JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Yihao Li,Rongrong Cui,Xiyue Li,Lintao Yang,Yanbing Zhu,Yongzhe Li,Haiqin Zhang,Hongyao Xue
Regulating the electronic spin state of electrocatalysts is critical for enhancing the hydrogen evolution reaction (HER). Unlike multi-step catalytic reactions that require dynamic spin-state transitions, HER demands a stable, high-activity spin state throughout the catalytic process. However, maintaining this specific spin state remains challenging. The intrinsic high-spin Co 3+ sites of Co 3 Se 4 provide excellent theoretical HER activity, but intermediate adsorption during the reaction drains local electron density, altering the crystal field and causing the high-spin state to degrade. Herein, we propose an interfacial electron injection strategy to stabilize the highly active spin state by constructing a CoSe@Co 3 Se 4 heterostructure. The built-in electric field arising from the work-function difference promotes interfacial electron redistribution from CoSe toward the Co 3 Se 4 active sites. In situ spectroscopy and theoretical calculations reveal that interfacial electronic redistribution substantially mitigates the local electron depletion induced by intermediate adsorption. Consequently, the interfacial electronic and structural buffering provides a favorable local environment for stabilizing the high-spin Co 3+ state at the catalytically relevant Co sites, which optimizes orbital interactions with intermediates and significantly lowers the energy barrier for water dissociation. Benefiting from this stabilized high-spin Co 3+ state, the CoSe@Co 3 Se 4 catalyst achieves an ultralow overpotential of 12 mV at 10 mA cm −2 for HER. This work provides a fundamental understanding of spin-state instability and offers a promising interface-engineering pathway to stabilize the highly active spin-state for advanced electrocatalysis. Download: Download high-res image (195KB) Download: Download full-size image
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Dandan Chen,Yang Ding,Zhihui Feng,Lei Hu,Yupeng Tian,Jiahan Cheng,Xiaohe Tian
Methylglyoxal (MGO), a reactive dicarbonyl metabolite generated during glycolysis, has been implicated in oxidative stress and neuroinflammation associated with Alzheimer’s disease (AD), but its spatial relationship with amyloid-β (Aβ) pathology in brain tissue remains incompletely characterized. Here, we report two cyclometalated iridium(III) complexes, Ir-MA and Ir-DA, for reaction-based phosphorescent sensing of MGO. Ir-DA contains an ortho-diamino recognition unit that reacts with MGO to form the quinoxaline product Ir-DA-Qx, producing a pronounced phosphorescence turn-on response consistent with attenuation of photoinduced electron-transfer-mediated quenching. Compared with the mono-amino analogue Ir-MA, Ir-DA exhibited a preferential response toward MGO over structurally related dicarbonyl species under the tested conditions, with a regression-derived detection limit of 0.32 μM and nonlinear optical properties suitable for multiphoton imaging. Ir-DA enabled imaging of exogenous and endogenous MGO-related changes in living cells and revealed increased phosphorescence signals under inflammatory and amyloidogenic stress. In APP/PS1 mouse brain sections, Ir-DA-associated signals were elevated at 6 months relative to wild-type controls and further increased at 12 months, with quantitative colocalization analysis demonstrating a close spatial association with Aβ-positive plaque core and peri-plaque regions. Collectively, these results establish Ir-DA as a reaction-based phosphorescent platform for imaging MGO-associated carbonyl stress and provide quantitative imaging evidence linking MGO dysregulation with amyloid pathology.
✓ 已验证
产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2026
·
IF 6.6
Zhuoran Song,Haoqi Zhang,Xiaoqin Yang,Xiaoping Rao,Ping Zhao,Qian Jiang
As a key chemical raw material, hydrazine hydrate (N 2 H 4 ) is widely used in chemical manufacturing, aerospace propulsion and pharmaceuticals synthesis. However, excessive N 2 H 4 causes serious harms to the environment and organisms. Herein, a ratiometric fluorescence probe CDP has been designed and synthesized from p -hydroxycinnamic acid. Upon interaction with N 2 H 4 , the major fluorescence emission peak at 570 nm is blue-shifted to 455 nm, accompanied by a fluorescence color change from pale orange to blue. The detection limit of CDP for N 2 H 4 is determined as 17.08 nM. Experimental data further indicate that probe CDP can effectively detect N 2 H 4 across a broad pH range (5–12). More notably, probe CDP demonstrates significant potential for imaging N 2 H 4 in living cells and mice models. Moreover, probe CDP can be employed for the detection of N 2 H 4 in soil samples and water samples. This work describes a versatile fluorescence probe for detecting N 2 H 4 , underscoring its considerable potential in environmental analysis and public health monitoring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2026
·
IF 5.1
Zihao Tao,Zhongshun Sun,Huili Huang,Bolun Yang,Zhiqiang Wu
Efficient and resource- abundant heterogeneous catalysts for formic acid (FA) dehydrogenation are essential for realizing a sustainable hydrogen energy cycle. However, earth-abundant non-noble metal catalysts are severely limited by intrinsically sluggish C–H activation, acid-induced metal leaching and rapid CO poisoning from the competing dehydration pathway. To address these challenges, we propose a synergistic strategy integrating spatial confinement with alloy electronic modulation to synthesize a series of bimetallic nanoparticles encapsulated within biocarbon shells (NiM@BC). Among the synthesized catalysts, NiCo@BC exhibits outstanding catalytic performance, achieving a gas generation rate of 634 mL·g −1 ·h −1 at 95 °C (nearly twice that of monometallic Ni@BC) and drastically reducing the CO concentration from 8350 to 1240 ppm, along with excellent durability over multiple cycles. Structural characterizations confirm that NiCo alloy nanoparticles are uniformly encapsulated within a robust graphitic carbon shell, which prevents metal leaching and suppresses aggregation. Kinetic analysis and density functional theory calculations reveal that Co incorporation moderately shifts the Ni d-band center to an optimal position. The electronic modulation lowers the energy barrier of the rate-determining C–H bond cleavage, while simultaneously raising the dehydration barrier significantly, thereby widening the energetic gap between dehydrogenation and CO-forming pathways. This work provides a systematic theoretical foundation for the high-value utilization of biomass and the development of CO-resistant, durable, and precious-metal-free catalytic systems for FA dehydrogenation.
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL RESEARCH
·
2026
·
IF 8.2
Bin Dong,Chengxu Lai,Mengwei Han,Sanping Zhao,Songhao Luo,Yongbing Zhu
2,4,6-Trinitrotoluene (TNT) contamination presents serious threats to ecological safety and human health due to its high toxicity, carcinogenicity, and environmental persistence. Although microbial bioremediation is eco-friendly and cost-effective, its efficiency is often limited by low removal rates and weak microbial tolerance under TNT stress. This study utilized biochar to facilitate microbial biotransformation of TNT and systematically elucidated its synergistic mechanisms. Four types of biochar from different waste sources were screened, among which the wood biochar (MBC) exhibited the optimal performance. With MBC amendment, the TNT removal efficiency increased from 46.2% (strain-only control) to 88.7% within 48 h at an initial TNT concentration of 100 mg/L. Meanwhile, the first-order kinetic rate constant rose from 0.01323 h −1 (strain-only) to 0.03987 h −1 , revealing that MBC greatly accelerated the TNT removal rate. Biochar accelerated removal kinetics, alleviated TNT-induced growth inhibition of strain T22 via lowering aqueous TNT concentration, and stimulated extracellular polymeric substance secretion. Untargeted metabolomics revealed 330 up-regulated differential metabolites in the biochar-microbe system, indicating intensive metabolic reprogramming. Mechanistically, MBC directly enhanced TNT transformation via activation of the nitrotoluene degradation and cofactor biosynthesis pathways. The synergistic mechanisms were proposed to include: (1) weakened TNT exposure; (2) enhanced antioxidant metabolism; (3) activated core transformation pathways; and (4) supplemented basal metabolic supply. Although complete mineralization and soil-scale validation are beyond the present scope, our findings establish a mechanistic foundation for designing biochar-microbe systems for enhanced nitroaromatic remediation.
✓ 已验证
产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Qi-Jia Jiang,Ke Cao
A rhodium-catalyzed universal protocol for selective chalcogenation of B(4)-H of o-carboranes with diaryl diselenides, diaryl disulfides, and diphenyl ditelluride has been developed for the first time. A series of B(4)-Se/S/Te-o-carborane derivatives decorated with various kinds of active groups have been synthesized with excellent yields and regioselectivity. Based on control experiments, a plausible mechanism involving radical and direct oxidative addition process is proposed. This work would be an important reference for the design of new reactions for the chalcogenation of boron clusters.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Chonglin Zheng,Weifeng Zhang,Zijing Guo,Yujie Jin,Jinying Li,Shengxu Luo,Jihui Li
Pyrolysis impregnation of magnetic iron is a promising strategy for preparation of magnetic biochar, but high temperature is usually required to produce magnetic iron species. Herein, a novel co-oxidative pyrolysis using potassium permanganate and potassium ferrate was explored for synthesis of magnetic biochar at 250–400 °C. Additionally, the magnetic biochar was applied to remove tetracycline and copper(II) from aqueous solution. This co-oxidative pyrolysis successfully impregnated magnetite, zero-valent iron, and manganese ferrite into carbon matrix with manganese oxides at 250 °C. Meanwhile, porous structures were created, accompanying by abundant oxygen groups. This magnetic biochar displayed 720.7 and 267.9 mg/g adsorption capacities toward tetracycline and copper(II) at 35 °C correspondingly, with 21.79 emu/g saturation magnetization. High adsorption capability was still achieved in real water matrices, showing great potential of the magnetic biochar for wastewater treatment in industry. The adsorption could be primarily contributed to hydrogen bond/complexation/π-π interaction/pore filling for tetracycline and cation exchange/complexation/electrostatic interaction/pore filling for copper(II). The success in fabrication of highly adsorptive magnetic biochar by potassium permanganate and potassium ferrate co-oxidative pyrolysis at low temperature, demonstrating oxidative magnetization was a promising technology for synthesis of high performance magnetic biochar with low energy consumption.
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2020
·
IF 5.977
Mengtian Jia,Yanyan Zhu,Dong Guo,Xiaogang Bi,Xiaohong Hou
Core-shell magnetic Fe 3 O 4 @MIL-101(Cr) nanoparticles were synthesized via layer-by-layer self-assembly method. Using Fe 3 O 4 @MIL-101(Cr) as support, Fe 3 O 4 @MIL-101(Cr)@MIP was prepared with phenytoin as template, acrylamide as functional monomer , ethylene glycol dimethacrylate as cross-linker, methanol and acetonitrile as porogen , azoisobutyronitrile as initiator. The materials were characterized by a serious of characterization experiments. The prepared Fe 3 O 4 @MIL-101(Cr)@MIP was demonstrated to possess good separability, large adsorption capability, excellent adsorption selectivity , good durability and reusability via adsorption experiments. Subsequently, a magnetic solid phase extraction method (MSPE) based on Fe 3 O 4 @MIL-101(Cr)@MIP combined with high performance liquid chromatography-ultraviolet detector (HPLC-UV) was established for the determination of phenytoin sodium in plasma samples. Experimental parameters including pH, the amount of adsorbent, extraction time, elution conditions, the concentration of NaCl were investigated to optimize extraction process. The method was validated. The linearity was observed in the range of 0.05–40 μg mL −1 with a lower limit of quantification of 0.05 μg mL −1 . The calibration equations were y = 0.2514x + 0.0319 ( r 2 = 0.9938), y = 0.2888x + 0.0472 ( r 2 = 0.9943), y = 0.2565x + 0.0418 ( r 2 = 0.9976), respectively. The recoveries ranged from 89.2 to 94.3%, intra- and inter-day precision (RSDs) ranged from 2.1 to 9.7% and 2.9–9.2%, respectively. The established MSPE-HPLC-UV method was time-saving, sensitive, accurate, environmental friendly, and drastically reduced the complex matrix interferences. The established method was successfully applied for phenytoin sodium determination in real plasma samples, providing new directions for therapeutic drug monitoring.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHYTOTHERAPY RESEARCH
·
2015
·Vol. 29
·期 7
·996-1003
·
IF 2.66
Hao Liu,Zhi Song,Da-Guang Liao,Tian-Yi Zhang,Feng Liu,Kai Zhuang,Kui Luo,Liang Yang,Jing He,Jian-Ping Lei
This paper was designed to investigate anticonvulsant and sedative effects of eudesmin isolated from Acorus tatarinowii . The eudesmin (5, 10, and 20 mg/kg) was administered intraperitoneally (i.p.). The maximal electroshock test (MES) and pentylenetertrazole (PTZ)-induced seizures in male mice were used to evaluate anticonvulsant activities of eudesmin, and sedative effects of eudesmin were evaluated by pentobarbital sodium-induced sleeping time (PST) and locomotor activity in mice. Finally, the mechanisms of eudesmin were investigated by determining contents of glutamic acid (Glu) and gamma-aminobutyric acid (GABA) in epileptic mice, and expressions of glutamate decarboxylase 65 (GAD65), GABA A , Bcl-2, and caspase-3 in the brain of chronic epileptic rats. Results of MES and PTZ tests revealed that eudesmin possesses significant anticonvulsant effects, and the PST and locomotor activity tests demonstrated that eudesmin has significant sedative effects. Furthermore, our study revealed that after treatment with eudesmin, GABA contents increased, whereas Glu contents decreased, and ratio of Glu/GABA decreased. Our results also indicated that expressions of GAD65, GABAA, and Bcl-2 were up-regulated by treating with eudesmin, whereas the caspase-3 obviously was down-regulated. In conclusion, eudesmin has significant anticonvulsant and sedative effects, and the mechanism of eudesmin may be related to up-regulation of GABA A and GAD65 expressions, and anti-apoptosis of neuron the in brain. Copyright © 2015 John Wiley & Sons, Ltd.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2013
·Vol. 14
·期 12
·23751-23761
·
IF 2.464
Jun Xiang,Yugang Jiang
Our present study aimed to determine the antiepileptic activity of matrine, and explore the possible molecular mechanism. To evaluate the antiepileptic activity of matrine, seizures in mice induced by PTZ and MES were established, then the pentobarbital sodium-induced anaesthetizing time and locomotor activity tests in mice were also carried out. For the molecular mechanism investigations, contents of aspartic acid (Asp), gamma-aminobutyric acid (GABA), glutamic acid (Glu), glycine (Gly) in seizures mice were determined; then, the chronic seizures rats induced by PTZ were prepared, and western blotting was used to determine the expressions of GAD 65, GABAAand GABABin the brains. In the results, matrine showed significant antiepileptic effects on seizures mice induced by MES and PTZ. Moreover, the pentobarbital sodium-induced anaesthetizing time and locomotor activity tests were also demonstrated that matrine had obvious antiepileptic effects. Additionally, our results revealed that after treatment with matrine, contents of GABA can be elevated, and the contents of Glu were obviously decreased. Furthermore, western blotting revealed that the mechanism regarding the antiepileptic effect of may be related to the up-regulations of GAD 65 and GABAAin the brain. Collectively, we suggested that matrine can be developed as an effective antiseptic drug.Keywords:antiepileptic;matrine;gamma-aminobutyric acid;glutamic acid
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
·
2013
·
IF 2.608
Tao Yang,Bin Kong,Jian-Wen Gu,Yong-Qin Kuang,Lin Cheng,Wen-Tao Yang,Jing-Min Cheng,Yuan Ma,Xiao-Kun Yang
This study was designed to evaluate the anticonvulsant and sedative effects of paederosidic acid isolated from Paederia scandens (Lour.) Merrill. in mice and rats. In the present study, anticonvulsant activities of paederosidic acid were evaluated by maximal electroshock and pentylenetetrazole-induced seizures in male mice. Then, pentobarbital sodium-induced sleeping time and locomotor activity tests in mice were used to evaluate the sedative effects of paederosidic acid. Finally, the mechanism of paederosidic acid was explored by evaluating the contents of Glu and GABA in the brain, and Western blot was used to measure GAD65 expression in the mouse brain. Paederosidic acid (5, 10, 20, and 40 mg/kg, ip) had significant anticonvulsant and sedative effects. Moreover, paederosidic acid increased brain gamma-aminobutyric acid and decreased glutamic acid in the brain, and it up-regulated expressions of GAD 65. In conclusion, our results suggest that paederosidic acid may be a promising future therapeutic agent for treatment of epilepsy .
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Pharmacognosy Magazine
·
2017
·
IF 1.069
An Wu,Xia Ye,Qiang Huang,Wei-Min Dai,Jian-Min Zhang
Objective: This work aimed to investigate the anti-epileptic effects of valepotriate isolated from Valeriana jatamansi Jones and studied its possible mechanisms. Methods: The anti-epileptic effects of valepotriate were studied using maximal electroshock-induced seizure (MES), pentylenetetrazole (PTZ)-induced epilepsy, and pentobarbital sodium-induced sleeping model in mice. The possible anti-epileptic mechanisms of valepotriate were investigated by analyzing the expressions of GABA A , GABA B , glutamic acid decarboxylase (GAD65), Bcl-2, and caspase-3 in the brain using Western blot assay. Results: The results indicated that valepotriate showed significant anti-epileptic activity against MES- and PTZ-induced epilepsy at doses of 5, 10, and 20 mg/kg, and ED 50 values for MES- and PTZ-induced epilepsy were 7.84 and 7.19 mg/kg, respectively. Furthermore, valepotriate (10 and 20 mg/kg) can significantly prolong sleeping time and shorten the latency time on the pentobarbital sodium-induced sleeping time test. Furthermore, valepotriate (5, 10, and 20 mg/kg) could significantly up-regulate the expression of GABA A , GAD65, and Bcl-2 and down-regulate the expression of caspase-3, but had no significant effect on the expression of GABA B . Conclusion: The results indicated that valepotriate had anti-epileptic activity and the mechanisms might be associated with regulation of GABA and inhibition of neuronal apoptosis. SUMMARY Anti-epileptic effect of valepotriate was investigated for the 1 st time Valepotriate showed notable anti-epileptic activity Valepotriate can significantly increase the expression of GABA A , glutamic acid decarboxylase 65, and Bcl-2 and reduce the expression of caspase-3. Open in a separate window
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）