APPLIED SURFACE SCIENCE
·
2021
·
IF 6.707
Xiaogang Guo,Taotao Liang,Huisheng Huang,Binfang Yuan,Jing Wang
In 21st century, the microchip plays an essential role in data and information security, and preventing information leakage stored in chips becomes more challenging. This paper firstly introduced electrophoretic assembly technique and surface functionalization to design the C-doped nano-Al/Co 3 O 4 functional energetic material (nFEM) coating with triple stability of anti-wetting, micro-structure and energy-release for at least one year, and the energetic film was integrated with copper based-chip to construct the C-doped Al/Co 3 O 4 nFEM-chip to realize its self-destruction. Product shows outstanding anti-wetting properties with high water contact angle of 168 ± 1° and extremely low sliding angle of ∼ 1°, and well weather resistance in variable environments. Impressively, the output of heat (Q) of product can reach up to 3598 J/g nearly 85% of theoretical value with a relatively low activation energy of 235.46 kJ/mol, and keeps almost thermopositive stability even for immersed samples for fifty cycles after one year exposure test. In addition, C-doped Al/Co 3 O 4 nFEM-chip after immersion and exposure tests can also be effectively destroyed or ignited with a dazzling flame in an ultrashort time (<1ms), demonstrating the great advantage and huge application potentials for the design of other functional transient-chips with nano/micro-scale high-energy systems applied in different environments, even underwater.
研究领域:
材料科学
·
信息安全
·
能源材料
·
表面工程
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Haifeng Yang,Zhiqiang Qiao,Weimiao Wang,Pengfei Tang,Shuaishuai Man,Xiaodong Li,YuTing Xie,Deyun Tang,Xueming Li,Guangcheng Yang
Private information protection of electronic chips which store large amounts of sensitive data, is a crucial issue in electromechanical systems nowadays. Here, a self-destructive microchip based on an instantaneous thermite reaction is designed to prevent the leakage of electronic information. The device is consisted of a silicon test wafer and an upper energetic film coated by a simple drop-casting technique. A series of Al/BiOX-based nanothermites have been prepared for decreasing the reaction sensitivity, meanwhile optimizing the destruction efficiency of the energetic film system. Among them, Al/Bi 2 O 3 nanothermite containing 30 wt% BiOBr possesses a low sensitivity (45 J), the maximum pressure peak (1.93 MPa) and pressure effect duration due to multiple interactions of the three nano-scale energetic components. Besides, the energetic film prepared by this nanothermite fomula also exhibits a more effective destruction of the device. The high-speed photography results demonstrate that the violent reaction shatters the thick energetic microchip (∼1 mm) within merely 0.5 ms. Importantly, the efficient destruction of energetic microchips shows excellent reproducibility in different working scenes, including Air or Ar atmosphere. It is believed that this self-destructive device with environmentally friendly components and simple but adaptive design can be extensively used in various electric microcomponents.
研究领域:
材料科学
·
电子工程
·
安全技术
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Xueli Hu,Peng Lu,Min Fu,Yongheng Zhang,Xinyu Cao,Jiabo Chen,Shutao Lin,Juanjuan Yao,Zhi Zhang
Breaking through the inherent thinking, activating insulators with abundant and economical sources as photocatalysts to promote the practical application of photocatalysis has attracted attention. Herein, an insulator photocatalyst barium silicate (BSO) was successfully prepared by the hydrothermal method, and a solid–liquid photocatalytic reaction system combining solid-phase photocatalyst with liquid-phase antibiotic photosensitizer was constructed. In this reaction system, the insulator BSO achieved excellent photocatalytic activity, and the degradation of 30 mg/L tetracycline reached 93.2 % after 12 W LED illumination for 2 h. The mechanism of tetracycline as a liquid-phase photosensitizer to activate the photocatalytic activity of BSO was explored. Lewis acid-base interaction not only alkalizes tetracycline to expand BSO light absorption, but also constitutes an electron transport channel between the BSO and alkalization tetracycline to facilitate the separation of photogenerated carriers. Alkalized tetracycline as a photosensitizer improves the response of BSO to visible light, and is decomposed by active substances such as 1 O 2 and O 2 − , thereby purifying the water body. This work reveals for the first time the mechanism of action of antibiotic photosensitizers to activate the photocatalytic activity of insulators, and provides a new perspective for the activation and development of insulators in photocatalysis.
研究领域:
环境科学
·
材料科学
·
生物学
✓ 已验证
DOI
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2024
·Vol. 42
·期 5
·570-578
·
IF 4.1
Sun Xiao-Fei,Zhang Xu,Song Shu-Ping,Yao Ya-Qun,Zhang Yan,Wang Cheng-Liang,Sun Jing-Jiang,Wang Qing-Fu
L -glutamic acid (LA) is a bio-based, non-toxic, environmentally friendly material derived from biomass. The present study reports the application of Passerini three-component polymerization (P-3CP) for the straightforward preparation of LA-based light-responsive polyesters (PLTDs) under mild conditions. PLTDs with molar masses up to 8500 g/mol and high yields exceeding 90% are obtained. The chemical structures and light-responsive self-immolative behavior of PLTDs are comprehensively characterized by employing ultraviolet-visible (UV-Vis) spectroscopy, size exclusion chromatography (SEC), nuclear magnetic resonance (NMR) spectroscopy, and liquid chromatography mass spectrometry (LC-MS). Meanwhile, monodisperse PLTD-based doxorubicin-loaded nanoparticles (PLTD-DOX-NP) (size=193 nm, PDI=0.018) are formulated by nanoprecipitation method. Upon light-induced depolymerization, the PLTD-DOX-NP undergoes rapid decomposition, resulting in a burst release of 80% cargo within 13 s. Furthermore, according to biological toxicity tests, the PLTD-NP possesses adequate biosafety, both before and after irradiation. Overall, the incorporation of P-3CP with biorenewable LA-based monomer adheres to the principles of green chemistry, significantly simplifying the synthetic pathway of light-responsive polymers.
研究领域:
材料科学
·
生物医学工程
·
绿色化学
✓ 已验证
DOI
高影响因子
ACS Nano
·
2023
·
IF 17.1
Chao Huang,Yuanyuan Shang,Jiachuan Hua,Yadong Yin,Xuemin Du
Vaccines are undoubtedly a powerful weapon in our fight against global pandemics, as demonstrated in the recent COVID-19 case, yet they often face significant challenges in reliable cold chain transport. Despite extensive efforts to monitor their time–temperature history, current time–temperature indicators (TTIs) suffer from limited reliability and stability, such as difficulty in avoiding human intervention, inapplicable to subzero temperatures, narrow tracking temperature ranges, or susceptibility to photobleaching. Herein, we develop a class of structural color materials that harnesses dual merits of fluidic nature and structural color, enabling thermal-triggered visible color destruction based on triggering agent-diffusion-induced irreversible disassembly of liquid colloidal photonic crystals for indicating the time–temperature history of the cold chain transport. These self-destructive structural color liquids (SCLs) exhibit inherent irreversibility, superior sensitivity, tunable self-destructive time (minutes to days), and a wide tracking temperature range (−70 to +37 °C). Such self-destructive SCLs can be conveniently packaged into flexible TTIs for monitoring the storage and exposure status of diverse vaccines via naked-eye inspection or mobile phone scanning. By overcoming the shortcomings inherent in conventional TTIs and responsive photonic crystals, these self-destructive SCLs can increase their compatibility with cold chain transport and hold promise for the development and application of the next-generation intelligent TTIs and photonic crystals.
研究领域:
材料科学
·
生物医学工程
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2019
·
IF 13.903
Menglin Wang,Yinglei Zhai,Hao Ye,Qingzhi Lv,Bingjun Sun,Cong Luo,Qikun Jiang,Haotian Zhang,Youjun Xu,Yongkui Jing,Leaf Huang,Jin Sun,Zhonggui He
Photodynamic therapy (PDT) shows a promising synergy with chemotherapy in the therapeutic outcome of malignant cancers. The minimal invasiveness and nonsystemic toxicity are appealing advantages of PDT, but combination with chemotherapy brings in the nonselective toxicity. We designed a polymeric nanoparticle system that contains both a chemotherapeutic agent and a photosensitizer to seek improvement for chemo-photodynamic therapy. First, to address the challenge of efficient co-delivery, polymer-conjugated doxorubicin (PEG-PBC-TKDOX) was synthesized to load photosensitizer chlorin e6 (Ce6). Ce6 is retained with DOX by a π–π stacking interaction, with high loading (41.9 wt %) and the optimal nanoparticle size (50 nm). Second, light given in PDT treatment not only excites Ce6 to produce cytotoxic reactive oxygen species (ROS) but also spatiotemporally activates a cascade reaction to release the loaded drugs. Finally, we report a self-destructive polymeric carrier (PEG-PBC-TKDOX) that depolymerizes its backbone to facilitate drug release upon ROS stimulus. This is achieved by grafting the ROS-sensitive pendant thioketal to aliphatic polycarbonate. When DOX is covalently modified to this polymer via thioketal, target specificity is controlled by light, and off-target delivery toxicity is mostly avoided. An oral squamous cell carcinoma that is clinically relevant to PDT was used as the cancer model. We put forward a polymeric system with improved efficiency for chemo-photodynamic therapy and reduced off-target toxicity.
研究领域:
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOORGANIC & MEDICINAL CHEMISTRY
·
2012
·
IF 2.921
Hui-juan Jin,Jing Lu,Xue Wu
A new self-immolative spacer conjugate based on a chemical adaptor unit aiming at controlled releasing drugs was designed and synthesized. It releases a fluorophore which was used as a model drug via a spontaneous cyclization mechanism after cleavage of an enzyme substrate. This system was proved to be stable under physiological conditions and only decomposed triggered by enzyme. It provides a generic linkage allowing connection of a variety of drugs and targeted devices to the chemical adaptor.
研究领域:
药用化学
·
药物递送系统
·
酶学
✓ 已验证
DOI
PubMed
高影响因子
Defence Technology
·
2023
·
IF 5.1
Jialu Yang,Jiaheng Hu,Yinghua Ye,Jianbing Xu,Yan Hu,Ruiqi Shen
Self-destructing chips have promising applications for securing data. This paper proposes a new concept of energetic diodes for the first time, which can be used for self-destructive chips. A simple two-step electrochemical deposition method is used to prepare ZnO/CuO/Al energetic diode, in which N-type ZnO and P-type CuO are constricted to a PN junction. This paper comprehensively discusses the material properties, morphology, semiconductor characteristics, and exploding performances of the energetic diode. Experimental results show that the energetic diode has typical rectification with a turn-on voltage of about 1.78 V and a reverse leakage current of about 3 × 10 −4 A. When a constant voltage of 70 V loads to the energetic diode in the forward direction for about 0.14 s or 55 V loads in the reverse direction for about 0.17 s, the loaded power can excite the energetic diode exploding and the current rises to about 100 A. Due to the unique performance of the energetic diode, it has a double function of rectification and explosion. The energetic diode can be used as a logic element in the normal chip to complete the regular operation, and it can release energy to destroy the chip accurately.
研究领域:
材料科学
·
电气工程
·
半导体物理
·
纳米技术
·
安全技术
✓ 已验证
产品关联
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2025
·
IF 6.4
Yiqing Chen,Zhishan Chen,Xingzhong Chen,Ziqing Mao,Hongqiang Zhu,Jingrui Guo,Jialong Xu,Ziyi Lin,Shaoan Zhang,Yang Li
Persistent luminescence has emerged as a robust platform for anti-counterfeiting applications due to its exceptional spatial-temporal decoding capability. Yet, conventional strategies often suffer from uniform emission patterns and predictable replication, compromising their security. Herein, we present “Snap-PLNPs”—near-infrared emitting CaS:Tm persistent luminescent nanoparticles engineered to undergo aqueous-triggered self-destruction via a hydrolysis mechanism. In contrast to traditional photophysical approaches, this chemically initiated degradation irreversibly terminates the luminescence, ensuring that security information can be decoded only once. Moreover, by incorporating an additional SiO2 shell, we introduce a programmable delay in the hydrolysis process, thereby modulating the duration of the emission and adding a temporal regulation layer. This dual control—combining instantaneous chemical deactivation with time-resolved modulation—establishes a dynamic hierarchical security encoding framework. When embedded into laser-engraved logos, these CaS:Tm@SiO2 hybrids enable a novel triple-layer anti-counterfeiting strategy that integrates spatial, temporal, and chemical dimensions. Our results underscore the potential of Snap-PLNPs as a next-generation platform for robust and adaptive security technologies.
研究领域:
材料科学
·
纳米技术
·
光学安全
·
化学工程
·
应用物理
✓ 已验证
产品关联
DOI
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Jian Wang,Xinxing Zeng,Fude Nie,Renming Pan,Jie Chen,Yaofeng Mao,Haifu Wang,Xingquan Zhang,Jun Wang
Transient microchips have attracted considerable attention in the field of information security and privacy protection due to their self-destruction capability. Metastable intermolecular composites (MICs) are appealing for such applications due to their high energy density and rapid reaction kinetics, which meet the demands for miniaturization and fast response in transient microchips. However, weak interfacial interactions in conventional MICs limit the contact between components, hindering both microchip integration and ignition reliability. Herein, a hydrogen-bond assembly strategy is proposed to fabricate BC/GO/Al/CuO energetic films with exceptional flexibility and superior combustion performance. Dopamine modification introduces abundant hydroxyl groups onto the MIC particle surfaces, enabling the formation of a continuous hydrogen-bond network with binder bacterial cellulose (BC) binder and functional additive graphene oxide (GO).The integrated transient microchips retain structural integrity after 25 drop tests from 50 cm height, and the BC/GO/Al/CuO films are reliably ignited using a 3 V/3 A power supply, inducing complete destruction to the silicon substrate. This work demonstrates a novel strategy for creating highly flexible and reactive energetic films, showing great promise for application in advanced transient microchips.
研究领域:
材料科学
·
微电子学
·
能源材料
·
柔性电子学
·
信息安全
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jingtong Wang,Zhao Li,Yajing Chen,Ningbin Luo,Shengbin He
With a number of outstanding properties, gelatin is an ideal candidate for assembling nanoplatforms in biomedical applications. Generally, gelatin nanocarriers are cross-linked by aldehydes to improve their stability in water solution. However, aldehydes could cause multiple toxicities and their cross-linking products are uncontrollable. Here, we first used a self-immolative cross-linker to assemble gelatin nanocarriers for the controlled release of drugs and targeted cancer therapy. The cross-linker contains a disulphide bridge and two symmetrical succinimidyl-esters, endowing it with multiple functions: 1) to cross-link the gelatin nanocarriers and thus improve their stability in water; 2) to conjugate the drug and tumor-targeting ligands with nanocarriers through covalent linkage; 3) to redox-responsively degrade the nanocarriers through hydrolysis of disulphide bridge; and 4) to produce traceless drug molecules through self-immolative reaction. Good biocompatibility and controllable drug release were demonstrated by in vitro experiments. Both qualitative and quantitative analyses confirmed the intracellular uptake of the nanocarriers by using doxorubicin (DOX) as a drug model and phenylboronic acid (PBA) as the targeting ligand. In vivo results demonstrated high therapeutic efficiency and low toxic side effects of the DOX loaded nanocarriers against artificial liver tumors.
研究领域:
药学
·
纳米技术
·
癌症研究
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2024
·
IF 13
Wanyue Lu,Weidong Wang,Yimin Gong,Jianing Li,Yaming Zhou,Yannan Yang
Intracellular delivery of proteins has largely been relying on cationic nanoparticles to induce efficient endosome escape, which, however, poses serious concerns on the inflammatory and cytotoxic effects. Herein, a versatile noncationic nano biohybrid platform is introduced for efficient cytosolic protein delivery by utilizing a nano-confined biocatalytic reaction. This platform is constructed by co-immobilizing glucose oxidase (GOx) and the target protein into nanoscale hydrogen-bonded organic frameworks (HOFs). The biocatalytic reaction of nano-confined GOx is leveraged to induce controlled perturbation of intracellular redox homeostasis by sustained hydrogen peroxide (H 2 O 2 ) production and diminishing the flux of the pentose phosphate pathway (PPP). This in turn induces the endosome escape of nanobiohybrids. Concomitantly, GOx-mediated hypoxia leads to overexpression of azo reductase that initiated the materials' self-destruction for releasing target proteins. These biological effects collectively induce highly efficient cytosolic protein delivery. The versatility of this delivery platform is further demonstrated for various types of proteins, different protein loading approaches (in situ immobilization or post-adsorption), and in multiple cell lines. Finally, the protein delivery efficiency and biosafety are demonstrated in a tumor-bearing mouse model. This nanohybrid system opens up new avenues for intracellular protein delivery and is expected to be extensively applicable for a broad range of biomolecuels.
研究领域:
纳米技术
·
生物医学工程
·
药学
·
细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）