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Nano-Micro Letters · 2020 ·Vol. 12 ·期 1 ·1-19 · IF 12.264

Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy

Peng Xin,Chen Kun,Liu Wanhua,Cao Xiongfeng,Wang Mengru,Tao Jun,Tian Ying,Bao Lei,Lu Guangming,Teng Zhaogang

Soft mesoporous organosilica nanoplatforms modified with hyaluronic acid and cyanine 5.5 are constructed. Therapeutic efficacy of the soft nanoplatforms on tumor is higher both in vitro and in vivo after loading photosensitizer chlorin e6 compared to that of stiff counterparts.

CAS / MDL: 6066-82-6

研究领域: 纳米技术 · 癌症治疗 · 药学 · 材料科学

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MATERIALS & DESIGN · 2023 · IF 8.4

2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma

Peifeng Wang,Yang Du,Xingyang Zhao,Yueyang Hu,Tianjun Zhou,Xiaolong Liang,Chihua Fang,Jie Tian

Hepatocellular carcinoma is a common and highly malignant disease. As a currently designated systemic chemotherapeutic agent for advanced Hepatocellular carcinoma, sorafenib has been confronted with dilemma of drug-resistance caused by tumor hypoxia, which hinders the therapeutic efficacy of the drug. Based on this, a multifunctional mesoporous polydopamine nanoprobe 2Me-SPIO-CY5.5@AAZ-MPDA with a mesoporous frame loaded 2-Methoxyestradiol, Superparamagnetic Iron Oxide Nanoparticles and the near-infrared dye cyanine 5.5, conjugated with hypoxia Hepatocellular carcinoma-specific targeting molecule of sulfonamides acetazolamide, is fabricated for hypoxic region targeting, sorafenib resistance reversion and photothermal therapy of Hepatocellular carcinoma. In addition, the magnetic resonance imaging/fluorescence/photoacoustic tri-modal imaging ability enables the tracing of the nanoprobes and monitoring the treatment procedure in vivo, providing a new methods of imaging-guided Hepatocellular carcinoma synergic treatment which improves the long-term therapeutic effects of sorafenib.

CAS / MDL: 62-31-7 284461-73-0 108-67-8 77-86-1

研究领域: 药学 · 纳米技术 · 癌症研究 · 生物医学工程 · 医学影像

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Soft Mesoporous Organosilica Nanoplatforms Improve Blood Circulation, Tumor Accumulation/Penetration, and Photodynamic Efficacy

2-Methoxyestradiol loaded mesoporous polydopamine nanoprobes for hypoxia alleviation and sorafenib synergistic treatment of hepatocellular carcinoma