MICROCHEMICAL JOURNAL
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2026
·
IF 5.1
Qing Huang,Ruixian Bi,Yalai Cen,Chendong Ling,Wenfeng Zhuge,Jinyun Peng,Cuijie Nong,Cuizhong Zhang,Qiongfang Zhou
This experiment constructed a heterostructure composite material of copper tungstate and molybdenum disulfide (CuWO 4 @MoS 2 ) through an interfacial regulation strategy. The samples were analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS). Based on CuWO 4 @MoS 2 heterojunction materials, electrochemical sensors were constructed for the detection of o-aminophenol (OAP). Research has indicated that interface regulation CuWO 4 @MoS 2 it can effectively improve electron transfer ability, enhance structural stability, and thus improve electrochemical activity. Under optimal conditions, differential pulse voltammetry (DPV) was used to detect OAP in the concentration range of 0.3–14.8 μM and 14.8–74.1 μM, and the electrochemical response peak current showed two linear segments, namely, Ip (μA) = 7.27 × 10 −2 C (μM) - 1.76 × 10 −2 (R 2 = 0.9983) and Ip (μA) = 2.40 × 10 −2 C (μM) + 0.7 (R 2 = 0.9904). This method achieved a detection limit as low as 0.027 μM. The actual sample of OAP was detected using the spiked recovery method, and the recovery rate was measured to be 98.00% - 100.00%, with favorable results. In summary, the electrochemical sensor constructed in this experiment has easy operation, low cost, anti-interference, and reliable stability and can be used for rapid detection of OAP in river water.
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 2
·94
·
IF 5.3
Cai Minghui,Zhang Wenwen,Yao Haixu,Su Huiyu,Cao Yang,Li Jiaxin,Min Xinyu,Cui Feiyun,Zhu Hui
Thrombotic diseases remain a major global health concern with high morbidity and mortality. Four biomarkers (TAT, t-PAIC, TM, PIC) enable real-time monitoring of coagulation, addressing limitations of traditional diagnostics. Herein, we developed a multiplex electrochemical immunosensor for the simultaneous detection of these biomarkers. The sensing platform is constructed on a glassy carbon electrode modified with gold nanoparticles and laser-induced graphene (AuNPs-LIG), which enhances conductivity and signal output. A “One-for-Four” strategy was employed using four distinct redox probes (AQ, OAP, MB, PPD), each conjugated to a specific antibody via amidation and anchored to functionalized carbon nanotubes (Au@CNTs), forming a multichannel signal amplification system with high sensitivity. The immunosensor exhibited excellent linearity (10–100 ng/mL, R 2 > 0.98) and low detection limits: 3.99 ng/mL (TAT), 5.25 ng/mL (t-PAIC), 2.51 ng/mL (TM), and 4.20 ng/mL (PIC). It also demonstrated high selectivity, reproducibility and long-term stability. Recovery in human plasma ranged from 84.1% to 112.21%, indicating strong applicability to complex clinical samples. This work presents a robust, portable POCT platform with great potential for early diagnosis and dynamic monitoring of thrombotic diseases. Graphical
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BIORESOURCE TECHNOLOGY
·
2026
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IF 9
Tianyin Huang,Yifan Yu,Wentao Zhang,Yue Zhao,Yiliang Tao,Wenguang Huang,Bingdang Wu
Antibiotic residues, as emerging environmental contaminants, have raised significant concerns, underscoring the urgent need for efficient laccase–mediator systems (LMS) to facilitate their removal. However, the screening and design of high-performance mediators remain largely empirical, lacking robust theoretical guidance. In this study, we systematically evaluated the kinetic performance of Trametes versicolor laccase coupled with 19 redox mediators for sulfamethoxazole (SMX) degradation in the presence of humic acid (HA). Among the mediators tested, syringaldehyde (SA) exhibited superior degradation efficiency. By promoting laccase-catalyzed generation of phenoxyl radicals, the kinetics of antibiotic removal was improved. Toxicity assessments revealed that the degradation products of SMX in the SA-mediated LMS with HA exhibited low ecological risk. The system maintained high SMX degradation performance in various real water matrices (with a removal rate of up to 95 % and a reaction rate of up to 0.11 min −1 ), demonstrating its applicability in environmentally relevant scenarios. Furthermore, we established a structure–activity relationship between the electronic properties of natural mediators and SMX removal efficiency, demonstrating that catalytic performance is closely correlated with frontier molecular orbital energy levels and HOMO (Highest Occupied Molecular Orbital)–LUMO (Lowest Unoccupied Molecular Orbital) gaps. High-efficiency mediators typically possess higher HOMO energies and narrower energy gaps. This study offers molecular-level insights and design principles for developing efficient mediators, advancing the targeted application of LMS technology for the remediation of emerging contaminants.
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RSC Advances
·
2026
·
IF 6.1
Mingchao Yang,Yaqi Liang,Danhong Zhang,Linfeng Wan,Junsong Liu,Xiaoxi Yuan,Hongdong Li
The development of rapid, sensitive, stable, and reliable detection methods for 2-aminophenol is critical for accurately monitoring its environmental concentration and effectively mitigating the associated health risks. In this work, a boron-doped diamond (BDD) film is proposed as a high-performance electrode to systematically investigate the electrochemical behavior and enable trace-level determination of 2-aminophenol. The oxidation peak current ( I p ) increased significantly with the increasing concentration of 2-aminophenol in the standard phosphate buffer solution (pH = 5). The BDD electrode presents a broad linear detection range of 0.5 to 10 µmol L −1 , with a sensitive detection limit of 0.115 µmol L −1 . The BDD electrode also demonstrated excellent reproducibility and repeatability. Furthermore, considering its unique properties, including super-hardness, chemical inertness, biocompatibility, and outstanding reusability, the BDD electrode offers a robust electrochemical platform for the rapid, accurate, and stable detection of 2-aminophenol in diverse practical applications. The development of rapid, sensitive, stable, and reliable detection methods for 2-aminophenol is critical for accurately monitoring its environmental concentration and effectively mitigating the associated health risks.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Junyuan Shi,Jun Wu,Yunkai Zhang,Jingqi Wang,Siting Peng,Wendi Xiao,Yafei Hou,Da Chen
Dual-excitation N, Cl-CDs are synthesized for ratiometric RIF sensing. • Ratiometric detection of RIF is achieved with a detection limit of 58 nM. • The sensing mechanism involves synergistic IFE and FRET. • A smartphone integrated finger-actuated microfluidic device enables on-site visual RIF detection. • The platform exhibits satisfactory recovery in aquatic product samples. The increasing environmental prevalence of the antibiotic rifampicin (RIF) poses potential hazards to public health and ecological stability. Herein, a novel ratiometric assay is established by utilizing the dual-excitation nitrogen and chlorine co-doped carbon dots (N, Cl-CDs) for the quantification of trace amounts of RIF. Benefiting from the synergistic effects of the inner filter effect and Förster resonance energy transfer, the N, Cl-CDs act as a sensitive nanoprobe for RIF detection over a concentration range of 0.058–35 μM, with a detection limit of 58 nM. Furthermore, a novel finger-actuated microfluidic sensing platform has been developed through the integration of N, Cl-CDs. By combining the dual-excitation property of the probe with a smartphone-based RGB readout, the platform achieves on-site and visual quantification of RIF in real samples, as validated by high recovery rates ranging from 98.8% to 101.0%. Therefore, this work offers an innovative strategy for RIF sensing and establishes a versatile platform boasting prominent prospects for on-site food safety monitoring. Download: Download high-res image (150KB) Download: Download full-size image
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 8
·563
·
IF 5.4
Liu Huan,Chen Yuhan,Sun Han,Wang Boyan,Liu Aihua
The sensitive monitoring of bisphenol A (BPA) concentration remains a critical challenge in environmental analysis and public healthcare. In this study, Mn 3 O 4 nanorods were facilely prepared in an aqueous solution at room temperature using Mn 2+ as the precursor, NaOH as the basic source and L-histidine as the mediator. The as-prepared Mn 3 O 4 nanorods exhibit excellent laccase-mimicking activity with a catalytic efficiency of 3.85 × 10 − 3 min − 1 . The catalytic mechanism was confirmed to be oxygen vacancies by electron paramagnetic resonance spectrum and enzymatic inhibition experiment. Taking advantage of the excellent laccase-mimetic properties of the Mn 3 O 4 nanozyme, a sensitive and selective colorimetric sensing platform for BPA detection was constructed. The colorimetric sensing platform achieved a linear detection range of 1–60 µM BPA and a detection limit of 0.23 µM for BPA (3σ/S). The proposed method was applicable to the determination of BPA in plastic-packaged white vinegar, bottled water and milk with good recoveries and reproducibility. This work not only provides a novel and efficient analytical tool for the rapid detection of BPA but also offers a new insight into the design and synthesis of other amino acid-mediated nanozymes for environmental monitoring applications. Graphical
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POLYMER ENGINEERING AND SCIENCE
·
2026
·
IF 3.6
Qinglong Zhang,Wen Zheng,Wangyang Lu,Wenxing Chen
In traditional polyphosphoric acid (PPA) systems, polybenzoxazole (PBO) synthesis suffers from long reaction times and high energy consumption. To address this, a rapid model-reaction–based screening protocol using the terephthalic acid (TPA)/o-aminophenol (OAP) system was developed to qualitatively rank catalyst activity. Fourteen imidazole-based derivatives were evaluated, revealing structure–activity trends and enabling selection of two optimal catalysts, 4,5-dimethyl-2-phenyl-1 H -imidazole (Cat-2) and 2-methyl-1 H -benzimidazole (Cat-3). Both accelerated polymerization of aromatic AB-type monomers (3,4-AHBA, 4,3-AHBA, 3,4-AHPA·HCl, ACBP), yielding polymers with higher intrinsic viscosities within the same reaction times. The resulting PBOs maintained intact benzoxazole backbones and exhibited excellent thermal stability under nitrogen ( T 5% = 598°C–654°C; char yield 67%–72%). Solid-state 13 C NMR, FT-IR, XPS, and TGA, together with viscosity measurements, support a plausible mechanism in which imidazole catalysts may form N-acyl-imidazole intermediates, facilitating acyl transfer and lowering the early condensation barrier. Overall, this work proposes an efficient catalytic strategy and mechanistic insights for the investigated aromatic AB-type PBO monomers, providing guidance for catalyst design in related PBO and heterocyclic polymer systems. Highlights TPA/OAP model enables qualitative catalyst screening. Cat-2 and Cat-3 boost AB-type PBO polymerization. A plausible N-acyl-imidazole pathway is proposed. Polymers show high thermal stability under N 2 .
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MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 11
·1-8
·
IF 6.408
Li Shuhuai,Wu Yuwei,Pang Chaohai,Ma Xionghui,Wang Mingyue,Luo Jinhui,Zhi Xu,Li Bei
A highly sensitive kanamycin electrochemiluminescence (ECL) switch sensor was constructed. A signal element consisting of ordered mesoporous carbon loaded with indium oxide nanoparticles/carbon quantum dots (OMC/In 2 O 3 /C-dots) was assembled on the surface of a gold electrode. Then, a molecularly imprinted polymer (MIP) was prepared on the modified electrode surface using kanamycin as the template molecule and o -aminophenol as the functional monomer. After kanamycin elution, the prepared sensor retained specific kanamycin recognition sites. OMC/In 2 O 3 effectively amplified the ECL signal of the C-dots, thereby enhancing the detection sensitivity, whereas kanamycin quenched the signal. Therefore, the imprinted sites acted as a switch, providing a new method for detecting kanamycin. Under the optimal experimental conditions, the concentration of kanamycin was proportional to the degree of ECL quenching within a linear range of 5–4500 × 10 −12 mol L −1 at 0.8 V (vs. Ag/AgCl electrode electrode), and the detection limit was 5.8 × 10 −13 mol L −1 . When applied to the detection of kanamycin in actual samples, such as chicken, duck, pork, and milk, the recovery for spiked samples was in the range 92.7–110%. Graphical abstract
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MACROMOLECULAR RESEARCH
·
2023
·Vol. 31
·期 1
·45-52
·
IF 2.4
Zhao Wenqian,Yang Richie,Yang Shengfu,Zhang Kan
We observed an unusual low polymerization temperature for the ortho -amide benzoxazine in comparison with its para -isomer. Density functional theory (DFT) calculations suggested that the intramolecular hydrogen bond between the oxazine ring and the adjacent amide softens the C–O bond, resulting in a reduced activation energy and thus a low ring-opening polymerization temperature. In addition, the polymerization kinetics of both para - and ortho -amide functional benzoxazines were investigated using the Starink method, which confirmed a relatively lower activation energy for the ortho -amide functional benzoxazine compared with its para -isomer. Our work suggests that softening chemical bonds by intramolecular hydrogen bonding may become a new strategy for the design of high-performance polybenzoxazine thermosets with low processing temperatures. Graphical abstract
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NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 46
·22412-22418
·
IF 3.925
Xiaoyan Jiang,Min Wang,Li Hou,Tianran Lin
A one-step colorimetric sensing platform had been constructed for catechol determination based on polyacrylic acid-coated cerium oxide (PAA-CeO2) with a significant laccase-like activity. Compared with the traditional nanozyme-based colorimetric determination methods for catechol, the PAA-CeO2 nanozyme with laccase-like activity did not require biotoxic and poor stability H2O2 in this method. PAA-CeO2 could directly catalyze the oxidation of catechol to o-quinone in the presence of dissolved O2, and the oxidation product was coupled with 4-aminoantipyrine (4-AAP) to form a pink product at the maximum absorption of 512 nm (OD512). By utilizing the relationship between the concentration of catechol and the OD512 intensity to achieve sensitivity quantitative analysis and visual determination of catechol in an ordered and one-step reaction, which provided a dynamic range from 0.5 to 50 μmol L−1 within a low detection limit of 0.121 μmol L−1. In addition, this colorimetric sensing platform based on PAA-CeO2 had satisfactory repeatability and stability, which could be used for the catalytic degradation of other phenolic compounds in the environment to ensure public health and environmental safety.
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Foods
·
2023
·Vol. 12
·期 3
·544
·
IF 5.2
Shujuan Chen,Yiting Zhu,Jing Han,Tianyi Zhang,Runwen Chou,Aiping Liu,Shuliang Liu,Yong Yang,Kaidi Hu,Likou Zou
Norfloxacin (NOR) is a common antibiotic used in humans and animals, and its high levels can cause intolerance or poisoning. Therefore, NOR levels in animal-derived foods must be monitored due to potential side effects and illegal use phenomena. This research centered on the development of an environmentally friendly electrochemical sensor for NOR detection. Potassium carbonate activated tea branch biochar (K-TBC) as an efficient use of waste was coated on the surface of glassy carbon electrode (GCE), and a molecular-imprinted polymer (MIP) layer was subsequently electropolymerized onto the modified electrode. NOR was used as template molecule and o-phenylenediamine (o-PD) and o-aminophenol (o-AP) were used as bifunctional monomers. The electrochemical sensor was built and its electrochemical behavior on NOR was investigated. The sensor demonstrated an excellent linear current response to NOR concentrations in the ranges of 0.1–0.5 nM and 0.5–100 nM under ideal experimental circumstances, with a detection limit of 0.028 nM (S/N = 3). With recoveries ranging from 85.90% to 101.71%, the designed sensor was effectively used to detect NOR in actual samples of milk, honey, and pork. Besides, the fabricated sensor had low price, short detection time, good selectivity and stability, which can provide a theoretical and practical basis for the actual monitoring of NOR residues.Keywords:norfloxacin;biochar;molecular-imprinted polymer;double functional monomer;electrochemical trace detection
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JOURNAL OF HAZARDOUS MATERIALS
·
2022
·
IF 14.224
Liang Zhu,Xuecui Mei,Zhengchun Peng,Jiao Yang,Yingchun Li
Paper-based microfluidic analytical devices (μPADs) have recently attracted attention as a rapid test kit owing to their low cost and nonrequirement for external driving pump. However, low accuracy and poor anti-interference ability of μPADs under complex detection condition limit their practical applications. Here, we present a facile way to prepare a novel fluorescence sensor-array μPAD for multi-analyte discrimination based on molecular imprinting technology , and its sensing behavior was studied by using three nitrophenol (NP) isomers (2-, 3-, and 4-NP) as the testing models. Carbon quantum dots (CQDs) emitting blue light were grafted on glass-fiber paper, followed by in-situ modification of three types of molecularly imprinted polymers (MIPs) with 2-, 3-, and 4-NP as template. Each sensing unit on the array showed differential yet cross-reactive binding affinity to NP isomers, resulting in distinct fluorescence quenching efficiency. Thus, precise distinguishment of the three NPs was realized with the MIPs/CQDs/paper-based sensor array. Furthermore, the discrimination ability of the platform was evaluated in mixtures of the NP isomers. Practicability of this apparatus was validated by identification of blind samples and 100% accuracy was achieved. The μPAD has proven to be highly sensitive and accurate, which will serve as an ideal analytical tool in the fields of environment monitoring, disease prognosis, food safety and so on.
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