JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2023
·
IF 4.5
Haifeng Yao,Yahui Zhang,Yongping Dong,Mingfu Ye
Graphdiyne (GDY) is considered as another promising carbon material in biosensing field. However, the application of GDY in ECL sensing is in its infancy stage, and different roles of GDY are urgent to be discovered. In this work, strong anodic Ru(bpy) 3 2+ electrochemiluminescence (ECL) was obtained at a cucurbit[8]uril (Q[8]) modified electrode. Although GDY exhibited electrocatalytic effect on the oxidation of Ru(bpy) 3 2+ , an apparent inhibiting effect of GDY on the ECL signal was observed due to the energy transfer. An “on-off-on” mode ECL sensor was fabricated to detect pancuronium (PMD) based on the competitive host–guest interaction between ferrocene (Fc), PMD and Q[8]. Fc modified single-stranded DNA was immobilized onto the surface of GDY, which could be attached onto the electrode through the interaction between Fc and Q[8]. The quenching effect of GDY could apparently decrease ECL signal. PMD exhibited stronger combining ability with Q[8] than Fc, and could replace Fc from the cavity of Q[8], leading to the recovery of ECL signal. The variation of ECL intensity changed linearly with the PMD concentration in the range of 10 nM to 50 μM with a detection limit of 5 nM (3σ). The proposed sensor has high sensitivity, outstanding specificity and accuracy, indicating that GDY has promising potential application in ECL sensing field based on its inhibiting effect.
研究领域:
分析化学
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生物传感
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材料科学
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产品关联
DOI
高影响因子
ANALYTICAL SCIENCES
·
2020
·Vol. 36
·期 11
·1379-1385
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IF 2.049
Zhongxia WANG,Yuanfei GAO,Wenjuan WANG,Fenying KONG,Hengye LI,Dahe FAN,Wei WANG
Here, we present an excellent strategy of unmodified near-ultraviolet fluorescence nitrogen doping carbon nanobelts (NFNCBs) for detecting nimesulide (Nim). After a simple hydrothermal process of uric acid and hydroquinone in DMF solvent, NFNCBs shows the shape of corroded stalactite-like composed of nanobelts aggregates, near-ultraviolet luminescence and a narrowed full width at half maximum. This could improve/change the electronic properties and surface chemical active site, as the result of a sensitive response to Nim. By employing this sensor, the quantitative measurement displays a linear range of 2.0 nM – 100.0 μM with a lower detection limit of 0.21 nM (3σ/k) for Nim. Our work has provided a high selectivity for Nim, which may be capable for pharmaceutical sample analysis in real tablets. Furthermore, the results concerning the recoveries (96.3 – 106.2%) for real sample analysis indicate that this nanoprobe might expand a good avenue to design an effective luminescence nanoprobe for other biologically related drugs.
研究领域:
材料科学
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分析化学
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药学
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DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2022
·Vol. 414
·期 26
·7675-7681
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IF 4.478
Sheng Yilun,Huang Zhongnan,Chen Yaling,Guo Xiaoyun,Chen Lan,Peng Huaping,Chen Wei
Monitoring of dihydropyridine drugs, such as nifedipine (NIF), has attracted considerable attention owing to the side effects arising from the consumption of such drugs. Herein, a highly sensitive and facile fluorescence-sensing platform based on a high-quantum-yield sulfur quantum dot (SQDs) probe for NIF detection is proposed. Based on the principle of the inner filter effect, the rapid detection of NIF with high sensitivity is successfully realized on the basis of the change in the fluorescence signal due to the quenching effect of NIF on SQDs. The results show a good linear relationship between the NIF concentration and fluorescence intensity within the range of 5–150 μmol/L, with a low detection limit of 1.63 μmol/L (S/N = 3). Moreover, because no surface modification or establishment of any coupling between the receptor and the fluorophore is necessary, this approach provides considerable flexibility and simplicity for the construction of a fluorescence sensor and substantially reduces the detection time. A systematic investigation was conducted to verify the applicability of this method for the analysis of pharmaceutical components in NIF tablets. This study not only promotes the design and development of a fluorescence analysis platform for NIF detection, but also facilitates the fabrication of novel SQD-based fluorescence-sensing systems for the molecular detection of drugs. Graphical abstract
Proposal for a facile nifedipine assay method based on the inner filter effect of nifedipine to high-quantum-yield sulfur quantum dots, and realizing nifedipine detection in tablets and human urine samples.
研究领域:
分析化学
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药物化学
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生物医学工程
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DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2020
·
IF 4.049
Yuwei Wang,Yuwang Jie,Qingkun Hu,Ying Yang,Yuxin Ye,Shichun Zou,Jianqiao Xu,Gangfeng Ouyang
A novel disposable styrene based solid-phase microextraction (SPME) fiber was synthesized for the detection of lipid-lowering and antihypertensive drugs in real aquatic environment. Styrene and poly(ethylene glycol) diacrylate were co-polymerized on quartz fibers by thermal polymerization in capillary molds. The polymeric fiber possessed a homogeneous, dense as well as porous surface, showing excellent chemical and mechanical stability. The performance of the fiber was evaluated through the extraction of seven pharmaceuticals by coupling SPME with high performance liquid chromatography-tandem mass spectrometry under the optimized extraction conditions. The extraction efficiency of the fiber was up to 278 times of PDMS fiber and the enrichment factors ranged from 55 to 1183. The limits of detection were in the range from 1.7 ng L −1 to 11.7 ng L −1 , with good reproducibility. Moreover, the fiber was used in the real water samples of the Pearl River Delta. The recoveries of the target analytes from river water and sea water samples at different spiked concentrations were in the range from 84.1% to 133.4% and from 81.5% to 105.5%, respectively.
研究领域:
环境科学
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分析化学
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
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2020
·Vol. 187
·期 7
·1-12
·
IF 6.232
Kalambate Pramod K.,Dhanjai,Sinha Ankita,Li Yankai,Shen Yue,Huang Yunhui
New multi-walled carbon nanotubes supported on Ti 3 C 2 –MXene and chitosan (chit) composite film–based electrochemical sensor for ifosfamide (IFO), acetaminophen (ACOP), domperidone (DOM), and sumatriptan (SUM) have been developed. Ti 3 C 2 –MXene was synthesized by a fluoride method. Structural and chemical characterizations suggested the successful preparation of Ti 3 C 2 –MXene with clearly seen layered morphology, defined 0 0 2 diffraction peak at 7.5° and complete absence of 1 0 4 plane at 39°. The electrochemical performance of the sensor was investigated by cyclic voltammetry and adsorptive stripping differential pulse voltammetry. The Ti 3 C 2 /MWCNT/Chit modified glassy carbon electrode exhibits enhanced electrocatalytic activities toward the oxidation of target analytes. Excellent conductivity, large surface area, and high catalytic properties of the Ti 3 C 2 –MXene showed synergistic effects with MWCNTs and helped in achieving low detection limits of targets with high selectivity and reproducibility. The assay allows determination of IFO, ACOP, DOM, and SUM in the concentration ranges 0.0011–1.0, 0.0042–7.1, 0.0046–7.3, and 0.0033–61 μM with low detection limits of 0.00031, 0.00028, 0.00034, and 0.00042 μM, respectively. The sensor was successfully applied for voltammetric screening of target analytes in urine and blood serum samples with recoveries > 95.21%. Schematic illustration of the synthesis of self-assembled MXene/MWCNT/chitosan nanocomposite is given and its application to the voltammetric determination of ifosfamide, acetaminophen, domperidone, and sumatriptan described.
Graphical abstract
研究领域:
分析化学
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材料科学
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医学检测
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
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2023
·
IF 1.8
Qin Yang,Shenshu Chen,Yaqing Li,Taifeng Jiao,Lianghong Cheng,Quan Yu,Xinqiong Lu
In this study, we introduce the design, characterization, and application of an integrated thermal desorption corona discharge ionization (TD-CDI) device, which was developed for direct mass spectrometry (MS) analysis of drugs in solid or liquid samples. The structure and operational parameters of the TD module were optimized through simulation and experimental investigations. For the CDI module, a hollow needle was used as the discharge electrode and sample inlet , allowing self-aspiration and efficient ionization of the desorbed samples. The TD-CDI device was tested and characterized using different mass spectrometers , exhibiting satisfactory stability and quantitative performance. Owing to its compact structure, it can be coupled to a miniature MS instrument to implement rapid identification of various drugs in urine solutions.
研究领域:
分析化学
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医学检测
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仪器科学
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DOI
高影响因子
JOURNAL OF MASS SPECTROMETRY
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2024
·Vol. 59
·期 11
·e5098
·
IF 1.9
Dimei Hu,Lulu Yu,Zijian Wei,Lingpeng Zhan,Peiqi Luo
A novel inorganic nonmetallic material boron carbide (B 4 C) was applied in paper spray ionization to analyze organic molecules in both negative and positive modes. The utilization of B 4 C has led to a notable enhancement in signal responses for various molecules, including bisphenols and drugs, by approximately two to four times. The limit of detection (LOD) of bisphenol AF and nilotinib standard solutions can reach 1 and 0.5 μg/mL, respectively. Moreover, linear relationships for bisphenol AF was established within the concentration range of 1–100 μg/mL, exhibiting strong correlation coefficients. Recovery experiments for BPAF in water samples from the inlet and outlet of a sewage treatment plant, conducted without any pretreatment, achieved a maximum recovery rate of 98.8% and an RSD below 9.78%.
研究领域:
分析化学
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材料科学
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环境科学
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2019
·Vol. 11
·期 34
·16026-16035
·
IF 6.97
Liang Huang,Jiening Jin,Jing Wang,Chenxing Jiang,Meng Xu,Huimin Wen,Tao Liao,Jun Hu
Controllable integration of gold building blocks into mesoscopic architecture produces improved optical signals with preferable stability for biological sensing. Here, we developed novel optical labels with homogeneous and high-density implanted hydrophobic gold nanoparticles (AuNPs) throughout three-dimensional silica scaffolds. The dendritic silica supports with an extra-large pore size and highly accessible central-radial channels were employed as metal-affinity templates, for anchoring with AuNPs directly from the organic phase. The nano-assemblies exhibited a high unit loading capacity while maintaining the intrinsic optical characteristics of AuNPs. After phase transfer by the alkylsilane intermediate layer and exterior silica shell encapsulation, the nanocomposites revealed an amplified plasmonic absorption signal, excellent colloidal/optical stability and convenient surface functionalization. By integrating the silica labels into the lateral flow immunoassay strip for signal enhancement, the sensitive point-of-care detection of methamphetamine in urine was established. The limit of detection achieved 0.026 ng mL−1, with a detection range from 0.023 to 375 ng mL−1 in a 10 min assay, allows both visual and on-site quantitative analysis. Encouragingly, the potential interfering drugs in the sample matrix showed a negligible influence on the results, validating the superior specificity of the current immunoassay. The newly developed gold-implanted optical labels show prospects for point-of-care testing in a complex biological matrix with the desirable stability and signal amplification.
研究领域:
生物传感
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纳米医学
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分析化学
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产品关联
DOI
PubMed
高影响因子
RAPID COMMUNICATIONS IN MASS SPECTROMETRY
·
2015
·Vol. 29
·期 14
·1328-1334
·
IF 2.253
Ping Liu,Yongjun Hu,Jiaxin Chen,Qing Yang
Rationale Traditionally, drug analysis in biological tissue by mass spectrometry has required complicated sample pre-treatment, which not only wasted time, but also had adverse effects on the results. In order to assist assessment of potential drugs rapidly and accurately, a direct analytical method for drug detection in tissues is needed. The development of such a method is described in this study. Methods An anti-cancer drug, 9-phenylacridine (ACPH), injected into the kidney of mice, was directly analysed from tissues placed on the surface of a graphite rod by near-infrared (1064 nm) laser desorption single photon ionization mass spectrometry (LD/SPI-MS). Results The LD/SPI-MS method was successfully validated by direct analysis of ACPH in kidney sections of mice, without any complicated and time-consuming sample pre-treatment. The sensitivity of detection was down to about 100 fmol per spot and the wide linear dynamic range allowed quantitative detection of ACPH in complex biological samples. A drug-time curve was acquired of ACPH in the kidney of mice after the drug had been injected into the caudal vein. Conclusions It was demonstrated that the anti-tumor drug ACPH could be directly and rapidly detected by LD/SPI-MS in biological tissues without any time-consuming pre-treatment procedure. This method could potentially be applied to the selective localization and analysis of small molecule drugs in tissues and to the study of the pharmacokinetics of new drugs. Copyright © 2015 John Wiley & Sons, Ltd.
研究领域:
分析化学
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药理学
·
肿瘤学
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2021
·
IF 6.986
Bin Jiao,Huimin Ye,Xinwei Liu,Jiexun Bu,Junhan Wu,Wenpeng Zhang,Yunfeng Zhang,Zheng Ouyang
The development of miniature mass spectrometry (MS) systems with simple analysis procedures is important for the transition of applying MS analysis outside traditional analytical laboratories. Here, we present Mini 14, a handheld MS instrument with disposable sample cartridges designed based on the ambient ionization concept for intrasurgical tissue analysis and surface analysis. The instrumentation architecture consists of a single-stage vacuum chamber with a discontinuous atmospheric interface and a linear ion trap. A major effort in this study for technical advancement is on making handheld MS systems capable of automatically adapting to complex conditions for in-field analysis. Machine learning is used to establish the model for autocorrecting the mass offsets in the mass scale due to temperature variations and a new strategy is developed to extend the dynamic concentration range for analysis. Mini 14 weighs 12 kg and can operate on battery power for more than 3 h. The mass range exceeds m/z 2000, and the full peak width at half-maximum is Δm/z 0.4 at a scanning speed of 700 Th/s. The direct analysis of human brain tissue for identifying glioma associated with isocitrate dehydrogenase mutations has been achieved and a limit of detection of 5 ng/mL has been obtained for analyzing illicit drugs in blood.
研究领域:
分析化学
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医学技术
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人工智能应用
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2021
·
IF 2.262
Miao Qin,Xia Zhou,Jun Zhu,Mutian Ma,Hongyan Wang,Liangbao Yang
We herein report the preparation, optical properties, and use of gold nanorods for the detection and analysis of additives and impurities in weight-loss healthcare products. Gold nanorods with different aspect ratios were synthesized by controlling the silver nitrate content. The resulting self-assembled gold nanorods, combined with a portable Raman spectrometer, were used as surface-enhanced Raman scattering substrates to analyze and detect phenolphthalein and sibutramine hydrochloride in a simulated aqueous solution. The obtained results indicate the high sensitivity and stability of this detection method owing to the use of gold nanorod substrates prepared from 100 μL silver nitrate. Therefore, the proposed detection method has potential for promoting the application of Raman spectroscopy in the detection of such drugs.
研究领域:
材料科学
·
分析化学
·
药学
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产品关联
DOI
高影响因子
DIAMOND AND RELATED MATERIALS
·
2025
·
IF 5.1
Siyu Xu,Xiaoyu Li,Yueling Zhang,Danhong Zhang,Nan Gao
Boron-doped diamond (BDD) is suitable for use as an electrochemical analytical electrode for real-time detection because of its ultra-wide electrochemical potential window and low background current. However, the practical application of planar BDD electrodes is limited by their low conductivity, few active sites, and insufficient detection sensitivity, which need to be improved by surface modification. In this study, submicron carbon spheres (SMCS) were deposited on BDD substrate by a simple CVD method. The composite structure (SMCS/BDD) has a large specific surface area and high conductivity, which improves the sensitivity for drug detection. These results indicate that BDD-based all‑carbon materials have the potential to be used as electrodes for medical sensors.
研究领域:
材料科学
·
医学检测
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）