SENSORS AND ACTUATORS A-PHYSICAL
·
2025
·
IF 4.9
Jiayi Su,Cunao Feng,Yuxia Wang,Yu Guo,Xinyue Zhang,Kai Chen,Xiaowei Li,Dekun Zhang
Traditional TENG (Triboelectric Nanogenerator) research has primarily focused on static loads, limiting their applicability of multimodal composite dynamic loads in practical operating conditions. Therefore, this study centers on the performance and response mechanisms of encapsulated TENGs under multimodal dynamic loads, optimizing TENG structure and performance by using Fe₃O₄-doped MWCNTs-PDMS as the friction layer and encapsulation material. The fabricated TENG demonstrates outstanding performance under both static and dynamic loads, with its output voltage exhibiting a strong linear relationship with both frequency and load. A linear fit accuracy (R²) of up to 98.18 % was achieved under specific conditions. The study indicates that the displacement of the encapsulated TENG correlates well with voltage, with normal signal transmission, and exhibits excellent environmental adaptability, sensitivity, and durability, offering broad application prospects in industrial monitoring and intelligent systems. The TENG device developed in this study shows great potential as a core sensing unit for predictive maintenance systems in engineering applications involving vibrational environments. It is expected to advance fields such as intelligent monitoring and human-machine interaction toward higher sensitivity and broader detection ranges.
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Xianjing Zhou,Yanxin Qi,Zhijun Zhang,Jingjing Nie,Yubin Huang,Binyang Du
Novel engineered microgels with amphipathic network structures were designed and synthesized by copolymerizing N-isopropylacrylamide, 1-vinylimidazole, and 2-(cinnamoyloxy)ethyl methacrylate in the presence of 1,6-dibromohexane. The engineered microgels possess hydrophilic quaternization cross-linking structures and hydrophobic cross-linking inner nanodomains, which are suitable for loading and simultaneous release of hydrophilic nonsteroidal anti-inflammatory drug diclofenac sodium (DS) and hydrophobic antic cancer drug doxorubicin (DOX), respectively. The engineered microgels exhibited excellent stability, low cytotoxicity, and long blood circulation time and could be uptaken into the cytoplasm of cells, metabolized, and excreted from the living body by the kidney and the liver. In vivo experiments showed that with injection of DS and DOX dual-drug-loaded microgels, simultaneous antitumor treatment and inflammation depression were achieved along with high antitumor efficacy and low drug-related toxicity. Such microgels with amphipathic network structures have promising applications for combination therapy.
研究领域:
生物材料学
·
药剂学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Yonggan Yan,Yeyu Zhao,Luxing Wei,Limin Zhang,Jiuyu Cui,Xiaoyong Qiu,Jun Huang
Hydrogel friction exhibits dynamical instability under an unstable load force, and comparatively less effort has been devoted to understanding the load-dependent behavior of hydrogel friction. In this work, the load-dependent behavior of hydrogel friction was observed, and the underlying mechanism was investigated using a glass substrate rotating against polyacrylamide-based hydrogels. As the load force (Fn) increases, the friction coefficients (μ) for hydrogels exhibit an initial rapid decrease followed by a gradual increase. In the μ-decrease regime, the dramatic decrease in μ can primarily be attributed to the deformation and desorption of polymer chains from the substrate surface under shearing. In the μ-increase regime, the μ-increase rate is determined by the hydrogel network and charge behavior at the gel–substrate interface. An underneath load-dependent mechanism is proposed to explain the unique friction behavior of hydrogels. During the whole process, increasing the load force can result in an increase in viscosity (η) and a decrease in thickness (h) of the solution at the gel–substrate interface, further leading to a gradual increase in μ. In the μ-decrease regime, the terminal polymer chains adjacent to the substrate surface play dominant roles, and the desorption of the polymer chains from the substrate surface can lead to a sharp decrease in μ. In the μ-increase regime, h and η of the solution at the interface play dominant roles, therefore leading to a gradual increase in μ. Overall, this work provides fundamental insights into understanding hydrogel friction and facilitates the development of water-based lubricants in biomedical applications.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2022
·
IF 5.999
Min Du,Jing Jin,Feng Zhou,Jiayue Chen,Wei Jiang
Antibacterial and hemostatic properties are essential for wound healing dressing. In this study, a new type of hydrogel composed of gelatin methacryloyl (GelMA) and hyaluronic acid-aldehyde (HA-CHO) is fabricated by photo-crosslinking and respectively loaded with a single drug gentamicin sulfate (GS), and two drugs of GS and lysozyme (LZM). The composite hydrogel of GelMA and HA-CHO is successfully synthesized by the aldehyde and Schiff base reactions. The structures and compositions of the hydrogels with and without drug loaded are characterized by FT-IR, 1 H NMR, and XPS. Furthermore, the microstructure and swelling behaviour of hydrogels prove that the content of HA-CHO has a significant role in the formation of hydrogels with dense porous structures and super absorbent. pH 7.4 and pH 5.0 conditions are used to evaluate the drug release behaviour of the obtained hydrogels. The released amount of GS of the drug-loaded hydrogels in the acidic buffer is more than that of the physiological environment because of the cleaved Schiff base bonds and the electrostatic interaction. Especially for the dual drug-loaded hydrogel GelMA/HA-CHO/GS/LZM, the released ratio of GS is elevated from 59 % in pH 7.4 buffer to about 78 % in pH 5.0 buffer within the first 6 h, which verifies the excellent pH-stimulus responsiveness. These endow the GS-LZM dual drug-loaded hydrogels with superior antibacterial efficiencies to that of the single GS drug-loaded hydrogels, no drug-loaded hydrogels, and SEBS control, especially in inhibiting S. aureus in a lower concentration of 10 6 CFU mL −1 , which can be attributed to the synergistic effect of LZM and GS. For S. aureus at 10 6 CFU mL −1 , the bacterial survival of GelMA/HA-CHO/GS/LZM is 1.1 %, which shows outstanding antibacterial effect . Hence, the drug-loaded hydrogels, especially the dual drug-loaded hydrogels with pH-responsive, antibacterial, and hemostatic properties have great potential as wound healing materials.
研究领域:
生物材料学
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医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2020
·
IF 3.83
Yichao Gong,Junjie Li,Lin Liu,Lei Xu,Jie Cui,Guojun Zhang,Tiecheng Lu
Improving the lithium density and performance of lithium-based ceramics is the main direction for the development of advanced tritium breeder. In this work, the previously used polymers or organics were replaced by eutectic LiNO 3 –LiCl in wet process for preparing spherical green body, and then Li 4 SiO 4 pebbles were fabricated through molten salt assisted sintering. The eutectic salt used herein was eco-friendly and had little effect on the Li 4 SiO 4 pebbles. Instead, the incorporation of eutectic salt improved the lithium density and sinterability of Li 4 SiO 4 . The prepared Li 4 SiO 4 pebbles exhibited well-grained microstructure, and the grain size increased with the increasing contents of eutectic salt. Compressive tests showed that the crush load increased more than five times when 20 wt% eutectic salt was added. The proposed method may have great prospects in the preparation of tritium breeding materials.
研究领域:
核科学与技术
·
材料科学
✓ 已验证
DOI
高影响因子
POLYMER TESTING
·
2022
·
IF 4.931
Yiyu Wang,Wenlong Yu,Chunqing Niu,Guiting Yu,Xin Huang,Jian Shi,Da Ma,Xuezheng Lin,Kai Zhao
Microspheres produced from biodegradable poly (D, L-lactic-co-glycolic acid) (PLGA) have been studied widely as drug delivery carriers for therapeutics. This study aimed to develop a near-infrared (NIR) light-activated PLGA microsphere loaded with two kinds of drugs with different molecular weights respectively or simultaneously by the double emulsion method (bovine serum albumin (BSA) and tetracycline hydrochloride (TH) as the drug model agents, indocyanine green (ICG) as the NIR responsive component). To optimize the incorporation of drugs and particle size for PLGA microspheres loaded single drug, the effect of three processing parameters, including the amount of polymer, initial ICG content, and initial BSA or TH content on the drug entrapment efficiency (EE), drug loading and the particle size were investigated. The PLGA microspheres were spherical and ranged from 5 to 10 μm in diameter. The EE of ICG and BSA in PLGA@ICG-BSA was 78.41 ± 0.71% and 69.88 ± 5.14%, respectively. The EE of ICG and TH in PLGA@ICG-TH was 71.52 ± 5.07% and 28.39 ± 3.39%. The PLGA microspheres exhibited desirable biodegradability and low cytotoxicity. Based on the optimized processing of single drug-loaded microspheres, dual-drug-loaded microspheres containing both large and small molecule drugs were further prepared. The EE of ICG, BSA, and TH was 83.37 ± 0.59%, 52.65 ± 3.48%, and 12.88 ± 2.53%; the particle size was ∼7.21 μm. All the NIR-responsive PLGA microspheres exhibited an efficient photothermal property and enhanced photothermal stability under multiple NIR irradiation cycles. The drugs from the different PLGA microspheres were released continuously over 18 days, mainly determined by Fick's diffusion. Furthermore, the drugs can be controlled released through a NIR light trigger, resulting in a dosage increase at a specific time point.
研究领域:
生物医学工程
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药剂学
✓ 已验证
DOI
高影响因子
Journal of Materials Research and Technology-JMR&T
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2025
·
IF 6.6
Guangzhi Jin,Peng Li,Yuzhen Gong,Yu Wang,Runguo Wang,Fanzhu Li,Yonglai Lu
The microstructure of casting polyurethane (CPU) affects its performance under high dynamic loads, which is critical for developing high-performance materials. Herein, NDI-based casting polyurethane materials with varying hard segment contents (20%, 30%, 40%) were synthesized, and their behaviors under tensile fatigue (a strain amplitude of 100%, a frequency of 10 Hz, and up to 50,000 cycles) was investigated. As the number of fatigue cycles increased, the applied load required to achieve the same strain decreased, primarily due to stress softening and plastic deformation in the CPU. Microstructural analysis revealed a reduction in hydrogen bonding degree, leading to a decrease in structural regularity and an increase in defects. Atomic force microscopy (AFM) images revealed that the hard segments gradually integrated into the soft segment matrix, which reduced the content of high- and medium-modulus phase regions and correspondingly increased the low- modulus phase region. Transmission electron microscopy (TEM) images clearly suggested the destruction process of the spherulites, in which the crystallization structure deteriorated more significantly after fewer cycles in CPUs with higher hard segment content. The crystallinity, long period, and transition layer thickness of the CPUs demonstrated a decreasing trend with increasing fatigue cycles. This study provides valuable insights into the performance of CPUs under dynamic loading, laying a theoretical foundation for designing durable, and fatigue-resistant materials.
研究领域:
材料科学
·
力学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2019
·
IF 3.45
Shuang Yin,Senchuan Jiang,Limei Pan,Lin Guo,Zhenghao Zhang,Jingxian Zhang,Xiaoyun Li,Tai Qiu,Jian Yang
Herein, a low–toxic N, N–dimethylacrylamide (DMAA) system was used in preparation of porous Si 3 N 4 ceramics by aqueous gelcasting, and variations in microstructure and properties with solid loading and calcination temperature were systematically investigated. In the considered solid loading range of 28–44 vol%, all the slurries exhibited superior rheological properties (≤145 mPa⋅s at 95.40 s −1 for 44 vol% solid loading) perfectly suitable for casting. With increasing solid loading, a decreased bulk density (1.71–1.69 g/cm 3 ), volume shrinkage (37.73–13.77%) and flexural strength (46.56–26.75 MPa) of green bodies were obtained, exhibiting better mechanical properties than those derived from the conventional acrylamide (AM) system. Regarding Si 3 N 4 ceramics with various solid loadings, the increase in calcination temperature favored the phase transformation α→β–Si 3 N 4 and β–Si 3 N 4 growth, however, the increased solid loading exhibited an inhibiting effect on those since mass transport in gas phase was blocked due to the disruption of pore connectivity. The resulting microstructure changes imparted Si 3 N 4 ceramics increasing flexural strength (110.36–367.88 MPa), fracture toughness (2.54–5.03 MPa⋅m 1/2 ), as well as decreasing porosity (54.21–41.05%) and pore size (0.38–0.33 μm). This work demonstrates the potential research value of DMAA system in preparing high–performance porous Si 3 N 4 ceramics through gelcasting technique.
研究领域:
材料科学
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陶瓷工程
✓ 已验证
DOI
高影响因子
POLYMER COMPOSITES
·
2025
·
IF 4.7
Feng Qi,Chunyang Di,Jun Gao,Shiying Tang,Fugang Qi,Biao Zhang,Nie Zhao,Honghao Ma,Xiaoping Ouyang
Explosive blasts are considered a distinct hazard in modern military conflicts, which cause extensive damage to buildings and people. Although conventional impact-resistant materials, consisting of metals/ceramics and polymers, have been researched systematically, the study of lightweight polymer matrix materials on explosive blast attenuation is limited. Therefore, we designed two main structural materials to evaluate the protective ability and mechanical properties of polyurethane elastomer (PUE) and polyurea (PUA) engineering materials under explosive blast loads. The first material was obtained by doping reinforced carbon nanofibers into PUE composites, and the second material was designed based on the mechanical properties of the PUE and PUA single-layer plates. The attenuation rate of PUE nanocomposites with different nanofiller masses was found to be reduced by 48.44%. Involving multilayers between different types of polymers, PUE/PUA composite plates exhibited an attenuation rate of 84.82% by altering the structure and materials based on their mechanical properties under explosive loads. Therefore, they can provide a favorable and practical strategy for the preparation and structural design of protection materials to withstand the shock wave in vehicle applications, gas explosions, and military events. Highlights Lightweight polymer matrix materials on explosive blast attenuation were studied systematically. Composite plates were made up of polyurea and polyurethane elastomer. Two main structural materials were designed. Carbon nanofibers were used to enhance the composites. PUE/PUA composite plates exhibited an attenuation rate of 84.82% under the explosion.
研究领域:
材料科学
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防护工程
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Yating Wu,Guihua Wei,Xin Cao,Ran Wang,Xue Gou
The healing of infected wounds is a complex and dynamic process requiring tailored treatment strategies that address both antimicrobial and reparative needs. Despite the development of numerous drugs, few approaches have been devised to optimize the timing of drug release for targeting distinct phases of infection control and tissue repair, limiting the overall treatment efficacy. Here, a stimuli-responsive microsphere encapsulating dual drugs was developed to facilitate differential drug release during distinct phases of antibacterial and repair promotion, thereby synergistically enhancing wound healing. Specifically, zeolite imidazolate backbone in poly (lactic-co-glycolic acid) (PLGA) microsphere was employed for the encapsulation of ciprofloxacin (CIP), responding to acidic environment of bacteria and releasing antibiotic for antibacterial therapy. Meanwhile, curcumin (CUR) encapsulated in PLGA exhibited a gradual release profile, contributing to synergistic antibacterial effects. During the tissue repair phase, near-infrared light stimulation of Fe 3 O 4 embedded in PLGA generated heat, elevating the temperature to the glass transition point of PLGA, which significantly enhanced the release of CUR thereby promoting tissue repair. In vitro experiments demonstrated that the release of CIP and CUR achieved significant antibacterial effects in the early stages of treatment. Additionally, CUR could effectively enhance fibroblast migration and proliferation. In vivo studies using a mouse abscess model revealed that the microspheres exhibited remarkable antibacterial and wound-healing capabilities, effectively enhancing the re-epithelialization of wound tissue and reducing the infiltration of inflammatory cells. This study provides novel strategies for constructing drug delivery systems that match dynamic stages of wound healing, offering improved therapeutic outcomes for infected wounds.
研究领域:
生物材料学
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药物递送系统
·
伤口愈合研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2025
·
IF 4.5
Pengfei Tang,Wentao Huang,Xiaohang Liu,Wanqi Cui,Yongjie Liu,Liwei Wu,Youhong Tang,Hongping Zhang,Qingyuan Wang
The microstructure of carbon fiber—including its crystal structure and defect characteristics—is a critical factor governing its mechanical properties and ensuring the long-term stability of carbon fiber-reinforced composites. However, advancements in carbon fiber–resin matrix interface reinforcement technology have altered the stress distribution in CFRP, leaving the evolution mechanisms of carbon fiber microstructure still largely unexplored. These knowledge gaps pose significant challenges to the development of high-performance carbon fiber-reinforced composites. Therefore, this study explored the evolution of the carbon fiber microstructure in the interface-reinforced CFRP under cyclic tensile loading based on polydopamine coating interface-reinforced CFRP (PDA-CFRP). Mechanical experimental evaluation found that the mechanical properties and fatigue properties of PDA-CFRP were significantly improved due to the polydopamine coating-reinforced interface between carbon fiber and epoxy resin. In addition, after tensile fatigue testing, it can be clearly observed that the defect level in PDA-CFRP is lower than that in CFRP, as well as the reduction of (002) crystal plane spacing. These results suggest that cyclic tensile loading leads to an increase in carbon fiber defects and a decrease in the (002) interplanar spacing in CFRP, and that interface modification can reduce these evolutions by uniformly distributing stress. This study not only reveals theoretical insights into the damage and fracture of carbon fibers in CFRP under cyclic tensile loading but also provides theoretical guidance for the design of high-performance CFRP.
研究领域:
材料科学
·
力学
✓ 已验证
产品关联
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 3
·715
·
IF 4.2
Zhe Li,Xiaosui Luo,Qiong Li,Zhengji Jin,Abid Naeem,Weifeng Zhu,Lihua Chen,Yi Feng,Liangshan Ming
Porous materials are widely used as an effective strategy for the solubilization of insoluble drugs. In order to improve the solubility and bioavailability of low water-solubility drugs, it is necessary to prepare porous materials. Mannitol is one of the most popular excipients in food and drug formulations. In this study, porous mannitol was investigated as a drug carrier for low water solubility drugs. Its fabrication, drug loading, and drug release mechanisms were investigated. Porous mannitol was fabricated using the co-spray–antisolvent process and utilizing polyvinylpyrrolidone K30 (PVP K30) as the template agent. Porous mannitol particles were prepared by changing the proportion of the template agent, spraying the particles with mannitol, and eluting with ethanol in order to regulate their pore structure. In subsequent studies, porous mannitol morphology and characteristics were determined systematically. Furthermore, curcumin and ibuprofen, two poorly water-soluble drugs, were loaded into porous mannitol, and their release profiles were analyzed. The results of the study indicated that porous mannitol can be prepared using PVP K30 as a template and that the amount of template agent can be adjusted in order to control the structure of the porous mannitol. When the template agent was added in amounts of 1%, 3%, and 5%, the mannitol pore size increased by 167.80%, 95.16%, and 163.98%, respectively, compared to raw mannitol. Molecular docking revealed that mannitol and drugs are adsorbents and adhere to each other by force interaction. The cumulative dissolution of curcumin and ibuprofen-loaded porous mannitol reached 69% and 70%, respectively. The release mechanism of curcumin and ibuprofen from drug-loaded mannitol was suitable for the Korsmeyer–Peppas kinetic model. In summary, the co-spray–antisolvent method proved effective in fabricating porous materials rapidly, and porous mannitol had a remarkable effect on drug solubilization. The results obtained are conducive to the development of porous materials.
研究领域:
药剂学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）