CRYSTENGCOMM
·
2022
·Vol. 24
·期 42
·7420-7426
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IF 3.756
Mingming Ruan,Anqi Li,Yaping Wen,Lian Zhou,Jun Zhang,Xiaopeng Xuan
Ammonia capture is of great importance to environmental protection and resource conservation. In this work, two isoreticular bio-MOFs, namely, Zn(3-AIN)(AD)·DMF and Zn(3-AIN)(AD)·DMA, were constructed with inexpensive, easily available and low-toxicity/non-toxic ligands and Zn2+ in different solvents, respectively. They possess 1D channels decorated by four free amine groups and N atoms from pyrimidine rings and can retain their crystallinity and porosity even after soaking in boiling water for 4 hours and in aqueous solution with various pH values ranging from 1 to 14. These two bio-MOFs can serve as promising sorbents for NH3, exhibiting a large uptake of about 7–10 mmol g−1 at 1 bar.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2019
·
IF 3.206
Juan Yue,Li Li,Peng Miao,Zheng Wang,Zhimin Chang,Dan Shao,Haohua Shao,Qian Mei,Shi-zhong Luo,Wen-Fei Dong
Adenine detection is important in biomedicine. Here, we report acriflavine-based carbon dots prepared via a one-step synthesis that can detect adenine in aqueous solution via fluorescence. Titration experiments show that the fluorescence intensity of carbon dots increases by up to 35% as the concentration of adenine increases. High-resolution transmission electron microscopy images show that carbon dots have a recognizable lattice structure. Based on this, we built a theoretical model using the DFT method to explain the mechanism by which adenine enhances fluorescence on the carbon dots.
研究领域:
生物医学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
SURFACE & COATINGS TECHNOLOGY
·
2024
·
IF 5.3
Qing Zang,Xiang Gao,Juan Qiu,Min Yu,Zhaoyu Mao,Kangwei Gongsun,Chunchao Chen,Changming Bu,Houyi Ma
A nanometer-thick adenine (Ade/NaClO) film with interlocking structure was successfully prepared by regulating the micro-etching process of sodium hypochlorite and the adsorption process of adenine. Compared to single adenine film, the compactness, adhesion and anti-corrosion performance of Ade/NaClO film were obviously improved. Electrochemical tests demonstrated that the corrosion protection efficiency was improved from 85.8 % to 98.2 % and exhibited self-strengthen anti-corrosion performance. In-situ Raman spectroscopy indicated that the oxidative etching effect of NaClO played an important role in the formation of the film. The strategy proposed in this study exhibits guiding significance for improving the performance of conversion films on metal.
研究领域:
材料科学
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电化学
·
表面工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Hao Guo,Tingting Zhang,Mingyue Wang,Lei Sun,Junye Zhang,Meng Yang,Fan Yang,Ning Wu,Wu Yang
In this work, a novel sensor based on gold nanoparticle-modified zirconium-metal-organic frameworks (MOF-801) and carboxyl-functionalized carbon nanotube (MWCNT-COOH) composite material was built successfully for electrochemical detection of guanine and adenine in DNA sample, which exhibits diverse advantages such as fast, convenience and high efficiency. Guanine and adenine were detected by the cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under the optimal conditions, MOF-801/MWCNT-COOH/ AuNPs/GCE delivered linear DPV responses to guanine in the range of 0.8 ~ 60, 60 ~ 180 μM and the adenine in the range of 0.8 ~ 60, 60 ~ 180 μM with the low detection limit of 0.09 μM for guanine and 0.08 μM for adenine, respectively. The advantages of this method include simplicity, rapidity, high sensitivity, good selectivity as well as low cost. The modified GCE was successfully applied to the analysis of guanine and adenine in DNA samples.
研究领域:
生物化学
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分析化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Xin Liu,Qin Zhang,Zijian Gao,Ruibin Hou,Guanghui Gao
Bioinspired strategies have drawn much attention for designing intelligent hydrogels with promising performance. Herein, we present a bioinspired adhesive hydrogel driven by adenine and thymine, which are the basic units of DNA. The adhesive hydrogel exhibited promising adhesive property for the surface of various solid materials, including muscle tissues, plastics, rubbers, glasses, metals, ceramics, carnelians, and woods. The maximum peeling strength of hydrogels was 330 N m–1 on aluminum, superior to that of PAAm hydrogels with 70 N m–1. The strong adhesive behavior remained more than 30 times repeated peeling tests. Moreover, the swelling behavior, morphological structure, mechanical strength, and peeling adhesive strength were also investigated and confirmed the formation and various characteristics of adhesive hydrogels driven by adenine and thymine. Thus, the biomimetic strategy to design promising adhesive hydrogels can provide various opportunities in tissue engineering, such as wound dressing, bioglues, and tissue adhesives.
研究领域:
生物材料学
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组织工程学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Qihai Wang,Zhifeng Luo,Xiaoli Ren,Haoran Fu,Quan Zhou,Keyou Chen,Shenwen Fang
Adhesive hydrogels frequently demonstrate poor mechanical properties; therefore, it is still challenging to integrate excellent adhesiveness and self-healing properties in one hydrogel. In this work, adenine and thymine were modified by grafting double bonds and then introduced into the structure of the polyacrylamide gel together with N, N′-methylene bisacrylamide (MBA) using a hybrid crosslinking strategy, and then a series of hybrid cross-linked hydrogels with adhesiveness and self-healing properties were successfully prepared. The hybrid crosslinking hydrogel exhibited a tunable adhesive performance and strength, by varying the content of base pairs, monomer concentration, cross-linker concentration, and initiator concentration. The recommended synthesis conditions for the P(AM-mAT) hydrogel were as follows: mA-mT concentration of the total monomer weight 5 wt%, total monomer concentration of 25 wt%, crosslinker (MBA) concentration of 0.5 wt%, and initiator APS concentration of 1.25 wt%. Under optimal conditions, the gel synthesized showed a hardness of 282 g and an adhesive force of 154.5 g. This hydrogel material exhibited excellent adhesion properties to materials such as plastics, glass, metals, and wood, with the best adhesion observed on glass.
研究领域:
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 9
·期 36
·4535-4542
·
IF 4.927
Xin Liu,Qin Zhang,Yanchao Qiao,Lijie Duan,Guanghui Gao
Hydrogels generally possess either high strength or excellent adhesive behavior but not both, which limits their applications. Here, we present anti-fatigue, adhesive and tough hydrogels through introducing nucleobase pairs of adenine–uracil (A–U) and chemical crosslinkers of N,N′-methylene bis-acrylamide (MBA) into polyacrylamide hydrogels. The synergetic interaction of A–U and MBA endowed hydrogels with high mechanical performance and excellent adhesive behavior via the tunable balance of cohesion and adhesion. The hydrogels exhibited a tensile strength of 120 kPa, a superior stretchability of 2700%, and remarkable adhesive behavior for various materials and biological tissues, including wood, steel, copper, polytetrafluoroethylene, plastics, glass, rubber, silica rubber, spleen, liver and fat. For example, the adhesion strength of hydrogels at the surface of polytetrafluoroethylene was 190 N m−1. More importantly, the hydrogels exhibited excellent anti-fatigue compressive toughness and adhesiveness. It was envisioned that the nucleobase-tackified chemical crosslinking hydrogels with excellent anti-fatigue, tough and adhesive behavior would be widely applied in wound dressings, human wearable devices and biomedical sensors and electrodes.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Materials Today Communications
·
2023
·
IF 3.8
Ran Feng,Jiazhi Meng,Hualei Yuan,Xu Zhang,Chunlang Gao,Chaogang Ban,Yizhong Guo,Kaiwen Wang
Cancers, Down’s syndrome, Alzheimer’s and other diseases of gene mutation always occur with anomalous changes of DNA nucleic acid base. Therefore, the development of highly sensitive and reproducible nucleic acid sensors that based upon surface enhanced Raman scattering (SERS) is of immense interest for clinical medical analysis and diagnosis. Herein, a rationally designed core-shell assembly of Au nanoparticle wrapped with Au doped Bi 5 O 7 Br nanotube with eliminated fluorescent background and notable chemical enhancement effect was exploited and served as a SERS sensor for detection of adenine. Especially, we found the fluorescent background was remarkably suppressed in Raman spectra by introducing Au element into Bi 5 O 7 Br. The sensor exhibited a maximum SERS enhancement factor of up to 5.45 × 10 7 and a detection limit as low as 10 −11 M after constructing Au nanoparticle/Au atom doped Bi 5 O 7 Br heterojunction . More importantly, good reproducibility and long term stability under work condition were achieved. To gain in-depth understanding into chemical mechanism (CM) of the Raman signal enhancement, density functional calculations (DFTs) were combined with atom-specific model derived via aberration corrected transmission electron microscope (AC-TEM) to demonstrate the enhanced charge transfer (CT) and substrate-adsorbate adsorption. The doping and coupling strategy holds the potential to fabricate high signal-to-noise ratio SERS sensors for other molecule detection.
研究领域:
生物医学工程
·
分子生物学
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分析化学
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产品关联
DOI
高影响因子
ELECTROCHEMISTRY COMMUNICATIONS
·
2019
·
IF 4.197
Jian Zhang,Dong Han,Shu Wang,Xiaodi Zhang,Ruiqi Yang,Yanchen Ji,Xin Yu
In this work, a WS 2 nanosheet/graphite microfiber hybrid electrode has been fabricated by in situ synthesis of WS 2 nanosheets on the surface of graphite microfibers. The WS 2 nanosheets possess an excellent electrocatalytic oxidation response towards adenine and guanine that encourages the adsorption of nucleobases and charge transfer at the surface of the microfibers. The WS 2 nanosheet/graphite microfiber hybrid electrode shows high sensitivity and selectivity for the detection of adenine and guanine. This hybrid microfiber electrode represents an excellent candidate platform for development of an electrochemical biosensor due to its low cost, flexibility and 3D morphology.
研究领域:
生物化学
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材料科学
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分析化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2022
·
IF 6.371
Peng Fei Wu,Xiao Yang Fan,Hong Yan Xi,Niu Pan,Zi qian Shi,Ting Ting You,Yu Kun Gao,Peng Gang Yin
Gold nanorods (Au NRs)/Ti 3 C 2 T x composites were prepared by self-assembly method as surface enhanced Raman scattering (SERS) substrates. Due to strong electrostatic interaction , Au NRs are evenly arranged on the surface of Ti 3 C 2 T x nanosheets , forming rich SERS hotspots. Au NRs/Ti 3 C 2 T x have high sensitivity and good reproducibility for the determination of organic dyes such as rhodamine 6G, crystal violet and malachite green. The detection limits were 1 × 10 −13 , 1 × 10 −13 and 1 × 10 −12 M, respectively. The relative standard deviations of samples in 40 areas were 4.57 %, 2.79 % and 3.47 %, respectively. The synthesized SERS substrate is sensitive to adenine. For adenine molecules in the range of 1 × 10 −5 –1 × 10 −9 M, SERS results show that the peak intensity is linear with adenine molecular concentration, and the detection limit can be as low as 1 × 10 −9 M. In addition, adenine in aqueous solution has good anti-interference ability to other nucleic acids with similar structure, such as guanine, cytosine and thymine. Therefore, Au NRs/Ti 3 C 2 T x are expected to become a potential substrate for unmarked, rapid and sensitive SERS detection of adenine in the field of bioanalysis.
研究领域:
材料科学
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分析化学
·
生物医学
✓ 已验证
产品关联
DOI
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2022
·
IF 9.463
Hafezeh Nabipour,Shuilai Qiu,Xin Wang,Lei Song,Yuan Hu
In this study, adenine was used as an efficient adsorbent for in situ removal of zinc ions, resulting in the formation of a bio-based metal–organic framework (bioMOF). The as-prepared bioMOF was further used as flame retardant additives to prepare fire-safe polymers. TGA results indicated that the bioMOF can improve the char yield in the EP composites. The EP composite with 8.0 wt% bioMOF displayed a high limiting oxygen index (LOI) of 31.0% as well as a UL-94 V-0 rating. Additionally, the peak heat release rate, total heat release, and smoke production rate of the EP composite with 8.0 wt% bioMOF declined by 56.3%, 50.5%, and 72.0%, respectively. Furthermore, the EP composite with 8.0 wt% bioMOF also displayed higher glass transition temperature and better tensile strength than the pristine EP. This work provides a novel approach to preparing fire-safe polymers through recycling waste from adsorbent materials of water decontamination.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Xiaoyan Zhai,Hussein Hanibah,Nor Zakiah Nor Hashim,Juzheng Zhang,Xianli Ma,Lilan Wei,Xiaoqun Zhou
Platinum-based chemotherapeutics have played a critical role in oncology for decades. However, their broader utility is hindered by the advent of severe side effects and the emergence of drug resistance. The pursuit of alternative agents, particularly non-platinum (non-Pt) metal complexes, has gained momentum in current research. Designing efficacious non-Pt metal agents that target DNA poses a complex challenge. In this study, we present the strategic design, synthesis, and thorough characterization of two innovative copper(II) complexes leveraging adenine as a ligand, a potential avenue to overcome these challenges. Our investigation demonstrates the superior cytotoxicity of these copper(II) complexes compared to the benchmark cisplatin, with complex C2 exhibiting the most promising anticancer activity, showcasing an impressive IC 50 value of 4.51 μM in MGC-803 cells. Mechanistic insights underscore that complex C2 executes its cytotoxic effects by instigating DNA damage, orchestrating cell cycle arrest at the G2 phase, perturbing mitochondrial membrane potential, inducing ROS production, and ultimately triggering apoptotic pathways. These findings significantly emphasize the potential of designing novel adenine-based anticancer metal complexes targeting DNA, portraying a compelling trajectory for advancing anticancer drug development.
研究领域:
药理学
·
肿瘤学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
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