JOURNAL OF BIOTECHNOLOGY
·
2019
·
IF 3.163
Xiao-Ling Tang,Nan-Nan Zhang,Guo-Yan Ye,Yu-Guo Zheng
( R )-3-amino-1-butanol is a key intermediate of Dolutegravir for the treatment of HIV/AIDS and its green and efficient biosynthesis has attracted a great deal of attention. Transaminases are currently used as promising biocatalyst for the synthesis of chiral amines. However, many transaminases have ( S )-specificity and ( R )-selective transaminases were less exploited and studied, making the production of ( R )-amines remain challenging. In this study, a novel transaminase from Actinobacteria sp. ( As -TA) was obtained and applied for the biosynthesis of ( R )-3-amino-1-butanol by transferring the amino group from isopropylamine to 4-hydroxy-2-butanone. After optimization of the reaction condition and using a substrate fed-batch strategy, the conversion of 100, 200, 300, 400 and 500 mM 4-hydroxy-2-butanone reached 100%, 94.9%, 86.1%, 76.1% and 70.9%, respectively. ( R )-3-amino-1-butanol with a maximum yield of 29.6 g/L and 99.9% e.e. value was obtained. This was the first time demonstrating the successful biosynthesis of ( R )-3-amino-1-butanol with transaminase as biocatalyst and the obtained As -TA enriched the enzyme pool of transaminase with ( R )-specificity.
研究领域:
生物化学
·
酶工程
·
药物合成
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DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2021
·Vol. 32
·期 10
·4041-4051
·
IF 3.665
Biao Wang,Dongsheng Zhao
In this study, sulfonated nanofiltration membranes were synthesized via interfacial polymerization (IP) of aqueous-phase piperazine (PIP), 3-amino-1-propanesulfonic acid (APA), and organic-phase trimesoyl chloride (TMC) monomers on porous substrates. Membranes with different APA contents were thoroughly characterized to determine how APA affected the physicochemical characteristics and perm-selectivity of the membranes. Membrane characterization confirmed the incorporation of APA into the generated polyamide (PA) layer. The optimal membrane performance was obtained at a 0.8 w/v% aqueous-phase APA content, where the enhanced membrane molecular weight cutoff (MWCO) and surface hydrophilicity resulted in a pure water permeability of 11.9 L m −2 h −1 bar −1 , approximately 13.1% higher than that of the blank membrane. Enhanced electrostatic repulsion of the APA-modified membrane on Na 2 SO 4 resulted in up to a 96.2% Na 2 SO 4 rejection rate. The 24.3% NaCl rejection rate resulted in NaCl/Na 2 SO 4 selectivity for the mixed-salt solution of the optimized membrane of 19.9, which was a significant increase over that of the blank. The embedding of APA did not affect the long-term stability of the NF membrane. The combined effects of the hydrophilicity, charge, and roughness of the membrane surface slightly enhanced the antifouling ability of the APA-modified membrane over that of the blank. This study provides a facile strategy for the fabrication of NF membranes with high perm-selectivity.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2020
·
IF 8.758
Ruiting Fan,Li Song,Yongsheng Hu,Xiaoyang Guo,Xingyuan Liu,Lishuang Wang,Chong Geng,Shu Xu,Yonghui Zhang,Zihui Zhang,Nannan Luan,Wengang Bi
Properties of the underlying hole transport layer (HTL) in perovskite light-emitting devices (PeLEDs) play a critical role in determining the optoelectronic performance through influencing both the charge transport and the quality of the active perovskite emission layer (EML). This work focuses on manipulating the carrier transport behavior and obtaining a high-quality EML film by tailoring the poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) HTL with previously unused amino alcohol 3-amino-1-propanol (3AP). The modified PEDOT:PSS rendered a deeper work function that is more suitable for the hole injection from the HTL to EML. More importantly, the 3AP-modified PEDOT:PSS film can induce a low-dimensional perovskite phase that can passivate the defects in the EML, resulting in a significantly improved light emission. Such ameliorations consequently result in a dramatical enhancement in performance of PeLED with a low turn-on voltage of 2.54 V, a maximum luminance of 23033 cd/m2, a highest current efficiency of 29.38 cd/A, a corresponding maximum external quantum efficiency of 9.4%, and a prolonged lifetime of 6.1 h at a proper Cs/Pb ratio.
研究领域:
材料科学
·
光电化学
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DOI
高影响因子
CHEMICAL ENGINEERING & TECHNOLOGY
·
2025
·
IF 1.6
Jiadi Zhou,Weilong Zhang,Shangkun Bai,Yinghui Shao,Yuanyuan Tang,Mengqian Jing,Zhiqun Yu
3-Amino-1-adamantanol (3AA) is an important intermediate of vildagliptin. In this work, a fully continuous flow synthesis of 3-amino-1-adamantanol has been proposed. Selecting amantadine sulfate (AS) as the starting material, the effects of process parameters were systematically investigated, such as the molar ratio of reactants, the amount of sulfuric acid and reaction temperature. The kinetics of nitration reaction were carried out in both batch and continuous flow processes to explain the relationship between the amount of sulfuric acid and the reaction rate constant. Based on the apparent reaction rate constants and thermodynamic parameters, a fully continuous flow synthesis of 3AA combining nitration, hydrolysis and neutralization reaction has been realized. Compared with the batch method, the reaction time was shortened from 8 h to 36 min, the side reactions were significantly inhibited, and the yield increased from 87.8 % to 95.2 % by continuous flow strategy.
研究领域:
有机化学
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制药工程
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化学工程
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DOI
高影响因子
CORROSION SCIENCE
·
2022
·
IF 7.72
Youmin Qiu,Jie Li,Yifeng Bi,Xiaopeng Lu,Xiaohui Tu,Junjie Yang
A novel mixture, comprising sodium fluoride (NaF) and 3-amino-1,2,4-triazole-5-thiol (ATT), was reported as an effective hybrid corrosion inhibitor for magnesium alloy in pH neutral NaCl solution. The highest efficiency (95.8%) was achieved when 50 mM NaF and 5 mM ATT were mixed. Both experimental and theoretical approaches were employed for addressing the synergism. The synergism was proposed as the formation of a double-layered inhibitors film, in which the lower layer is a uniform fluoride-enriched precipitate layer and the upper one is a hydrophobic adsorption layer. These two layers were mutually strengthened to produce an excellent inhibition effect as a whole.
研究领域:
材料科学
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化学工程
·
理论化学
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Li Song,Lixin Huang,Yuan Liu,Yongsheng Hu,Xiaoyang Guo,Yulei Chang,Chong Geng,Shu Xu,Zihui Zhang,Yonghui Zhang,Nannan Luan
Perovskite light-emitting devices (PeLEDs) have drawn a great deal of attention because of their exceptional optical and electrical properties. However, as for the blue PeLEDs based on low-dimensional (LD) CsPbBr3, the low conductivity of the widely used organic spacers as well as the difficulty of forming pure and uniform LD CsPbBr3 phase have severely inhibited the device performance such as stability and efficiency. In this work, we report an effective strategy to obtain high-quality LD CsPbBr3 by using a novel spacer of inorganic Cs4PbBr6 instead of the common long-chain ammonium halides. We found that a 3-amino-1-propanol (3AP)-modified PEDOT:PSS was helpful to stimulate the formation of the LD blue emissive CsPbBr3:Cs4PbBr6 composite. We also revealed that an additive of poly(vinylpyrrolidone) (PVP) in the precursor can limit further growth of LD perovskite phase into 3D perovskite phase upon annealing, thus resulting in a uniformly distributed LD perovskite with high color stability. Consequently, efficient blue PeLEDs @ 485 nm with a brightness of 2192 cd/m2, current efficiency of 2.68 cd/A, and external quantum efficiency of 2.3% was successfully achieved. More importantly, the device showed much improved working stability compared to those with the spacer of organic ammonium halides. Our results provide some helpful insights into developing efficient and stable blue PeLEDs.
研究领域:
材料科学
·
光电技术
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DOI
高影响因子
ACS Omega
·
2022
·
IF 4.132
Huan Song,Bing Li,Xuezhi Gao,Fenglin Shan,Xiaoxia Ma,Xiaoyan Tian,Xiaoyan Chen
For energetic materials (EMs), the key point of the present research is to improve the energetic property and reduce sensitivity. In this work, two new energetic complexes, Mn(atzc)2(H2O)2·2H2O (1) and Zn(atzc)2(H2O) (2) (Hatzc = 3-amino-1,2,4-triazole-5-carboxylic acid), were synthesized by solvent evaporation and diffusion methods, respectively. The structural analyses illustrate that 1 and 2 exhibit zero-dimensional structural units, which are linked by hydrogen-bonding interactions to give three-dimensional supramolecular architectures. For complexes 1 and 2, the detonation velocities (D) are 10.4 and 10.2 km·s–1 and detonation pressures (P) are 48.7 and 48.6 GPa, respectively. They are higher than most of the reported EMs, which present prominent detonation characteristics. In addition, two complexes can accelerate the thermal decomposition of ammonium perchlorate and exhibit excellent catalytic activity. Therefore, the two complexes can serve as a new class of promising EMs, which have potential application in the design of new high-efficiency solid catalysts.
研究领域:
化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
Chemical Science
·
2024
·
IF 7.6
Yan Zhao,Weiheng Kong,Jianqing Zhu,Fengli Qu
Simultaneous implementation of tumor-associated macrophage (TAM) repolarization and immunogenic tumor cell death (ICD) elicitation enables tumor immunotherapy with high efficacy. However, the inconsistency of stimulation tolerance restricts simultaneous implementation. To address this obstacle, we validate that an H2O2-mediated regulatory strategy could achieve coordinated occurrences. To accomplish this, a bimodal responsive modulator is constructed, namely ZnO2-ATM (ATM: 3-amino-1,2,4-triazole), as an immune adjuvant to coordinate the occurrence of TAM repolarization and ICD elicitation through the endo/exogenous synergistic responsive production of H2O2. H2O2 produced by ZnO2-ATM reverses the immune-suppressive TAM from an M2 to an M1 phenotype, but induces tumor cell necrosis and promotes damage-related molecular pattern release, thereby evoking ICD. This H2O2-mediation bimodal responsive therapeutic strategy to induce the synergistic occurrence of TAM repolarization and ICD elicitation promotes effective immune effects against tumors, demonstrating that the ZnO2-ATM nanoadjuvant could be expected to provide new tools and paradigms for antitumor immunotherapy.
研究领域:
肿瘤免疫学
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生物化学
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药理学
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Jie Zhou,Yang Zhao,Jiaheng Wang,Haoxiang Yang,Jingyue He,Lingzhi Ma,Bozhou Wang,Yatang Dai
In order to promote the green development of the nitration process of energy-containing materials and to reduce the environmental pollution and resource waste caused by the traditional nitration reaction. We used a solvent-free mechanochemical reaction to nitrify 3-amino-1,2,4-triazole and 3,5-diamino-1,2,4-triazole and successfully obtained 3-nitro-1,2,4-triazole and 3,5-dinitro-1,2,4-triazole by using sodium nitrite and molybdenum trioxide as catalysts. Several parameters affecting the nitration reaction were explored, and the structures of the products were analyzed by combining Gaussian, Multiwfn, and other computational software; also, single crystals of 3,5-dinitro-1,2,4-triazole sodium salt were cultivated and analyzed for their crystal structure and surface properties, and their copper and lead salts were obtained by reacting with metal salts. The present work provides a new idea for the development of green nitration of energy-containing materials.
研究领域:
化学工程
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材料科学
·
环境科学
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产品关联
DOI
PubMed
高影响因子
Advanced Energy Materials
·
2025
·
IF 26
Jiazhen Wei,Qingshun Dong,Mingzhu Pei,Hongru Ma,Yaling Han,Shiqi Rong,Zhiyong Wang,Zheng Lv,Zicheng Liu,Siao Li,Yuzhong Chen,Wenzhe Shang,Wenqi Han,Jie Zhang,Yuan Qin,Hao Xian,Mingyan Wu,Wei Liu,Wenming Tian,Shengye Jin,Yantao Shi
Self-assembled molecules (SAMs) have served as a pivotal interfacial engineering enabler for advancing the performance of perovskite solar cells. However, the spontaneous aggregation of SAMs leads to uneven deposition, particularly in the fabrication of large-area perovskite solar modules (PSMs) by blade-coating. Here, a co-adsorption strategy utilizing 3-amino-1-propanesulfonic acid (3NS) is proposed as a blade-coating-compatible strategy to achieve a uniform SAMs anchoring across a 10 × 10 cm 2 substrate. Acting as a co-adsorbate with SAMs, 3NS leverages synergistic multiple intermolecular interactions—such as electrostatic forces, hydrogen bonding, and cation-π interactions—to effectively disrupt the aggregation of SAMs, enabling their high-density anchoring on NiO x substrate. Meanwhile, the 3NS-SAMs co-adsorption layer system optimizes interfacial energy level alignment and passivates defects. By virtue of this co-adsorption strategy, the PSM achieves a champion power conversion efficiency (PCE) of 20.16% (active area: 63.09 cm 2 ). Moreover, the modules retain 87.64% and 72.70% of their initial PCE after 1100 h of ambient aging and 264 h of continuous thermal aging at 80 °C, respectively. This work presents a scalable blade-coating-compatible strategy for controlling the deposition of SAMs, advancing the development of high-performance PSMs.
研究领域:
材料科学
·
纳米技术
·
可再生能源
·
表面工程
·
薄膜太阳能电池
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Youhuan Gong,Xueying Zhao,XiaoJie Yan,Wenfu Zheng,Huanwen Chen,Le Wang
The biofilm-mediated implant infections pose a huge threat to human health. It is urgent to explore strategies to reverse this situation. Herein, we design 3-amino-1,2,4-triazole-5-thiol (ATT)-modified gold nanoclusters (AGNCs) to realize biofilm-targeting and near-infrared (NIR)-II light-responsive antibiofilm therapy. The AGNCs can interact with the bacterial extracellular DNA through the formation of hydrogen bonds between the amine groups on the ATT and the hydroxyl groups on the DNA. The AGNCs show photothermal properties even at a low power density (0.5 W/cm 2 ) for a short-time (5 min) irradiation, making them highly effective in eradicating the biofilm with a dispersion rate up to 90 %. In vivo infected catheter implantation model demonstrates an exceptional high ability of the AGNCs to eradicate approximately 90 % of the bacteria encased within the biofilms. Moreover, the AGNCs show no detectable toxicity or systemic effects in mice. Our study suggests the great potential of the AGNCs for long-term prevention and elimination of the biofilm-mediated infections.
研究领域:
纳米技术
·
生物医学工程
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药学
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传染病学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Xiaotao Liu,Shanshan Xing,Yuanteng Xu,Ruiqing Chen,Chang Lin,Liangqia Guo
Graphitic carbon nitride (g-C 3 N 4 ) has been shown as a promising visible-light photosensitizer for photodynamic therapy (PDT) application. Nevertheless, its therapeutic efficiency is limited by the low efficiency of visible-light utilization. To overcome this issue, 3-amino-1,2,4-triazole-derived graphitic carbon nitride nanosheets (g-C 3 N 5 NSs) are prepared for PDT application. The addition of nitrogen-rich triazole group into the g-C 3 N 4 motif significantly makes the light absorption of g-C 3 N 5 NSs red-shift with the band gap down to 1.95 eV, corresponding to a absorption edge at a wavelength of 636 nm. g-C 3 N 5 NSs generate superoxide anion radicals (O 2 •– ) and singlet oxygen ( 1 O 2 ) under the irradiation of a low-intensity white light emitting diode. Owing to the high efficiency of visible-light utilization, g-C 3 N 5 NSs show about 9.5 fold photocatalytic activity of g-C 3 N 4 NSs. In vitro anticancer studies based on the results of CCK-8 assay, Calcein-AM/PI cell-survival assay and photo-induced intracellular ROS level analysis in living HeLa cells demonstrate the potential of g-C 3 N 5 NSs as a low-toxic and biocompatible high-efficient photosensitizer for PDT.
研究领域:
材料科学
·
纳米技术
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光动力治疗
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癌症研究
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）