiprofen (FLB) to treat anterior uveitis. FLB loaded VPGs (FLB VPGs), composed of FLB and egg yolk lecithin , were prepared by high-pressure homogenization technique. The effects of egg yolk lecithin content and homogenization pressure on properties of FLB VPGs, including size, encapsulation efficiency, yield and in vitro release profile were investigated. The resultant FLB VPGs were characterized by the transmission electron microscopy , differential scanning calorimetry , X-ray diffraction, fourier transform infrared spectroscopy , rheological behavior, and storage stability. Corneal permeation experiments revealed that VPGs could improve the transcorneal delivery of FLB under ex vivo conditions. VPGs were nonirritant toward to the rabbit eye, as indicated by slit lamp observation and histological observation. The results of tear pharmacokinetics and in vivo fluorescence imaging showed that VPGs could significantly prolong the precorneal retention time. In vivo biodistribution study indicated that VPGs could significantly improve drug bioavailability in ocular tissues. Moreover, FLB VPGs exhibited excellent anti-inflammatory effect in endotoxin induced uveitis in rabbits. Overall, VPGs are a promising ophthalmic drug delivery system for the treatment of anterior uveitis.
研究领域:
药剂学
·
眼科学
·
药物递送系统
·
炎症
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）