Soft Matter
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2025
·
IF 2.8
Chaobao Wang,Yangyu Xi,Xinqi Zou,Xiuqin Bai,Jiale Chen,Binlu Zhang
Water lubrication, a green lubrication solution for underwater equipment, has attracted growing research attention. However, the creation of stable lubricating films in open-water environments remains a stubborn challenge. To address this issue, a facile method put forward to achieve the self-targeted transfer of hydration lubrication films underwater by preparing the polydopamine nanoparticles (PDA NPs) and PDA NPs/polyurethane (PU) composites. The self-targeted transfer behavior is intrinsically attributed to the adhesive and hydration properties of catechol groups within PDA NPs, nanoscale of PDA NPs and the designed structure of the nanocomposites. Comprehensive topographical and chemical analyses, along with tribological characterizations, verify the lubrication and anti-wear effects resulting from the self-targeted hydration lubrication of the nanocomposites. This research presents a novel method for enhancing the load-bearing capacity and stability of water lubrication, and demonstrates excellent performance in water-lubricated bearings.
研究领域:
材料科学
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摩擦学
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表面工程
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产品关联
DOI
PubMed
高影响因子
Nano-Micro Letters
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2020
·Vol. 12
·期 1
·1-18
·
IF 12.264
Li Yang,Lin Jinyan,Wang Peiyuan,Luo Qiang,Zhu Fukai,Zhang Yun,Hou Zhenqing,Liu Xiaolong,Liu Jingfeng
A pH/ROS cascade-responsive carrier-free nanodrug with self-targeting activation and ROS regeneration abilities.
On-demand release of VES in response to intracellular ROS to accelerate drug release via positive-feedback loop.
Highly synergistic therapeutic efficiency via orchestrated cooperation of oxidation-chemotherapy.
研究领域:
癌症研究
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纳米医学
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药剂学
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诊疗学
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产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2019
·
IF 13.903
Yang Li,Jinyan Lin,Peiyuan Wang,Qiang Luo,Huirong Lin,Yun Zhang,Zhenqing Hou,Jingfeng Liu,Xiaolong Liu
Tumor microenvironment responsive multimodal synergistic theranostic strategies can significantly improve the therapeutic efficacy while avoiding severe side effects. Inspired by the fact that special morphology could enhance photothermal conversion efficiency (PCE) and cellular delivery, we developed an acidic tumor microenvironment responsive shape-reversal metal–organic virus-inspired nanodrug for enhancing near-infrared (NIR)-II PCE, increasing cell adhesion, and activating tumor targeting. First, a NIR-I fluorescence probe (IR825), a chemo-drug (pemetrexed, PEM), and a rare-earth metal ion (Nd(III)) were chosen to synthesize a virus-like nanodrug via coordination-driven assembly. Then, the spike-like surface of the nanodrug was further camouflaged by an acidity-sensitive poly(ethylene glycol) “shell” to create virus-core and sphere-shell hierarchical nanoassemblies, which could efficiently prevent immune clearance and prolong systemic circulation. Interestingly, the acidic tumor microenvironment could trigger the shell detachment of nanoassemblies for shape reversal to produce a virus-like surface followed by re-exposure of PEM to synergistically amplify the cellular internalization while enhancing NIR-II PCE. By utilizing the shell-detached virus-like nanodrug core, the tumor microenvironment specific enhanced NIR-II photothermal chemotherapy can be realized under the precise guidance of fluorescence/photoacoustic imaging, thereby achieving complete tumor elimination without recurrence in a single treatment cycle. We envision that integrating the tumor microenvironment responsive ability with “sphere-to-virus” shape reversal will provide a promising strategy for biomimetic targeted cancer therapy.
研究领域:
癌症治疗
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纳米技术
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药学
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生物医学工程
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成像技术
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产品关联
DOI
PubMed
高影响因子
Bioactive Materials
·
2021
·
IF 14.593
Xiaomin Li,Licheng Yu,Chuangnian Zhang,Xiaoyan Niu,Mengjie Sun,Zichao Yan,Wei Wang,Zhi Yuan
Low accumulation and penetration of nanomedicines in tumor severely reduce therapeutic efficacy. Herein, a pH-responsive gold nanoassembly is designed to overcome these problems. Polyethylene glycol linked raltitrexed (RTX, target ligand and chemotherapy drug) and two tertiary amine molecules (1-(2-aminoethyl) pyrrolidine and N, N -dibutylethylenediamine) are modified on the surface of the 6-nm gold nanoparticles by lipoic acid to form gold nanoassembly defined as Au-NNP(RTX). The Au-NNP (RTX) nanoassembly could remain at about 160 nm at the blood circulation (pH 7.4), while split into 6-nm gold nanoparticles due to tertiary amine protonation at tumor extracellular pH (pH 6.8). This pH-responsive disassembly behavior endows Au-NNP(RTX) better tumor tissue permeability through the better diffusion brought by the size reduction. Meanwhile, after disassembly, more RTXs on the surface of gold nanoparticles are exposed from the shielded state of assembly along with 2.25-fold augment of cellular uptake capability. Most importantly, the results show that Au-NNP(RTX) possesses of high tumor accumulation and effective tumor penetration, thereby enhancing the tumor chemo-radiotherapy efficiency.
研究领域:
纳米技术
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癌症治疗
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药学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）