JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2019
·Vol. 103
·期 4
·2548-2554
·
IF 3.094
Zhigang Zheng,Ye Tong,Rongfei Wei,Fangfang Hu,Xinyuan Sun,Hai Guo
Commercial Bi 4 Ge 3 O 12 (BGO) monocrystal scintillator is relatively complicated to produce and too expensive. Therefore, it is desired to look for alternative scintillating materials with simple process, low consumption, large size, and high efficiency. Here, glass-ceramics (GC) with high volume fraction of crystal phase and high density by increasing the proportion of heavy metal fluorides in the composition were designed. And bulk Tb 3+ -doped transparent BaGdF 5 glass-ceramics with 23.3% crystal volume ratio and density of 4.65 g/cm 3 have been prepared. The structural, optical, and luminescent properties of precursor glass and GC were systematically explored through series of characterization techniques including X-ray diffraction (XRD), transmittance spectra, transmission electron microscope (TEM), photoluminescence (PL) spectra, and X-ray excited luminescence (XEL). After heat treatment, both PL emission and XEL intensity of GC are enhanced because of the movement of Tb 3+ ions from the amorphous glass matrix into BaGdF 5 nanocrystals, which possess lower phonon energy and better crystal field. The luminescent quantum efficiency of GC reaches 30.7% and the XEL intensity of GC is around 140% of that of the commercial BGO scintillating crystal. Our results demonstrate that BaGdF 5 :Tb 3+ GC may act as efficient scintillator for X-ray detection.
研究领域:
材料科学
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光学
·
医学影像
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
·
2016
·Vol. 63
·期 12
·977-984
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IF 0.879
Rongjin Sun,Ting Yin,Peng Huang,Guo Gao,Joseph George Shapter,Yulan Shen,Jingjing Zhang,Daxiang Cui
In this paper, we report the development of a facile one-pot hydrothermal method for the controlled synthesis of monodispersed BaGdF 5 :Yb/Er nanoparticles for computed tomography (CT) and magnetic resonance (MR) imaging. The as-prepared nanoparticles have uniform size with a diameter of 20–25 nm. MTT tests show that the cell viability surpasses 90% even with a concentration of nanoparticles of 500 µg/mL, suggesting that the as-prepared BaGdF 5 :Yb/Er nanoparticles possess low toxicity. For both BaGdF 5 :Yb/Er nanoparticles and iopromide, the Hounsfield unit (HU) values increase with the their concentration. The slope of BaGdF 5 :Yb/Er nanoparticles is about 26.47, which is much higher than that of iopromide (16.98), indicating a better CT imaging effect. Interestingly, we find that the synthesized BaGdF 5 :Yb/Er nanoparticles exhibit paramagnetism. Our in vitro and in vivo imaging experiments demonstrate that the synthesized monodispersed BaGdF 5 :Yb/Er nanoparticles can serve as effective contrast agents for CT and MR imaging.
研究领域:
材料科学
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医学影像学
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生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2017
·Vol. 28
·期 5
·1-11
·
IF 2.325
Zhu Wei,Liang Shuang,Wang Jing,Yang Zhe,Zhang Li,Yuan Tianmeng,Xu Zushun,Xu Haibo,Li Penghui
Abstract Multifunctional nanocomposites based on BaGdF 5 nanoparticles (NPs) and metal phenolic network (MPN) have been engineered as novel contrast agents for potential applications in X-ray computed tomography, magnetic resonance and luminescence imaging. The BaGdF 5 @MPN nanocomposites were synthesized at room temperature by coating BaGdF 5 NPs with europium-phenolic network, which was obtained by the coordination of europium (III) with tannic acid (TA). The in vitro cytotoxicity assays against HepG2 cells revealed that the BaGdF 5 @MPN nanocomposites presented better cytocompatibility and lower cytotoxity than pure BaGdF 5 NPs. In addition, vivid red and green luminescence can be observed by confocal laser scanning microscope (CLSM) from the BaGdF 5 @MPN nanocomposites laden HepG2 cells under the excitation of UV (390 nm) and visible light (440 nm), respectively. The longitudinal relaxivity value (r 1 ) of the nanocomposites was 2.457 mM −1 s −1 . Moreover, the nanocomoposites exhibited X-ray computed tomography (CT) and T 1 -weighted magnetic resonance (MR) imaging capacities, and the intensities of the enhanced signals of in vitro CT and MR images were proportional to the concentrations of the nanocomposites. These results indicated that the as-prepared BaGdF 5 @MPN nanocomposites are promising contrast agents for CT/MR/luminescence imaging. Graphical Abstract
研究领域:
医学影像学
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
BIOMATERIALS
·
2013
·
IF 7.604
Dongmei Yang,Yunlu Dai,Jianhua Liu,Ying Zhou,Yinyin Chen,Chunxia Li,Ping'an Ma,Jun Lin
A new type of drug-delivery system (DDS) was constructed, in which the anti-cancer drug doxorubicin (DOX) was conjugated to the ultra-small sized (sub-10 nm) BaGdF 5 :Yb 3+ /Tm 3+ based upconversion nanoparticles (UCNPs). This multifunctional DDS simultaneously possesses drug delivery and optical/magnetic/X-ray computed tomography imaging capabilities. The DOX can be selectively released by cleavage of hydrazone bonds in acidic environment, which shows a pH-triggered drug release behavior. The MTT assay shows these DOX-conjugated UCNPs exhibit obvious cytotoxic effect on HeLa cells . Moreover, to improve the upconversion luminescence intensity, core–shell structured UCNPs were constructed. The in vitro upconversion luminescence images of these UCNPs uptaken by HeLa cells show bright emission with high contrast. In addition, these UCNPs were further explored for T 1 -weighted magnetic resonance (MR) and X-ray computed tomography (CT) imaging in vitro . Long-term in vivo toxicity studies indicated that mice intravenously injected with 10 mg/kg of UCNPs survived for 40 days without any apparent adverse effects to their health. The results indicate that this multifunctional drug-delivery system with optimized size, excellent optical/MR/CT trimodal imaging capabilities, and pH-triggered drug release property is expected to be a promising platform for simultaneous cancer therapy and bioimaging .
研究领域:
纳米医学
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生物医学工程
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 42
·期 14
·11565-11572
·
IF 3.201
Tao Wang,Guorong Jia,Chao Cheng,Qiuhu Wang,Xiao Li,Yanyan Liu,Chaofan He,Luguang Chen,Gaofeng Sun,Changjing Zuo
Multimodal imaging can improve the accuracy of cancer diagnosis by combining two or more imaging modalities into one system. In this study, PEGylated BaGdF5 nanoparticles (NPs) were synthesized by a hydrothermal method, and the formed PEG-BaGdF5 NPs showed good X-ray attenuation properties and positive MR contrast effects in vitro. Considering that the overexpression of integrin αvβ3 in the endothelial cells of angiogenic tumor vasculature is universal, RGD peptide, which can recognize and bind integrin αvβ3 specifically, was connected to the surface of PEG-BaGdF5 NPs. The resulting RGD-PEG-BaGdF5 NPs had good biocompatibility and a long half-life in vivo. In VX2 tumor-bearing mice, the HU values and MR signal enhancement of tumor sites in the targeted group were both higher than that in the non-targeted group after intravenous injection of RGD-PEG-BaGdF5 NPs or PEG-BaGdF5 NPs, respectively. Therefore, the RGD-PEG-BaGdF5 NPs may be used as dual-modal CT/MR contrast agents of different types of solid tumors via an active RGD-mediated vasculature targeting pathway.
研究领域:
医学影像
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纳米技术
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
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2020
·
IF 0.936
Feng-Zhi CUI,Jian-Hua LIU,Yang LIU,Bi-Ying YUAN,Xue GONG,Qing-Hai YUAN,Ting-Ting GONG,Lei WANG
Molecular imaging (MI) techniques have extremely significant effect on the diagnosis and prognosis of diseases, such as gastrointestinal (GI) tract-related diseases. Furthermore, nanomaterials as contrast agents have attracted a great deal of research attention, due to their rational fabrication and biomedical. Herein, we reported a facile process to synthesis PEGylated BaGdF 5 nanoparticles via a one-pot solvothermal route as CT/MRI dual-modal contrast agents for in vivo imaging of GI tract. Compared to the commercially used iodine contrast agents, the well-prepared nanoparticles exhibited enhancement in computed tomography (CT) imaging. In the presence of Gd, nanoparticles could also be used in magnetic resonance imaging (MRI). PEGylated BaGdF 5 nanoparticles were characterized by transmission electron microscopy (TEM), X-ray powder diffraction analysis (XRD), Fourier transform infrared (FT-IR) spectroscopy and thermogravimetric analysis (TGA). Besides, MTT assay revealed that the prepared nanoparticles proved to be low toxicity and high biocompatibility for Hela cells. Hemolytic assay illustrated nanoparticles possess favorable hemocompatibility. H & E (Hematoxylin and Eosin) histological staining assessed long-term toxicity of oral PEGylated BaGdF 5 nanoparticles, and the results showed that the nanoparticles had overall safety for GI tissue with comparatively high compatibility. Based on above results, PEGylated BaGdF 5 nanoparticles were admired multi-functional contrast agents to apply in CT and MRI imaging with prominent prospects.
研究领域:
医学影像学
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纳米医学
·
分子影像
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 17
·14283-14289
·
IF 3.289
Peng Zhang,Yangyang He,Jianhua Liu,Jing Feng,Zhiqiang Sun,Pengpeng Lei,Qinghai Yuan,Hongjie Zhang
Lanthanide-doped nanocrystals have been researched extensively and used for bioimaging because of their optical properties, magnetic properties and X-ray absorption. Core–shell-structured lanthanide-doped nanocrystals have been developed and characterized by TEM and XRD analysis. The nanocrystals are composed of BaYbF5:0.5% Tm as the core and BaGdF5:20% Yb, 0.5% Tm as the shell. Apart from characterization of the nanocrystals, evaluation of both their cytotoxicity via MTT assays and their long-term toxicity via histological analysis showed that their cytotoxicity was low, indicating the possibility of further in vivo imaging. This work combined the functions of trimodal imaging into one nanoplatform and then UCL, CT, and MR imaging with core–shell-structured nanocrystals were investigated both in vitro and in vivo. Taking into consideration its structural characteristics and trimodal imaging abilities, it is expected that the developed multifunctional nanoplatform may be potentially useful for diagnosing diseases at an early stage.
研究领域:
生物医学工程
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材料科学
·
影像医学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Jingjing Liu,Jing Huang,Meng Lv,Shuguo Wang,Gaoqi chen,Zhihao Zhang,Jiajun Tao,Xu Hou,Xudong Yang,Yu Wang,Shuo Wang,Fei Li,Tong Xu,Yunru Wan,Jiaying Zhao,Xiangyu Gong
RE 3+ -activated BaGdF 5 phosphors have broad applications in LED-based fluorescence displays and biological tracing. In this research, various types (GdF 3 :5%Eu 3+ , BaGdF 5 :5%Eu 3+ ) and different morphologies (peanut, octahedron, microsphere) of gadolinium-based fluoride micro/nano-materials with down-shifting luminescence were synthesized via the hydrothermal method. The coordination environments of Gd 3+ , Eu 3+ , Ba 2+ , and F - ions were tuned by systematically varying the reaction time (6–36 h), the initial pH (3–11), and surfactants/chelating agents (CTAB, EDTA-2Na, Na 3 Cit and PVP). The optimal synthesis conditions (36 h, pH=3) were identified through X-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis. The samples were comprehensively characterized using thermogravimetric analysis (TGA), Brunauer–Emmett–Teller (BET) surface area measurements, Fourier-transform infrared (FT-IR) spectroscopy, and photoluminescence (PL) spectroscopy. The octahedral BaGdF 5 :5%Eu 3+ particles synthesized with CTAB demonstrated good thermal stability and the strongest fluorescence emission intensity at 595 nm, producing an orange-red light with CIE chromaticity coordinates of (0.5141, 0.4845). The luminescence intensity was 2.23 times greater than that of samples prepared with PVP. Moreover, the signal intensity in MRI T 1 -weighted imaging exhibits a positive correlation with Gd 3+ concentration. The composite material containing 2% wt% BaGdF 5 :5% Eu 3+ within the chitin matrix demonstrated optimal performance in CT imaging. Research indicates that the synthesised octahedral BaGdF 5 :5% Eu 3+ compound holds potential applications for down-shifting luminescence and multimodal MRI/CT imaging.
研究领域:
材料科学
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纳米技术
·
生物医学成像
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发光材料
·
无机化学
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2015
·Vol. 45
·期 4
·1708-1716
·
IF 4.197
Fei He,Chunxia Li,Xinyang Zhang,Yinyin Chen,Xiaoran Deng,Bei Liu,Zhiyao Hou,Shanshan Huang,Dayong Jin,Jun Lin
808 nm excited upconversion nanoparticles (UCNPs) have received extensive attention in the biomedical areas. However, one of the limitations of UCNPs is their lower luminescence efficiency. Aimed at this problem, a series of BaGdF5-based UCNPs were prepared by a layer-by-layer procedure. And UC luminescence properties are optimized by varying the doping concentration of rare earth ions, amount and types of shells. It is found that if the amount of core BaGdF5:20%Yb3+/2%Er3+ was fixed at 0.5 mmol, the optimized conditions of three shell layers are 0.3 mmol of BaGdF5:10%Yb3+, 0.5 mmol of BaNdF5 and 0.5 mmol of BaGdF5. Thus the UC luminescence intensity of the resultant nanoparticles BaGdF5:20%Yb3+/2%Er3+@BaGdF5:10%Yb3+@BaNdF5@BaGdF5 (Er@Yb@Nd@Gd) is enhanced more than four times compared with that of BaGdF5:20%Yb3+/2%Er3+@BaGdF5:10%Yb3+@BaNdF5 (Er@Yb@Nd). To further improve the biocompatibility and applications in the biological field, carboxymethyl chitosan (CMC), a type of biocompatible water-transfer agent, was used as a capping ligand to modify the surface of Er@Yb@Nd@Gd. An antitumor drug doxorubicin (DOX) was loaded to the CMC-modified Er@Yb@Nd@Gd nanocarriers by electrostatic interactions. The DOX can be selectively released in an acidic environment, which shows a pH-triggered drug release behavior. On the other hand, Er@Yb@Nd@Gd nanoparticles have excellent magnetic properties due to the presence of Gd components. T1-weighted magnetic resonance imaging (MRI) reveals the concentration-dependent brightening effect with longitudinal relaxivity (r1) as high as 43.77 s−1 (mM)−1, much higher than that of previous Gd3+-based counterparts. The results indicate that this multifunctional drug delivery system is expected to be a promising platform for simultaneous cancer therapy and bioimaging.
研究领域:
生物医学
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Science of Advanced Materials
·
2019
·Vol. 11
·期 6
·893-901
·
IF 1.158
Zhang Zhongtao,Zhang Guangkun,Ji Jingtian,Gao Zhonghui
Nuclear magnetic resonance imaging (MRI) has high image resolution and is widely used in the medical field, but it has the problem of inadequate sensitivity. Therefore, contrast material is needed to enhance the image clarity and accuracy of MRI. In order to further improve the cell
resolution of magnetic resonance imaging (MRI), a new contrast agent, BaYbF5/BaGdF5-Tm, Yb, is obtained by using BaYbF5 and BaGdF5 as the main raw materials and using high temperature thermal decomposition method. A layer of polyethylene glycol (PEG) is added to the material
from the point of view of biocompatibility. TEM and XRD are used to characterize the material, and MTT is used to test the cytotoxicity of the material. The material is used in the imaging process of stem cell-Danhong in the treatment of cerebral infarction. Bioluminescence imaging, immunofluorescence
testing and autoradiography are carried out. A large number of tests have confirmed that the material has low cytotoxicity and is similar to the existing contrast agents in MRI imaging. In bioluminescent imaging experiments, using BaYbF5/BaGdF5-Tm, Yb contrast agent can enhance the optical
density of imaging. In autoradiography test, using BaYbF5/BaGdF5-Tm, Yb contrast agent can clearly show the changes of various tissues. In immunofluorescence test, using BaYbF5/BaGdF5-Tm, Yb contrast agent can find more vascular proliferation cells survive. The new contrast agent proposed
in this study can enhance the imaging ability of MRI. Compared with conventional contrast agents, it has higher cell resolution and lower cytotoxicity. It has positive significance for future disease detection in medicine.
研究领域:
医学影像学
·
神经病学
·
材料科学
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2021
·
IF 3.712
Jingzhi Dou,Bei Chen,Guixia Liu,Xiangting Dong,Wensheng Yu,Jinxian Wang,Yunxiao Zhang,Zhanguo Li,Jiang Zhu
Photothermal therapy (PTT) has presented its inherent application value in cancer treatment. Nevertheless, single-functional photothermal materials cannot meet the precise diagnosis and treatment of cancer. Therefore, it is important to design a nanocomposite that has both high therapeutic efficiency and multimodal imaging capabilities. In our work, a new nanostructure of gold nanorods (AuNRs) with silver shells decorated by BaGdF 5 :Yb 3+ ,Er 3+ nanoparticle was synthesized by a simple way. The biostability of AuNRs is increased by coating with silver shells, and the AuNR@Ag nanoparticles can be used as excellent surface enhanced Raman scattering (SERS) probe. Moreover, the modification of BaGdF 5 :Yb 3+ ,Er 3+ nanoparticles provides the possibility of real-time optical imaging of the tumor area. Under the irradiation of NIR laser, the AuNR@Ag/BaGdF 5 :Yb 3+ ,Er 3+ nanocomposites (NCs) have strong upconversion emission and excellent photothermal conversion efficiency. Meanwhile, the NCs show low cytotoxicity and good biocompatibility in MTT cytotoxicity test. Moreover, the NCs are also exceptional contrast agents for CT imaging. For in vitro photothermal therapy test, NCs show excellent killing efficiency on tumor cells. Therefore, the multifaceted research of AuNR@Ag/BaGdF 5 :Yb 3+ ,Er 3+ multifunctional nanomaterials provides a break for high-efficiency tumor photothermal therapy and multimodal imaging.
研究领域:
纳米技术
·
癌症治疗
·
生物医学工程
·
材料科学
·
光学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）