SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Xiaoxiang Cheng,Zhe Xu,Xinsheng Luo,Yi Chai,Jiajian Xing,Xinyu Zhang,Jingtao Xu
Inorganic membranes are prime candidates for organic solvent recovery in the pharmaceutical industry due to their excellent solvent resistance, mechanical strength and durability. However, constructing high-performance inorganic separation layers is still the most challenging aspect in the fabrication of inorganic membranes for organic solvent nanofiltration (OSN). Prussian blue analogues (PBAs) exhibit high chemical stability for their rigid cubic framework with strong covalent metal-cyanide coordination bonds. Inspired by the interfacial polymerization (IP) strategy, this study proposes a simple synthesis method for prussian blue analog thin films (PBA TFs) on porous ceramic substrates, using coordination reactions between K 3 [Fe(CN) 6 ] and acetylacetonate (e.g. Cu(acac) 2 , Mn(acac) 3 or Co(acac) 2 ). The Mn-Fe PBA membrane exhibits high solvent permeance (e.g., 176.4 L·m −2 ·h −1 ·bar −1 for ethyl acetate) and demonstrates a molecular weight cut-off ranging from 665 to 760 Da across six tested solvents. To evaluate the industrial potential of Mn-Fe PBA membranes, solvent recovery experiments were conducted in a twin-stage OSN system using seven active pharmaceutical ingredient (API)/solvent systems. In the tylosin/dimethyl sulfoxide system, the Mn-Fe PBA membrane achieved over 80 % total API retention, maintaining stable performance across multiple cycles. The formation process of PBA TFs was analyzed by adjusting monomer diffusion conditions. Furthermore, molecular dynamics simulations elucidated the film formation mechanism. The self-limiting nature of the IP strategy not only inhibits the formation of PBA large crystals, but also induces the self-assembly of PBA nanocrystals along the n-hexane/water interface, resulting in a complete PBA TF. This IP strategy blazes a new trail for fabrication of high-performance inorganic OSN membranes.
研究领域:
材料科学
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化学工程
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膜分离技术
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制药工程
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DOI
高影响因子
JOURNAL OF HETEROCYCLIC CHEMISTRY
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2014
·Vol. 52
·期 6
·1839-1843
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IF 0.873
Min Wang,Lingtian Wang,Qin Guo,Junjun Ge,Deqing Lin,Xiaoxia Ye
A facile and efficient method has been developed for the preparation of seven-membered heterocycles 1,5-benzoxazepines 3 by MeSiCl 3 /DMF-catalyzed domino reaction via the addition of in situ generated enamines to aldehydes 1 . The advantages of this method are that it operates easily and achieves good yields for a broad scope of aldehyde substrates. And the corresponding products can be readily transformed to other categories of compounds, such as the hydrogenated products 4 , which may have potential application in drug industry.
研究领域:
有机化学
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药物化学
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DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2019
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IF 4.191
Yong Guo,Jiangping Fan,Lailiang Qu,Chongnan Bao,Qian Zhang,Hong Dai,Ruige Yang
Sesamol, a natural phenolic compound with good antioxidant activity, is a nonoil component of sesame seed oil. Two series of novel Mannich bases, 4-(aminoalkyl)-6-allyl-sesamols were synthesized from sesamol, substituted benzaldehydes and piperidine/morpholine via the one-pot reaction. An efficient way using toluene as solvent, catalyst-free and one-pot reaction for the synthesis of these sesamol derivatives was developed. The structures of all 4-(aminoalkyl)-6-allyl-sesamols were determined by spectral analysis. Compound 6f was unambiguously confirmed by X-ray diffraction further. The antioxidant assays have demonstrated that the sesamol derivative 7i displayed excellent antioxidant activity. The structure–activity relationships (SARs) of these sesamol derivatives were also observed. Further, the representative compounds 7a , 7g and 7i exhibited relative low toxicity to normal cells. Based on these characteristics, these sesamol derivatives will have great potential application in food and drugs.
研究领域:
有机化学
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药学
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食品科学
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DOI
高影响因子
ACS Omega
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2024
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IF 3.7
Yang Xie,Peng Li,Dong Fu,Fan Yang,Xin Sui,Bo Huang,Jiaying Liu,Jialong Chi
Cannabidiol (CBD) has demonstrated its potential to enhance depression treatment through various biological pathways. However, the application potential of CBD is significantly impeded by its polymorphic nature, limited water solubility, and hepatic first-pass metabolism. To improve chemical stability and water solubility, nanostructured lipid carriers loaded with CBD (CBD-NLCs) were developed using a hot-melt emulsification method and optimized by response surface methodology (RSM). The process parameters were optimized using a four-factor and three-level Box–Behnken experimental design consisting of 29 experiments. The CBD-NLCs were formulated and characterized, demonstrating desirable properties, including a mean particle size of 54.33 nm, a PDI value of 0.118, a zeta potential of −29.7 mV, and an impressive encapsulation efficiency rate of 87.58%. The nanoparticles were found to possess an approximately spherical shape, as revealed by scanning and transmission electron microscopy. The stability studies have demonstrated that CBD-NLCs effectively mitigated the photodegradation of CBD and exhibited a stable behavior for 42 days when stored. The CBD-NLCs displayed a biphasic release profile characterized by an initial burst release (over 50% of CBD released within 20 min) followed by a subsequent gradual and sustained release, aligned with first-order kinetics and Fickian diffusion. These findings demonstrate the potential suitability of this formulation as a carrier for CBD in food fortification and pharmaceutical applications.
研究领域:
药剂学
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纳米技术
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药物递送系统
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生物药剂学
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DOI
PubMed
高影响因子
Surfaces and Interfaces
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2025
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IF 6.3
Saimeng Zhang,Yan Wang,Zixuan Zhu,Lifei Zhi,Guoyong Wang
Carbosilane surfactant, with carbosilane as a hydrophobic group linked to hydrophilic groups, have attracted considerable attention owing to hydrolysis resistance. In this study, a novel nonionic carbosilane surfactant series (i.e., trialkylsilylpropanol polyoxyethylene ethers) was designed and synthesized. The structures of the surfactants were then characterized, and their surface activities, aggregation properties, wettabilities, and foaming behaviors were investigated. The surfactants exhibited a lower surface tension, superior wetting properties, low foam height, no gel phase, and high detergency. These properties render them suitable for preparing concentrated liquid detergents, for which gel formation is undesirable. Notably, the surfactants form onion-like vesicular structures in an aqueous solution, demonstrating their potential to be applied as drug carriers in the pharmaceutical sector.
研究领域:
胶体与界面化学
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材料科学
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药物应用
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洗涤剂化学
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DOI
高影响因子
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