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Cycloartane triterpene glycosides from Actaea vaginata

Min-Li Zhang,Yi-Min Li,Zi-Xuan Zhao,Xiang-Yuan Li,Zhao-Cui Sun,Guo-Xu Ma,Mei-Hua Yang,Xu-Dong Xu,Xiao-Feng Zhang,Hai-Feng Wu,Qiong-Yu Zou,Nelbon Giloi

Phytochemical investigation of the whole plant of Actaea vaginata led to the isolation of five cycloartane triterpene glycosides , including three new Actaeoside A−C ( 1 − 3 ) along with two known analogues, beesiosides E ( 4 ) and N ( 5 ). Their structures were elucidated by NMR , HRESIMS and chemical analysis. The cytotoxicity of compounds ( 1 − 5 ) was assayed against HT-29 and HepG2 cancer cell lines. All the isolates showed moderate degrees of inhibitory activity against the HT-29 with IC 50 values in a range of 18.2–27.8 μM.